scholarly journals Chitosan-Based Carbon Quantum Dots for Biomedical Applications: Synthesis and Characterization

Nanomaterials ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 274 ◽  
Author(s):  
Łukasz Janus ◽  
Marek Piątkowski ◽  
Julia Radwan-Pragłowska ◽  
Dariusz Bogdał ◽  
Dalibor Matysek
Keyword(s):  
Amino Acids ◽  
Quantum Dots ◽  
Biomedical Applications ◽  
Rapid Development ◽  
Carbon Quantum Dots ◽  
Dermal Fibroblasts ◽  
Quantum Yields ◽  
Visible Range ◽  
Cell Labelling ◽  
Morphological Studies

Rapid development in medicine and pharmacy has created a need for novel biomaterials with advanced properties such as photoluminescence, biocompability and long-term stability. The following research deals with the preparation of novel types of N-doped chitosan-based carbon quantum dots. Nanomaterials were obtained with simultaneous nitrogen-doping using biocompatible amino acids according to Green Chemistry principles. For the carbon quantum dots synthesis chitosan was used as a raw material known for its biocompability. The nanomaterials obtained in the form of lyophilic colloids were characterized by spectroscopic and spectrofluorimetric methods. Their quantum yields were determined. Additionally the cytotoxicity of the prepared bionanomaterials was evaluated by XTT (2,3-Bis-(2-methoxy-4-nitro5-sulfophenyl)-2H-tetrazolium-5-carboxanilide salt) method. Our results confirmed the formation of biocompatible quantum dots with carbon cores exhibiting luminescence in visible range. Performed studies showed that modification with lysine (11.5%) and glutamic acid (7.4%) had a high impact on quantum yield, whereas functionalization with amino acids rich in S and N atoms did not significantly increase in fluorescence properties. XTT assays as well as morphological studies on human dermal fibroblasts confirmed the lack of cytotoxicity of the prepared bionanomaterials. The study shows chitosan-based quantum dots to be promising for biomedical applications such as cell labelling, diagnostics or controlled drug delivery and release systems.

scholarly journals Organic dots (O-dots) for theranostic applications: preparation and surface engineering

RSC Advances ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 2253-2291
Author(s):  
Amin Shiralizadeh Dezfuli ◽  
Elmira Kohan ◽  
Sepand Tehrani Fateh ◽  
Neda Alimirzaei ◽  
Hamidreza Arzaghi ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Photodynamic Therapy ◽  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Surface Engineering ◽  
Graphene Quantum Dots ◽  
Carbon Quantum Dots ◽  
Cargo Delivery ◽  
Bio Imaging ◽  
Theranostic Applications

Organic dots is a term used to represent materials including graphene quantum dots and carbon quantum dots because they rely on the presence of other atoms (O, H, and N) for their photoluminescence or fluorescence properties. Cargo delivery, bio-imaging, photodynamic therapy and photothermal therapy are major biomedical applications of organic dots.

scholarly journals Preparation and Properties of Cyanobacteria-Based Carbon Quantum Dots/Polyvinyl Alcohol/ Nanocellulose Composite

Polymers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1143 ◽  
Author(s):  
Li Xu ◽  
Ying Li ◽  
Shiyu Gao ◽  
Yue Niu ◽  
Huaxuan Liu ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Polyvinyl Alcohol ◽  
Water Resistance ◽  
Composite Films ◽  
Barrier Properties ◽  
Carbon Quantum Dots ◽  
Infrared Light ◽  
Quantum Yields ◽  
Hydroxyl Groups ◽  
Light Barrier

Blue luminescent carbon quantum dots (CQDs) were prepared from cyanobacteria by a hydrothermal method. The PL quantum yields of the obtained CQDs was 5.30%. Cyanobacteria-based carbon quantum dots/polyvinyl alcohol/nanocellulose composite films were prepared, which could emit bright blue under UV light. FTIR characterization showed that the composite films had hydroxyl groups on the surface and no new groups were formed after combining the three materials. The photoluminescence (PL) spectra revealed that the emission of the prepared CQDs was excitation dependent. Studies on the water resistance performance and light barrier properties of the composite films showed that they possessed higher water resistance properties and better UV/infrared light barrier properties. Therefore, we report the cyanobacteria-based carbon quantum dots/polyvinyl alcohol/nanocellulose composite films have the potential to be applied in flexible packaging materials, anti-fake materials, UV/infrared light barrier materials and so on.

scholarly journals Rapid Synthesis of highly luminescent Carbon Quantum Dots using Low-Pressurized Microwave Solvothermal Heating

2019 ◽  
Author(s):  
Kenta Hagiwara ◽  
Satoshi Horikoshi
Keyword(s):  
Quantum Dots ◽  
Carbon Quantum Dots ◽  
Synthetic Methods ◽  
Quantum Yields ◽  
Protective Agent ◽  
The Novel ◽  
Microwave Chemistry ◽  
High Quantum ◽  
Surface Modified ◽  
The Relationship

