scholarly journals Inflammation, not Cholesterol, Is a Cause of Chronic Disease

Nutrients ◽  
2018 ◽  
Vol 10 (5) ◽  
pp. 604 ◽  
Author(s):  
Alexandros Tsoupras ◽  
Ronan Lordan ◽  
Ioannis Zabetakis

Since the Seven Countries Study, dietary cholesterol and the levels of serum cholesterol in relation to the development of chronic diseases have been somewhat demonised. However, the principles of the Mediterranean diet and relevant data linked to the examples of people living in the five blue zones demonstrate that the key to longevity and the prevention of chronic disease development is not the reduction of dietary or serum cholesterol but the control of systemic inflammation. In this review, we present all the relevant data that supports the view that it is inflammation induced by several factors, such as platelet-activating factor (PAF), that leads to the onset of cardiovascular diseases (CVD) rather than serum cholesterol. The key to reducing the incidence of CVD is to control the activities of PAF and other inflammatory mediators via diet, exercise, and healthy lifestyle choices. The relevant studies and data supporting these views are discussed in this review.

Proceedings ◽  
2020 ◽  
Vol 70 (1) ◽  
pp. 70
Author(s):  
Ronan Lordan ◽  
Ioannis Zabetakis ◽  
Alexandros Tsoupras

Cardiovascular diseases (CVD) are the leading cause of death globally. The focus of scientists and practitioners for decades has been on cholesterol levels and pharmacological ways to control them. Over the past few years, a new school of thought has emerged: inflammation is the underlying cause of chronic non-communicable diseases (NCDs) such as CVD. Therefore, the key to reducing the incidence of chronic diseases is to control the activities of various inflammatory mediators, such as platelet-activating factor (PAF), via diet, exercise, and healthy lifestyle choices. One proposal has been that the polar lipids (PL) present in foods can play a key role via their antithrombotic and anti-inflammatory bioactivities. In this paper, we present our latest views on PAF and how it is related to CVD, and we discuss the role of diet and PL against PAF-induced inflammation.


Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2332 ◽  
Author(s):  
Panchal ◽  
Brown

Tsoupras and colleagues have postulated, in a recent review in Nutrients, that the key to reducing the incidence of cardiovascular disease is to control the activities of inflammatory mediators such as platelet-activating factor (PAF) by diet, exercise, and healthy lifestyle choices [...]


2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Sasha A. Fleary ◽  
Reynolette Ettienne-Gittens ◽  
Robert W. Heffer

This paper examines Head Start parents’ perceptions of preventive health and healthy lifestyle choices and Head Start administrators’ perceptions of the needs of parents they serve. To address the preventive health of the population, it is necessary that we explore perceptions, risks, and protective factors of preventive health. Focus groups were conducted with parents and administrators to elicit this information and to obtain suggestions for improving preventive health and healthy lifestyle choices among this group. Overall, nutrition and physical activity emerged as themes in parents’ definition of preventive health and healthy lifestyle choices. They further identified social support and education as major protective factors for engaging in preventive health and healthy lifestyle choices. Results of this study can be used to inform research and practice to develop interventions to increase preventive health and healthy lifestyle choices among low income families.


2011 ◽  
Vol 25 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Elizabeth Vaczy ◽  
Brenda Seaman ◽  
Kathleen Peterson-Sweeney ◽  
Carol Hondorf

2007 ◽  
Vol 61 (10) ◽  
pp. 871-876 ◽  
Author(s):  
N. W J Wainwright ◽  
P. G Surtees ◽  
A. A Welch ◽  
R. N Luben ◽  
K.-T. Khaw ◽  
...  

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Tomislav Jukic ◽  
Alojz Ihan ◽  
Vojko Strojnik ◽  
David Stubljar ◽  
Andrej Starc

Abstract Background The aim of the study was to address the working population with an occupational stress prevention program using mHealth solution and encourage them for healthy lifestyle choices. Methods Seventeen participants were randomized from the corporate setting. A 24alife app with a good compliance program was selected. Test battery has been designed to test the physical readiness, psychological evaluation and biological blood markers for stress. Participants were followed up after 30, 60 and 90 days, respectively, within the intervention period. Weight of participants was tracked three times per month. Univariate analysis compared the continuous variables by One-Way Repeated-Measures ANOVA test when the data were normally distributed, or Wilcoxon rank sum test for abnormal distribution of variables. Results Participants used the app with a compliance rate of 94.1%. The psychological evaluation revealed higher motivation for work, lower burnout scores and participants gave subjective responses of better general wellbeing. Some of the participants lost up to four kg of body mass. Physical readiness has also improved. Conclusions Results of mHealth projects on corporate could include primary health care institutions and health ministry to extend the existing system to patients’ pockets where they can monitor their disease and increase the ability of self-care.


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