scholarly journals Sensitive SQUID Bio-Magnetometry for Determination and Differentiation of Biogenic Iron and Iron Oxide Nanoparticles in the Biological Samples

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1993
Author(s):  
Martin Škrátek ◽  
Andrej Dvurečenskij ◽  
Michal Kluknavský ◽  
Andrej Barta ◽  
Peter Bališ ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Biological Samples ◽  
Superparamagnetic Iron Oxide ◽  
Histochemical Staining ◽  
Superoxide Production ◽  
Magnetic Characteristics ◽  
Iron Oxide Nanoparticle ◽  
Control Group ◽  
Wistar Kyoto

This study aimed to develop the method for determination of the ultra-small superparamagnetic iron oxide nanoparticle (USPION)-originated iron (UOI) in the tissues of rats on the basis of the magnetic characteristics (MC) in the liver, left heart ventricle (LHV), kidneys, aorta and blood of Wistar-Kyoto (WKY). Rats were treated intravenously by USPIONs dispersed in saline (transmission electron microscope (TEM) mean size ~30 nm, hydrodynamic size ~51 nm, nominal iron content 1 mg Fe/mL) at the low iron dose of 1 mg/kg. MC in the form of the mass magnetisation (M) versus the magnetic field (H) curves and temperature dependences of M (determined using the SQUID magnetometer), histochemical determination of iron (by Perl’s method) and USPION-induced superoxide production (by lucigenin-enhanced chemiluminescence) were investigated 100 min post-infusion. USPIONs significantly elevated superoxide production in the liver, LHV, kidney and aorta vs. the control group. Histochemical staining confirmed the presence of iron in all solid biological samples, however, this method was not suitable to unequivocally confirm the presence of UOI. We improved the SQUID magnetometric method and sample preparation to allow the determination of UOI by measurements of the MC of the tissues at 300 K in solid and liquid samples. The presence of the UOI was confirmed in all the tissues investigated in USPIONs-treated rats. The greatest levels were found in blood and lower amounts in the aorta, liver, LHV and kidneys. In conclusion, we have improved SQUID-magnetometric method to make it suitable for detection of low amounts of UOI in blood and tissues of rats.

Trace level electrochemical determination of the neurotransmitter dopamine in biological samples based on iron oxide nanoparticle decorated graphene sheets

2018 ◽  
Vol 5 (3) ◽  
pp. 705-718 ◽  
Author(s):  
Thangavelu Kokulnathan ◽  
Allen Joseph Anthuvan ◽  
Shen-Ming Chen ◽  
Viswanathan Chinnuswamy ◽  
Krishna Kadirvelu
Keyword(s):  
Iron Oxide ◽  
Graphene Sheet ◽  
Modified Electrode ◽  
Biological Samples ◽  
Electrochemical Determination ◽  
Iron Oxide Nanoparticle ◽  
Graphene Sheets ◽  
Trace Level ◽  
Oxide Nanoparticle

The trace level electrochemical determination of dopamine in biological samples based on an iron oxide nanoparticle-capped graphene sheet modified electrode.

scholarly journals Reversible magnetism switching of iron oxide nanoparticle dispersions by controlled agglomeration

2021 ◽  
Author(s):  
Stephan Müssig ◽  
Björn Kuttich ◽  
Florian Fidler ◽  
Daniel Haddad ◽  
Susanne Wintzheimer ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Iron Oxide ◽  
Light Scattering ◽  
Superparamagnetic Iron Oxide ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticles ◽  
X Ray ◽  
X Ray Scattering ◽  
Nanoparticle Dispersions ◽  
Oxide Nanoparticle

The controlled agglomeration of superparamagnetic iron oxide nanoparticles (SPIONs) was used to rapidly switch their magnetic properties. Small-angle X-ray scattering (SAXS) and dynamic light scattering showed that tailored iron oxide...

Succinylated heparin monolayer coating vastly increases superparamagnetic iron oxide nanoparticle T2 proton relaxivity

Nanoscale ◽  
2019 ◽  
Vol 11 (27) ◽  
pp. 12905-12914 ◽  
Author(s):  
Manman Xie ◽  
Shijia Liu ◽  
Christopher J. Butch ◽  
Shaowei Liu ◽  
Ziyang Wang ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticles ◽  
Clinical Use ◽  
History Of ◽  
Oxide Nanoparticle ◽  
Superparamagnetic Iron Oxide Nanoparticle

Superparamagnetic iron oxide nanoparticles (SPIONs) have a history of clinical use as contrast agents in T2 weighted MRI, though relatively low T2 relaxivity has caused them to fall out of favor as new faster MRI techniques have gained prominence.

scholarly journals Superparamagnetic Iron Oxide Nanoparticle-Aptamer Bioconjugates for Combined Prostate Cancer Imaging and Therapy

ChemMedChem ◽  
2008 ◽  
Vol 3 (9) ◽  
pp. 1311-1315 ◽  
Author(s):  
Andrew Z. Wang ◽  
Vaishali Bagalkot ◽  
Christophoros C. Vasilliou ◽  
Frank Gu ◽  
Frank Alexis ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Iron Oxide ◽  
Cancer Imaging ◽  
Superparamagnetic Iron Oxide ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticle ◽  
Superparamagnetic Iron Oxide Nanoparticle

scholarly journals Green Synthesis of Magnetic Iron Oxide Nanoparticle for Antibacterial Activity: A Review

2021 ◽  
Vol 64 (2) ◽  
pp. 202-210
Author(s):  
Muhammad Isa Khan ◽  
Aliza Zahoor ◽  
Tahir Iqbal ◽  
Abdul Majid ◽  
Mohsin Ijaz
Keyword(s):  
Iron Oxide ◽  
Green Synthesis ◽  
Biomedical Applications ◽  
Synthesis Method ◽  
Antibacterial Activities ◽  
Magnetic Characteristics ◽  
Iron Oxide Nanoparticle ◽  
The Past ◽  
Wide Range ◽  
Oxide Nanoparticle

  Recently, different researchers find nanoparticles as an auspicious alternative to antibacterial agents due to their antibacterial behaviour. This antibacterial behaviour contributes in many biomedical applications including; tissue engineering, drug and gene delivery and, imaging. Furthermore, iron oxide nanoparticle gains much importance due to their magnetic characteristics and wide range of application. Iron oxide nanoparticle (IONPs) have exhibits great potential against bacteria. During the past decade, various routes were developed to synthesize iron oxide nanoparticle with suitable size and composition. This article reviews the recent iron oxide nanoparticle obtained by green synthesis with a focus on their response to antibacterial activities. The iron nanoparticles synthesized by green synthesis method has accumulated a vital attention over the last couple of years due to their unique characteristic as it makes sure environmental friendly, nontoxic and safe reagents.

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