scholarly journals SERS-Based Aptasensor for Rapid Quantitative Detection of SARS-CoV-2

Nanomaterials ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1394
Author(s):  
Elena Zavyalova ◽  
Oganes Ambartsumyan ◽  
Gleb Zhdanov ◽  
Dmitry Gribanyov ◽  
Vladimir Gushchin ◽  
...  
Keyword(s):  
Quantitative Determination ◽  
Virus Detection ◽  
High Sensitivity ◽  
Quantitative Detection ◽  
Colloidal Solutions ◽  
New Techniques ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

During the COVID-19 pandemic, the development of sensitive and rapid techniques for detection of viruses have become vital. Surface-enhanced Raman scattering (SERS) is an appropriate tool for new techniques due to its high sensitivity. SERS materials modified with short-structured oligonucleotides (DNA aptamers) provide specificity for SERS biosensors. Existing SERS-based aptasensors for rapid virus detection are either inapplicable for quantitative determination or have sophisticated and expensive construction and implementation. In this paper, we provide a SERS-aptasensor based on colloidal solutions which combines rapidity and specificity in quantitative determination of SARS-CoV-2 virus, discriminating it from the other respiratory viruses.

scholarly journals SERS-Based Colloidal Aptasensors for Quantitative Determination of Influenza Virus

2021 ◽  
Vol 22 (4) ◽  
pp. 1842
Author(s):  
Dmitry Gribanyov ◽  
Gleb Zhdanov ◽  
Andrei Olenin ◽  
Georgii Lisichkin ◽  
Alexandra Gambaryan ◽  
...  
Keyword(s):  
Quantitative Determination ◽  
Influenza A ◽  
Virus Detection ◽  
High Sensitivity ◽  
Surface Enhanced Raman Spectroscopy ◽  
New Techniques ◽  
New Approach ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Development of sensitive techniques for rapid detection of viruses is on a high demand. Surface-enhanced Raman spectroscopy (SERS) is an appropriate tool for new techniques due to its high sensitivity. DNA aptamers are short structured oligonucleotides that can provide specificity for SERS biosensors. Existing SERS-based aptasensors for rapid virus detection had several disadvantages. Some of them lacked possibility of quantitative determination, while others had sophisticated and expensive implementation. In this paper, we provide a new approach that combines rapid specific detection and the possibility of quantitative determination of viruses using the example of influenza A virus.

scholarly journals Graphene-Based Biosensors for Detection of Biomarkers

2019 ◽  
Author(s):  
Yunlong Bai ◽  
Tailin Xu ◽  
Xueji Zhang
Keyword(s):  
Small Molecules ◽  
High Sensitivity ◽  
High Specific Surface Area ◽  
Quantitative Detection ◽  
Graphene Derivatives ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Resonance Surface ◽  
Detection Of Biomarkers

The development of biosensors with high sensitivity and low-detection limits provides a new direction for medical and personal care. Graphene and graphene derivatives have been used to prepare various types of biosensors due to their excellent sensing performance (e.g. high specific surface area, extraordinary electronic properties, electron transport capabilities and ultrahigh flexibility). This perspective review focuses on graphene-based biosensors for quantitative detection of cancer related biomarkers such as DNA, miRNA, small molecules and proteins by integrating with different signal outputting approaches including fluorescent, electrochemistry, surface plasmon resonance, surface enhanced Raman scattering etc. The article also discussed their challenges and potential solutions along with future prospects.

scholarly journals Graphene-Based Biosensors for Detection of Biomarkers

Micromachines ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 60 ◽  
Author(s):  
Yunlong Bai ◽  
Tailin Xu ◽  
Xueji Zhang
Keyword(s):  
Small Molecules ◽  
High Sensitivity ◽  
High Specific Surface Area ◽  
Quantitative Detection ◽  
Graphene Derivatives ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Resonance Surface ◽  
Detection Of Biomarkers

The development of biosensors with high sensitivity and low-detection limits provides a new direction for medical and personal care. Graphene and graphene derivatives have been used to prepare various types of biosensors due to their excellent sensing performance (e.g., high specific surface area, extraordinary electronic properties, electron transport capabilities and ultrahigh flexibility). This perspective review focuses on graphene-based biosensors for quantitative detection of cancer-related biomarkers such as DNA, miRNA, small molecules and proteins by integrating with different signal outputting approaches including fluorescent, electrochemistry, surface plasmon resonance, surface enhanced Raman scattering, etc. The article also discussed their challenges and potential solutions along with future prospects.

A novel immunochromatographic assay (ICA) based on surface-enhanced Raman scattering for the sensitive and quantitative determination of clenbuterol

2015 ◽  
Vol 7 (2) ◽  
pp. 513-520 ◽  
Author(s):  
Yun Xie ◽  
Huafang Chang ◽  
Kang Zhao ◽  
Jianguo Li ◽  
Hong Yang ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Quantitative Determination ◽  
Surface Enhanced Raman Scattering ◽  
Urine Samples ◽  
Immunochromatographic Assay ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

In this study, we present a novel immunochromatographic assay (ICA) based on surface-enhanced Raman scattering (SERS) for the sensitive and quantitative determination of clenbuterol in urine samples.

scholarly journals Functionalization of metal Nanoparticles for SERS-based Detections of illicit drugs in biological samples

2020 ◽  
Author(s):  
shamim Azimi
Keyword(s):  
Illicit Drugs ◽  
Point Of Care ◽  
High Sensitivity ◽  
Metal Nanoparticle ◽  
General View ◽  
Precise Control ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

Surface-enhanced Raman scattering (SERS) has been widely used for the detection of illicit drugs due to its excellent chemical fingerprint information, high sensitivity by plasmon-enhanced excitation and scattering, and independence of aqueous solution impact. Even though it has been more than one decade since the first SERS was synthesized, extensive effort has recently been undertaken to improve hand-held Raman analyzer and make SERS a practical point-of-care (POC) device for the detection of illicit drugs in real samples. Lately, there has been a fast growth in improving methods for precise control over metal nanoparticle size and modification of their detection performance with functionalizing agents, which will dramatically enhance their application in various biomedical applications.In this study, a general view on the background of the SERS and several basic concepts and focuses are discussed. Then we put forward a summary of the progress in trace determination of illicit drugs using various functionalization methods for enhancing characteristics of the substrate toward a more selective detection of the analytes.

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