scholarly journals Dietary Carotenoids Intake and the Risk of Gastric Cancer: A Case—Control Study in Korea

Nutrients ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 1031 ◽  
Author(s):  
Ji Hyun Kim ◽  
Jeonghee Lee ◽  
Il Ju Choi ◽  
Young-Il Kim ◽  
Oran Kwon ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Fruits And Vegetables ◽  
Case Control Study ◽  
Case Control ◽  
Cancer Center ◽  
Inverse Association ◽  
Tomato Ketchup ◽  
Center Hospital ◽  
H Pylori ◽  
Control Study

Although the incidence of gastric cancer (GC) has declined, it remains the second most common cancer in Korea. As a class of phytochemicals, carotenoids are fat-soluble pigments that are abundant in fruits and vegetables and have health-promoting properties, including cancer prevention effects. This case-control study investigated the effects of total dietary carotenoids, dietary carotenoid subclasses (α-carotene, β-carotene, β-cryptoxanthin, lutein/zeaxanthin, and lycopene), and foods contributing to the dietary intake of each carotenoid on the risk of GC. Four hundred and fifteen cases and 830 controls were recruited from the National Cancer Center Hospital in Korea between March 2011 and December 2014. A significant inverse association between total dietary carotenoids and GC risk was observed among women (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.32–0.99). A higher intake of dietary lycopene was inversely associated with GC risk overall in the subjects (OR 0.60, 95% CI 0.42–0.85, p for trend = 0.012), men (OR 0.60, 95% CI 0.39–0.93), and women (OR 0.54, 95% CI 0.30–0.96, p for trend = 0.039). This significant association between dietary lycopene intake and GC risk was also observed in the subgroups of Helicobacter pylori (H. pylori)-positive subjects and those who had ever smoked. Among the major contributing foods of dietary lycopene, consumption of tomatoes and tomato ketchup was inversely associated with GC risk in the overall subjects, men, and women. Based on our findings, a higher intake of dietary lycopene and contributing foods of lycopene (tomatoes and tomato ketchup) may be inversely associated with the risk of GC.

Ethnicity and H. Pylori as Risk Factors for Gastric Cancer in Malaysia: A Prospective Case Control Study

2007 ◽  
Vol 102 (1) ◽  
pp. 40-45 ◽  
Author(s):  
Khean-Lee Goh ◽  
Phaik-Leng Cheah ◽  
Noorfaridah Md ◽  
Kia-Fatt Quek ◽  
Navaratnam Parasakthi
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Case Control Study ◽  
Case Control ◽  
H Pylori ◽  
Control Study ◽  
Prospective Case Control Study

scholarly journals Association between Gastric Cancer with Behavioral and Dietary Factors: A Hospital Based Case-Control Study in South Asia

2021 ◽  
Author(s):  
Arun Shahi ◽  
Venkata Pradeep Babu Koyyala ◽  
Ela Singh Rathaur ◽  
Md. Assaduzaman Biddut ◽  
Anwor Hossain ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Red Meat ◽  
Dietary Factors ◽  
Inverse Association ◽  
Effective Prevention ◽  
Regular Consumption ◽  
History Of ◽  
Control Study

Abstract Background Gastric cancer (GC) is one of the most common malignancies and a leading cause of mortality and morbidity worldwide. It is the fourth leading cancer in Bangladesh. Identification of risk factors, effective prevention, and early diagnosis are the most important interventions against GC. Objectives To find an association of dietary and behavioral factors in the development of GC among the Bangladeshi population. Methods This case–control study was conducted from January 2017 to December 2018 at the National Institute of Cancer Research and Hospital, Dhaka, Bangladesh. A total of 178 patients were studied (89 case and 89 controls). Data were collected via face-to-face interview using a standard structured questionnaire, posing questions about socio-demographic, behavioral and dietary habits, and clinical factors. A binary logistic regression method was used to calculate the odds ratio (OR). Results Among 178 patients, the age group ranged from 30 to 80 years and most patients were between 51 to 60 years. The results showed that regular consumption of red meat, duration of smoking, smokeless tobacco, fast food and fatty food, and family history of any type of cancer were directly associated with the risk of GC. On the contrary, a habit of regular walking and playing sports has an inverse association with GC. Adjusted OR shows regular consumption of red meat has 2.6 times more risk (OR = 2.661) of developing GC compared with irregular meat consumption, and a person with a history of Helicobacter pylori infection is 53% (OR = 7.263; 95% confidence interval: 3.614–14.597) more likely to develop cancer. In contrast, people who were doing exercise regularly for at least 30 minutes/day are 62.7% (OR = 0.373) less likely to develop GC than those who did not. Conclusion The study showed an association of some dietary and behavioral factor in the development of GC. However, more research in this field is required to understand the etiology, for the development of suitable screening test, for demarcation of high-risk population, and to develop and evaluate the effectiveness of primary prevention programs.

