scholarly journals Biopolymers for Biomedical and Pharmaceutical Applications: Recent Advances and Overview of Alginate Electrospinning

Nanomaterials ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 404 ◽  
Author(s):  
Jolanta Wróblewska-Krepsztul ◽  
Tomasz Rydzkowski ◽  
Iwona Michalska-Pożoga ◽  
Vijay Kumar Thakur
Keyword(s):  
Antibacterial Properties ◽  
Electrospinning Process ◽  
Fiber Formation ◽  
Biologically Active ◽  
Food Sector ◽  
Natural Substances ◽  
Pharmaceutical Applications ◽  
Recent Advances ◽  
Electrospinning Method ◽  
Nanofiber Mats

Innovative solutions using biopolymer-based materials made of several constituents seems to be particularly attractive for packaging in biomedical and pharmaceutical applications. In this direction, some progress has been made in extending use of the electrospinning process towards fiber formation based on biopolymers and organic compounds for the preparation of novel packaging materials. Electrospinning can be used to create nanofiber mats characterized by high purity of the material, which can be used to create active and modern biomedical and pharmaceutical packaging. Intelligent medical and biomedical packaging with the use of polymers is a broadly and rapidly growing field of interest for industries and academia. Among various polymers, alginate has found many applications in the food sector, biomedicine, and packaging. For example, in drug delivery systems, a mesh made of nanofibres produced by the electrospinning method is highly desired. Electrospinning for biomedicine is based on the use of biopolymers and natural substances, along with the combination of drugs (such as naproxen, sulfikoxazol) and essential oils with antibacterial properties (such as tocopherol, eugenol). This is a striking method due to the ability of producing nanoscale materials and structures of exceptional quality, allowing the substances to be encapsulated and the drugs/ biologically active substances placed on polymer nanofibers. So, in this article we briefly summarize the recent advances on electrospinning of biopolymers with particular emphasis on usage of Alginate for biomedical and pharmaceutical applications.

scholarly journals Fabrication of Poly (Acrylonitrile-Co-Methyl Methacrylate) Nanofibers Containing Boron via Electrospinning Method: A Study on Size Distribution, Thermal, Crystalline, and Mechanical Strength Properties

2021 ◽  
Vol 13 (8) ◽  
pp. 4342
Author(s):  
Meisam Sadeghi ◽  
Zahra Moghimifar ◽  
P. Senthil Kumar ◽  
Hamedreza Javadian ◽  
Majid Farsadrooh
Keyword(s):  
Methyl Methacrylate ◽  
Average Diameter ◽  
Strength Properties ◽  
Electrospinning Process ◽  
Fiber Formation ◽  
Gravimetric Analysis ◽  
Chemical Reagents ◽  
Polymeric Nanofibers ◽  
Electrospinning Method ◽  
Poly Acrylonitrile

Electrospun polymeric nanofibers have attracted great attention in filtration systems and protective clothes. One of them is polyacrylonitrile (PAN) nanofibers, which are a suitable choice for the fabrication of protective clothes in the defense industry, due to their good fiber formation and easy optimization with chemical reagents. They do not possess adequate properties for protection against chemical, biological, and radiological agents. In this research, poly (acrylonitrile-co-methyl methacrylate) (PANMM) nanofibers and PANMM nanofibers containing 10B were fabricated via the electrospinning method. The study of the morphology of nanofibers, using scanning electron microscopy (SEM), revealed that smooth and knotted fibers with an average diameter of 259 ± 64 nm were obtained, using 12% (w/v) of PANMM in the solution as the optimal concentration for the electrospinning process. This sample was doped with boron (10%, 30%, and 50% (w/w)) to fabricate the samples of PANMM + boric acid (BA) nanofibers. The results demonstrated an increasing trend in the diameter of the nanofibers with an increase in BA up to 50%. At this concentration, smooth fibers were formed with lower knots. Furthermore, the presence of B-O and O-H groups was observed using Fourier transform infrared (FTIR) spectroscopy. To study the tensile properties, the nanofibrous web was tested, and the results showed that introducing 10B to PANMM nanofiber structures reduced the strength of the nanofibers. Thermal gravimetric analysis (TGA) showed that BA-modified PANMM nanofibers had lower thermal degradability, as compared with pure PANMM.

scholarly journals Upward Needleless Electrospinning of Nanofibers

2012 ◽  
Vol 7 (2_suppl) ◽  
pp. 155892501200702 ◽  
Author(s):  
Haitao Niu ◽  
Xungai Wang ◽  
Tong Lin
Keyword(s):  
Electric Field ◽  
High Intensity ◽  
Electrospinning Process ◽  
Fiber Formation ◽  
Diameter Distribution ◽  
Fiber Morphology ◽  
Wire Surface ◽  
Elementary Method ◽  
Needleless Electrospinning ◽  
Electrospinning Method

