scholarly journals Exposure to a Farm Environment During Pregnancy Increases the Proportion of Arachidonic Acid in the Cord Sera of Offspring

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 238 ◽  
Author(s):  
Malin Barman ◽  
Karin Jonsson ◽  
Agnes E. Wold ◽  
Ann-Sofie Sandberg
Keyword(s):  
Fatty Acids ◽  
Arachidonic Acid ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Breast Milk ◽  
Acid Composition ◽  
Post Partum ◽  
Maternal Diet ◽  
Circulation System ◽  
Adrenic Acid

Growing up in a farm environment is protective against allergy development. Various explanations have been put forward to explain this association. Fatty acids are regulators of immune function and the composition of fatty acids in the circulation system may affect immune development. Here, we investigate whether the fatty acid composition of cord serum differs for infants born to Farm (n = 26) or non-Farm mothers (n =29) in the FARMFLORA birth-cohort. For comparison, the levels of fatty acids in the maternal diet, serum and breast milk around 1 month post-partum were recorded. The fatty acids in the cord sera from infants born to Farm mothers had higher proportions of arachidonic acid (20:4 n-6) and adrenic acid (22:4 n-6) than those from infants born to non-Farm mothers. No differences were found for either arachidonic acid or adrenic acid in the diet, samples of the serum, or breast milk from Farm and non-Farm mothers obtained around 1 month post-partum. The arachidonic and adrenic acid levels in the cord blood were unrelated to allergy outcome for the infants. The results suggest that a farm environment may be associated with the fatty acid composition to which the fetus is exposed during pregnancy.

scholarly journals Dietary Fatty Acids and Host–Microbial Crosstalk in Neonatal Enteric Infection

Nutrients ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 2064 ◽  
Author(s):  
Candice Quin ◽  
Deanna L. Gibson
Keyword(s):  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Breast Milk ◽  
Acid Composition ◽  
Disease Susceptibility ◽  
Dietary Fatty Acids ◽  
Enteric Infection ◽  
Human Breast Milk ◽  
Human Breast

Human milk is the best nutritional choice for infants. However, in instances where breastfeeding is not possible, infant formulas are used as alternatives. While formula manufacturers attempt to mimic the performance of human breast milk, formula-fed babies consistently have higher incidences of infection from diarrheal diseases than those breastfed. Differences in disease susceptibility, progression and severity can be attributed, in part, to nutritional fatty acid differences between breast milk and formula. Despite advances in our understanding of breast milk properties, formulas still present major differences in their fatty acid composition when compared to human breast milk. In this review, we highlight the role of distinct types of dietary fatty acids in modulating host inflammation, both directly and through the microbiome-immune nexus. We present evidence that dietary fatty acids influence enteric disease susceptibility and therefore, altering the fatty acid composition in formula may be a potential strategy to improve infectious outcomes in formula-fed infants.

Occurrence of Conjugated Polyenoic Fatty Acids in Seaweeds from the Indian Ocean

2004 ◽  
Vol 59 (5-6) ◽  
pp. 310-314 ◽  
Author(s):  
Narayan Bhaskar ◽  
Tomohisa Kinami ◽  
Kazuo Miyashita ◽  
Si-Bum Park ◽  
Yasushi Endo ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Arachidonic Acid ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Indian Ocean ◽  
Eicosapentaenoic Acid ◽  
Acid Composition ◽  
Lipid Classes ◽  
Conjugated Polyenes ◽  
The Indian Ocean

Three species of red marine macro algae (Rhodophyta) from the Indian Ocean were analysed for the occurrence of conjugated polyenes. The composition of different lipid classes in these seaweeds along with their fatty acid composition has also been reported. Analysis of lipid classes of these seaweeds revealed that both Acanthophora spicifera (Ceramiales, Rhodophyta) and two species of Gracilaria, viz. G. edulis and G. folifera (Gracilariales, Rhodophyta) were rich in glycolipids followed by neutral- and phospholipids. The fatty acid composition of these seaweeds revealed C16:0 as the predominant fatty acid in all three species. However, A. spicifera had significantly higher amounts of eicosapentaenoic acid (EPA) and arachidonic acid (AA) as compared to negligible amount of these fatty acids in both species of Gracilaria. The red seaweed Acanthophora spicifera contained conjugated eicosapentaenoic acid (CEPA) and conjugated arachidonic acid (CAA) in all lipid classes except glycolipids.

