scholarly journals Bee Collected Pollen with Enhanced Health Benefits, Produced by Fermentation with a Kombucha Consortium

Nutrients ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1365 ◽  
Author(s):  
Elena Uțoiu ◽  
Florentina Matei ◽  
Agnes Toma ◽  
Camelia Diguță ◽  
Laura Ștefan ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Soluble Sugar ◽  
Health Benefits ◽  
Short Chain Fatty Acids ◽  
Sem Images ◽  
Pollen Content ◽  
Health Related ◽  
Anti Oxidant ◽  
Soluble Silicon

The bioavailability of pollen bioactive compounds for humans is limited. In this study, our aim was to enhance the health-related benefits of pollen by fermentation with a Kombucha/SCOBY (symbiotic culture of bacteria and yeasts) consortium. We performed the fermentation of pollen suspended from the beginning with SCOBY on sweetened green tea or on Kombucha vinegar, by adding pollen after 20 days of Kombucha fermentation. We analyzed: formation of bioactive compounds (anti-oxidant polyphenols, soluble silicon, hydroxy-acids, short chain fatty acids—SCFA); parameters related to Kombucha fermentation (dynamics of lactic acid bacteria—LAB, formation of organic acids, soluble sugar evolution on Kombucha vinegar); the influence of Kombucha fermentation on pollen morphology and ultrastructure; in vitro cytotoxic and antitumoral effects of the Kombucha fermented pollen. The pollen addition increases LAB proportion in the total number of SCOBY microbial strains. SEM images highlight the adhesion of the SCOBY bacteria to pollen. Ultrastructural analysis reveals the release of the pollen content. The content of bioactive compounds (polyphenols, soluble silicon species and SCFA) is higher in the fermented pollen and the product shows a moderate antitumoral effect on Caco-2 cells. The health benefits of pollen are enhanced by fermentation with a Kombucha consortium.

scholarly journals Beneficial Effects of Marine Algae-Derived Carbohydrates for Skin Health

2018 ◽  
Author(s):  
Ji Hye Kim ◽  
Jae-Eun Lee ◽  
Kyoung Heon Kim ◽  
Nam Joo Kang
Keyword(s):  
Bioactive Compounds ◽  
Marine Algae ◽  
Health Benefits ◽  
Value Added ◽  
Skin Aging ◽  
Beneficial Effects ◽  
Cosmetic Formulations ◽  
Health Promoting ◽  
Anti Oxidant ◽  
Thickening Agents

Marine algae have been considered as abundant source of bioactive compounds with cosmeceutical potential. Recently, a great deal of interest has focused on the health-promoting effects of marine bioactive compounds. Carbohydrate is a major and abundant constitute of marine algae that have been utilized in cosmetic formulations, such as moisturizing and thickening agents. In addition, marine carbohydrates have been suggested as promising bioactive biomaterials for various skin beneficial properties, such as anti-oxidant, anti-melanogenic and anti-skin aging. Therefore, marine algae carbohydrates have potential of skin health benefits for value-added cosmeceutical application. The present review focused on the various biological capacities and potential skin health benefits of bioactive marine carbohydrates.

scholarly journals Preparation and characterization of Pomegranate for Cough Treatment

2021 ◽  
Vol 9 (12) ◽  
pp. 2227-2233
Author(s):  
Mr. Chate Mahesh Madhukar
Keyword(s):  
Health Management ◽  
Neuroprotective Effect ◽  
Health Benefits ◽  
In Vivo Studies ◽  
Promoting Effect ◽  
Health Promoting ◽  
Anti Oxidant

