scholarly journals Content of n-3 LC-PUFA in Breast Milk Four Months Postpartum is Associated with Infancy Blood Pressure in Boys and Infancy Blood Lipid Profile in Girls

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 235 ◽  
Author(s):  
Signe Bruun ◽  
Lenie van Rossem ◽  
Lotte Lauritzen ◽  
Steffen Husby ◽  
Lotte Neergaard Jacobsen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Breast Milk ◽  
Lipid Profile ◽  
Hdl Cholesterol ◽  
Blood Lipid ◽  
Blood Lipid Profile ◽  
Long Term Effect ◽  
Maternal Educational Level ◽  
Changes Over Time

Blood pressure (BP) and blood lipid profile (BLP) have been shown to track from childhood into adulthood, and n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) in breast milk have been suggested as mediators of the beneficial long-term effect of breastfeeding on BP and BLP. We aimed to investigate associations between n-3 LC-PUFA content in breast milk at 4 months postpartum and offspring BP and BLP in early life. BP and BLP were measured at 4, 18, and 36 months. Statistical analyses were sex-stratified and adjusted for gestational age, maternal pre-pregnancy body mass index (BMI), and maternal educational level. Based on 336 mother-child dyads, high n-3 LC-PUFA in breast milk was inversely associated with systolic and diastolic BP in boys at 4 months (β = −20.0 (95% CI = −33.4, −6.7), p = 0.004 and β = −10.2 (95% CI = −19.8, −0.5), p = 0.039, respectively); inversely associated with HDL cholesterol, and directly associated with triglyceride in girls at 4 months (β = −0.7 (95% CI = −1.1, −0.3), p = 0.001 and β = 3.1 (95% CI = 1.0, 5.2), p = 0.005, respectively). Associations observed at the later time points were non-significant. Furthermore, we observed sex-specific changes over time in both size and direction of the associations. Our results indicate that early intake of n-3 LC-PUFA can affect early development in cardiometabolic factors such as BP and BLP in a sex-specific manner. Follow-up and further investigation in later childhood is planned.

scholarly journals Potential of garlic (Allium sativum) essence in changing blood lipid profile of hypertension patients with hypercholesterolemia

2019 ◽  
Vol 3 (1) ◽  
pp. 14
Author(s):  
Hadi Hadi ◽  
Suharyo Hadisaputro ◽  
Djamaluddin Ramlan
Keyword(s):  
Blood Pressure ◽  
Lipid Profile ◽  
Effect Size ◽  
Allium Sativum ◽  
Intervention Group ◽  
Hdl Cholesterol ◽  
Blood Lipid ◽  
Control Group ◽  
Blood Lipid Profile ◽  
Significant Difference

Background: As like hypertension, hypercholesterolemia is a major risk factor for cardiovascular disease and hypertension and its complications are one of the highest causes of death in the world.Aims: This study aims to determine the potential of garlic essence (Allium sativum) mixed with honey in changing blood pressure and lipid profile of blood in the hypertension patients with hypercholesterolemia, and to compare the effectiveness with those who received Simvastatin, the most preferred pharmacological treatment of hyperlipidemia.Methods: This research is a quasy experiment study with a Nonequivalent control group design. There were 22 hypercholesterolemia outpatients purposively selected from local health centers. The respondents were then divided equally to (a) a control group where the patients were provided with generic Simvastatin 10 mg single dose taken once in the afternoon, and (b) an intervention group where the respondents received a non-pharmacological supplement of garlic essence in 2 grams honey. The blood pressure and the blood lipid profile were examined before (Pretest) and at the Day 22 after the treatment (Posttest). The collected data was then analyzed using a T-test to define the significant mean difference between two groups, and a Cohen’s effect was measured to interpret the size of changes.Results: Either the additions of Simvastatin or the provision of garlic essence mixed with honey decreased the blood pressure (systole and diastole) and the cholesterol, triglyceride, and LDL cholesterol, but increased the HDL cholesterol. While significant difference was observed for all parameters at the intervention group, the improvement at the control group for triglyceride was not significant (p value = 0.041). Overall, by the Cohen's effect size effect, we can interpret that the changes was moderate for diastole and systole blood pressure, and also triglyceride and DLD-cholesterol; however the effect size was low for Cholesterol and HDL-cholesterol. Conclusion: The findings show the importance of the garlic essence mixed with honey to be offered as a nutritional supplement for hypertensive patients with hypercholesterolemia.  Keywords: Garlic (Allium sativum) essence, Simvastatin, Hypertension, Hypercholesterolemia, Blood pressure, Blood lipid profile.

scholarly journals Blood lipid profile changes in type 2 diabetic rats after tail suspension and reloading

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Shoji Tanaka ◽  
Sachiko Madokoro ◽  
Pleiades Tiharu Inaoka ◽  
Toshiaki Yamazaki
Keyword(s):  
Lipid Profile ◽  
Hdl Cholesterol ◽  
Blood Lipid ◽  
Tail Suspension ◽  
Blood Lipid Profile ◽  
Cholesterol Levels ◽  
Intramuscular Lipid ◽  
Muscle Catabolism ◽  
Activity Dependent

