scholarly journals The Vitamin D–Folate Hypothesis as an Evolutionary Model for Skin Pigmentation: An Update and Integration of Current Ideas

Nutrients ◽  
2018 ◽  
Vol 10 (5) ◽  
pp. 554 ◽  
Author(s):  
Patrice Jones ◽  
Mark Lucock ◽  
Martin Veysey ◽  
Emma Beckett
Keyword(s):  
Vitamin D ◽  
Skin Pigmentation ◽  
Evolutionary Model

scholarly journals Reply: “Comment on: The Vitamin D–Folate Hypothesis as an Evolutionary Model for Skin Pigmentation: An Update and Integration of Current Ideas, Nutrients 2018, 10, 554”

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1759
Author(s):  
Patrice Jones ◽  
Mark Lucock ◽  
Martin Veysey ◽  
Emma Beckett
Keyword(s):  
Vitamin D ◽  
Skin Pigmentation ◽  
Evolutionary Model

We thank Elias and Williams for their interest in our review [...]

scholarly journals Comment on: The Vitamin D–Folate Hypothesis as an Evolutionary Model for Skin Pigmentation: An Update and Integration of Current Ideas, Nutrients 2018, 10, 554

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1753 ◽  
Author(s):  
Peter Elias ◽  
Mary Williams
Keyword(s):  
Vitamin D ◽  
Recent Article ◽  
Skin Pigmentation ◽  
Evolutionary Model ◽  
Homo Erectus ◽  
Modern Humans ◽  
Distinctive Features

In response to a recent article by Jones et al. (Nutrients 10: 554–568, 2018) [1], we agree that three distinctive features evolved in Homo erectus prior to the emergence of modern humans.[...]

scholarly journals Nutrigenomics of Vitamin D

Nutrients ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 676 ◽  
Author(s):  
Carsten Carlberg
Keyword(s):  
Vitamin D ◽  
Human Genome ◽  
Vitamin D3 ◽  
Skin Pigmentation ◽  
Adaptive Immune System ◽  
Molecular Response ◽  
Dihydroxyvitamin D3 ◽  
Clinical Benefits ◽  
Prevention Of Osteoporosis ◽  
Endogenous Synthesis

Nutrigenomics studies how environmental factors, such as food intake and lifestyle, influence the expression of the genome. Vitamin D3 represents a master example of nutrigenomics, since via its metabolite 1α,25-dihydroxyvitamin D3, which binds with high-affinity to the vitamin D receptor, the secosteroid directly affects the epigenome and transcriptome at thousands of loci within the human genome. Vitamin D is important for both cellular metabolism and immunity, as it controls calcium homeostasis and modulates the response of the innate and adaptive immune system. At sufficient UV-B exposure, humans can synthesize vitamin D3 endogenously in their skin, but today’s lifestyle often makes the molecule a true vitamin and micronutrient that needs to be taken up by diet or supplementation with pills. The individual’s molecular response to vitamin D requires personalized supplementation with vitamin D3, in order to obtain optimized clinical benefits in the prevention of osteoporosis, sarcopenia, autoimmune diseases, and possibly different types of cancer. The importance of endogenous synthesis of vitamin D3 created an evolutionary pressure for reduced skin pigmentation, when, during the past 50,000 years, modern humans migrated from Africa towards Asia and Europe. This review will discuss different aspects of how vitamin D interacts with the human genome, focusing on nutritional epigenomics in context of immune responses. This should lead to a better understanding of the clinical benefits of vitamin D.

Adaptation and co‐adaptation of skin pigmentation and vitamin D genes in native Americans

2020 ◽  
Vol 184 (4) ◽  
pp. 1060-1077
Author(s):  
Bruna Oliveira Missaggia ◽  
Guillermo Reales ◽  
Gabriela B. Cybis ◽  
Tábita Hünemeier ◽  
Maria Cátira Bortolini
Keyword(s):  
Vitamin D ◽  
Native Americans ◽  
Skin Pigmentation

scholarly journals Human skin pigmentation, migration and disease susceptibility

2012 ◽  
Vol 367 (1590) ◽  
pp. 785-792 ◽  
Author(s):  
Nina G. Jablonski ◽  
George Chaplin
Keyword(s):  
Vitamin D ◽  
Human Skin ◽  
High Speed ◽  
Homo Sapiens ◽  
Skin Pigmentation ◽  
Disease States ◽  
Disease Risks ◽  
Genetic And Environmental Factors ◽  
Serious Disease ◽  
The Tropics

Human skin pigmentation evolved as a compromise between the conflicting physiological demands of protection against the deleterious effects of ultraviolet radiation (UVR) and photosynthesis of UVB-dependent vitamin D 3 . Living under high UVR near the equator, ancestral Homo sapiens had skin rich in protective eumelanin. Dispersals outside of the tropics were associated with positive selection for depigmentation to maximize cutaneous biosynthesis of pre-vitamin D 3 under low and highly seasonal UVB conditions. In recent centuries, migrations and high-speed transportation have brought many people into UVR regimes different from those experienced by their ancestors and, accordingly, exposed them to new disease risks. These have been increased by urbanization and changes in diet and lifestyle. Three examples—nutritional rickets, multiple sclerosis (MS) and cutaneous malignant melanoma (CMM)—are chosen to illustrate the serious health effects of mismatches between skin pigmentation and UVR. The aetiology of MS in particular provides insight into complex and contingent interactions of genetic and environmental factors necessary to trigger lethal disease states. Low UVB levels and vitamin D deficiencies produced by changes in location and lifestyle pose some of the most serious disease risks of the twenty-first century.

Validation of Brief Questionnaire Measures of Sun Exposure and Skin Pigmentation Against Detailed and Objective Measures Including Vitamin D Status

2012 ◽  
Vol 89 (1) ◽  
pp. 219-226 ◽  
Author(s):  
Jessica Cargill ◽  
Robyn M. Lucas ◽  
Peter Gies ◽  
Kerryn King ◽  
Ashwin Swaminathan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Skin Pigmentation ◽  
Sun Exposure ◽  
Objective Measures ◽  
Vitamin D Status ◽  
Questionnaire Measures

Global vitamin D levels in relation to age, gender, skin pigmentation and latitude: an ecologic meta-regression analysis

2008 ◽  
Vol 20 (1) ◽  
pp. 133-140 ◽  
Author(s):  
T. Hagenau ◽  
R. Vest ◽  
T. N. Gissel ◽  
C. S. Poulsen ◽  
M. Erlandsen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Regression Analysis ◽  
Skin Pigmentation ◽  
Vitamin D Levels ◽  
Meta Regression ◽  
Meta Regression Analysis
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