scholarly journals Zak Gene֝s Expression in Patients With Helicobacter Pylori Infection

2021 ◽  
Author(s):  
Delniya Khani ◽  
Manouchehr Ahmadi Hedayati ◽  
Farshad Sheikhesmaeili ◽  
Roghaie Ghadiany ◽  
Sherko Nasseri
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Cell Cycle ◽  
Helicobacter Pylori ◽  
Gastric Adenocarcinoma ◽  
Case Control Study ◽  
Case Control ◽  
Rt Pcr ◽  
H Pylori ◽  
Control Study

Abstract Background: ZAK protein is a member of the MLK family proteins defined as mediators in the cell cycle. A survey of zak gene expression in gastric antral epithelial cells (GAECs) of gastritis and gastric adenocarcinoma patients with Helicobacter pylori genotypes infection can elucidate carcinogenesis of H. pylori genotypes.Methods: In a case-control study, zak gene expression was evaluated in GAECs biopsy samples of gastritis patients with (n 23) and without H. pylori infection (n 27) and gastric adenocarcinoma patients with (n 21) and without (n 32) H. pylori infection. The zak gene expression was measured using the relative Real-Time RT PCR.Results: zak gene expression was higher in GAECs of gastritis cancer than in gastric adenocarcinoma, indicating the protective effect of ZAK against gastric cancer (p< 0.005). Conclusion: Reducing zak gene expression has the negative corelations with H. pylori infection and gastric adenocarcinoma.

scholarly journals Risk factors for gastric cancer and related serological levels in Fujian, China: hospital-based case–control study

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e042341
Author(s):  
Ping Yuan ◽  
Lan Lin ◽  
Kuicheng Zheng ◽  
Wen Wang ◽  
Sihan Wu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Case Control Study ◽  
Early Stage ◽  
Case Control ◽  
Early Stage Cancer ◽  
Control Subjects ◽  
H Pylori ◽  
Pickled Vegetables ◽  
Control Study

ObjectiveTo explore the relationships between gastric cancer and serum pepsinogen I (PG I), PG II, PG I/II ratio, gastrin 17 (G-17) and Helicobacter pylori infection, and to investigate dietary and lifestyle risk factors for gastric cancer in Fujian Province, China.DesignA hospital-based, 1:1 matched case–control study.SettingPatients with newly diagnosed gastric cancer were recruited from the Fujian Provincial Hospital and the No. 900 Hospital of the Joint Support Force of the Chinese People’s Liberation Army between July 2014 and December 2016.ParticipantsA total of 180 pairs of patients with gastric cancer and control subjects were recruited in the study, including 134 (74.4%) male pairs and 46 (25.6%) female pairs.Investigation and analysis measuresSerological indicators were tested with ELISA kits. Dietary, lifestyle and psychological factors were investigated through face-to-face questionnaire. Relationships between gastric cancer and these influencing factors were examined by Χ2 test and conditional logistic regression.ResultsSerum PG II and G-17 levels and H. pylori infection rate were higher in patients with gastric cancer than in control subjects (p<0.05), while PG I/II ratio was lower in patients with gastric cancer (p<0.05). Serum G-17 levels were higher in patients with corpus gastric cancer than in patients with antral gastric cancer (p<0.05). Serum PG II levels were higher in patients with advanced gastric cancer than in patients with early-stage cancer (p<0.05), however, PG I/II ratio was lower in patients with advanced-stage gastric cancer than in patients with early-stage cancer (p<0.05). Eating hot food (OR=2.32), eating pickled vegetables (OR=4.05) and often feel troubled (OR=2.21) were found to significantly increase the risk of gastric cancer (all p<0.05), while consuming onion or garlic (OR=0.35), drinking tea (OR=0.26), eating fresh fruits (OR=0.55), and high serum PG I (OR=0.99) or PG I/II ratio (OR=0.73) were found to be protective against gastric cancer.ConclusionStudy results showed that serum PG, G-17 and H. pylori antibodies could be useful indicators for early diagnosis of gastric cancer. Increase in serum G-17 level might indicate the location of gastric cancer. Increase in serum PG II level and decrease in PG I/II ratio might imply the clinical stage. Eating hot food, eating pickled vegetables and often feel troubled may be risk factors for gastric cancer, while eating fresh fruits, eating onion or garlic, and drinking tea may be protective factors against the disease.

scholarly journals Appendicectomy, childhood hygiene, Helicobacter pylori status, and risk of inflammatory bowel disease: a case control study

Gut ◽  
1998 ◽  
Vol 43 (4) ◽  
pp. 494-498 ◽  
Author(s):  
A E Duggan ◽  
I Usmani ◽  
K R Neal ◽  
R F A Logan
Keyword(s):  
Ulcerative Colitis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Case Control Study ◽  
Case Control ◽  
Hot Water ◽  
Inverse Association ◽  
Inflammatory Bowel ◽  
H Pylori ◽  
Control Study

