scholarly journals Early-Life Exposure to Non-Nutritive Sweeteners and the Developmental Origins of Childhood Obesity: Global Evidence from Human and Rodent Studies

Nutrients ◽  
2018 ◽  
Vol 10 (2) ◽  
pp. 194 ◽  
Author(s):  
Alyssa Archibald ◽  
Vernon Dolinsky ◽  
Meghan Azad
Keyword(s):  
Childhood Obesity ◽  
Early Life ◽  
Developmental Origins ◽  
Early Life Exposure ◽  
Global Evidence

scholarly journals Early-life exposure to endocrine disrupting chemicals associates with childhood obesity

2018 ◽  
Vol 23 (4) ◽  
pp. 182-195 ◽  
Author(s):  
Chunxue Yang ◽  
Hin Kiu Lee ◽  
Alice Pik Shan Kong ◽  
Lee Ling Lim ◽  
Zongwei Cai ◽  
...  
Keyword(s):  
Childhood Obesity ◽  
Early Life ◽  
Endocrine Disrupting Chemicals ◽  
Early Life Exposure ◽  
Endocrine Disrupting

scholarly journals Adverse Life Trajectories Are a Risk Factor for SARS-CoV-2 IgA Seropositivity

2021 ◽  
Vol 10 (10) ◽  
pp. 2159
Author(s):  
Cyrielle Holuka ◽  
Chantal J. Snoeck ◽  
Sophie B. Mériaux ◽  
Markus Ollert ◽  
Rejko Krüger ◽  
...  
Keyword(s):  
Early Life ◽  
Traumatic Experiences ◽  
Developmental Origins ◽  
Influenza Pandemics ◽  
Life Trajectories ◽  
Early Life Exposure ◽  
Health And Disease ◽  
Life Trajectory ◽  
Asymptomatic Individuals ◽  
Dose Dependent

Asymptomatic individuals, called “silent spreaders” spread SARS-CoV-2 efficiently and have complicated control of the ongoing COVID-19 pandemic. As seen in previous influenza pandemics, socioeconomic and life-trajectory factors are important in disease progression and outcome. The demographics of the asymptomatic SARS-CoV-2 carriers are unknown. We used the CON-VINCE cohort of healthy, asymptomatic, and oligosymptomatic individuals that is statistically representative of the overall population of Luxembourg for age, gender, and residency to characterise this population. Gender (male), not smoking, and exposure to early-life or adult traumatic experiences increased the risk of IgA seropositivity, and the risk associated with early-life exposure was a dose-dependent metric, while some other known comorbidities of active COVID-19 do not impact it. As prior exposure to adversity is associated with negative psychobiological reactions to external stressors, we recorded psychological wellbeing during the study period. Exposure to traumatic events or concurrent autoimmune or rheumatic disease were associated with a worse evolution of anxiety and depressive symptoms throughout the lockdown period. The unique demographic profile of the “silent spreaders” highlights the role that the early-life period plays in determining our lifelong health trajectory and provides evidence that the developmental origins of health and disease is applicable to infectious diseases.

Chemically Contaminated Eel Fed to Pregnant and Lactating Mouse Dams Causes Hyperactivity in Their Offspring

2016 ◽  
Vol 86 (1-2) ◽  
pp. 36-47 ◽  
Author(s):  
Imen Dridi ◽  
Nidhal Soualeh ◽  
Torsten Bohn ◽  
Rachid Soulimani ◽  
Jaouad Bouayed
Keyword(s):  
Open Field ◽  
Early Life ◽  
Home Cage ◽  
Anguilla Anguilla ◽  
Acetylcholinesterase Activity ◽  
Female Offspring ◽  
Significant Inhibition ◽  
Standard Diet ◽  
Early Life Exposure ◽  
Cage Test

