scholarly journals Chondroprotective Effects of a Standardized Extract (KBH-JP-040) from Kalopanax pictus, Hericium erinaceus, and Astragalus membranaceus in Experimentally Induced In Vitro and In Vivo Osteoarthritis Models

Nutrients ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 356 ◽  
Author(s):  
Md. Rahman ◽  
Hyun-Kyu Kim ◽  
Seong-Eun Kim ◽  
Myung-Jin Kim ◽  
Do-Hyung Kim ◽  
...  
Keyword(s):  
Astragalus Membranaceus ◽  
Hericium Erinaceus ◽  
Kalopanax Pictus ◽  
Experimentally Induced

scholarly journals Current Trends in the Pharmacotherapy of Cataracts

2020 ◽  
Vol 13 (1) ◽  
pp. 15 ◽  
Author(s):  
Segewkal H. Heruye ◽  
Leonce N. Maffofou Nkenyi ◽  
Neetu U. Singh ◽  
Dariush Yalzadeh ◽  
Kalu K. Ngele ◽  
...  
Keyword(s):  
Low Income ◽  
Ex Vivo ◽  
Radical Scavenging ◽  
Antioxidant Defense System ◽  
Enzymatic Antioxidants ◽  
Repair Mechanisms ◽  
Blurry Vision ◽  
Experimentally Induced

Cataracts, one of the leading causes of preventable blindness worldwide, refers to lens degradation that is characterized by clouding, with consequent blurry vision. As life expectancies improve, the number of people affected with cataracts is predicted to increase worldwide, especially in low-income nations with limited access to surgery. Although cataract surgery is considered safe, it is associated with some complications such as retinal detachment, warranting a search for cheap, pharmacological alternatives to the management of this ocular disease. The lens is richly endowed with a complex system of non-enzymatic and enzymatic antioxidants which scavenge reactive oxygen species to preserve lens proteins. Depletion and/or failure in this primary antioxidant defense system contributes to the damage observed in lenticular molecules and their repair mechanisms, ultimately causing cataracts. Several attempts have been made to counteract experimentally induced cataract using in vitro, ex vivo, and in vivo techniques. The majority of the anti-cataract compounds tested, including plant extracts and naturally-occurring compounds, lies in their antioxidant and/or free radical scavenging and/or anti-inflammatory propensity. In addition to providing an overview of the pathophysiology of cataracts, this review focuses on the role of various categories of natural and synthetic compounds on experimentally-induced cataracts.

scholarly journals Hericerin derivatives from Hericium erinaceus exert BDNF-like neurotrophic activity in central hippocampal neurons and enhance memory

2020 ◽  
Author(s):  
Ramón Martínez-Mármol ◽  
YeJin Chai ◽  
Zahra Khan ◽  
Seon Beom Kim ◽  
Seong Min Hong ◽  
...  
Keyword(s):  
Recognition Memory ◽  
Hippocampal Neurons ◽  
Peripheral Nerve Regeneration ◽  
Neurotropic Activity ◽  
Biologically Active ◽  
Hericium Erinaceus ◽  
Neurotrophic Activity ◽  
Trkb Receptors

AbstractThe traditional medicinal mushroom Hericium erinaceus has long been known for enhancing the peripheral nerve regeneration through targeting nerve growth factor (NGF) neurotrophic activity. It was also reported to protect against ageing-dependent cognitive decline in wildtype and in Alzheimer’s disease mouse models suggesting a yet to be defined action on neurons of the central nervous system. Here, we purified and identified biologically active compounds from H. erinaceus, based on their ability to promote neurite outgrowth in hippocampal neurons. N-de phenylethyl isohericerin (NDPIH), an isoindoline compound from this mushroom together with its hydrophobic derivative hericene A, were highly potent in inducing extensive axon outgrowth and neurite branching in the absence of serum demonstrating high neurotropic activity. NDPIH also induced enlarged growth cones suggestive of a brain-derived neurotrophic factor (BDNF)-like activity. Pharmacological inhibition of tropomyosin receptor kinase B (TrkB) by ANA12 prevented NDPIH-induced neurotrophic activity providing evidence that NDPIH acts via TrkB receptors to mediate its neurotrophic effect in central neurons. Finally, in vivo treatment with H. erinaceus crude extract and hericene A significantly increased BDNF and downstream pathway and enhanced learning and memory in the novel object recognition memory test. Our results suggest that hericene A can promote BDNF-like activity in neurons in vitro and in vivo thereby enhancing recognition memory.

scholarly journals The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology

2021 ◽  
Vol 71 (1) ◽  
pp. 1-16
Author(s):  
Mateusz Winder ◽  
Weronika Bulska-Będkowska ◽  
Jerzy Chudek
Keyword(s):  
Trametes Versicolor ◽  
Therapeutic Effects ◽  
Immunomodulatory Effects ◽  
Edible Fungi ◽  
Hericium Erinaceus ◽  
Natural Medicine ◽  
The Subject ◽  
New Challenges

AbstractSubstances available in nature with potential therapeutic effects are the subject of research that raises tremendous hopes for new challenges in medicine. Fungi are the most common organisms in the ecosystem and the most interesting in this respect. This review discusses two species of edible fungi, used for centuries in Eastern natural medicine, with the best-documented effect – Hericium erinaceus (He) and Trametes versicolor (Tv). The results of in vivo and in vitro studies conducted on mice and human cell lines demonstrate immunomodulatory, potentially, anticancer, anti-inflammatory and neuroregenerative effects of substances isolated from these fungi. The substances contained in the extracts of He and Tv seem to have immunomodulatory effects that may support chemotherapy. The use of these extracts is justified stronger than the other supportive treat ments based on supplements.

