scholarly journals Human Milk Oligosaccharides: 2′-Fucosyllactose (2′-FL) and Lacto-N-Neotetraose (LNnT) in Infant Formula

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1161 ◽  
Author(s):  
Yvan Vandenplas ◽  
Bernard Berger ◽  
Virgilio Carnielli ◽  
Janusz Ksiazyk ◽  
Hanna Lagström ◽  
...  
Keyword(s):  
Human Milk ◽  
Infant Formula ◽  
Normal Growth ◽  
In Vivo Studies ◽  
Published Evidence ◽  
Need To Evaluate ◽  
Health Promoting ◽  
Changes Over Time

The authors reviewed the published evidence on the presence of oligosaccharides in human milk (HMO) and their benefits in in vitro and in vivo studies. The still limited data of trials evaluating the effect of mainly 2′-fucosyllactose (2′-FL) on the addition of some of HMOs to infant formula were also reviewed. PubMed was searched from January 1990 to April 2018. The amount of HMOs in mother’s milk is a dynamic process as it changes over time. Many factors, such as duration of lactation, environmental, and genetic factors, influence the amount of HMOs. HMOs may support immune function development and provide protection against infectious diseases directly through the interaction of the gut epithelial cells or indirectly through the modulation of the gut microbiota, including the stimulation of the bifidobacteria. The limited clinical data suggest that the addition of HMOs to infant formula seems to be safe and well tolerated, inducing a normal growth and suggesting a trend towards health benefits. HMOs are one of the major differences between cow’s milk and human milk, and available evidence indicates that these components do have a health promoting benefit. The addition of one or two of these components to infant formula is safe, and brings infant formula closer to human milk. More prospective, randomized trials in infants are need to evaluate the clinical benefit of supplementing infant formula with HMOs.

scholarly journals Human Milk Oligosaccharides: 2’-fucosyllactose (2’-FL) and Lacto-N-neotetraose (LNnT) in Infant Formula

2018 ◽  
Author(s):  
Y. Vandenplas ◽  
B. Berger ◽  
V.P. Carnielli ◽  
J. Ksiazyk ◽  
H. Lagström ◽  
...  
Keyword(s):  
Human Milk ◽  
Infant Formula ◽  
Health Benefit ◽  
Normal Growth ◽  
In Vivo Studies ◽  
Published Data ◽  
Published Evidence ◽  
The Many

Introduction The authors reviewed the published evidence on the presence of oligosaccharides in human milk (HMO) and their benefits in in vitro and in vivo studies, as well as to evaluate published data on the addition of some of HMOs to infant formula. Method PubMed was searched from inception to April 2018 Results The presence of HMOs is a dynamic process, determined by many factors such as duration of lactation, environmental and genetic factors. HMOs may support immune function development and provide protection against infectious diseases directly through the interaction of the gut epithelial cells or indirectly through the modulation of the gut microbiota, including the stimulation of the bifidobacteria. Only a few of the many HMOs can be made industrially, and are added to infant formula. They have been shown to be safe and well tolerated, including normal growth and a trend towards health benefit. Conclusions HMOs are one of the major differences between cow’s milk and human milk , and evidence indicates that these components do have a health promoting benefit. The addition of one or two of these components to infant formula is safe, and brings infant formula closer to human milk.

scholarly journals Comparison of the Bifidogenic Effects of Goat and Cow Milk-Based Infant Formulas to Human Breast Milk in an in vitro Gut Model for 3-Month-Old Infants

2020 ◽  
Vol 7 ◽  
Author(s):  
Sophie Gallier ◽  
Pieter Van den Abbeele ◽  
Colin Prosser
Keyword(s):  
Human Milk ◽  
Infant Formula ◽  
Goat Milk ◽  
Cow Milk ◽  
Common Source ◽  
Human Breast Milk ◽  
Infant Formulas ◽  
Infant Gut Microbiome