Abstract: Pomegranates fruits have innumerable health benefits and its implication in diseases cure have been widely recognized since ancient time. Moreover, pomegranate fruits, seeds and peels are intensively used in traditional medicine as a natural therapy. It contains numerous valuable ingredients such as flavonoids, ellagitannin, punicalagin, ellagic acid, vitamins and minerals. The principal constituents including punicalagins and ellagitannin are responsible for immeasurable health benefits due to its strong antioxidant activity. Additionally, constituents of pomegranate show health promoting effect through the modulation of physiological and biochemical pathways. Recent evidences suggested that pomegranates fruits, peels and seeds illustrate therapeutics implications in health management via inhibition of free radical effect and modulation of enzymes activity linked with diseases development and progression. In this review, we summarize the therapeutic role of pomegranate fruits, seeds and peels in the health managements based on in vitro and in vivo studies. Keywords: Pomegranates, Anti-oxidant, Anti-inflammatory effect, Heptoprotective effect, Neuroprotective effect and antimicrobial effects.

scholarly journals Effects of in vitro metabolism of a broccoli leachate, glucosinolates and S-methylcysteine sulphoxide on the human faecal microbiome

2020 ◽  
Author(s):  
Lee Kellingray ◽  
Gwénaëlle Le Gall ◽  
Joanne F. Doleman ◽  
Arjan Narbad ◽  
Richard F. Mithen
Keyword(s):  
Health Benefits ◽  
Short Chain Fatty Acids ◽  
Bacterial Isolates ◽  
Important Food ◽  
Human Gut ◽  
Important Food Source ◽  
And Function ◽  
Faecal Microbiome

Abstract Purpose Brassica are an important food source worldwide and are characterised by the presence of compounds called glucosinolates. Studies indicate that the glucosinolate derived bioactive metabolite sulphoraphane can elicit chemoprotective benefits on human cells. Glucosinolates can be metabolised in vivo by members of the human gut microbiome, although the prevalence of this activity is unclear. Brassica and Allium plants also contain S-methylcysteine sulphoxide (SMCSO), that may provide additional health benefits but its metabolism by gut bacteria is not fully understood. Methods We examined the effects of a broccoli leachate (BL) on the composition and function of human faecal microbiomes of five different participants under in vitro conditions. Bacterial isolates from these communities were then tested for their ability to metabolise glucosinolates and SMCSO. Results Microbial communities cultured in vitro in BL media were observed to have enhanced growth of lactic acid bacteria, such as lactobacilli, with a corresponding increase in the levels of lactate and short-chain fatty acids. Members of Escherichia isolated from these faecal communities were found to bioconvert glucosinolates and SMCSO to their reduced analogues. Conclusion This study uses a broccoli leachate to investigate the bacterial-mediated bioconversion of glucosinolates and SMCSO, which may lead to further products with additional health benefits to the host. We believe that this is the first study that shows the reduction of the dietary compound S-methylcysteine sulphoxide by bacteria isolated from human faeces.

scholarly journals Phytochemicals Derived from Catharanthus roseus and Their Health Benefits

Technologies ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 80
Author(s):  
Hong Ngoc Thuy Pham ◽  
Quan Van Vuong ◽  
Michael C. Bowyer ◽  
Christopher J. Scarlett
Keyword(s):  
Bioactive Compounds ◽  
Catharanthus Roseus ◽  
Anticancer Agents ◽  
Human Cancer ◽  
Biological Activities ◽  
Health Benefits ◽  
Traditional Use ◽  
Human Cancer Cell Lines ◽  
Promising Source

Catharanthus roseus (C. roseus) is an important medicinal plant distributed in many countries. It has attracted increasing attention due to it being shown to possess a range of phytochemicals with various biological activities such as antioxidant, antibacterial, antifungal, antidiabetic and anticancer properties. Remarkably, vinblastine and vincristine isolated from this plant were the first plant-derived anticancer agents deployed for clinical use. Recently, new isolated indole alkaloids from this plant including catharoseumine, 14′,15′-didehydrocyclovinblastine, 17-deacetoxycyclovinblastine and 17-deacetoxyvinamidine effectively inhibited human cancer cell lines in vitro. Moreover, vindoline, vindolidine, vindolicine and vindolinine isolated from C. roseus leaf exhibited in vitro antidiabetic property. These findings strongly indicate that this plant is still a promising source of bioactive compounds, which should be further investigated. This paper provides an overview of the traditional use and phytochemical profiles of C. roseus, and summarises updated techniques of the preparation of dried material, extraction and isolation of bioactive compounds from this plant. In addition, purported health benefits of the extracts and bioactive compounds derived from this plant were also addressed to support their potential as therapeutic agents.

