scholarly journals Laminated Copper Nanocluster Incorporated Antioxidative Paper Device with RGB System-Assisted Signal Improvement

Nanomaterials ◽  
2018 ◽  
Vol 8 (2) ◽  
pp. 97 ◽  
Author(s):  
Chong-You Chen ◽  
Chia-Lin Chen ◽  
Chang-Ming Wang ◽  
Wei-Ssu Liao
Keyword(s):  
Paper Device ◽  
Signal Improvement ◽  
Rgb System

Highly efficient sample stacking by enhanced field amplification on a simple paper device

Lab on a Chip ◽  
2016 ◽  
Vol 16 (18) ◽  
pp. 3460-3465 ◽  
Author(s):  
Biao Ma ◽  
Yi-Zhen Song ◽  
Ji-Cheng Niu ◽  
Zhi-Yong Wu
Keyword(s):  
Sample Stacking ◽  
Highly Efficient ◽  
Field Amplification ◽  
Paper Device ◽  
Signal Improvement ◽  
Electrokinetic Stacking ◽  
Analytical Device

Electrokinetic stacking based on field amplification was firstly introduced to a paper-based analytical device, and over 1000-fold signal improvement was achieved.

scholarly journals Are Nanobiosensors an Improved Solution for Diagnosis of Leishmania?

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 491
Author(s):  
Sona Jain ◽  
Wanessa Santana ◽  
Silvio S. Dolabella ◽  
André L. S. Santos ◽  
Eliana B. Souto ◽  
...  
Keyword(s):  
Low Income ◽  
Neglected Tropical Diseases ◽  
Diagnostic Techniques ◽  
Cross Reactivity ◽  
Low Income Countries ◽  
Future Research ◽  
Immunological Tests ◽  
Diagnostic Approaches ◽  
Signal Improvement ◽  
Adequate Management

Leishmaniasis is one of the deadliest neglected tropical diseases affecting 12–15 million people worldwide, especially in middle- and low-income countries. Rapid and accurate diagnosis of the disease is important for its adequate management and treatment. Several techniques are available for the diagnosis of leishmaniasis. Among these, parasitological and immunological tests are most widely used. However, in most cases, the utilized diagnostic techniques are not good enough, showing cross-reactivity and reduced accuracy. In recent years, many new methods have been reported with potential for improved diagnosis. This review focuses on the diagnosis of Leishmania exploring the biosensors and nanotechnology-based options for their detection. New developments including the use of nanomaterials as fluorophores, fluorescence quenchers as reducing agents and as dendrimers for signal improvement and amplification, together with the use of aptamers to replace antibodies are described. Future research opportunities to overcome the current limitations on the available diagnostic approaches are also discussed.

Microanalysis based on paper device functionalized with cuprizone to determine Cu2+ in sugar cane spirits using a smartphone

2021 ◽  
Vol 253 ◽  
pp. 119580
Author(s):  
Mathews de Oliveira Krambeck Franco ◽  
Willian Toito Suarez ◽  
Vagner Bezerra dos Santos ◽  
Ian Santana Resque ◽  
Marcelo Henrique dos Santos ◽  
...  
Keyword(s):  
Sugar Cane ◽  
Paper Device

Chemiluminescence excited photoelectrochemical competitive immunosensing lab-on-paper device using an integrated paper supercapacitor for signal amplication

2015 ◽  
Vol 208 ◽  
pp. 546-553 ◽  
Author(s):  
Yanhu Wang ◽  
Haiyun Liu ◽  
Panpan Wang ◽  
Jinghua Yu ◽  
Shenguang Ge ◽  
...  
Keyword(s):  
Paper Device

Explosive colorimetric discrimination using a smartphone, paper device and chemometrical approach

2014 ◽  
Vol 6 (7) ◽  
pp. 2047-2052 ◽  
Author(s):  
M. O. Salles ◽  
G. N. Meloni ◽  
W. R. de Araujo ◽  
T. R. L. C. Paixão
Keyword(s):  
Paper Device

Application of middle-down approach in quantitation and catabolite identification of protein by LC–high-resolution mass spectrometry

Bioanalysis ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 465-479
Author(s):  
Lijuan Kang ◽  
Shengsheng Xu ◽  
Yongle Pang ◽  
Tom Kirchner ◽  
Yue-mei Zhang ◽  
...  
Keyword(s):  
High Resolution Mass Spectrometry ◽  
Resolving Power ◽  
Detection Sensitivity ◽  
Intact Protein ◽  
Top Down ◽  
Assay Performance ◽  
Model Protein ◽  
Bioanalytical Assay ◽  
Signal Improvement

Aim: To further enhance the detection sensitivity and increase resolving power of top-down intact protein bioanalysis, middle-down approach was explored. Materials & methods: An monoclonal antibody (mAb) was used as a model protein to evaluate quantitative bioanalytical assay performance and a disulfide linked dimer protein was investigated for its pharmacokinetics properties and catabolism in vivo by middle-down approach. Results & Conclusion: For quantitation of the mAb, different subunits generated by middle-down approach provided different level of signal improvement in biological samples with Lc and half Fc giving five-times better sensitivity than intact mAb. For the dimer protein, middle-down analysis by reduction enabled effective differentiation of the unchanged protein and its oxidized form, and clearly elucidated their respective proteolytic catabolites.

scholarly journals Identifying key targets for interventions to improve psychological wellbeing: replicable results from four UK cohorts

2018 ◽  
Vol 49 (14) ◽  
pp. 2389-2396 ◽  
Author(s):  
J. Stochl ◽  
E. Soneson ◽  
A.P. Wagner ◽  
G.M. Khandaker ◽  
I. Goodyer ◽  
...  
Keyword(s):  
Mental Health ◽  
Public Mental Health ◽  
Well Being ◽  
Psychological Wellbeing ◽  
Self Perception ◽  
Health And Wellbeing ◽  
Self Confidence ◽  
Mental Health Interventions ◽  
Mental Well Being ◽  
Signal Improvement

AbstractBackgroundAn increasing importance is being placed on mental health and wellbeing at individual and population levels. While there are several interventions that have been proposed to improve wellbeing, more evidence is needed to understand which aspects of wellbeing are most influential. This study aimed to identify key items that signal improvement of mental health and wellbeing.MethodsUsing network analysis, we identified the most central items in the graph network estimated from the well-established Warwick-Edinburgh Mental Well-being Scale (WEMWBS). Results were compared across four major UK cohorts comprising a total of 47,578 individuals: the Neuroscience in Psychiatry Network, the Scottish Schools Adolescent Lifestyle and Substance Use Survey, the Northern Ireland Health Survey, and the National Child Development Study.ResultsRegardless of gender, the three items most central in the network were related to positive self-perception and mood: ‘I have been feeling good about myself’; ‘I have been feeling confident’; and ‘I have been feeling cheerful’. Results were consistent across all four cohorts.ConclusionsPositive self-perception and positive mood are central to psychological wellbeing. Psychotherapeutic and public mental health interventions might best promote psychological wellbeing by prioritising the improvement of self-esteem, self-confidence and cheerfulness. However, empirical testing of interventions using these key targets is needed.

Titelbild: Target-Induced and Equipment-Free DNA Amplification with a Simple Paper Device (Angew. Chem. 8/2016)

2016 ◽  
Vol 128 (8) ◽  
pp. 2649-2649 ◽  
Author(s):  
Meng Liu ◽  
Christy Y. Hui ◽  
Qiang Zhang ◽  
Jimmy Gu ◽  
Balamurali Kannan ◽  
...  
Keyword(s):  
Dna Amplification ◽  
Free Dna ◽  
Paper Device
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