Human milk contains prebiotic components, such as human milk oligosaccharides (HMOs), which stimulate the growth of specific members of the infant gut microbiota (e.g., Bifidobacteria). Plant-based or synthetic oligosaccharides are often added to infant formulas to simulate the bifidogenic effect of HMOs. Cow milk, the most common source of protein in infant formula, and goat milk, used increasingly in the manufacture of infant formula, contain naturally-occurring prebiotics. This study compared the upper gastrointestinal digestion and subsequent colonic fermentation of human milk vs. goat and cow milk-based infant formulas (goat IF and cow IF, respectively), without additional oligosaccharides using an in vitro model for 3-month-old infants based on the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®). First, a dialysis approach using 3.5 kDa membranes was demonstrated to simulate small intestinal absorption of carbohydrates in conditions similar to those in vivo. During the in vitro digestion experiment, oligosaccharides were detected in human milk and goat IF but barely detected in the cow IF. Further, all three milk matrices decreased colonic pH by boosting acetate, lactate, and propionate production, which related to increased abundances of acetate/lactate-producing Bifidobacteriaceae for human milk (+25.7%) and especially goat IF (33.8%) and cow IF (37.7%). Only cow IF stimulated butyrate production which correlated with an increase in Lachnospiraceae and Clostridiaceae. Finally, Enterobacteriaceae and Acidaminococcaceae also increased with all three milk matrices, while production of proteolytic metabolites (branched-chain fatty acids) was only detected for the cow IF. Overall, goat and cow milk-based formulas without added oligosaccharides impacted gut microbial activity and composition similarly to human milk. This suggests that even without supplementation of formula with oligosaccharides, whole goat milk, whole cow milk and cow milk ingredients already supply compounds in formulas that exert beneficial bifidogenic effects. Further clinical research is warranted to elucidate the effect of whole goat milk-based formulas on the infant gut microbiome.

scholarly journals Preparation and characterization of Pomegranate for Cough Treatment

2021 ◽  
Vol 9 (12) ◽  
pp. 2227-2233
Author(s):  
Mr. Chate Mahesh Madhukar
Keyword(s):  
Health Management ◽  
Neuroprotective Effect ◽  
Health Benefits ◽  
In Vivo Studies ◽  
Promoting Effect ◽  
Health Promoting ◽  
Anti Oxidant

Abstract: Pomegranates fruits have innumerable health benefits and its implication in diseases cure have been widely recognized since ancient time. Moreover, pomegranate fruits, seeds and peels are intensively used in traditional medicine as a natural therapy. It contains numerous valuable ingredients such as flavonoids, ellagitannin, punicalagin, ellagic acid, vitamins and minerals. The principal constituents including punicalagins and ellagitannin are responsible for immeasurable health benefits due to its strong antioxidant activity. Additionally, constituents of pomegranate show health promoting effect through the modulation of physiological and biochemical pathways. Recent evidences suggested that pomegranates fruits, peels and seeds illustrate therapeutics implications in health management via inhibition of free radical effect and modulation of enzymes activity linked with diseases development and progression. In this review, we summarize the therapeutic role of pomegranate fruits, seeds and peels in the health managements based on in vitro and in vivo studies. Keywords: Pomegranates, Anti-oxidant, Anti-inflammatory effect, Heptoprotective effect, Neuroprotective effect and antimicrobial effects.

scholarly journals Bioactive Compounds and Bioactivities of Brassica oleracea L. var. Italica Sprouts and Microgreens: An Updated Overview from a Nutraceutical Perspective

Plants ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 946 ◽  
Author(s):  
Thanh Ninh Le ◽  
Chiu-Hsia Chiu ◽  
Pao-Chuan Hsieh
Keyword(s):  
Brassica Oleracea ◽  
Bioactive Compounds ◽  
Biological Properties ◽  
In Vivo Studies ◽  
Bioactive Constituents ◽  
Potential Health ◽  
Health Promoting ◽  
Brassica Oleracea L

