scholarly journals Antimicrobial Lock Therapy in Clinical Practice: A Scoping Review Protocol

2020 ◽  
Vol 3 (1) ◽  
pp. 16
Author(s):  
Aniello Alfieri ◽  
Sveva Di Franco ◽  
Maria Beatrice Passavanti ◽  
Maria Caterina Pace ◽  
Agata Stanga ◽  
...  

Our objective is to review the scientific literature on the use of antimicrobial lock therapy (ALT). To achieve this result, our scoping review will address the following seven key questions: (1) Who are the patients who will benefit from this technique? (2) What are the techniques utilized? (3) What are the settings in which the technique is performed? (4) When the technique is performed? (5) Why the technique is performed? (6) How the technique is performed? (7) In how much amount, of such technique performed? This review considers all studies published in full and in peer-reviewed journals, with no restrictions on language, on the year of publication and age of the participants. Both randomized controlled trials and observational studies will be included. This scoping review has been planned on a five-stage framework: 1. Identifying the review question; 2. identifying relevant studies; 3. study selection; 4. charting the data; 5. collating, summarizing, and reporting the results. It is conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Guidelines. The databases utilized will include MEDLINE via PubMed, EMBASE and Cochrane Central Register of Controlled Trials and Grey Literature. SCOPING REVIEW REGISTRATION: Open Science Framework https://osf.io/vphwm/.

2021 ◽  
Author(s):  
Navin Kumar ◽  
Nathan Walter ◽  
Kate Nyhan ◽  
Kaveh Khoshnood ◽  
Joseph D Tucker ◽  
...  

Abstract Background: The duration and impact of the COVID-19 pandemic depends in a large part on individual and societal actions which is influenced by the quality and salience of the information to which they are exposed. Unfortunately, COVID-19 misinformation has proliferated. To date, no systematic efforts have been made to evaluate interventions that mitigate COVID-19-related misinformation. We plan to conduct a scoping review that seeks to fill several of the gaps in the current knowledge of interventions that mitigate COVID-19-related misinformation.Methods: A scoping review focusing on interventions that mitigate COVID-19 misinformation will be conducted. We will search (from January 2020 onwards) MEDLINE, EMBASE, CINAHL, PsycINFO, Web of Science Core Collection, Africa-Wide Information, Global Health, WHO Global Literature on Coronavirus Disease Database, WHO Global Index Medicus, and Sociological Abstracts. Grey literature will be identified using Disaster Lit, Google Scholar, Open Science Framework, governmental websites and preprint servers (e.g. EuropePMC, PsyArXiv, MedRxiv, JMIR Preprints). Study selection will conform to Joanna Briggs Institute Reviewers’ Manual 2020 Methodology for JBI Scoping Reviews. Only English language, original studies will be considered for inclusion. Two reviewers will independently screen all citations, full-text articles, and abstract data. A narrative summary of findings will be conducted. Data analysis will involve quantitative (e.g. frequencies) and qualitative (e.g. content and thematic analysis) methods.Discussion: Original research is urgently needed to design interventions to mitigate COVID-19 misinformation. The planned scoping review will help to address this gap.Systematic Review registrations: Systematic Review Registration: Open Science Framework (osf/io/etw9d).


Author(s):  
Rocío Bravo-Jeria ◽  
María Ximena Rojas Reyes ◽  
Juan Víctor Ariel Franco ◽  
María Paz Acuña ◽  
Luz Ángela Torres López ◽  
...  

ABSTRACTObjectiveTo determine the relative impact of the use of chloroquine and hydroxychloroquine on outcomes important to patients with COVID 19.DesignThis is the protocol of a living systematic review.Data sourcesWe will conduct searches in PubMed/Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), trial registries, grey literature and in a centralised repository in L·OVE (Living OVerview of Evidence). L·OVE is a platform that maps PICO questions to evidence from Epistemonikos database. In response to the COVID-19 emergency, L·OVE was adapted to expand the range of evidence it covers and customised to group all COVID-19 evidence in one place. The search will cover the period until the day before submission to a journal.Eligibility criteria for selecting studies and methodsWe will follow a common protocol for multiple parallel systematic reviews, already published and submitted to PROSPERO (awaiting ID allocation).We will include randomised controlled trials evaluating the effect of chloroquine and hydroxychloroquine — as monotherapy or in combination with other drugs — versus placebo or no treatment in patients with COVID-19. Randomised trials evaluating chloroquine and hydroxychloroquine in infections caused by other coronaviruses, such as MERS-CoV and SARS-CoV, and non-randomised studies in COVID-19 will be searched in case no direct evidence from randomised trials is found, or if the direct evidence provides low- or very low-certainty for critical outcomes.Two reviewers will independently screen each study for eligibility, extract data, and assess the risk of bias. We will perform random-effects meta-analyses and use GRADE to assess the certainty of the evidence for each outcome.A living, web-based version of this review will be openly available during the COVID-19 pandemic. We will resubmit it if the conclusions change or there are substantial updates.Ethics and disseminationNo ethics approval is considered necessary. The results of this review will be widely disseminated via peer-reviewed publications, social networks and traditional media.


