scholarly journals Dietary Iron Bioavailability: Agreement between Estimation Methods and Association with Serum Ferritin Concentrations in Women of Childbearing Age

Nutrients ◽  
2018 ◽  
Vol 10 (5) ◽  
pp. 650 ◽  
Author(s):  
Eduardo De Carli ◽  
Gisele Dias ◽  
Juliana Morimoto ◽  
Dirce Marchioni ◽  
Célia Colli
2008 ◽  
Vol 99 (2) ◽  
pp. 416-420 ◽  
Author(s):  
Xiao-Ming Lin ◽  
Wei Tian ◽  
Le Ma ◽  
Zhu Long ◽  
Juan Zhang ◽  
...  

We aimed to study the response of serum transferrin receptors (sTfR) to Fe supplementation in women of childbearing age with Fe-deficiency erythropoiesis (IDE) and Fe-deficiency anaemia (IDA). Primary screening was performed in 942 women ranging in age from 18 to 45 years. After Fe-related biochemical indices such as serum ferritin, Zn protoporphyrin and Hb were determined, the subjects were divided into four groups: normal, Fe store depletion, IDE and IDA. A total of 131 women were randomly selected from the normal, IDE and IDA groups. Subsequently, seventy-six women with IDE and IDA were given various doses of Fe (14 mg/d for IDE; 28 mg/d for IDA) with ferrousl-threonate capsules for twelve consecutive weeks. After receiving Fe supplements, the levels of Fe and sTfR were determined at weeks 0, 3, 6, 9 and 12.The levels of sTfR in women of childbearing age with IDE and IDA were significantly higher than those in the normal group. After receiving Fe supplements, the levels of sTfR were significantly decreased in women of childbearing age with IDE and IDA, while the levels of serum ferritin were significantly increased. In conclusion, STfR can be used as a reliable indicator for assessing the efficacy of Fe supplements.


2021 ◽  
Vol 8 (12) ◽  
pp. 45-53
Author(s):  
Rahmani Welan ◽  
Verty Ratna Monika ◽  
Yulistini .

Background: Among the causes of high Maternal Mortality Rate (MMR) in Indonesia is anemia. Iron deficiency anemia, the most common type of anemia, frequently occurs in women of childbearing age because they experience menstruation each month. To diagnose iron deficiency, serum ferritin level could be used as one of the indicators. This study aims to know whether there is an association between menstruation patterns and serum ferritin level in brides-to-be in Padang. Method: This study was conducted using an analytic observational method with a cross-sectional design. A Total of seventy samples of brides-to-be aged 20-30 years were gathered using a consecutive sampling technique. This study was conducted from November 2019 until April 2020. Data on menstruation patterns were collected through a questionnaire. Data of serum ferritin levels were acquired from venous blood sampling and measurement of serum ferritin levels with The Electro Chemiluminescence Immuno Assay (ECLIA) method. Bivariate analysis of this study used Independent T-test. Results: This study showed sixty-eight point six percent of respondents were experiencing abnormal menstruation patterns while the mean of serum ferritin levels was normal (sixty-two point zero seven ± thirty-nine point forty-five ng/ml). The Independent T-test showed p-value = 0,921. Conclusion: There was no significant association between menstruation pattern and serum ferritin level in brides-to-be in Padang. Keywords: iron deficiency anemia, women of childbearing age, menstruation patterns, serum ferritin levels.


2018 ◽  
Vol 49 ◽  
pp. 8-12 ◽  
Author(s):  
Valeria Candia ◽  
Israel Ríos-Castillo ◽  
Frank Carrera-Gil ◽  
Berta Vizcarra ◽  
Manuel Olivares ◽  
...  