Sprouts and microgreens, the edible seedlings of vegetables and herbs, have received increasing attention in recent years and are considered as functional foods or superfoods owing to their valuable health-promoting properties. In particular, the seedlings of broccoli (Brassica oleracea L. var. Italica) have been highly prized for their substantial amount of bioactive constituents, including glucosinolates, phenolic compounds, vitamins, and essential minerals. These secondary metabolites are positively associated with potential health benefits. Numerous in vitro and in vivo studies demonstrated that broccoli seedlings possess various biological properties, including antioxidant, anticancer, anticancer, antimicrobial, anti-inflammatory, anti-obesity and antidiabetic activities. The present review summarizes the updated knowledge about bioactive compounds and bioactivities of these broccoli products and discusses the relevant mechanisms of action. This review will serve as a potential reference for food selections of consumers and applications in functional food and nutraceutical industries.

scholarly journals Phenolic Compounds from Five Ericaceae Species Leaves and Their Related Bioavailability and Health Benefits

Molecules ◽  
2019 ◽  
Vol 24 (11) ◽  
pp. 2046 ◽  
Author(s):  
Bianca Eugenia Ștefănescu ◽  
Katalin Szabo ◽  
Andrei Mocan ◽  
Gianina Crişan
Keyword(s):  
Phenolic Compounds ◽  
Biological Activities ◽  
Health Impact ◽  
In Vivo Studies ◽  
Chemical Components ◽  
Phenolic Components ◽  
Health Promoting ◽  
Ancient Times

Some species of the Ericaceae family have been intensively studied because of the beneficial health impact, known since ancient times, of their chemical components. Since most studies focus on the effects of fruit consumption, this review aims to highlight the phenolic components present in the leaves. For this purpose, five species from Ericaceae family (bilberry—Vaccinium myrtillus L., lingonberry—V. vitis-idaea L., bog bilberry—V. uliginosum L., blueberry—V. corymbosum L. and bearberry—Arctostapylos uva-ursi L.) were considered, four of which can be found in spontaneous flora. The chemical composition of the leaves revealed three major phenolic compounds: chlorogenic acid, quercetin and arbutin. The health promoting functions of these compounds, such as antioxidant and anti-inflammatory properties that could have preventive effects for cardiovascular disease, neurodegenerative disorders, cancer, and obesity, have been exemplified by both in vitro and in vivo studies in this review. Furthermore, the importance of bioaccessibility and bioavailability of the phenolic compounds have been summarized. The findings highlight the fact that leaves of some Ericaceae species deserve increased attention and should be studied more profoundly for their biological activities, especially those from spontaneous flora.

scholarly journals Ginsenoside Compound K: Insights into Recent Studies on Pharmacokinetics and Health-Promoting Activities

Biomolecules ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 1028 ◽  
Author(s):  
Anshul Sharma ◽  
Hae-Jeung Lee
Keyword(s):  
Clinical Studies ◽  
Water Solubility ◽  
Parent Compound ◽  
Clinical Trial Data ◽  
In Vivo Studies ◽  
Compound K ◽  
Health Promoting ◽  
Preclinical And Clinical Studies

Ginseng (Panax ginseng) is an herb popular for its medicinal and health properties. Compound K (CK) is a secondary ginsenoside biotransformed from major ginsenosides. Compound K is more bioavailable and soluble than its parent ginsenosides and hence of immense importance. The review summarizes health-promoting in vitro and in vivo studies of CK between 2015 and 2020, including hepatoprotective, anti-inflammatory, anti-atherosclerosis, anti-diabetic, anti-cancer, neuroprotective, anti-aging/skin protective, and others. Clinical trial data are minimal and are primarily based on CK-rich fermented ginseng. Besides, numerous preclinical and clinical studies indicating the pharmacokinetic behavior of CK, its parent compound (Rb1), and processed ginseng extracts are also summarized. With the limited evidence available from animal and clinical studies, it can be stated that CK is safe and well-tolerated. However, lower water solubility, membrane permeability, and efflux significantly diminish the efficacy of CK and restrict its clinical application. We found that the use of nanocarriers and cyclodextrin for CK delivery could overcome these limitations as well as improve the health benefits associated with them. However, these derivatives have not been clinically evaluated, thus requiring a safety assessment for human therapy application. Future studies should be aimed at investigating clinical evidence of CK.

scholarly journals Health-Promoting Role of Lactiplantibacillus plantarum Isolated from Fermented Foods