Since the first serendipity of carbon quantum dots (CQDs)1, it is expected to be used for imaging materials for reusable living bodies (e.g. Hela cells). However, the reported CQDs synthetic methods have yet to be at the practical levels; the quantum yields is low, and synthetic condition is over 5 hrs under more than 30 atms. In this research, we ameliorated the problems of CQDs synthesis and luminescence (quantum yields) by the novel synthesis protocol using microwave chemistry. Specifically, we synthesized high quantum yields CQDs (61%) by utilizing a microwave chemical synthesis, synthesizing at low pressure condition (lower than 5 atom) and short reaction time (3 hrs). The achievement of this high quantum yields made it clear that the contribution of polyethylene glycol (PEG) shell to CQDs is large. It was confirmed from the DLS and TEM image that the particle size of the synthesized particles was 8 to 13 nm (Fig. 1). On the other hand, the relationship between the polymerization degree of added PEG and the quantum yields to the addition amount is summarized in Table 1. The quantum yields of CQDs without addition of PEG was 16.7 %, while it was improved at 61.1 % when 0.6 g of PEG6000 (Molecular weight: 6000) was added.We succeeded in remarkably improving the quantum yields by using PEG, which is usually used as a protective agent, as a shell. By using this method, we succeeded in improving the quantum yields of the existing report by approximately 3 times. From the surface modified structure of PEG, the mechanism of improvement of quantum yields will be considered.[1] X. Xu et al., J. Am. Chem. Soc., 2004, 126, 12736–12737. 

scholarly journals Carbon Quantum Dots: Synthesis, Characterization and Biomedical Applications

2018 ◽  
Vol 15 (2) ◽  
pp. 219-230 ◽  
Author(s):  
Inderbir SINGH ◽  
Riya ARORA ◽  
Hardik DHIMAN ◽  
Rakesh PAHWA
Keyword(s):  
Quantum Dots ◽  
Biomedical Applications ◽  
Carbon Quantum Dots

scholarly journals Carbon Quantum Dots for Biomedical Applications: Review and Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Nayab Azam ◽  
Murtaza Najabat Ali ◽  
Tooba Javaid Khan
Keyword(s):  
Quantum Dots ◽  
Biomedical Applications ◽  
Near Infrared ◽  
Pharmaceutical Formulations ◽  
Carbon Quantum Dots ◽  
Excitation Wavelength ◽  
Physiochemical Properties ◽  
Electrochemical Biosensing ◽  
New Type ◽  
Low Toxicity

Carbon quantum dots (CQDs) are a new type of nano-carbons that are currently favored over semiconductor quantum dots (QDs) because of their solubility, low toxicity, eco-friendliness, and cheap and facile synthesis giving desired optical characteristics. Moreover, their physiochemical properties can be controlled by their synthetic route. CQDs can emit fluorescence in the range from the UV to the near-infrared (NIR) region, making them suitable for biomedical applications. Fluorescence in these nano-carbon atoms can be tuned by varying the excitation wavelength. As of now, CQDs have been used in various applications such as in bioimaging, biosensing, electrochemical biosensing, drug delivery, gene delivery, photodynamic therapy in the treatment of cancers, pharmaceutical formulations, and treating inflammation. This article highlights the current progress and advancement of CQDs with focus on their synthetic routes, chemical and optical properties, and biomedical applications along with new perceptions in this interesting and promising field.

scholarly journals Synthesis of green-emitting carbon quantum dots with double carbon sources and their application as a fluorescent probe for selective detection of Cu2+ ions

RSC Advances ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 2536-2544 ◽  
Author(s):  
Jun Xu ◽  
Congling Wang ◽  
Huizhi Li ◽  
Weilin Zhao
Keyword(s):  
Quantum Dots ◽  
Fluorescent Probe ◽  
Tartaric Acid ◽  
Carbon Sources ◽  
Carbon Quantum Dots ◽  
Quantum Yields ◽  
Selective Detection ◽  
One Pot ◽  
Solvothermal Treatment

Green-emitting carbon quantum dots (G-CQDs) were prepared using tartaric acid and bran by one-pot solvothermal treatment and had photoluminescence quantum yields (PL QY) as high as 46%.

scholarly journals Carbon Quantum Dots as Fluorescence Nanochemosensors for Selective Detection of Amino Acids

2021 ◽  
Author(s):  
Nunzio Tuccitto ◽  
Luca Fichera ◽  
Roberta Ruffino ◽  
Valentina Cantaro ◽  
Gianfranco Sfuncia ◽  
...  
Keyword(s):  
Amino Acids ◽  
Quantum Dots ◽  
Carbon Quantum Dots ◽  
Selective Detection

scholarly journals Microwave-Assisted Green Synthesis of Carbon Quantum Dots Derived from Calotropis Gigantea as a Fluorescent Probe for Bioimaging

2021 ◽  
Author(s):  
Neetu Sharma ◽  
Indu Sharma ◽  
Milan Kumar Bera
Keyword(s):  
Quantum Dots ◽  
Aqueous Suspension ◽  
Significant Proportion ◽  
Carbon Quantum Dots ◽  
Quantum Yields ◽  
Microwave Assisted Synthesis ◽  
Nuclear Magnetic Resonance Analysis ◽  
Synthetic Dyes ◽  
Calotropis Gigantea ◽  
Microwave Assisted

Abstract In this study, an eco-friendly, cost-effective, and convenient method for preparing biocompatible fluorescent carbon quantum dots (CQDs) by one-pot microwave assisted synthesis from the leaf extract of the medicinal plant Calotropis gigantea, also known as crown flower, has been demonstrated. As-synthesized CQDs demonstrated fluorescence quantum yields up to 4.24 percent. The size distribution of the as-synthesized CQDs varied from 2.7 to 10.4 nm, with a significant proportion of sp2 and sp3 carbon groups verified by nuclear magnetic resonance analysis. The zeta potential of as-synthesized CQDs was measured to be –13.8 mV, indicating the existence of a negatively charged surface with incipient instability in aqueous suspension. Furthermore, as an alternative to organic or synthetic dyes, the development of simple, inexpensive, and non-destructive fluorescence-based staining agents are highly desired. In this regard, as-synthesized CQDs shown remarkable fluorescent staining capabilities in this work and may be utilised as a suitable probe for optical and bio-imaging of bacteria, fungi, and plant cells.

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