Polyacrylonitrile (PAN) nanofibers were prepared by a needleless electrospinning method using three rotating fiber generators, cylinder, disc and coil. The effects of the spinneret shape on the electrospinning process and resultant fiber morphology were examined. The disc spinneret needed the lowest voltage to initiate fiber formation, followed by the coil and cylinder. Compared to cylinder, the disc and coil produced finer fibers with narrower diameter distribution. The productivity of a coil was 23 g/hr, which was much larger than that of the cylinder spinneret having the same length and diameter. Finite elementary method was used to analyze the electric field. Stronger electric field was found to be formed on disc and coil surface, which concentrated on the disc circumferential edge and coil wire surface, respectively. For cylinder, the high intensity electric field was mainly concentrated on the end area. Concentrated electric field on the fiber generating surface could be used to explain the better electrospinning performance of coil, which may form a new concept for designing needleless electrospinning spinnerets.

Study of the Optical Properties of Electrospun PAN/GO Nanocomposites

2021 ◽  
Vol 326 ◽  
pp. 17-31
Author(s):  
Tomasz Tański ◽  
Wiktor Matysiak ◽  
Weronika Smok ◽  
Zaborowska Marta
Keyword(s):  
Optical Properties ◽  
Chemical Structure ◽  
Composite Nanofibers ◽  
Electrospinning Process ◽  
Energy Band Gap ◽  
Influence Of Process Parameters ◽  
X Ray ◽  
Electrospinning Method ◽  
Nanofiber Mats ◽  
Composite Samples

Polymer nanocomposites with unique optical properties are currently one of the materials most desired by the industry. An effective method of producing this type of materials is the method of electrospinning from a solution or melted polymers, which allows to obtain a nanocomposite in the form of a mat composed of nanofibers. This paper describes the process of producing nanofibers from polyacrylonitrile (PAN) and composite thin nanofiber mats from PAN with the addition of graphene oxide (GO) particles using the electrospinning method. In addition, the aim of the work was to investigate the influence of process parameters and filler on the morphology and optical properties of the nanomaterial. By changing the configuration of the distance between the nozzle and the collector (10 and 20 cm) and keeping the remaining parameters of the electrospinning process constant, two PAN polymer samples and two PAN/GO composite samples were manufactured. The analysis of the chemical composition and morphology of the obtained materials was performed using X-ray microanalysis (EDX) and scanning electron microscopy (SEM), respectively. In order to examine the chemical structure of the polymer and composite nanofibers, Fourier-Transform Infrared Spectroscopy (FTIR) was used. The analysis of the optical properties and the energy band gap of the prepared nanofibers was determined by spectral analysis using a UV–Vis spectrophotometer. The research showed a significant influence of the filler on the morphology.

scholarly journals Investigation of Antibacterial Properties of Ag Doped TiO2 Nanofibers Prepared by Electrospinning Process

2018 ◽  
Vol 16 (1) ◽  
pp. 732-737 ◽  
Author(s):  
Nalan Çiçek Bezir ◽  
Atilla Evcin ◽  
Ramazan Diker ◽  
Burcu Özcan ◽  
Esengül Kır ◽  
...  
Keyword(s):  
Antibacterial Effect ◽  
Antibacterial Properties ◽  
Electrospinning Process ◽  
Chemical Components ◽  
Gravimetric Analysis ◽  
Energy Dispersive Analysis ◽  
X Ray Diffraction ◽  
Tio2 Nanofibers ◽  
X Ray ◽  
Electrospinning Method

AbstractIn this study, undoped and 1, 2,3, 4, and 5 wt % Ag-doped TiO2 nanofibers have been fabricated by the electrospinning method applying 20 kV voltages at 8 cm height with a flow rate 0.1 mL/h. The antibacterial properties of undoped and doped Ag/TiO2 nanofibers were tested on Staphylococcus aureus bacteria. The antibacterial effect of these fabricated nanofibers has been determined by disc diffusion and Baird parker methods. The results have shown that Ag/TiO2 nanofibers have an excellent antibacterial effect on this bacterium compared to pure TiO2 nanofibers. As a result, developed nanofibers can easily be applied in various fields such as biomedical sector and tissue engineering. In addition, the chemical components, morphology, and crystal structure of the nanofibers have been performed by scanning electron microscopy energy dispersive analysis (SEM-EDX), differential thermal analysis/thermal gravimetric analysis (DTA/TG), and X-ray diffraction (XRD) methods.

