scholarly journals Aluminum Exposure from Parenteral Nutrition: Early Bile Canaliculus Changes of the Hepatocyte

Nutrients ◽  
2018 ◽  
Vol 10 (6) ◽  
pp. 723 ◽  
Author(s):  
Amanda Hall ◽  
Ha Le ◽  
Chris Arnold ◽  
Janet Brunton ◽  
Robert Bertolo ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Bile Canaliculus ◽  
Aluminum Exposure

scholarly journals Aluminum in Pediatric Parenteral Nutrition Products: Measured Versus Labeled Content

2011 ◽  
Vol 16 (2) ◽  
pp. 92-97
Author(s):  
Robert L. Poole ◽  
Kevin P. Pieroni ◽  
Shabnam Gaskari ◽  
Tessa K. Dixon ◽  
KT Park ◽  
...  
Keyword(s):  
United States ◽  
Parenteral Nutrition ◽  
Clinical Setting ◽  
Aluminum Content ◽  
The United States ◽  
Published Data ◽  
Measured Concentration ◽  
Aluminum Exposure ◽  
Product Release

ABSTRACT OBJECTIVE Aluminum is a contaminant in all parenteral nutrition solutions. Manufacturers currently label these products with the maximum aluminum content at the time of expiry, but there are no published data to establish the actual measured concentration of aluminum in parenteral nutrition solution products prior to being compounded in the clinical setting. This investigation assessed quantitative aluminum content of products commonly used in the formulation of parenteral nutrition solutions. The objective of this study is to determine the best products to be used when compounding parenteral nutrition solutions (i.e., those with the least amount of aluminum contamination). METHODS All products available in the United States from all manufacturers used in the production of parenteral nutrition solutions were identified and collected. Three lots were collected for each identified product. Samples were quantitatively analyzed by Mayo Laboratories. These measured concentrations were then compared to the manufacturers' labeled concentration. RESULTS Large lot-to-lot and manufacturer-to-manufacturer differences were noted for all products. Measured aluminum concentrations were less than manufacturer-labeled values for all products. CONCLUSIONS The actual aluminum concentrations of all the parenteral nutrition solutions were significantly less than the aluminum content based on manufacturers' labels. These findings indicate that 1) the manufacturers should label their products with actual aluminum content at the time of product release rather than at the time of expiry, 2) that there are manufacturers whose products provide significantly less aluminum contamination than others, and 3) pharmacists can select products with the lowest amounts of aluminum contamination and reduce the aluminum exposure in their patients.

scholarly journals Aluminum Exposure in Neonatal Patients Using the Least Contaminated Parenteral Nutrition Solution Products

Nutrients ◽  
2012 ◽  
Vol 4 (11) ◽  
pp. 1566-1574 ◽  
Author(s):  
Robert Poole ◽  
Kevin Pieroni ◽  
Shabnam Gaskari ◽  
Tessa Dixon ◽  
John Kerner
Keyword(s):  
Parenteral Nutrition ◽  
Aluminum Exposure

Potential Aluminum Exposure from Parenteral Nutrition in Patients with Acute Kidney Injury

2008 ◽  
Vol 42 (10) ◽  
pp. 1410-1415 ◽  
Author(s):  
Rex O Brown ◽  
Laurie M Morgan ◽  
Syamal K Bhattacharya ◽  
Patti L Johnson ◽  
Gayle Minard ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Kidney Injury ◽  
Parenteral Nutrition ◽  
Aluminum Toxicity ◽  
Healthcare Providers ◽  
Kidney Injury ◽  
Analysis Data ◽  
Aluminum Exposure ◽  
Exact Test ◽  
High Aluminum

Background: Patients' exposure to and potential toxicity from aluminum in parenteral nutrition (PN) formulations is an important concern of healthcare providers. Objective: To determine the potential for aluminum toxicity caused by PN in hospitalized adults who have risk factors of both acute kidney injury and PN. Methods: Adults who required PN and had a serum creatinine (SCr) level at least 1.5 times greater than the admission SCr on the first day of PN were studied in a retrospective fashion. Protein was administered based on whether hemodialysis was being used (0 6-1 g/kg/day without hemodialysis; 1.2-1.5 g/kg/day with hemodialysis). Aluminum exposure was determined for each patient by multiplying the volume of each PN component by its concentration of aluminum Unpaired f-tests, Fisher's exact test, and analysis of variance were used for statistical analysis. Data are presented as mean ± SD. Results: Thirty-six patients (aged 50.4 ± 20.4 y; weight 90.2 ± 32.8 kg) were studied. Initial serum urea nitrogen and SCr were 47 ± 23 and 3.3 ± 1.4 mg/dL. respectively. Twelve patients received hemodialysis. The mean aluminum exposure was 3.8 ± 2 μg/kg/day in the 36 patients, Of these, 29 had safe calculated aluminum exposure (<5 μg/kg/day) and 7 had high calculated aluminum exposure (>5 μg/kg/day), Patients with safe aluminum exposure had significantly higher SCr levels than did those with high aluminum exposure (3.5 ± 1.5 vs 2.2 ± 0.7 mg/dL; p < 0.04). Patients with high aluminum exposure received significantly more aluminum from calcium gluconate compared with those who had safe aluminum exposure (357 ± 182 vs 250 ± 56 μg/day; p < 0.02). Limitations of the study include its retrospective design, which resulted in calculated versus direct measurement of aluminum. Conclusions: Using our calculations, we believe that most patients with acute kidney injury who require PN do not receive excessive exposure to aluminum from the PN formulation, despite having 2 risk factors (acute kidney injury, PN) for aluminum toxicity,