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 3353-3353
Author(s):  
Alix O'Meara ◽  
Laura Infanti ◽  
Jörg Sigle ◽  
Martin Stern ◽  
Andreas S. Buser

Abstract Abstract 3353 Iron store depletion is a common side effect of whole-blood donation. Iron loss may lead to iron deficiency symptoms such as fatigue, decreased physical and job performance then gradually result in iron deficiency anemia. As of 2004, routine serum ferritin testing was implemented at our Center. We analyzed the impact of this measure on our donor population with regard to hemoglobin level, anemia occurrence and donor deferral due to low hemoglobin. A total of 160'612 intended donations of 23'557 healthy blood donors at a single institution (Blutspendezentrum beider Basel, Basel, Switzerland) between 1996 and 2009 were analyzed. At each visit, complete blood counts were taken from fingerprick samples and donors were deferred if the capillary hemoglobin concentration proved <133 g/L (m) or <123 g/L (f). From 2004 on, serum ferritin was measured systematically. Upon detection of ferritin levels indicative of iron depletion or iron deficiency anemia, donors were contacted by a blood bank physician and received medical counseling. The further procedure of iron supplementation, donation interval extension or GP referral in the case of abnormal history remained at the physician and donor's discretion.Our donor population consisted of 10'893 males and 12'664 females, 8165 being women of childbearing age (age 18–45). Mean hemoglobin concentration of male donors rose from 151.7 g/L (before 2004) to 153.6 g/L after 2004 (difference 1.9 g/L, 95% CI 1.7 – 1.9 g/L). In women of all ages, the mean hemoglobin concentration increased from 135.7 to 138.3 g/L (difference 2.6 g/L, 95% CI 2.4 – 2.7 g/L) (Figure 1). The hemoglobin concentration of women of childbearing age was 134.2 g/L before 2004 and 137.0 g/L thereafter (difference 2.8 g/L, 95% CI 2.6 – 3.0 g/L). To rule out an alternative cause for the increase in hemoglobin, we assessed the evolution of hemoglobin levels in the periods of 1996–2003 and 2004–2009. In the former period, hemoglobin levels decreased at a mean rate of 0.22 g/L (95% CI -0.19 - -0.26 g/L) per year in male donors, whereas no significant change was seen in female donors (mean change 0.04 g/L, 95% CI -0.01 – 0.09 g/L). In the second period (2004 – 2009), mean hemoglobin levels increased in both male (mean increase per year 0.20 g/L, 95% CI 0.14 – 0.25 g/L) and female donors (mean increase per year 0.16 g/L, 95% CI 0.09 – 0.23 g/L). Before the introduction of routine ferritin measuring, 1.6% (95% CI 1.5 – 1.7%) of donors showed anemia according to WHO definitions (m: Hb<130; f: Hb<120). Anemia occurred in 1.1% of our donors after 2004 (95% CI 1.0 – 1.2%, difference before/after 2004 0.5%, 95% CI -0.6 – -0.3%). Frequency of anemia declined in both male donors (before 2004 0.7%, after 2004 0.5%) and in female donors (before 2004 3.6%, after 2004 2.2%). In the group of women of childbearing age, 4.9% (95% CI 4.6 – 5.3%) were anemic before and 3.1% (95% CI 2.7– 3.4%) after 2004 (difference before/after 2004 -1.8%, 95% CI -1.4 – -2.4%). In all visits to our center before 2004, 2.8% of donors (95% CI 2.7 – 2.9%) were not accepted for phlebotomy due to a hemoglobin count below the mandatory threshold. After 2004, the percentage of rejected donors due to a low hemoglobin count decreased to 1.9% (95% CI 1.8 – 2.0%, difference before/after 2004 -0.9%, 95% CI -0.7 – -1.0%). In particular in the group of women in childbearing age a clear reduction of the rejection rates was noted (before 2004: 7.6% CI 7.2 – 8.1%, thereafter: 4.8% CI 4.4 – 5.2%, difference before/after 2004 -2.8%, 95% CI -2.2 – -3.4%). In conclusion, the introduction of systematic serum ferritin measurements allowed an optimized management of donors with iron deficiency, with efficacious prevention of iron deficiency anemia. This resulted in an increase of mean hemoglobin levels in blood donors particularly in women of childbearing age, the population at highest risk for iron deficiency anemia. Both the incidence of pre-donation anemia and the frequency of donors rejected due to low hemoglobin decreased significantly. Disclosures: No relevant conflicts of interest to declare.