A REVIEW ON RECENT ADVANCES IN CHEMISTRY, SYNTHESIS AND BIOLOGICAL APPLICATIONS OF ISATIN DERIVATIVES

2018 ◽  
pp. 16-22
Author(s):  
Shukla PK ◽  
Singh MP ◽  
Patel R
Keyword(s):  
Heterocyclic Compounds ◽  
Biologically Active ◽  
Biological Applications ◽  
Plant Origin ◽  
Recent Past ◽  
Pharmacological Activities ◽  
Naturally Occurring ◽  
Recent Advances ◽  
Biological Aspects ◽  
Isatin Derivatives

Indole and its derivatives have engaged a unique place in the chemistry of nitrogen heterocyclic compounds. The recognition of the plant growthhormone, heteroauxin, the significant amino acids, tryptamine & tryptophan and anti-inflammatory drug, indomethacine are the imperativederivatives of indole which have added stimulus to this review work. Isatin (1H-indole-2,3-dione), an indole derivative of plant origin. Althoughit is a naturally occurring compound, but was synthesized by Erdmann and Laurent in 1840 before it was found in nature. Isatin is a versatileprecursor for many biologically active molecules and its diversified nature makes it a versatile substrate for further modifications. It is concernedin many pharmacological activities like anti-malarial, antiviral, anti-allergic, antimicrobial etc; isatin and its derivatives have been also found todemonstrate promising outcomes against various cancer cell lines. This review provides a brief overview on the recent advances and futureperspectives on chemistry and biological aspects of isatin and its derivatives reported in the recent past.

scholarly journals Transformed tissue of Dionaea muscipula J. Ellis as a source of biologically active phenolic compounds with bactericidal properties

2021 ◽  
Vol 105 (3) ◽  
pp. 1215-1226
Author(s):  
Wojciech Makowski ◽  
Aleksandra Królicka ◽  
Anna Nowicka ◽  
Jana Zwyrtková ◽  
Barbara Tokarz ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Phenolic Acids ◽  
Antibacterial Properties ◽  
Biologically Active ◽  
Plant Genome ◽  
Resistant Bacteria ◽  
Shoot Cultures ◽  
Transformed Plants ◽  
Dionaea Muscipula ◽  
Bactericidal Properties

Abstract The Venus flytrap (Dionaea muscipula J. Ellis) is a carnivorous plant able to synthesize large amounts of phenolic compounds, such as phenylpropanoids, flavonoids, phenolic acids, and 1,4-naphtoquinones. In this study, the first genetic transformation of D. muscipula tissues is presented. Two wild-type Rhizobium rhizogenes strains (LBA 9402 and ATCC 15834) were suitable vector organisms in the transformation process. Transformation led to the formation of teratoma (transformed shoot) cultures with the bacterial rolB gene incorporated into the plant genome in a single copy. Using high-pressure liquid chromatography, we demonstrated that transgenic plants were characterized by an increased quantity of phenolic compounds, including 1,4-naphtoquinone derivative, plumbagin (up to 106.63 mg × g−1 DW), and phenolic acids (including salicylic, caffeic, and ellagic acid), in comparison to non-transformed plants. Moreover, Rhizobium-mediated transformation highly increased the bactericidal properties of teratoma-derived extracts. The antibacterial properties of transformed plants were increased up to 33% against Staphylococcus aureus, Enterococcus faecalis, and Escherichia coli and up to 7% against Pseudomonas aeruginosa. For the first time, we prove the possibility of D. muscipula transformation. Moreover, we propose that transformation may be a valuable tool for enhancing secondary metabolite production in D. muscipula tissue and to increase bactericidal properties against human antibiotic-resistant bacteria. Key points • Rhizobium-mediated transformation created Dionaea muscipula teratomas. • Transformed plants had highly increased synthesis of phenolic compounds. • The MBC value was connected with plumbagin and phenolic acid concentrations.

scholarly journals Natural Coatings on Titanium Surfaces to Improve Their Biological Response

2020 ◽  
Vol 2 (1) ◽  
pp. 18
Author(s):  
Sara Ferraris ◽  
Enrica Verné ◽  
Gissur Örlygsson ◽  
Paulo Tambasco ◽  
Felipe Perraro Sehn ◽  
...  
Keyword(s):  
Natural Products ◽  
Metal Ion ◽  
Antibacterial Properties ◽  
Biological Response ◽  
Aqueous Environment ◽  
Natural Substances ◽  
Ion Doping ◽  
Keratin Fibers ◽  
Scratch Tests ◽  
Titanium Substrates