scholarly journals Evaluating Differences in Aluminum Exposure through Parenteral Nutrition in Neonatal Morbidities

Nutrients ◽  
2017 ◽  
Vol 9 (11) ◽  
pp. 1249 ◽  
Author(s):  
Megan Fortenberry ◽  
Lela Hernandez ◽  
Jacob Morton
Keyword(s):  
Parenteral Nutrition ◽  
Aluminum Exposure

Aluminum Exposure From Pediatric Parenteral Nutrition: Meeting the New FDA Regulation

2008 ◽  
Vol 32 (3) ◽  
pp. 242-246 ◽  
Author(s):  
Robert L. Poole ◽  
Susan R. Hintz ◽  
Nicol I. Mackenzie ◽  
John A. Kerner
Keyword(s):  
Parenteral Nutrition ◽  
Aluminum Exposure

ALUMINUM EXPOSURE FROM PARENTERAL NUTRITION IN HOSPITALIZED INFANTS.

2007 ◽  
Vol 55 (1) ◽  
pp. S79
Author(s):  
S. Majidi ◽  
A. Bhatt ◽  
R. Ybarra ◽  
N. F. Krebs
Keyword(s):  
Parenteral Nutrition ◽  
Aluminum Exposure

scholarly journals Improving Pediatric Outcomes through Intravenous and Oral Medication Standardization

2009 ◽  
Vol 14 (4) ◽  
pp. 226-235
Author(s):  
Mark W. MacKay ◽  
Jared Cash ◽  
Fred Farr ◽  
Marc Holley ◽  
Kevin Jones ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Turnaround Time ◽  
Statistical Correlation ◽  
Error Rates ◽  
Quality Improvements ◽  
Product Testing ◽  
Aluminum Exposure ◽  
Oral Formulations ◽  
Invaluable Tool ◽  
Program Description

BACKGROUND Standardization is an invaluable tool to promote safety, improve care, and decrease costs, which ultimately improves outcomes. However, a pediatric setting presents unique challenges with its wide variety of weights, medications, and needs that are distinctly different. Our goal was to develop and implement standards in complex high risk areas that show improved outcomes and safety. PROGRAM DESCRIPTION A computerized prescriber order entry program with decision support for pediatrics was developed for parenteral nutrition prescribing. The program included dosing, calculations, calcium phosphate compatibility checks, automated IV compounder interface, osmolarity route calculation, end product testing verification, aluminum exposure and many other quality improvements. This same electronic order program, interface to sterile compounders, and end product testing was used to standardize and make common non-manufactured intravenous solutions. The drip compounding process was reengineered to include standard concentrations, label changes, and beta-testing of a smart syringe pump with dosing ranges for pediatrics. Common standard oral doses were developed along with standard oral formulations. CONCLUSIONS Total parenteral nutrition (TPN) error rates decreased from 7% to less than 1% and compatibility issues decreased from 36 to 1 per year. Neonatal osteopenia rates decreased from 15% to 2%. Results from end product testing of TPN solutions were within USP standards showing statistical correlation (p&lt;0.001). Intravenous standardization decreased error rates by 15% and compounding time decreased by 12 minutes (64%). Drip standardization allowed for drug concentration and smart pump standardization and decreased drip errors by 73% from 3.1 to 0.8 per 1000 doses. Compounding errors decreased from 0.66 to 0.16 per 1000 doses and ten-fold errors decreased from 0.41 to 0.08 per 1000 doses. Eleven oral liquids, including 329 different doses, were standardized, decreasing the number of doses to 59 (83% change). This decreased workload 15%, wastage 90%, improved turnaround time 32%, and saved $15,000/year. One hundred evidence-based standard oral formulations were developed and used in 22 different hospitals.

Sign in / Sign up

Export Citation Format

Share Document