scholarly journals Neurotoxicity of Nanomaterials: An Up-to-Date Overview

Nanomaterials ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 96 ◽  
Author(s):  
Daniel Teleanu ◽  
Cristina Chircov ◽  
Alexandru Grumezescu ◽  
Raluca Teleanu
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Quantum Dots ◽  
Cancer Therapy ◽  
Biomedical Applications ◽  
Environmental Science ◽  
Bulk Materials ◽  
Food And Agriculture ◽  
Neurotoxic Effects

The field of nanotechnology, through which nanomaterials are designed, characterized, produced, and applied, is rapidly emerging in various fields, including energy, electronics, food and agriculture, environmental science, cosmetics, and medicine. The most common biomedical applications of nanomaterials involve drug delivery, bioimaging, and gene and cancer therapy. Since they possess unique properties which are different than bulk materials, toxic effects and long-term impacts on organisms are not completely known. Therefore, the purpose of this review is to emphasize the main neurotoxic effects induced by nanoparticles, liposomes, dendrimers, carbon nanotubes, and quantum dots, as well as the key neurotoxicology assays to evaluate them.

scholarly journals Patent Review of Nanoparticles in Drug Delivery and Cancer Therapy in The Last Decade

2021 ◽  
Vol 14 ◽  
Author(s):  
Nur Umairah Binti Ali Hazis ◽  
Nagender Aneja ◽  
Rajan Rajabalaya ◽  
Sheba R David
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Quantum Dots ◽  
Clinical Practice ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Patent Analysis ◽  
The Past ◽  
Patent Review ◽  
Site Of Action

Background: The application of nanotechnology has been considered a powerful platform in improving the current situation in drug delivery and cancer therapy, especially in targeting the desired site of action. Objective: The main objective of the patent review is to survey and review patents from the past ten years that are related to the two particular areas of nanomedicines. Methods: The patents related to the nanoparticle-based inventions utilized in drug delivery and cancer treatment from 2010 onwards were browsed in databases like USPTO, WIPO, Google Patents, and Free Patents Online. After conducting numerous screening processes, a total of 40 patents were included in the patent analysis. Results: Amongst the selected patents, an overview of various types of nanoparticles are presented in this paper, including polymeric, metallic, silica, lipid-based nanoparticles, quantum dots, carbon nanotubes, and albumin-based nanomedicines. Conclusion: Nanomedicines advantages include improvements in terms of drug delivery, bioavailability, solubility, penetration, and stability of drugs. It is concluded that the utilization of nanoparticles in medicines is essential in the pursuit of better clinical practice.

Role of Nanostructured Materials in Health and Medicine

2021 ◽  
pp. 310-329
Author(s):  
Rafia Bashir ◽  
Hamida Tun-Nisa Chisti ◽  
Tauseef Ahmad Rangreez ◽  
Rizwana Mobin
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Quantum Dots ◽  
Cancer Therapy ◽  
Nanostructured Materials ◽  
Tuberculosis Treatment ◽  
Human Diseases ◽  
Site Specific

In the recent times, nanotechnology has been the most explored and extensively studied area. With the application of nanotechnology, many devices were devised at a lightning speed, which were earlier impossible to imagine. Nanotechnology offers multiple benefits in treating chronic human diseases by site-specific and target-oriented delivery of precise medicines. This chapter describes the importance of nanoparticle-based devices like nanotubes, quantum dots, carbon nanotubes, dendrimers, etc. and their applications for the treatment of several diseases. Applications of nanoparticles in drug delivery, tuberculosis treatment, and cancer therapy are also explained in this chapter. Nanomedicines can also be used to detect diseases at much earlier stages.