Biomolecules and extracts from natural products are gaining increasing interest due to their beneficial properties for human health, low toxicity, environmental compatibility and sustainability. In this work, keratin, chitosan and peppermint essential oil have been used for the preparation of coatings on titanium substrates for biomedical implants/devices. All these coatings were obtained from local natural products/byproducts: keratin from discarded wool, chitosan from shrimp shells and peppermint essential oils from a local production. The above cited molecules were selected for their ability to stimulate soft tissue adhesion (keratin), anti-inflammatory activity (chitosan) and antibacterial activity (keratin after metal ion doping, chitosan and mint oil). The coatings were characterized by means of SEM-EDS, FTIR, zeta potential, wettability, tape and scratch tests, and cell and bacteria cultures. The coatings were successfully obtained for all the considered natural substances with good adhesion to the titanium substrates. All the coatings are chemically stable in water and the continuous coatings are mechanically resistant and protective for the metallic substrates. The keratin coatings are hydrophilic while the mint oil and chitosan coatings are hydrophobic; nanofibers, instead of continuous coatings, behave as more hydrophobic. At the physiological pH, the keratin and mint oil coatings are negatively charged when in contact with an aqueous environment, while the chitosan ones are positively charged. The oriented keratin fibers are able to drive fibroblast alignment. The Ag-doped keratin fibers and mint coating show antibacterial properties.

Efficient Synthesis of Novel N-[4-Methyl-3-(4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl)thiazol-2(3H)-ylidene]benzamide Hybrid Ring System as Potential Antibacterial Agents

2021 ◽  
Vol 17 ◽  
Author(s):  
Hummera Rafique ◽  
Aamer Saeed ◽  
Muhammad Naseem ◽  
Tauqeer Riaz ◽  
Fouzia Perveen ◽  
...  
Keyword(s):  
Bacterial Resistance ◽  
Antioxidant Activities ◽  
Antibacterial Properties ◽  
Antibacterial Activities ◽  
Structural Features ◽  
Ring System ◽  
Biologically Active ◽  
Thiazole Ring ◽  
Spectroscopic Techniques ◽  
Hybrid Ring

Background: Heterocyclic compounds display versatile biological applications, so the aim of this paper was to prepare biologically important heterocycles with enhanced bacterial resistance and to evaluate for their various structural features that are responsible for their biological properties. Objective: The objective was to synthesize bacterial resistance compounds with enhanced antibacterial properties. Method: Ester moiety containing thiazole ring was converted into its hydrazide derivatives. These heterocyclic derivatives were cyclized into another ring oxadiazole; hence a hybrid ring system of two biologically active rings was prepared. Result: All the synthesized compounds were characterized by spectroscopic techniques and were screened for their antibacterial potential; they possess significant antibacterial activities. Conclusion: New hybrid heterocyclic ring systems were synthesized by cyclization of hydrazide derivatives by adopting two step strategy in good yields. All the synthesized compounds were evaluated for their antioxidant activities; they showed moderate to significant activities. QSAR and Molecular docking studies were performed to determine the mode of interaction. Experimental and computational data is in accordance with the determined antibacterial activities.

scholarly journals Electrospun Nylon-6 Nanofibers and Their Characteristics

2020 ◽  
Vol 9 (1) ◽  
pp. 9-19
Author(s):  
Ida Sriyanti ◽  
Meily P Agustini ◽  
Jaidan Jauhari ◽  
Sukemi Sukemi ◽  
Zainuddin Nawawi
Keyword(s):  
Fiber Diameter ◽  
Peak Shift ◽  
Nylon 6 ◽  
Electrospinning Process ◽  
Electrospinning Technique ◽  
Fiber Concentration ◽  
Air Filters ◽  
Xrd Pattern ◽  
Electrospinning Method ◽  
Small Wave

The purposes of this research were to investigate the synthesized Nylon-6 nanofibers using electrospinning technique and their characteristics. The method used in this study was an experimental method with a quantitative approach. Nylon-6 nanofibers have been produced using the electrospinning method. This fiber was made with different concentrations, i.e. 20% w/w (FN1), 25% w/w (FN2), and 30% w/w (FN3). The SEM results show that the morphology of all nylon-6 nanofibers) forms perfect fibers without bead fiber. Increasing fiber concentration from 20% w/w to 30% w/w results in bigger morphology and fiber diameter. The dimensions of the FN1, FN2, and FN3 fibers are 1890 nm, 2350 nm, and 2420 nm, respectively. The results of FTIR analysis showed that the increase in the concentration of nylon-6 (b) and the electrospinning process caused a peak shift in the amide II group (CH2 bond), the carbonyl group and the CH2 stretching of the amide III group from small wave numbers to larger ones. The results of XRD characterization showed that the electrospinning process affected the changes in the XRD pattern of nylon-6 nanofiber (FN1, FN2, and FN3) in the state of semi crystal. Nylon-6 nanofibers can be used for applications in medicine, air filters, and electrode for capacitors

Sign in / Sign up

Export Citation Format

Share Document