scholarly journals Recent Advances in Nanomicelles Delivery Systems

Nanomaterials ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 70
Author(s):  
Salah M. Tawfik ◽  
Shavkatjon Azizov ◽  
Mohamed R. Elmasry ◽  
Mirkomil Sharipov ◽  
Yong-Ill Lee
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Aqueous Media ◽  
New Drugs ◽  
Therapeutic Interventions ◽  
Stimuli Responsive ◽  
Molecular Weights ◽  
Therapeutic Drugs ◽  
Shape Selective ◽  
Selective Delivery

The efficient and selective delivery of therapeutic drugs to the target site remains the main obstacle in the development of new drugs and therapeutic interventions. Up until today, nanomicelles have shown their prospective as nanocarriers for drug delivery owing to their small size, good biocompatibility, and capacity to effectively entrap lipophilic drugs in their core. Nanomicelles are formed via self-assembly in aqueous media of amphiphilic molecules into well-organized supramolecular structures. Molecular weights and structure of the core and corona forming blocks are important properties that will determine the size of nanomicelles and their shape. Selective delivery is achieved via novel design of various stimuli-responsive nanomicelles that release drugs based on endogenous or exogenous stimulations such as pH, temperature, ultrasound, light, redox potential, and others. This review summarizes the emerging micellar nanocarriers developed with various designs, their outstanding properties, and underlying principles that grant targeted and continuous drug delivery. Finally, future perspectives, and challenges for nanomicelles are discussed based on the current achievements and remaining issues.

scholarly journals Luminescent Supramolecular Nano- or Microstructures Formed in Aqueous Media by Amphiphile-Noble Metal Complexes

2020 ◽  
Vol 2020 ◽  
pp. 1-24 ◽  
Author(s):  
Carmen Cretu ◽  
Loredana Maiuolo ◽  
Domenico Lombardo ◽  
Elisabeta I. Szerb ◽  
Pietro Calandra
Keyword(s):  
Noble Metal ◽  
Smart Materials ◽  
Self Assembly ◽  
Noble Metals ◽  
Photophysical Properties ◽  
Aqueous Media ◽  
Molecular Architecture ◽  
Stimuli Responsive ◽  
Panoramic View ◽  
Amphiphilic Molecules

The involvement of metal ions within the self-assembly spontaneously occurring in surfactant-based systems gives additional and interesting features. The electronic states of the metal, together with the bonds that can be established with the organic amphiphilic counterpart, are the factors triggering new photophysical properties. Moreover, the availability of stimuli-responsive supramolecular amphiphile assemblies, able to disassemble in a back-process, provides reversible switching particularly useful in novel approaches and applications giving rise to truly smart materials. In particular, small amphiphiles with an inner distribution, within their molecular architecture, of various polar and apolar functional groups, can give a wide variety of interactions and therefore enriched self-assemblies. If it is joined with the opportune presence and localization of noble metals, whose chemical and photophysical properties are undiscussed, then very interesting materials can be obtained. In this minireview, the basic concepts on self-assembly of small amphiphilic molecules with noble metals are shown with particular reference to the photophysical properties aiming at furnishing to the reader a panoramic view of these exciting problematics. In this respect, the following will be shown: (i) the principles of self-assembly of amphiphiles that involve noble metals, (ii) examples of amphiphiles and amphiphile-noble metal systems as representatives of systems with enhanced photophysical properties, and (iii) final comments and perspectives with some examples of modern applications.

scholarly journals Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

2021 ◽  
Vol 9 (1) ◽  
pp. 38-50
Author(s):  
Hien Phan ◽  
Vincenzo Taresco ◽  
Jacques Penelle ◽  
Benoit Couturaud
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Amphiphilic Block Copolymers ◽  
Stimuli Responsive ◽  
Site Specific ◽  
On Demand ◽  
Redox Agents

Stimuli-responsive amphiphilic block copolymers obtained by PISA have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, redox agents, light or temperature.

Self-assembly of Stimuli Responsive Coiled-coil Fibrous Hydrogels

Soft Matter ◽  
2021 ◽  
Author(s):  
Michael Meleties ◽  
Priya Katyal ◽  
Bonnie Lin ◽  
Dustin Britton ◽  
Jin Kim Montclare
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Self Assembly ◽  
Coiled Coil ◽  
Stimuli Responsive ◽  
Tunable Properties ◽  
Stimuli Sensitive ◽  
Biomedical Fields

Owing to their tunable properties, hydrogels comprised of stimuli sensitive polymers are one of the most appealing scaffolds with applications in tissue engineering, drug delivery and other biomedical fields. We...