Modern Possibilities of Organ-Preserving Treatment in Children with Intraocular Retinoblastoma

2018 ◽  
Vol 5 (3) ◽  
pp. 175-187 ◽  
Author(s):  
O. V. Gorovtsova ◽  
T. L. Ushakova ◽  
V. G. Polyakov
Keyword(s):  
Drug Delivery ◽  
Survival Rate ◽  
Cancer Therapy ◽  
Neoadjuvant Chemotherapy ◽  
Patient Survival ◽  
Focal Therapy ◽  
Local Drug Delivery ◽  
Large Size ◽  
Intraocular Retinoblastoma

Retinoblastoma is one of highly curable diseases; today the total 5-year survival rate in patients with retinoblastoma exceeds 95%. The article summarizes the current world experience on treatment of patients with intraocular retinoblastoma. The treating skills of intraocular malignant tumor in children are a balance between the patient’s life and the preservation of an eye and its visual functions. The complex and challenging task is the treatment of common intraocular retinoblastoma groups «C», «D», «E» when the large size or localization of the tumor does not allow performing the local (focal) destruction of the tumor. As a rule, in such cases neoadjuvant chemotherapy (CT) is performed at the first stage in order to reduce the size of the tumor for further focal therapy. However, the analysed data on the effectiveness of neoadjuvant CT in combination with focal or radiotherapy demonstrated the limited possibilities of the proposed therapy. Local drug delivery in cancer therapy became a real breakthrough in the organ-preserving treatment of children with large intraocular retinoblastoma. The most widely used current methods of local drug delivery are intravitreal (IVitC) and selective intra-arterial chemotherapy (SIAC) as monotherapy or in combination with neoadjuvant CT and focal therapy which significantly increased the percentage of preserved eyes without radiotherapy administration or damage to the patient survival. The review discusses the different IVitC and SIAC techniques, chemotherapy schemes, dosages of chemotherapy, immediate and long-term complications of treatment.

Carbon Nanotubes, Quantum Dots and Dendrimers as Potential Nanodevices for Nanotechnology Drug Delivery Systems

2013 ◽  
Vol 6 (3) ◽  
pp. 2113-2124
Author(s):  
Prashant Malik ◽  
Neha Gulati ◽  
Raj Kaur Malik ◽  
Upendra Nagaich
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Quantum Dots ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Atomic Scale ◽  
Sustained Drug Delivery ◽  
Pharmaceutical Nanotechnology ◽  
Conventional Device

Nanotechnology deal with the particle size in nanometers. Nanotechnology is ranging from extensions of conventional device physics to completely new approaches based upon molecular self assembly, from developing new materials with dimensions on the nanoscale to direct control of matter on the atomic scale. In nanotechnology mainly three types of nanodevices are described: carbon nanotubes, quantum dots and dendrimers. It is a recent technique used as small size particles to treat many diseases like cancer, gene therapy and used as diagnostics. Nanotechnology used to formulate targeted, controlled and sustained drug delivery systems. Pharmaceutical nanotechnology embraces applications of nanoscience to pharmacy as nanomaterials and as devices like drug delivery, diagnostic, imaging and biosensor materials. Pharmaceutical nanotechnology has provided more fine tuned diagnosis and focused treatment of disease at a molecular level.    

MPA-capped CdTe quantum dots exposure causes neurotoxic effects in nematode Caenorhabditis elegans by affecting the transporters and receptors of glutamate, serotonin and dopamine at the genetic level, or by increasing ROS, or both

Nanoscale ◽  
2015 ◽  
Vol 7 (48) ◽  
pp. 20460-20473 ◽  
Author(s):  
Tianshu Wu ◽  
Keyu He ◽  
Qinglin Zhan ◽  
Shengjun Ang ◽  
Jiali Ying ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Caenorhabditis Elegans ◽  
Biomedical Applications ◽  
Biological Properties ◽  
Cdte Quantum Dots ◽  
Nematode Caenorhabditis Elegans ◽  
Neurotoxic Effects ◽  
Genetic Level

As quantum dots (QDs) are widely used in biomedical applications, the number of studies focusing on their biological properties is increasing.

Functional Nanodiamond Internalization Mechanisms and Kinetics

2010 ◽  
Author(s):  
Robert Lam ◽  
Xueqing Zhang ◽  
Mark Chen ◽  
Dean Ho
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Surface Modification ◽  
Aspect Ratio ◽  
Biomedical Applications ◽  
Internalization Mechanism ◽  
Mechanism And Kinetics ◽  
Energy Dependent ◽  
The Relationship ◽  
Kinetics Of

Several reports have described the relationship between size, aspect ratio, surface modification and internalization for a variety of nanoparticles (i.e. gold, polymer, carbon nanotubes). Nanodiamonds (NDs) in particular have recently been implicated in a variety of biomedical applications. One of the most promising is in utilizing NDs as drug delivery carriers where successful internalization is of utmost importance. A few reports recently have demonstrated the energy dependent internalization of bare NDs. In this report, we investigate the internalization mechanism and kinetics of functional ND-conjugate translocation.