Abstract.This study examined whether perinatal exposure to polluted eels (Anguilla anguilla L.) induces changes in the locomotor activity of offspring mice across lifespan (post-natal days (PNDs) 47 – 329), using the open field and the home cage activity tests. Dams were exposed during gestation and lactation, through diets enriched in eels naturally contaminated with pollutants including PCBs. Analysis of the eel muscle focused on the six non-dioxin-like (NDL) indicator PCBs (Σ6 NDL-PCBs: 28, 52, 101, 138, 153 and 180). Four groups of dams (n = 10 per group) received either a standard diet without eels or eels (0.8 mg/kg/day) containing 85, 216, or 400 ng/kg/day of ϵ6 NDL-PCBs. The open field test showed that early-life exposure to polluted eels increased locomotion in female offspring of exposed dams but not in males, compared to controls. This hyperlocomotion appeared later in life, at PNDs 195 and 329 (up to 32 % increase, p < 0.05). In addition, overactivity was observed in the home cage test at PND 305: exposed offspring females showed a faster overall locomotion speed (3.6 – 4.2 cm/s) than controls (2.9 cm/s, p <0.05); again, males remained unaffected. Covered distances in the home cage test were only elevated significantly in offspring females exposed to highest PCB concentrations (3411 ± 590 cm vs. 1377 ± 114 cm, p < 0.001). These results suggest that early-life exposure to polluted eels containing dietary contaminants including PCBs caused late, persistent and gender-dependent neurobehavioral hyperactive effects in offspring mice. Furthermore, female hyperactivity was associated with a significant inhibition of acetylcholinesterase activity in the hippocampus and the prefrontal cortex.

Prenatal and Early-Life Exposure to Indoor Air-Polluting Factors and Allergic Sensitization at 2 Years of Age

PEDIATRICS ◽  
2020 ◽  
Vol 146 (Supplement 4) ◽  
pp. S332.2-S333
Author(s):  
Suzanne R. Kochis ◽  
Jennifer Dantzer
Keyword(s):  
Indoor Air ◽  
Early Life ◽  
Allergic Sensitization ◽  
Early Life Exposure

Early Life Exposure to Antibiotic Alters Energy Balance during Chronic High-Fat Feeding in Adult Male and Female Mice

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1999-P ◽  
Author(s):  
HYE LIM NOH ◽  
SUJIN SUK ◽  
RANDALL H. FRIEDLINE ◽  
KUNIKAZU INASHIMA ◽  
DUY A. TRAN ◽  
...  
Keyword(s):  
Energy Balance ◽  
Adult Male ◽  
Early Life ◽  
High Fat ◽  
Male And Female ◽  
Female Mice ◽  
Early Life Exposure ◽  
Fat Feeding

scholarly journals Early Origins of Body Mass in Later Life: Examining Childhood Risks and Adult Pathways

2021 ◽  
pp. 002214652110054
Author(s):  
Sarah A. Mustillo ◽  
Miao Li ◽  
Patricia Morton ◽  
Kenneth F. Ferraro
Keyword(s):  
Physical Activity ◽  
Body Mass ◽  
Health Risks ◽  
Early Life ◽  
Life Experiences ◽  
Later Life ◽  
Childhood Experiences ◽  
Older Adulthood ◽  
Early Life Exposure ◽  
Nationally Representative

Prior research reveals that negative early-life experiences play a major role in the development of obesity in later life, but few studies identify mechanisms that alter the lifetime risk of obesity. This study examines the influence of negative childhood experiences on body mass index (BMI) and obesity (BMI ≥30) during older adulthood and the psychosocial and behavioral pathways involved. Using a nationally representative sample, we examine the influence of cumulative misfortune as well as five separate domains of misfortune on BMI and obesity. Results show that four of the five domains are associated with BMI and obesity either directly, indirectly, or both. The influence of cumulative misfortune on the outcomes is mediated by three adult factors: socioeconomic status, depressive symptoms, and physical activity. The mediators identified here provide targets for intervention among older adults to help offset the health risks of excess BMI attributable of early-life exposure to misfortune.

Early life exposure to phthalates and the development of childhood asthma among Canadian children

2021 ◽  
pp. 110981
Author(s):  
Garthika Navaranjan ◽  
Miriam L. Diamond ◽  
Shelley A. Harris ◽  
Liisa Jantunen ◽  
Sarah Bernstein ◽  
...  
Keyword(s):  
Childhood Asthma ◽  
Early Life ◽  
Early Life Exposure

Early-life exposure to the Chinese famine, genetic susceptibility and the risk of type 2 diabetes in adulthood

Diabetologia ◽  
2021 ◽  
Author(s):  
Bin Wang ◽  
Jing Cheng ◽  
Heng Wan ◽  
Yuying Wang ◽  
Wen Zhang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Susceptibility ◽  
Early Life ◽  
Early Life Exposure
Sign in / Sign up

Export Citation Format

Share Document