Abstract Purpose The effects of the tail suspension and reloading on the protein and lipid metabolism in muscle and blood in type 2 diabetes mellitus (T2DM) are unclear. This study evaluated the hypothesis that skeletal muscle catabolism is greater in T2DM than in non-diabetes mellitus (non-DM) rats and that the activity-dependent changes in the intramuscular lipid accumulation and blood lipid profile are poorer in T2DM than in non-DM rats. Methods T2DM and non-DM rats were suspended for two weeks followed by reloading for two weeks. The muscle and blood were then examined. Results In contrast to our hypothesis, there was no marked difference between the T2DM and non-DM groups in terms of the skeletal muscle catabolism and activity-dependent changes in intramuscular lipid accumulation. However, the blood lipid profile increased in the T2DM group compared to the non-DM group. One interesting finding in this study was the decrease in non-high-density lipoprotein (non-HDL) cholesterol levels after one week of reloading followed by a significant increase in the non-HDL cholesterol levels after two weeks of reloading in the T2DM group. Conclusion These results suggest that a dramatic increase in activity after a period of inactivity may rapidly improve the blood lipid profile in T2DM rats.

scholarly journals Calcium intake and the associations with faecal fat and energy excretion, and lipid profile in a free-living population

2017 ◽  
Vol 6 ◽  
Author(s):  
Louise Kjølbæk ◽  
Janne K. Lorenzen ◽  
Lesli H. Larsen ◽  
Arne Astrup
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Calcium Intake ◽  
Blood Lipid ◽  
Normal Weight ◽  
Urine Collection ◽  
Free Living ◽  
Blood Lipid Profile ◽  
Habitual Diet

AbstractThe aim of the present study was to investigate the associations between the habitual Ca intake and faecal fat and energy excretion as well as blood lipid profile in free-living normal-weight and overweight individuals. The participants were enrolled for an 8-d period where data from a 7-d diet registration (days 1–7), a 5-d faeces collection (days 3–7), a 2-d urine collection (days 5–7), and anthropometric measurements and a fasting blood sample (day 8) were collected. Analyses showed that dietary Ca intake (g/10 MJ per d) was positively associated with excretion of faecal fat (P = 0·004) and energy (P = 0·031) when adjusted for BMI, age, sex and intake of Ca-containing supplements. However, after adjustment for intake of fibre, the effect of Ca intake disappeared. Nevertheless, total cholesterol (CHOL) and LDL-CHOL concentrations were associated negatively with Ca intake (β −0·62 (95 % CI −0·96, −0·28) mmol/l, P < 0·001, and β −0·49 (95 % CI −0·78, −0·20) mmol/l, P = 0·001, respectively, per 1000 mg/10 MJ per d increase in Ca intake). In conclusion, incorporation of Ca-rich food products in a habitual diet was associated with reduced total CHOL and LDL-CHOL concentrations, which may lower the risk of CVD in the long term.

scholarly journals Egg consumption and blood lipid parameters according to the presence of chronic metabolic disorders: The EVIDENT II Study

2021 ◽  
Author(s):  
Arthur Eumann Mesas ◽  
Miriam Garrido-Miguel ◽  
Rubén Fernández-Rodríguez ◽  
Sofía Fernández Franco ◽  
Cristina Lugones-Sánchez ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Metabolic Disorders ◽  
Metabolic Diseases ◽  
Hdl Cholesterol ◽  
Blood Lipid ◽  
Linear Regression Models ◽  
Blood Lipid Profile ◽  
Cross Sectional ◽  
Egg Consumption ◽  
Lipid Parameters

Abstract Context Egg consumption is one of the main dietary sources of cholesterol, but whether individuals who eat more eggs have a worse blood lipid profile remains controversial. Objective We examined the relationship between egg consumption and lipid parameters and explored whether this relationship changes according to the presence of chronic metabolic disorders. Methods A multicenter cross-sectional study was conducted with adult participants in the EVIDENT II trial. Adjusted linear regression models were stratified by the main chronic metabolic disorders. Results Among the 728 participants (61.9% women, mean age 52.1±11.9 years), the mean egg consumption was equivalent to 5-to-6 eggs per week for a 70 kg individual. In the fully-adjusted analysis, no association was found of egg consumption with total and HDL cholesterol, and triglyceride levels. Furthermore, compared to the first quartile of consumption, the fourth quartile was associated with lower LDL-c levels (coefficient: -7.01; 95%CI: -13.39, -0.62) and a lower LDL-c/HDL-c ratio (coefficient: -0.24, 95%CI: -0.41, -0.06). In the analyses stratified by chronic metabolic diseases, higher egg consumption was not associated with lipid profile in those with obesity, hypertension, type 2 diabetes, dyslipidemia, or treated with hypolipidemic drugs, and was associated with a better lipid profile in participants without these conditions. Conclusions Higher egg consumption was not associated with blood lipids in individuals with chronic metabolic disorders. In individuals without such conditions, the lipid profile was better among those who consumed more eggs. Our findings support current guidelines recommending eggs as part of a healthy diet.