scholarly journals The influence of dietary fatty acid composition on N-ethyl-N- nitrosourea-induced mammary tumour incidence in the rat and on the composition of inositol- and ethanolamine-phospholipids of normal and tumour mammary tissue

1994 ◽  
Vol 71 (4) ◽  
pp. 543-552 ◽  
Author(s):  
Christinem Williams ◽  
Karen Maunder
Keyword(s):  
Fatty Acids ◽  
Arachidonic Acid ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Fish Oil ◽  
Olive Oil ◽  
Acid Composition ◽  
Dietary Fatty Acid ◽  
Tumour Tissue ◽  
Maize Oil

This study has investigated the influence of dietary fatty acid composition on mammary tumour incidence in N-ethyl-N-nitrosourea (ENU)-treated rats and has compared the susceptibility to dietary fatty acid modification of the membrane phospholipids phosphatidylinositol (PI) and phosphatidylethanolamine (PE) from normal and tumour tissue of rat mammary gland. The incidence of mammary tumours was significantly lower in fish oil- (29%), compared with olive oil- (75%; P < 0.04) but not maize oil-(63%; P < 0.1) fed animals. No differences in PI fatty acid composition were found in normal or tumour tissue between rats fed on maize oil, olive oil or fish oil in diets from weaning. When normal and tumour tissue PI fatty acids were compared, significantly higher amounts of stearic acid (18:0) were found in tumour than normal tissue in rats given olive oil (P < 0.05). A similar trend was found in animals fed on maize oil, although differences between normal and tumour tissue did not reach a level of statistical significance (P < 0.1). In mammary PE, maize oil-fed control animals had significantly higher levels of linoleic acid (18:2n−6) than either olive oil- or fish oil-fed animals (P < 0.05, both cases) and levels of arachidonic acid were also higher in maize oil- compared with fish oil-fed animals (P < 0.05). In tumour-bearing animals no differences in PE fatty acid composition were found between the three dietary groups. When normal and tumour tissue PE fatty acids were compared, significantly lower amounts of linoleic acid (18:2n-6; P < 0.01) and significantly greater amounts of arachidonic acid (20:4n−6; P < 0.05) were found in tumour than normal tissue of rats fed on maize oil. The present study shows that the fatty acid composition of PI from both normal and tumour tissue of the mammary gland is resistant to dietary fatty acid modification. The PE fraction is more susceptible to dietary modification and in this fraction there is evidence of increased conversion of linoleic acid to arachidonic acid in tumour compared with normal tissue. Lower tumour incidence rates in rats given fish oils may in part be due to alteration in prostanoid metabolism secondary to displacement of arachidonic acid by eicosapentaenoic acid, but PE rather than PI would appear to be the most likely locus for diet-induced alteration in prostanoid synthesis in this tissue. Effects of dietary fatty acids other than on the balance of n−6 and n−3 fatty acids, and on prostanoid metabolism, should also be considered. The significance of increased stearic acid content of PI in tumours of olive oil-fed animals and the possible influence of dietary fatty acids on the capacity for stearic acid accumulation requires further study.

scholarly journals Inflammatory response to dietary linoleic acid depends on FADS1 genotype

2019 ◽  
Vol 109 (1) ◽  
pp. 165-175 ◽  
Author(s):  
Maria A Lankinen ◽  
Alexander Fauland ◽  
Bun-ichi Shimizu ◽  
Jyrki Ågren ◽  
Craig E Wheelock ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Arachidonic Acid ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Linoleic Acid ◽  
Acid Composition ◽  
Plasma Lipids ◽  
Fasting Glucose ◽  
Saturated Fatty Acids ◽  
Limited Information

