scholarly journals Carbon Nano-Onions as Non-Cytotoxic Carriers for Cellular Uptake of Glycopeptides and Proteins

Nanomaterials ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 1069 ◽  
Author(s):  
Marta d’Amora ◽  
Viviana Maffeis ◽  
Rosaria Brescia ◽  
Danielle Barnes ◽  
Eoin Scanlan ◽  
...  
Keyword(s):  
Surface Modification ◽  
Bovine Serum Albumin ◽  
Cellular Uptake ◽  
Bovine Serum ◽  
Biomedical Applications ◽  
Addition Reaction ◽  
Covalent Immobilization ◽  
Endocytosis Pathway ◽  
Good Biocompatibility ◽  
Protein Bovine Serum Albumin

Carbon nano-onions (CNOs) possess favorable properties that make them suitable for biomedical applications, including their small size, ready surface modification, and good biocompatibility. Here, we report the covalent immobilization of a synthetic glycopeptide and the protein bovine serum albumin (BSA) onto the surface of carbon nano-onions using the maleimide–thiol “addition reaction”. The glycopeptide and BSA are readily transported inside different cell lines, together with carbon nano-onions, through the endocytosis pathway. Our results show that carbon nano-onions are excellent scaffolds for glycopeptides and proteins immobilization and act as intracellular carriers for these biomolecules. These findings open new perspectives in the application of carbon nano-onions as intracellular transporters in diverse biomedical applications.

Influence of Terahertz Radiation of Various Ranges on Molecule Conformation of Bovine Serum Albumin

2010 ◽  
Vol 5 (4) ◽  
pp. 182-185
Author(s):  
Angelina V. Kapralova ◽  
Aleksandr S. Pogodin
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Radiation Power ◽  
Uv Spectrophotometry ◽  
Absorption Bands ◽  
Conformation Changes ◽  
Protein Molecules ◽  
Molecule Conformation ◽  
Protein Bovine Serum Albumin

We investigated the influence of THz laser radiation of frequencies of 1.15 THz and 3.68 THz and radiation power of about 10 Mw on protein (bovine serum albumin). Using UV spectrophotometry, we revealed increase in the optical density of irradiated samples of bovine serum albumin at the characteristic absorption bands, which is evidence of conformation changes in protein molecules

Polypyrrole Based Nanotheranostic Agent for MRI Guided Photothermal-Chemodynamic Synergistic Cancer Therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Bangyi Zhou ◽  
Chenhui Yin ◽  
Qiang Feng ◽  
Yiting Wu ◽  
Xiaoyu Pan ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Photothermal Therapy ◽  
Polypyrrole Nanoparticles ◽  
Good Biocompatibility ◽  
Mri Guided

Polypyrrole nanoparticles (PPy) have been widely studied in tumor photothermal therapy (PTT) for their significant photostability, good biocompatibility, and excellent photothermal performance. Herein, we reported bovine serum albumin (BSA) stabilized...

Self-healing of thermally-induced, biocompatible and biodegradable protein hydrogel

RSC Advances ◽  
2016 ◽  
Vol 6 (61) ◽  
pp. 56183-56192 ◽  
Author(s):  
Jun Chen ◽  
Xiaoyu Ma ◽  
Qiuchen Dong ◽  
Donghui Song ◽  
Derek Hargrove ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Self Healing ◽  
Thermally Induced ◽  
External Heating ◽  
Good Biocompatibility ◽  
Recovery Performance

Almost 100% self-healing extent recovery performance was observed in thermal-induced bovine serum albumin hydrogel with external heating. Good biocompatibility and biodegradability of this materials were also demonstrated.

scholarly journals The Glass Transition Behavior of the Globular Protein Bovine Serum Albumin

2003 ◽  
Vol 85 (6) ◽  
pp. 3943-3950 ◽  
Author(s):  
Geoffrey J. Brownsey ◽  
Timothy R. Noel ◽  
Roger Parker ◽  
Stephen G. Ring
Keyword(s):  
Glass Transition ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Globular Protein ◽  
Transition Behavior ◽  
Protein Bovine Serum Albumin

scholarly journals The Effect of Fatty Acids and BSA Purity on Synthesis and Properties of Fluorescent Gold Nanoclusters