2021 ◽  
Vol 9 (2) ◽  
pp. 349
Author(s):  
Natalia Garcia-Gonzalez ◽  
Natalia Battista ◽  
Roberta Prete ◽  
Aldo Corsetti
Keyword(s):  
Fermented Food ◽  
Starter Cultures ◽  
In Vivo Studies ◽  
Fermented Foods ◽  
Adhesion Ability ◽  
Probiotic Strains ◽  
Health Promoting ◽  
Gastro Intestinal Tract

Fermentation processes have been used for centuries for food production and preservation. Besides the contribution of fermentation to food quality, recently, scientific interest in the beneficial nature of fermented foods as a reservoir of probiotic candidates is increasing. Fermented food microbes are gaining attention for their health-promoting potential and for being genetically related to human probiotic bacteria. Among them, Lactiplantibacillus (Lpb.) plantarum strains, with a long history in the food industry as starter cultures in the production of a wide variety of fermented foods, are being investigated for their beneficial properties which are similar to those of probiotic strains, and they are also applied in clinical interventions. Food-associated Lpb. plantarum showed a good adaptation and adhesion ability in the gastro-intestinal tract and the potential to affect host health through various beneficial activities, e.g., antimicrobial, antioxidative, antigenotoxic, anti-inflammatory and immunomodulatory, in several in vitro and in vivo studies. This review provides an overview of fermented-associated Lpb. plantarum health benefits with evidence from clinical studies. Probiotic criteria that fermented-associated microbes need to fulfil are also reported.

scholarly journals Natural Polyphenols as Modulators of Etoposide Anti-Cancer Activity

2021 ◽  
Vol 22 (12) ◽  
pp. 6602
Author(s):  
Magdalena Kluska ◽  
Katarzyna Woźniak
Keyword(s):  
Fruits And Vegetables ◽  
In Vivo Studies ◽  
Natural Polyphenols ◽  
Naturally Occurring ◽  
Anti Cancer ◽  
Health Promoting ◽  
Synthetic Derivative ◽  
Cancer Activity

Polyphenols are naturally occurring compounds found in abundance in fruits and vegetables. Their health-promoting properties and their use in the prevention and treatment of many human diseases, including cancer, have been known for years. Many anti-cancer drugs are derived from these natural compounds. Etoposide, which is a semi-synthetic derivative of podophyllotoxin, a non-alkaloid lignan isolated from the dried roots and rhizomes of Podophyllum peltatum or Podophyllum emodi (Berberidaceae), is an example of such a compound. In this review, we present data on the effects of polyphenols on the anti-cancer activity of etoposide in in vitro and in vivo studies.

Plant Bioactive Peptides: Current Status and Prospects Towards Use on Human Health

2020 ◽  
Vol 27 ◽  
Author(s):  
Tsun-Thai Chai ◽  
Kah-Yaw Ee ◽  
D. Thirumal Kumar ◽  
Fazilah Abdul Manan ◽  
Fai-Chu Wong
Keyword(s):  
Bioactive Peptides ◽  
Biological Effects ◽  
Natural Antioxidants ◽  
In Vivo Studies ◽  
Current Status ◽  
Plant Peptides ◽  
Potential Applications ◽  
Health Promoting

Abstract: Large numbers of bioactive peptides with potential applications in protecting against human diseases have been identified from plant sources. In this review, we summarized recent progress in the research of plant-derived bioactive peptides, encompassing their production, biological effects, and mechanisms. This review focuses on antioxidant, antimicrobial, antidiabetic, and anticancer peptides, giving special attention to evidence derived from cellular and animal models. Studies investigating peptides with known sequences and well-characterized peptidic fractions or protein hydrolysates will be discussed. The use of molecular docking tools to elucidate inter-molecular interactions between bioactive peptides and target proteins is highlighted. In conclusion, the accumulating evidence from in silico, in vitro and in vivo studies to date supports the envisioned applications of plant peptides as natural antioxidants as well as health-promoting agents. Notwithstanding, much work is still required before the envisioned applications of plant peptides can be realized. To this end, future researches for addressing current gaps were proposed.

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