ABSTRACT Background The health benefits of substituting dietary polyunsaturated fatty acids (PUFAs) for saturated fatty acids are well known. However, limited information exists on how the response to dietary intake of linoleic acid (LA; 18:2n–6) is modified by polymorphisms in the fatty acid desaturase (FADS) gene cluster. Objectives The aim of the current study was to test the hypothesis that the FADS1 rs174550 genotype modifies the effect of dietary LA intake on the fatty acid composition of plasma lipids, fasting glucose, and high-sensitivity C-reactive protein (hsCRP). Methods Associations were investigated between genotype, plasma PUFAs, fasting glucose, and hsCRP concentrations in the cross-sectional, population-based Metabolic Syndrome in Men cohort (n = 1337). In addition, 62 healthy men from the cohort who were homozygotes for the TT or CC genotype of the FADS1 rs174550 were recruited to a 4-wk intervention (FADSDIET) with an LA-enriched diet. The fatty acid composition of plasma PUFAs and concentrations of plasma fasting glucose, serum hsCRP, and plasma lipid mediators (eicosanoids and related analogs) were measured at the beginning and end of the 4-wk intervention period. Results In the FADSDIET trial, the plasma LA proportion increased in both genotype groups in response to an LA-enriched diet. Responses in concentrations of serum hsCRP and plasma fasting glucose and the proportion of arachidonic acid (20:4n–6) in plasma phospholipids and cholesteryl esters differed between genotype groups (interaction of diet × genotype, P < 0.05). In TT homozygous subjects, plasma eicosanoid concentrations correlated with the arachidonic acid proportion in plasma and with hsCRP (r = 0.4–0.7, P < 0.05), whereas in the CC genotype there were no correlations. Conclusions Our findings show that the FADS1 genotype modifies metabolic responses to dietary LA. The emerging concept that personalized dietary counseling should be modified by the FADS1 genotype needs to be tested in larger randomized trials. The study was registered at clinicaltrials.gov as NCT02543216.

scholarly journals Tissue lipids in calves suffering from muscular dystrophy

1966 ◽  
Vol 20 (2) ◽  
pp. 245-256 ◽  
Author(s):  
Ritva Poukka
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acids ◽  
Arachidonic Acid ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Muscular Dystrophy ◽  
Acid Composition ◽  
Acid Content ◽  
Monounsaturated Fatty Acids ◽  
Healthy Controls

1. Lipids of the heart muscle, skeletal muscle and liver were investigated in healthy calves and in calves suffering from enzootic muscular dystrophy with special regard to the fatty acid composition of the phospholipids and triglycerides. 2. Healthy young calves and older calves differed in the fatty acid composition of these tissues. The tissue phospholipids of healthy young calves contained less linoleic acid and more monounsaturated fatty acids than those of older calves. Of the saturated fatty acids, palmitic acid content tended to be higher in young calves and stearic acid content tended to be higher in older calves. 3. The stearic acid content of tissue triglycerides was lower in young calves than in older calves. 4. Fatty aldehydes were present in the phospholipid fraction of the heart muscle and of the skeletal muscle. Stearaldehyde content was higher in older calves than in young calves. 5. In calves with muscular dystrophy definite changes in the fatty acid composition of the phospholipids were found. In young calves the content of linoleic acid was higher and that of monounsaturated fatty acids lower in tissues of diseased animals than in the corresponding tissues of healthy controls. Both in young and older calves arachidonic acid content was higher in the degenerated areas of the skeletal muscle than in the healthy controls. 6. Possible relationships between the tocopherol and arachidonic acid contents of the tissues are discussed. 7. In the triglyceride fraction the differences between diseased and healthy tissues were less significant than in the phospholipid fraction in young calves. In older calves no significant differences were found. 8. An increase in lipid content was found in the degenerated areas of the skeletal muscle and a decrease in livers from diseased animals. An increase in free cholesterol was found in the degenerated areas of the skeletal muscle. The triglyceride content of livers from diseased animals was decreased. The relative proportion of phospholipids was less in skeletal muscle and higher in liver of diseased animals than in the corresponding tissues of healthy controls.

scholarly journals The influence of a maternal diet rich in linoleic acid on brain and retinal docosahexaenoic acid in the rat

1984 ◽  
Vol 51 (1) ◽  
pp. 57-66 ◽  
Author(s):  
T. A. B. Sanders ◽  
M. Mistry ◽  
D. J. Naismith
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Linoleic Acid ◽  
Docosahexaenoic Acid ◽  
Acid Composition ◽  
Post Partum ◽  
Maternal Diet ◽  
Docosapentaenoic Acid ◽  
Female Rats ◽  
Animal Fats