2018 ◽  
Vol 88 (3-4) ◽  
pp. 190-198 ◽  
Author(s):  
Maryam Ghaseminasab Parizi ◽  
Hadith Tangestani ◽  
Samane Rahmdel ◽  
Seyed Mohammad Aqaeinejad R. ◽  
Seyedeh Maryam Abdollahzadeh ◽  
...  

Abstract. Iron deficiency (ID) is one of the most common nutritional problems in the developing world, affecting primarily women of childbearing age. Poor dietary iron intake is a major reason of ID. Accurate measurement of iron intake is of crucial importance to combat the problem. The daily dietary iron intake of 67 female students aged between 20-30 years (a mean BMI of 21.8±3.4 kg/m2) was evaluated using three assessment methods: atomic absorption spectrometry of 3-day food duplicate samples, and food composition tables (FCTs) in combination with either food frequency questionnaire (FFQ) or dietary records. Iron status was examined using hematological and biochemical tests. The dietary iron intake determined by duplicate portion sampling (DPS; 4.12±1.84 mg/day) was significantly lower than the FCT-based estimates ( P<0.001), and it was less than ¼ of the recommended dietary allowance of 18 mg/day. No significant correlation was found between DPS technique and FCT-based assessment methods. Fifty percent of the participants had small or depleted iron stores (serum ferritin< 30 ng/mL), but only 4.5% had ID anemia (serum ferritin< 12 ng/mL and hemoglobin<12 g/dL). Dietary iron intakes and FFQ-based intakes of vitamin C were not significantly correlated with all the investigated hematological parameters. In order to take some steps toward more practical approaches to combat this health problem, development of an accurate iron intake assessment seems to be the first priority. In this regard, improvement and validation of national FCTs would be a promising solution.


GYNECOLOGY ◽  
2018 ◽  
Vol 20 (6) ◽  
pp. 48-52
Author(s):  
E N Kravchenko ◽  
R A Morgunov

The aim of the study. Assess the importance of pregravid preparation and outcomes of pregnancy and childbirth, depending on the reproductive attitudes of women in the city of Omsk. Materials and methods. The study included 92 women who were divided into groups: group A (n=43) - women whose pregnancy was planned; group B (n=49) - women whose pregnancy occurred accidentally. Each group was divided into subgroups depending on age: from 18 to 30 and from 31 to 49 years. For each patient included in the study, a specially designed map was filled out. These patients were interviewed at the City Clinical Perinatal Center. Results. Comparative analysis revealed the relationship between the reproductive settings of women of childbearing age and the peculiarity of the course of pregnancy and childbirth in these patients. Summary. The majority of women of fertile age are married: in subgroup AA - 25 (96.2%), AB - 13 (76.5%), BA - 25 (92.6%), BB - 20 (91.0%). The predominant number of women of fertile age have one or more abortions: in subgroup AA - 12 (46.2%), AB - 6 (35.3%), in subgroups of comparison BA - 8 (29.6%), BB - 6 (27.3%). More than half of the women of fertile age surveyed have a history of untreated cervical pathology (from 40.8% to 64.7%). The course of pregnancy in women planning pregnancy in most cases proceeded without complications: in subgroup AA - 13 (50.0%), AB - 11 (64.7%). The most common cause of complicated pregnancy in women whose pregnancy occurred accidentally is the threat of spontaneous miscarriage: in subgroup BA - 15 (55.6%), BB - 16 (72.7%). The uncomplicated course of labor more often [subgroup AA - 19 (73.0%), AB - 12 (70.6%)] was observed in women whose pregnancy was planned and they were motivated to give birth to a healthy child.


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