scholarly journals Bioactive Compounds, Antioxidants, and Health Benefits of Sweet Potato Leaves

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1820
Author(s):  
Hoang Chinh Nguyen ◽  
Chang-Chang Chen ◽  
Kuan-Hung Lin ◽  
Pi-Yu Chao ◽  
Hsin-Hung Lin ◽  
...  
Keyword(s):  
Sweet Potato ◽  
Bioactive Compounds ◽  
Ipomoea Batatas ◽  
Current Knowledge ◽  
Health Benefits ◽  
Health Promoting ◽  
New Compounds ◽  
Sweet Potato Leaves

Sweet potato (Ipomoea batatas) is one of the most important food crops worldwide and its leaves provide a dietary source of nutrients and various bioactive compounds. These constituents of sweet potato leaves (SPL) vary among varieties and play important roles in treating and preventing various diseases. Recently, more attentions in health-promoting benefits have led to several in vitro and in vivo investigations, as well as the identification and quantification of bioactive compounds in SPL. Among them, many new compounds have been reported as the first identified compounds from SPL with their dominant bioactivities. This review summarizes the current knowledge of the bioactive compositions of SPL and their health benefits. Since SPL serve as a potential source of micronutrients and functional compounds, they can be further developed as a sustainable crop for food and medicinal industries.

scholarly journals Bioactive Properties of Peptides and Polysaccharides Derived from Peanut Worms: A Review

Marine Drugs ◽  
2021 ◽  
Vol 20 (1) ◽  
pp. 10
Author(s):  
Yi Qi ◽  
Jingyi Zhou ◽  
Xiaoqin Shen ◽  
Meram Chalamaiah ◽  
Simin Lv ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Molecular Mechanisms ◽  
Shallow Waters ◽  
Bioactive Properties ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Pharmaceutical Industries ◽  
Marine Worms

Peanut worms (Sipunculids) are unsegmented marine worms that usually inhabit shallow waters. Peanut worms are good source of bioactive compounds including peptides and polysaccharides. Many recent studies have investigated the bioactive properties of peptides and polysaccharides derived from peanut worms in order to enhance their applications in food and pharmaceutical industries. The peptides and polysaccharides isolated from peanut worms have been reported to possess anti-hypertensive, anti-oxidant, immunomodulatory, anti-inflammatory, anti-cancer, anti-hypoxia and wound healing activities through the modulation of various molecular mechanisms. Most researchers used in vitro, cell culture and animal models for the determination of bioactivities of peanut worm derived compounds. However, studies in humans have not been performed considerably. Therefore, it is important to conduct more human studies for better utilization of marine bioactive compounds (peptides and polysaccharides) derived from peanut worms. This review mainly focuses on the bioactive properties of peptides and polysaccharides of peanut worms and their molecular mechanisms.

scholarly journals In Vitro Evaluation of Prebiotic Properties of a Commercial Artichoke Inflorescence Extract Revealed Bifidogenic Effects

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1552 ◽  
Author(s):  
Pieter Van den Abbeele ◽  
Jonas Ghyselinck ◽  
Massimo Marzorati ◽  
Agusti Villar ◽  
Andrea Zangara ◽  
...  
Keyword(s):  
Short Chain Fatty Acids ◽  
Gas Pressure ◽  
Microbial Metabolites ◽  
Short Term ◽  
Dry Extract ◽  
Health Related ◽  
Lactate Levels ◽  
Lactobacillus Spp ◽  
Measuring Ph