scholarly journals LONG-TERM TRENDS OF THE MAIN BLOOD LIPID PARAMETERS IN SIBERIAN POPULATION

2014 ◽  
Vol 13 (3) ◽  
pp. 32-35
Author(s):  
Yu. P. Nikitin ◽  
S. K. Malyutina ◽  
K. V. Makarenkova
Keyword(s):  
Lipid Profile ◽  
Population Analysis ◽  
Blood Lipid ◽  
Siberian Population ◽  
Blood Lipid Profile ◽  
Long Term Trends ◽  
The Absolute ◽  
Lipid Parameters ◽  
Representative Samples

Aim. To carry out the population analysis of blood lipid profile trends during the period from 1985 to 2005 in Novosibirsk population.Material and methods. The study was carried out based on the databases of two large international epidemiological projects done in Novosibirsk, WHO “MONIСA” and “HAPIEЕ”. The representative samples from nonorganized population of Novosibirsk were tested in compliance with protocol of the projects. The analysis included data of 10272 people aged from 45 to 64 years; among them 4783 were men and 5489 — women.Results. Blood TC, non-HDL–C and LDL–С levels from the citizens of Novosibirsk aged 45–64 were significantly lower in the year 1995: 5,50±0,03 mM/l, 4,07±0,03 and 3,48±0,03 mM/l, respectively. By 2005 these values increased significantly and became higher than those initial in 1985. For women 20-year changes in TC, non-HDL–C and LDL–С levels are more prominent than for men. Trends of blood triglyceride levels are analogous to the changes of the indexes described above: average levels were the lowest in 1995 and the highest — in 2005. During a twenty years period the gradual statistically significant increase of blood HDL–C concentrations was noted: in 1985 its concentration was 1,29±0,01 mM/l, in 1995–1,42±0,01 mM/l (p<0,001), in 2005–1,53±0,004 mM/l (p<0,001). HDL–C level for the first decade (1985–1995) increased at average by 10% for the all tenyear period, and for the twenty-year period — by 18,6%, at that for men the increase was more significant (20,2%) than for women (16,4%). By 1995 the absolute values of atherogenicity coefficient decreased significantly; for women in a greater degree. By 2005 the correlation of pro-atherogenic factor to atherogenic one has slightly increased however stayed lower in relation to 1985.Conclusion. In the year 1995 in Siberian population blood TC, non-HDL–C, LDL–С and TG levels appeared to be lower than in 1985 and 2005. Blood HDL–C content was increasing with each decade. Atherogenicity coefficient decreased during the first decade (by 1995), and during the subsequent years slightly increased for women, but did not change significantly for men.

scholarly journals ANALYSIS OF PREDICTIVE FACTORS OF MORTALITY IN HEMORRHAGIC STROKE PATIENTS AT SOEBANDI HOSPITAL JEMBER

2017 ◽  
Vol 2 (2) ◽  
pp. 134 ◽  
Author(s):  
Rida Darotin ◽  
Nurdiana Nurdiana ◽  
Tina Handayani Nasution
Keyword(s):  
Blood Pressure ◽  
Lipid Profile ◽  
Blood Sugar ◽  
Hemorrhagic Stroke ◽  
Blood Lipid ◽  
Dominant Factor ◽  
P Value ◽  
Elevated Blood ◽  
Stroke Patients ◽  
Blood Lipid Profile

Stroke is a cerebrovascular disease that is often found in developed countries and currently also presents in developing countries, and one of them is in Indonesia. The high prevalence of stroke in Indonesia is affected by several risk factors such as obesity, lack of physical activity, unhealthy diet, smoking, high blood pressure, elevated blood sugar, and elevated blood lipid profile. The purpose of this study was to analyze the relationship between predictors of hemorrhagic stroke such as obesity, blood pressure, blood sugar and blood lipid profile with mortality in hemorrhagic stroke patients in RSD dr. Soebandi Jember. This research was a quantitative research with a retrospective approach. The number of samples was 101 medical record data. Univariate analysis was used to identify the description of each variable, a chi-square test was applied to analyze the correlation between variables, and the logistic regression analysis was applied to identify the most dominant factor influencing mortality of hemorrhagic stroke. The result of bivariate test showed p-value of obesity= 0,039, p-value of blood pressure= 0,478, p-value of blood sugar= 0,04, p-value of blood lipid profile= 0,026. Logistic regression obtained p-value for obesity= 0.043, OR = 2.689; p-value of blood sugar= 0,042, OR = 2,656; p-value of blood lipid profile= 0.069, OR = 3,749. There was a significant association between obesity, blood sugar, and blood lipid profile with mortality in hemorrhagic stroke patients. Obesity and blood sugar are predictors that can be used to predict mortality in hemorrhagic stroke patients, where obesity is the most dominant factor affecting mortality in hemorrhagic stroke patients.

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