scholarly journals Frontiers in Bioengineering and Biotechnology: Plant Nanoparticles for Anti-Cancer Therapy

Vaccines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 830
Author(s):  
Erum Shoeb ◽  
Uzma Badar ◽  
Srividhya Venkataraman ◽  
Kathleen Hefferon
Keyword(s):  
Drug Delivery ◽  
Cancer Research ◽  
Cancer Therapy ◽  
Plant Virus ◽  
Biomedical Applications ◽  
Plant Viruses ◽  
Naturally Occurring ◽  
Anti Cancer ◽  
Diagnostic Agents ◽  
Stimuli Response

Naturally occurring viral nanomaterials have gained popularity owing to their biocompatible and biodegradable nature. Plant virus nanoparticles (VNPs) can be used as nanocarriers for a number of biomedical applications. Plant VNPs are inexpensive to produce, safe to administer and efficacious as treatments. The following review describes how plant virus architecture facilitates the use of VNPs for imaging and a variety of therapeutic applications, with particular emphasis on cancer. Examples of plant viruses which have been engineered to carry drugs and diagnostic agents for specific types of cancer are provided. The drug delivery system in response to the internal conditions is known as stimuli response, recently becoming more applicable using plant viruses based VNPs. The review concludes with a perspective of the future of plant VNPs and plant virus-like particles (VLPs) in cancer research and therapy.

Quantum Dots Conjugated with Fe3O4-Filled Carbon Nanotubes for Cancer-Targeted Imaging and Magnetically Guided Drug Delivery

Langmuir ◽  
2012 ◽  
Vol 28 (47) ◽  
pp. 16469-16476 ◽  
Author(s):  
Mei-Ling Chen ◽  
Ye-Ju He ◽  
Xu-Wei Chen ◽  
Jian-Hua Wang
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Quantum Dots ◽  
Targeted Imaging

scholarly journals Advances of Microneedles in Biomedical Applications

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5912
Author(s):  
Jie Xu ◽  
Danfeng Xu ◽  
Xuan Xuan ◽  
Huacheng He
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Minimally Invasive ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Wound Repair ◽  
Delivery Systems ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Different Shapes

A microneedle (MN) is a painless and minimally invasive drug delivery device initially developed in 1976. As microneedle technology evolves, microneedles with different shapes (cone and pyramid) and forms (solid, drug-coated, hollow, dissolvable and hydrogel-based microneedles) have been developed. The main objective of this review is the applications of microneedles in biomedical areas. Firstly, the classifications and manufacturing of microneedle are briefly introduced so that we can learn the advantages and fabrications of different MNs. Secondly, research of microneedles in biomedical therapy such as drug delivery systems, diagnoses of disease, as well as wound repair and cancer therapy are overviewed. Finally, the safety and the vision of the future of MNs are discussed.

scholarly journals Nanomaterials: Applications in Electronics

2021 ◽  
Vol 4 (6) ◽  
pp. 7-19
Author(s):  
Mrs. Harshada V. Mhetre ◽  
◽  
Dr. Yuvraj K. Kanse ◽  
Dr. Suhas S. Patil ◽  
◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Quantum Dots ◽  
Optical Properties ◽  
Solar Cells ◽  
Light Emission ◽  
Enabling Technology ◽  
Bulk Materials ◽  
Different Types ◽  
Basic Characteristics

Nanotechnology is steadily transgressing from the laboratory to the commercial sphere and is enhancing products in a variety of sectors. Nanotechnology R&D has evolved from foundational discoveries aimed at understanding and exploiting nanoscale behaviour to an enabling technology. Nanomaterials are materials which are sized between 1 to 100 nm. Due to the basic characteristics of nanomaterials such as optical properties, reflection, transmission, absorption, and light emission, which are different from those of bulk materials, nanomaterials are useful in a variety of applications in different fields. In this paper the different types of nanomaterials have been outlined based upon their dimensions and applications in the field of electronics such as Quantum dots (QD’s) in solar cells and Carbon Nanotubes and graphene in FETs.

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