Background: Prebiotics used as a dietary supplement, stimulate health-related gut microbiota (e.g., bifidobacteria, lactobacilli, etc.). This study evaluated potential prebiotic effects of an artichoke aqueous dry extract (AADE) using in vitro gut model based on the Simulator of Human Intestinal Microbial Ecosystem (SHIME®). Methods: Short-term colonic fermentations (48 h) of AADE, fructo-oligosaccharides (FOS), and a blank were performed. Microbial metabolites were assessed at 0, 6, 24, and 48 h of colonic incubation via measuring pH, gas pressure, lactate, ammonium, and short-chain fatty acids (SCFAs) levels. Community composition was assessed via targeted qPCRs. Results: After 24 and 48 h of incubation, bifidobacteria levels increased 25-fold with AADE (p < 0.05) and >100-fold with FOS (p < 0.05) compared to blank. Lactobacillus spp. levels only tended to increase with AADE, whereas they increased 10-fold with FOS. At 6 h, pH decreased with AADE and FOS and remained stable until 48 h; however, gas pressure increased significantly till the end of study. Acetate, propionate, and total SCFA production increased significantly with both at all time-points. Lactate levels initially increased but branched SCFA and ammonium levels remained low till 48 h. Conclusion: AADE displayed prebiotic potential by exerting bifidogenic effects that stimulated production of health-related microbial metabolites, which is potentially due to inulin in AADE.

scholarly journals Community Metabolic Interactions, Vitamin Production and Prebiotic Potential of Medicinal Herbs Used for Immunomodulation

2021 ◽  
Vol 12 ◽  
Author(s):  
Christine T. Peterson ◽  
Stanislav N. Iablokov ◽  
Sasha Uchitel ◽  
Deepak Chopra ◽  
Josue Perez-Santiago ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Immune Function ◽  
Immune Cell ◽  
Health Benefits ◽  
Cell Types ◽  
Short Chain Fatty Acids ◽  
Medicinal Herbs ◽  
Vitamin Production

Historically, the health benefits and immunomodulatory potential of medicinal herbs have been considered an intrinsic quality of the herb itself. We have hypothesized that the health benefits of medicinal herbs may be partially due to their prebiotic potential that alter gut microbiota leading to changes in short chain fatty acids and vitamin production or biotransformation of herb encoded molecules and secondary metabolites. Accumulating studies emphasize the relationship between the gut microbiota and host immune function. While largely unknown, these interactions are mediated by secreted microbial products that activate or repress a variety of immune cell types. Here we evaluated the effect of immunomodulatory, medicinal Ayurvedic herbs on gut microbiota in vitro using 16S rRNA sequencing to assess changes in community composition and functional potential. All immunomodulatory herbs displayed substantial prebiotic potential, targeting unique taxonomic groups. Application of genome reconstruction and analysis of biosynthetic capacity of herb selected communities suggests that many of the 11 herbs tested altered the community metabolism as the result of differential glycan harvest and sugar utilization and secreted products including multiple vitamins, butyrate, and propionate that may impact host physiology and immune function. Taken together, these results provide a useful framework for the further evaluation of these immunomodulatory herbs in vivo to maintain immune homeostasis or achieve desired regulation of immune components in the context of disease.

scholarly journals Inhibitory Effects of Pulse Bioactive Compounds on Cancer Development Pathways

Diseases ◽  
2018 ◽  
Vol 6 (3) ◽  
pp. 72 ◽  
Author(s):  
Shiwangni Rao ◽  
Kenneth Chinkwo ◽  
Abishek Santhakumar ◽  
Christopher Blanchard
Keyword(s):  
Fatty Acids ◽  
Bioactive Compounds ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Cancer Development ◽  
In Vivo Studies ◽  
Culture Models ◽  
Chain Fatty Acids

Previous studies suggest that pulses may have the potential to protect against cancer development by inhibiting pathways that result in the development of cancer. These pathways include those that result in inflammation, DNA damage, cell proliferation, and metastasis. Other studies have demonstrated extracts from pulses have the capacity to induce apoptosis specifically in cancer cells. Compounds reported to be responsible for these activities have included phenolic compounds, proteins and short chain fatty acids. The majority of the studies have been undertaken using in vitro cell culture models, however, there are a small number of in vivo studies that support the hypothesis that pulse consumption may inhibit cancer development. This review highlights the potential benefit of a diet rich in pulse bioactive compounds by exploring the anti-cancer properties of its polyphenols, proteins and short chain fatty acids.

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