Design and self-assembly of albumin nanoclusters as a dynamic-covalent targeting co-delivery and stimuli-responsive controlled release platform

2018 ◽  
Vol 6 (42) ◽  
pp. 6817-6830 ◽  
Author(s):  
Wen Liu ◽  
Jian Dai ◽  
Wei Xue
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Tumor Microenvironment ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Target Sites

Stimuli-responsive nanomaterial-based drug delivery systems that are able to actively target the tumor microenvironment, enhance intratumoral accumulation and release drugs at target sites are attractive therapeutic platforms at present.

scholarly journals Morphology-tunable and pH-responsive supramolecular self-assemblies based on AB2-type host–guest-conjugated amphiphilic molecules for controlled drug delivery

2019 ◽  
Vol 15 ◽  
pp. 1925-1932 ◽  
Author(s):  
Yang Bai ◽  
Cai-ping Liu ◽  
Di Chen ◽  
Long-hai Zhuo ◽  
Huai-tian Bu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Controlled Drug Delivery ◽  
Transition Process ◽  
Hydrodynamic Diameter ◽  
Cancer Cell Proliferation ◽  
Acidic Ph ◽  
Stimuli Responsive ◽  
Amphiphilic Molecules ◽  
Acidic Conditions

Although stimuli-responsive supramolecular self-assemblies have been constructed, the controlled drug delivery induced by morphology transitions of these supramolecular self-assemblies on the basis of host–guest-conjugated monomers (HGCMs) are few reported. In this paper, the self-assembly behaviors of AB2-type HGCMs, e.g., β-cyclodextrin-benzimidazole2 (β-CD-BM2), were investigated at neutral and acidic pH conditions, respectively. Specifically, β-CD-BM2 first self-assembled into fan-shaped supramolecular self-assemblies with a hydrodynamic diameter of 163 nm at neutral pH, whereas they were further dissociated into spherical supramolecular self-assemblies with a size of 52 nm under acidic conditions. This morphology transition process was utilized to conduct a two-stage DOX delivery under neutral and acidic pH. Basic cell experiments demonstrated that the drug-loaded β-CD-BM2-based supramolecular self-assemblies with varied morphology could inhibit cancer cell proliferation, indicating their potential application in the field of drug delivery.

scholarly journals Miktoarm Star Polymers: Branched Architectures in Drug Delivery

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 827 ◽  
Author(s):  
Victor Lotocki ◽  
Ashok Kakkar
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Polymeric Nanoparticles ◽  
Drug Loading ◽  
Therapeutic Interventions ◽  
Structure Property ◽  
Sustained Drug Release ◽  
Amphiphilic Macromolecules ◽  
Miktoarm Star ◽  
Core Junction

Delivering active pharmaceutical agents to disease sites using soft polymeric nanoparticles continues to be a topical area of research. It is becoming increasingly evident that the composition of amphiphilic macromolecules plays a significant role in developing efficient nanoformulations. Branched architectures with asymmetric polymeric arms emanating from a central core junction have provided a pivotal venue to tailor their key parameters. The build-up of miktoarm stars offers vast polymer arm tunability, aiding in the development of macromolecules with adjustable properties, and allows facile inclusion of endogenous stimulus-responsive entities. Miktoarm star-based micelles have been demonstrated to exhibit denser coronae, very low critical micelle concentrations, high drug loading contents, and sustained drug release profiles. With significant advances in chemical methodologies, synthetic articulation of miktoarm polymer architecture, and determination of their structure-property relationships, are now becoming streamlined. This is helping advance their implementation into formulating efficient therapeutic interventions. This review brings into focus the important discoveries in the syntheses of miktoarm stars of varied compositions, their aqueous self-assembly, and contributions their formulations are making in advancing the field of drug delivery.

Stimuli responsive hydrogels derived from a renewable resource: synthesis, self-assembly in water and application in drug delivery

2015 ◽  
Vol 3 (27) ◽  
pp. 5560-5568 ◽  
Author(s):  
Krishnamoorthy Lalitha ◽  
Y. Siva Prasad ◽  
C. Uma Maheswari ◽  
Vellaisamy Sridharan ◽  
George John ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Renewable Resource ◽  
Stimuli Responsive ◽  
Composite Gel ◽  
Drug Delivery Applications ◽  
Responsive Hydrogels

We report coumarin-tris based hydrogel and curcumin encapsulated composite gel for stimuli responsive drug delivery applications.

Biospecific Self-Assembly of a Nanoparticle Coating for Targeted and Stimuli-Responsive Drug Delivery

2015 ◽  
Vol 25 (9) ◽  
pp. 1404-1417 ◽  
Author(s):  
Jinyang Li ◽  
Xue Qu ◽  
Gregory F. Payne ◽  
Cheng Zhang ◽  
Yuxin Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Stimuli Responsive ◽  
Nanoparticle Coating

Poly(N-isopropylacrylamide) derived nanogels demonstrated thermosensitive self-assembly and GSH-triggered drug release for efficient tumor Therapy

2019 ◽  
Vol 10 (29) ◽  
pp. 4031-4041 ◽  
Author(s):  
Jiaojiao Chen ◽  
Ming Wu ◽  
Hanitrarimalala Veroniaina ◽  
Subhankar Mukhopadhyay ◽  
Juequan Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Tumor Therapy ◽  
Delivery Systems ◽  
Core Shell ◽  
Stimuli Responsive ◽  
Triggered Drug Release

Recently, interest in stimuli-responsive core–shell nanogels as drug delivery systems for tumor therapy has increased.

Sign in / Sign up

Export Citation Format

Share Document