Experimentally induced hip dislocation dislocation in vitro and in vivo

1983 ◽  
Vol 54 (sup199) ◽  
pp. 1-57 ◽  
Author(s):  
Stefan Asplund ◽  
Åke Hjelmstedt
Keyword(s):  
Hip Dislocation ◽  
Experimentally Induced

Aquaporin 1 (AQP1) expression in experimentally induced osteoarthritic knee menisci: An in vivo and in vitro study

2013 ◽  
Vol 45 (2) ◽  
pp. 145-152 ◽  
Author(s):  
G. Musumeci ◽  
R. Leonardi ◽  
M.L. Carnazza ◽  
V. Cardile ◽  
K. Pichler ◽  
...  
Keyword(s):  
In Vitro Study ◽  
Vitro Study ◽  
Osteoarthritic Knee ◽  
Aquaporin 1 ◽  
Aqp1 Expression ◽  
Experimentally Induced

scholarly journals Astragalus (Astragalus membranaceus Bunge): botanical, geographical, and historical aspects to pharmaceutical components and beneficial role

2021 ◽  
Author(s):  
Alessandra Durazzo ◽  
Amirhossein Nazhand ◽  
Massimo Lucarini ◽  
Amelia M. Silva ◽  
Selma B. Souto ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Therapeutic Potential ◽  
Folk Medicine ◽  
Astragalus Membranaceus ◽  
Special Focus ◽  
Comprehensive Overview ◽  
Historical Aspects ◽  
Therapeutic Properties

AbstractMedicinal plants always are part of folk medicine and are nowadays receiving worldwide attention for prophylaxis, management, and treatment of several diseases, as an alternative to chemical drugs. The current work provided a comprehensive overview and analysis of the Astragalus and health relationship in literature. The analysis of their therapeutic potential is thus instrumental to understand their bioactivity. Among these, the flowering medicinal plant Astragalus membranaceus has raised interest due to several beneficial health effects. This perspective review discussed the botanical, geographical, historical, and the therapeutic properties of A. membranaceus, with a special focus on its health improving effects and medicinal applications both in vitro and in vivo. Graphic abstract

Effects of ticagrelor, empagliflozin and tamoxifen against experimentally-induced vascular reactivity defects in rats in vivo and in vitro

2019 ◽  
Vol 71 (6) ◽  
pp. 1034-1043 ◽  
Author(s):  
Yasmin Moustafa Ahmed ◽  
Basim Anwar Shehata Messiha ◽  
Mahmoud El-Sayed El-Daly ◽  
Ali Ahmed Abo-Saif
Keyword(s):  
Vascular Reactivity ◽  
Experimentally Induced

scholarly journals Erinacine A Prevents Lipopolysaccharide-Mediated Glial Cell Activation to Protect Dopaminergic Neurons against Inflammatory Factor-Induced Cell Death In Vitro and In Vivo

2022 ◽  
Vol 23 (2) ◽  
pp. 810
Author(s):  
Shou-Lun Lee ◽  
Jing-Ya Hsu ◽  
Ting-Chun Chen ◽  
Chun-Chih Huang ◽  
Tzong-Yuan Wu ◽  
...  
Keyword(s):  
Cell Viability ◽  
Glial Cell ◽  
Cell Activation ◽  
Neuroprotective Effects ◽  
Hericium Erinaceus ◽  
Glial Cell Activation ◽  
Tnf Α ◽  
Erinacine A

Hericium erinaceus (HE) is a common edible mushroom consumed in several Asian countries and considered to be a medicinal mushroom with neuroprotective effects. Erinacine A (EA) is a bioactive compound in Hericium erinaceus mycelium (HEM) that has been shown to have a neuroprotective effect against neurodegenerative diseases, e.g., Parkinson’s disease (PD). Although the etiology of PD is still unclear, neuroinflammation may play an important role in causing dopaminergic neuron loss, which is a pathological hallmark of PD. However, glial cell activation has a close relationship with neuroinflammation. Thus, this study aimed to investigate the anti-neuroinflammatory and neuroprotective effects of EA on lipopolysaccharide (LPS)-induced glial cell activation and neural damage in vitro and in vivo. For the in vitro experiments, glial cells, BV-2 microglial cells and CTX TNA2 astrocytes were pretreated with EA and then stimulated with LPS and/or IFN-γ. The expression of proinflammatory factors in the cells and culture medium was analyzed. In addition, differentiated neuro-2a (N2a) cells were pretreated with EA or HEM and then stimulated with LPS-treated BV-2 conditioned medium (CM). The cell viability and the amount of tyrosine hydroxylase (TH) and mitogen-activated protein kinases (MAPKs) were analyzed. In vivo, rats were given EA or HEM by oral gavage prior to injection of LPS into the substantia nigra (SN). Motor coordination of the rats and the expression of proinflammatory mediators in the midbrain were analyzed. EA pretreatment prevented LPS-induced iNOS expression and NO production in BV-2 cells and TNF-α expression in CTX TNA2 cells. In addition, both EA and HEM pretreatment significantly increased cell viability and TH expression and suppressed the phosphorylation of JNK and NF- κB in differentiated N2a cells treated with CM. In vivo, both EA and HEM significantly improved motor dysfunction in the rotarod test and the amphetamine-induced rotation test and reduced the expression of TNF-α, IL-1β and iNOS in the midbrain of rats intranigrally injected with LPS. The results demonstrate that EA ameliorates LPS-induced neuroinflammation and has neuroprotective properties.

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