Aims—To examine the relation between inflammatory bowel disease and appendicectomy, childhood domestic hygiene, andHelicobacter pylori infection.Methods—Case control study involving 213 patients with ulcerative colitis, 110 with Crohn’s disease, and 337 controls having elective surgery.Results—Nine patients with ulcerative colitis (4.5%) reported a previous appendicectomy compared with 57 controls (19%) (odds ratio (OR) 0.20, 95% confidence interval (CI) 0.1–0.4, p<0.0001). The inverse association was unaffected by excluding operations performed after the age of onset of ulcerative colitis and was stronger for appendicectomy performed before age 20 (OR 0.14). No association with appendicectomy was found for Crohn’s disease and no associations with tonsillectomy for either disease. The availability of a fixed hot water supply in early childhood (before age 11) was associated with Crohn’s disease (OR for hot water not always versus always available 0.56, 95% CI 0.3–0.9, p=0.02) but not with ulcerative colitis. No other aspect of domestic hygiene before or after age 11 was associated with either Crohn’s disease or ulcerative colitis. Although H pylori seroprevalence was positively associated with overcrowding (p<0.001) and the absence of running hot water in childhood it was not associated with the presence of either Crohn’s disease or ulcerative colitis. H pyloriseroprevalence was no lower in patients who had been exposed to sulphasalazine than in controls or those not exposed.Conclusions—Our findings confirm the strong inverse association between previous appendicectomy and the development of ulcerative colitis and suggest that the protective effect is greater for appendicectomy performed in childhood.

scholarly journals Helicobacter pyloriInfection and Markers of Gastric Cancer Risk in Alaska Native Persons: A Retrospective Case-Control Study

2014 ◽  
Vol 28 (6) ◽  
pp. 305-310 ◽  
Author(s):  
James W Keck ◽  
Karen M Miernyk ◽  
Lisa R Bulkow ◽  
Janet J Kelly ◽  
Brian J McMahon ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Alaska Native ◽  
Case Control Study ◽  
Case Control ◽  
Native People ◽  
Retrospective Case ◽  
Pepsinogen I ◽  
H Pylori ◽  
Antibody Levels ◽  
Control Study

BACKGROUND: Alaska Native persons experience gastric cancer incidence and mortality rates that are three to four times higher than in the general United States population.OBJECTIVE: To evaluate pepsinogen I, pepsinogen I/II ratio, anti-Helicobacter pyloriand cytotoxin-associated gene A (CagA) antibody levels, and blood group for their associations with gastric cancer development in Alaska Native people.METHODS: The present analysis was a retrospective case-control study that matched gastric cancers reported to the Alaska Native Tumor Registry from 1969 to 2008 to three controls on known demographic risk factors forH pyloriinfection, using sera from the Alaska Area Specimen Bank. Conditional logistic regression evaluated associations between serum markers and gastric cancer.RESULTS: A total of 122 gastric cancer cases were included, with sera predating cancer diagnosis (mean = 13 years) and 346 matched controls. One hundred twelve cases (91.8%) and 285 controls (82.4%) had evidence of previous or ongoingH pyloriinfection as measured by anti-H pyloriantibody levels. Gastric cancer cases had a 2.63-fold increased odds of having positive anti-H pyloriantibodies compared with their matched controls (P=0.01). In a multivariate model, non-cardia gastric cancer (n=94) was associated with anti-H pyloriantibodies (adjusted OR 3.92; P=0.004) and low pepsinogen I level (adjusted OR 6.04; P=0.04). No association between gastric cancer and blood group, anti-CagA antibodies or pepsinogen I/II ratio was found.CONCLUSION: Alaska Native people with gastric cancer had increased odds of previousH pyloriinfection. Low pepsinogen I level may function as a precancer marker for noncardia cancer.

Carbohydrates metabolism and H. pylori: case-control study

2017 ◽  
Author(s):  
Isabel Ma Cornejo-Pareja ◽  
M Mar Roca-Rodriguez ◽  
Leticia Coin-Araguez ◽  
Araceli Munoz-Garach ◽  
Maria Molina-Vega ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
H Pylori ◽  
Control Study

Verification of the Utility of Palliative Radiotherapy for Hemostasis of Gastric Cancer Bleeding: a Case Control Study

2021 ◽  
Author(s):  
Hirofumi Sugita ◽  
Shinichi Sakuramoto ◽  
Yoshiaki Mihara ◽  
Kazuaki Matsui ◽  
Keiji Nishibeppu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Case Control Study ◽  
Palliative Radiotherapy ◽  
Case Control ◽  
Control Study
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