Nanomaterials ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 343
Author(s):  
Pavlína Andrýsková ◽  
Karolína Machalová Šišková ◽  
Šárka Michetschlägerová ◽  
Klára Jiráková ◽  
Martin Kubala ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Quantum Yield ◽  
Bovine Serum Albumin ◽  
Fluorescence Lifetime ◽  
Bovine Serum ◽  
Gold Nanoclusters ◽  
Alamar Blue ◽  
Hep G2 ◽  
Other Substances ◽  
Protein Bovine Serum Albumin

Fluorescent gold nanoclusters (AuNCs) are envisaged as a novel type of fluorophores. This work reports on the first comparative study investigating the effect of presence/absence/abundance of fatty acids (namely palmitic acid, PA) or other substances (like glycoproteins and globulins) in the protein (bovine serum albumin, BSA) on synthesis and properties of the final AuNCs. The most popular template (BSA) and microwave (MW)-assisted synthesis of AuNCs have been intentionally chosen. Our results clearly demonstrate that the fluorescent characteristics (i.e., fluorescence lifetime and quantum yield) are affected by the fatty acids and/or other substances. Importantly, the as-prepared AuNCs are biocompatible, as determined by Alamar Blue assay performed on Hep G2 cell line.

scholarly journals Anomalous protein kinetics on low-fouling surfaces

2020 ◽  
Vol 22 (9) ◽  
pp. 5264-5271
Author(s):  
Mohammadhasan Hedayati ◽  
Matt J. Kipper ◽  
Diego Krapf
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Single Molecule ◽  
Bovine Serum ◽  
Time Distribution ◽  
Dwell Time ◽  
Protein Kinetics ◽  
Single Molecule Tracking ◽  
Heavy Tailed ◽  
Protein Bovine Serum Albumin

Single-molecule tracking reveals the protein bovine serum albumin exhibits anomalous kinetics with a heavy-tailed dwell time distribution on PEG surfaces. This effect is shown to be caused by the ability of the protein to oligomerize in solution.

scholarly journals KONJUGASI ANHIDRAT KlORAMFENIKOL-PROTEIN (CAP-BSA DAN CAP-KLH) UNTUK PRODUKSI IgG DARI SERUM KELINCI

2011 ◽  
Vol 1 (2) ◽  
pp. 23-31
Author(s):  
Musyirna Rahmah Nst ◽  
Tri Budhi Murdiati
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Immunosorbent Assay ◽  
Bovine Serum ◽  
Keyhole Limpet Hemocyanin ◽  
Enzyme Linked Immunosorbent Assay ◽  
Protein Bovine Serum Albumin

 Dalam pengembangan metoda analisis residu antibiotik pada produk pangan hewani secara immunokimia telah dilakukan sintesis imunogen kloramfenikol (CAP) dengan protein Bovine Serum Albumin (BSA) dan Keyhole Limpet Hemocyanin (KLH) dengan metoda konjugasi mixed anhidrad. Hasil sintesis digunakan untuk produksi antibodi.Antigen dan antibodi yang dihasilkan dijadikan prangkat analisis residu antibiotik dengan Competitive Enzyme Linked Immunosorbent Assay (ELISA kompetitif). Hasil penelitian menunjukkan bahwa metoda konjugasi mixed anhidrad pada preparasi imunogen dengan jumlah CAP yang terkonjugasi ke grup amino bebas dari molekul protein BSA (CAP-BSA) adalah 18 unit dan ke protein KLH (CAP-KLH) adalah 782 unit. Antibodi poliklonal CAP-BSA dan CAP-KLH yang diproduksi dengan rata-rata kandungan IgG CAP-BSA 2,07 mg/ml dan IgG CAP-KLH 2,21 mg/ml.

scholarly journals Doxorubicin hinders DNA condensation promoted by the protein bovine serum albumin (BSA)

Biopolymers ◽  
2017 ◽  
Vol 107 (12) ◽  
pp. e23071
Author(s):  
C. H. M. Lima ◽  
H. M. C. de Paula ◽  
L. H. M. da Silva ◽  
M. S. Rocha
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Dna Condensation ◽  
Protein Bovine Serum Albumin
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