scholarly journals Antioxidative Efficacy of a Pistacia Lentiscus Supplement and Its Effect on the Plasma Amino Acid Profile in Inflammatory Bowel Disease: A Randomised, Double-Blind, Placebo-Controlled Trial

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1779 ◽  
Author(s):  
Efstathia Papada ◽  
Alastair Forbes ◽  
Charalampia Amerikanou ◽  
Ljilja Torović ◽  
Nick Kalogeropoulos ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Bowel Disease ◽  
Amino Acid ◽  
Density Lipoprotein ◽  
Pistacia Lentiscus ◽  
Oxidative Stress Biomarkers ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Stress Biomarkers ◽  
Inflammatory Bowel

Oxidative stress is present in patients with Inflammatory Bowel Disease (IBD), and natural supplements with antioxidant properties have been investigated as a non-pharmacological approach. The objective of the present study was to assess the effects of a natural Pistacia lentiscus (PL) supplement on oxidative stress biomarkers and to characterise the plasma-free amino acid (AA) profiles of patients with active IBD (Crohn’s disease (CD) N = 40, ulcerative colitis (UC) N = 20). The activity was determined according to 5 ≤ Harvey Bradshaw Index ≤ 16 or 2 ≤ Partial Mayo Score ≤ 6. This is a randomised, double-blind, placebo-controlled clinical trial. IBD patients (N = 60) were randomly allocated to PL (2.8 g/day) or to placebo for 3 months being under no treatment (N = 21) or under stable medical treatment (mesalamine N = 24, azathioprine N = 14, and corticosteroids N = 23) that was either single medication (N = 22) or combined medication (N = 17). Plasma oxidised, low-density lipoprotein (oxLDL), total serum oxidisability, and serum uric acid were evaluated at baseline and follow-up. OxLDL/LDL and oxLDL/High-Density Lipoprotein (HDL) ratios were calculated. The plasma-free AA profile was determined by applying a gas chromatography/mass spectrometry analysis. oxLDL (p = 0.031), oxLDL/HDL (p = 0.020), and oxLDL/LDL (p = 0.005) decreased significantly in the intervention group. The mean change differed significantly in CD between groups for oxLDL/LDL (p = 0.01), and, in the total sample, both oxLDL/LDL (p = 0.015) and oxLDL/HDL (p = 0.044) differed significantly. Several changes were reported in AA levels. PL ameliorated a decrease in plasma-free AAs seen in patients with UC taking placebo. In conclusion, this intervention resulted in favourable changes in oxidative stress biomarkers in active IBD.

Effects of cranberry beverage on oxidative stress and gut microbiota in subjects with Helicobacter pylori infection: a randomized, double-blind, placebo-controlled trial

2021 ◽  
Author(s):  
Tao Gao ◽  
Meiling Hou ◽  
Bo Zhang ◽  
Xin Pan ◽  
Chengxia Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Helicobacter Pylori ◽  
Gut Microbiota ◽  
Controlled Trial ◽  
Gastric Diseases ◽  
Oxidative Stress Biomarkers ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Stress Biomarkers ◽  
H Pylori

Helicobacter pylori-induced oxidative stress plays an important role in gastric diseases. H. pylori disturbs gut microbiota. The objective is to investigate the effects of cranberry beverages on oxidative stress biomarkers...

scholarly journals Regulation of faecal biomarkers in inflammatory bowel disease patients treated with oral mastiha (Pistacia lentiscus ) supplement: A double-blind and placebo-controlled randomised trial

2018 ◽  
Vol 33 (2) ◽  
pp. 360-369 ◽  
Author(s):  
Efstathia Papada ◽  
Aristea Gioxari ◽  
Charalampia Amerikanou ◽  
Alastair Forbes ◽  
Chara Tzavara ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Randomised Trial ◽  
Pistacia Lentiscus ◽  
Double Blind ◽  
Inflammatory Bowel

scholarly journals Oxidative Stress Biomarkers and Left Ventricular Hypertrophy in Children with Chronic Kidney Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Dorota Drożdż ◽  
Przemko Kwinta ◽  
Krystyna Sztefko ◽  
Zbigniew Kordon ◽  
Tomasz Drożdż ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Left Ventricular ◽  
Low Density ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers

Cardiovascular diseases remain the most frequent cause of morbidity and mortality in patients with chronic kidney disease (CKD). The aim of the study was to assess the association between oxidative stress biomarkers and cardiovascular risk factors and left ventricular hypertrophy in children with CKD.Material and Methods. The studied group consisted of 65 patients aged 1.4–18.6 (mean 11.2) years with stages 1 to 5 CKD. Serum oxidized low-density lipoprotein (oxLDL), protein carbonyl group, creatinine, cystatin C, albumin, lipids, high-sensitivity C-reactive protein, intercellular adhesion molecule-1, insulin, plasma renin activity, and aldosterone levels were measured. Patients were divided into groups depending on CKD stage. Anthropometric measurements, ambulatory blood pressure (BP) measurements, and echocardiography with left ventricular mass (LVM) calculation were performed.Results. Serum oxLDL strongly correlated with creatinine (R=0.246;p=0.048), cystatin C (R=0.346;p=0.006), total cholesterol (R=0.500;p<0.001), triglycerides (R=0.524;p<0.001), low-density lipoprotein concentrations (R=0.456;p<0.001), and 24 hour BP values of systolic (R=0.492;p=0.002), diastolic (R=0.515;p<0.001), and mean arterial pressure (R=0.537;p<0.001). A significant correlation between oxLDL levels and LVMz-scores (R=0.299;p=0.016) was found.Conclusions. Hypertension and dyslipidemia correlated with lipid oxidation in children with CKD. oxLDLs seem to be valuable markers of oxidative stress in CKD patients, correlating with left ventricular hypertrophy.

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