1. Female rats were given throughout pregnancy and lactation a semi-synthetic diet, in which the fat was provided entirely by a soft margarine rich in linoleic acid (18:2ω6) or by mixture of butter and lard, and the influence on the fatty acid composition of fetal and pup brain and retinal phosphoglycerides was studied.2. The percentage of docosahexaenoic acid (22:6ω3) was much lower but that of docosapentaenoic acid (22:5ω6) was correspondingly higher in the brains of the day-22 fetuses and the 21-d-old pups from the margarine group compared with those from the group given the animal fats. Similar changes were noted in the synaptosomal and retinal phosphoglycerides, being most marked in the ethanolamine phosphoglycerides.3. The remaining pups from two groups were weaned on day 21 post partum on to the same stock diet that contained preformed 22:6ω3. After 9 weeks of this diet, the differences between the two groups in the fatty acid composition of the brain phosphoglycerides were barely discernible. The percentage of 22:5ω6 had decreased and had been replaced by 22:6ω3.4. It is concluded that the consequences of consuming a diet rich in linoleic acid and almost devoid of 22:6ω3 on brain fatty acid composition deserve consideration in man.

scholarly journals Polyunsaturated fatty acids and conjugated linoleic acid isomers in breast milk are associated with plasma non-esterified and erythrocyte membrane fatty acid composition in lactating women

2006 ◽  
Vol 95 (3) ◽  
pp. 517-524 ◽  
Author(s):  
Alexandre G. Torres ◽  
Jacqueline G. Ney ◽  
Flávia Meneses ◽  
Nádia M. F. Trugo
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Breast Milk ◽  
Acid Composition ◽  
Milk Fatty Acid ◽  
Plasma Nefa ◽  
Chain Pufa ◽  
Long Chain

Maternal adipose tissue is a major contributor to breast milk long-chain fatty acids, probably through the pool of plasma NEFA. The fatty acid composition of the erythrocyte membrane (EM) is a biochemical index of the intake of fatty acids not synthesized endogenously and of PUFA and long-chain PUFA fatty acid status. The present study investigated the associations between breast milk fatty acid composition and the composition of plasma NEFA and of EM fatty acids with special reference to PUFA, long-chain PUFA and conjugated linoleic acid (CLA). The detailed fatty acid composition of mature breast milk was also reported. Thirty-three healthy, lactating Brazilian women donated milk samples; of these, twenty-four also donated blood samples in an observational cross-sectional study. Breast milk fatty acid composition presented several associations with NEFA and EM composition, which explained most (≥50%) of the variability of selected milk PUFA, long-chain PUFA and CLA. Milk CLA was associated with fatty acids that are markers of dairy fat intake in the diet, NEFA and EM. In general, breast milk n-3 fatty acids and CLA, but not n-6 fatty acids, were associated with EM composition, whereas both the n-6 and n-3 fatty acids and CLA in milk were associated with NEFA composition, possibly owing to its role as a direct source of fatty acids for breast milk. These findings emphasize the contribution of the NEFA pool derived from the adipose tissue to the long-chain fatty acid composition of breast milk.

scholarly journals nalysis of Fatty Acid Composition in the Flesh of Boal (Wallagu Attu)

2019 ◽  
Vol 16 (2) ◽  
pp. 477-481
Author(s):  
Pinak Dutta ◽  
Mita Dutta
Keyword(s):  
Fatty Acids ◽  
Arachidonic Acid ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
West Bengal ◽  
Unsaturated Fatty Acids ◽  
Saturated Fatty Acids ◽  
Fish Muscle ◽  
Nervonic Acid

The fatty acid composition of the muscle tissue of Wallagu attu found in Gangetic West Bengal, India was investigated to get an insight of its nutritional capacity. The fish muscle proved to be a rich source of both mono and poly unsaturated fatty acids. Of the saturated fatty acids Palmitic and Heneicosanoic acid is detected in considerable amount. Of the MUFA’s present Palmetoleic acid, Elaidic acid, Oleic acid and nervonic acid is found in good amount. Nutritionally important ω-6 PUFA’s like Linoleic acid and Arachidonic acid are found in the fish. EPA and DHA the two star ω-3 PUFA’s whose health benefits are beyond doubt are also detected in the fish. Wallagu attu is generally not farmed as it devours other fishes but considering its nutritional capacity and high market demands, its farming may prove beneficial for consumers and producers.

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