2020 ◽  
Author(s):  
Ziningi Nobuhle Jaya ◽  
Tivani P Mashamba-Thompson ◽  
Raveen Parboosing

Abstract Background: Research shows a high prevalence of sexual transmitted infections (STIs) among sexually active women throughout the world. Patient self-testing and self-sampling strategies are pivotal to facilitate rapid diagnosis of disease among key populations. The main objective of this study is to map evidence on self-sampling methods utilised to facilitate STIs diagnosis among women. Methods: We propose to conduct a scoping review, which will be guided by Arksey and O’Malley framework, Levac et al, 2010 and the Joanna Briggs Institution 2015 recommendations. We will conduct a database search for relevant peer-reviewed articles to answer our research question. We will search the following databases: PubMed, Google Scholar, Journal Storage, Science Direct, Web of Science, and MEDLINE (via EBSCOHost). We will also search for grey literature from World Health Organisation (WHO) and Department of Health websites. We will present the results of the review following the Preferred Resulting Items for Systematic reviews and Meta-Analyses extension for scoping reviews (PRISMA-ScR). We will employ Nvivo version 12 for thematic content analysis of the included studies. We will conduct quality appraisal of the included studies using the Mixed Method Appraisal Tool (MMAT)-version 2018.Discussion: It is anticipated that findings of this scoping review will highlight gaps for further investigation to address the global burden of STIs. This could assist policy makers and developers of diagnostic equipment to develop evidence-based interventions to enable self-sampling and early diagnosis of STIs among women. Systematic Review Registration Submitted to Open Science Framework on 25 July 2020.


Author(s):  
Francisca Verdugo-Paiva ◽  
Ariel Izcovich ◽  
Martín Ragusa ◽  
Gabriel Rada

ABSTRACTObjectiveTo assess the efficacy and safety of lopinavir/ritonavir for the treatment of patients with COVID-19.DesignThis is the protocol of a living systematic review.Data sourcesWe will conduct searches in PubMed/Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), grey literature and in a centralised repository in L·OVE (Living OVerview of Evidence). L·OVE is a platform that maps PICO questions to evidence from Epistemonikos database. In response to the COVID-19 emergency, L·OVE was adapted to expand the range of evidence it covers and customised to group all COVID-19 evidence in one place. The search will cover the period until the day before submission to a journal.Eligibility criteria for selecting studies and methodsWe adapted an already published common protocol for multiple parallel systematic reviews to the specificities of this question.We will include randomised trials evaluating the effect of lopinavir/ritonavir— as monotherapy or in combination with other drugs — versus placebo or no treatment in patients with COVID-19. Randomised trials evaluating lopinavir/ritonavir in infections caused by other coronaviruses, such as MERS-CoV and SARS-CoV, and non-randomised studies in COVID-19 will be searched in case no direct evidence from randomised trials is found, or if the direct evidence provides low- or very low-certainty for critical outcomes.Two reviewers will independently screen each study for eligibility, extract data, and assess the risk of bias. We will perform random-effects meta-analyses and use GRADE to assess the certainty of the evidence for each outcome.A living, web-based version of this review will be openly available during the COVID-19 pandemic. We will resubmit it if the conclusions change or there are substantial updates.Ethics and disseminationNo ethics approval is considered necessary. The results of this review will be widely disseminated via peer-reviewed publications, social networks and traditional media.PROSPERO RegistrationSubmitted to PROSPERO (awaiting ID allocation).


2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Vuyelwa Ndlovu ◽  
Moses John Chimbari ◽  
Elopy Sibanda

Abstract Background Asthma is one of the most common chronic respiratory conditions in the world and is increasing in prevalence, particularly in Africa and other low-income countries. The disproportionately high numbers of premature deaths and severe or uncontrolled cases in many African countries are indicative of their inability to cope with a costly disease like asthma. Progress has, however, been made in understanding the complex and heterogeneous nature of the disease. The objective of this study will be to summarise the epidemiological literature on the nature of asthma in African countries. Methods We registered a study protocol for a scoping review. The review was designed following the Arksey and O’Malley framework. We will search PubMed/MEDLINE, African Journals Online (AJOL) and relevant grey literature (e.g. Google Scholar, EBSCOhost) from January 1990 onwards. Only primary epidemiological studies of asthma (e.g. frequency, disease mechanisms, associated risk factors and comorbidities) written in English and conducted in Africa will be included. Two reviewers will independently screen all citations, full-text articles and abstract data. Potential conflicts will be resolved through discussion. Findings will be reported using narrative synthesis and tabulation of the summaries. Discussion This scoping review will capture the state of the current epidemiological literature on asthma in African countries. Results will be published in a peer-reviewed journal. We anticipate this review will identify gaps and make recommendations for future areas of study. Scoping review registration Open Science Framework http://osf.io/n2p87/


Medwave ◽  
2020 ◽  
Vol 20 (10) ◽  
pp. e8062-e8062
Author(s):  
Giuliano Duarte ◽  
Luis Ortiz-Muñoz ◽  
María Belén Morales ◽  
María Paz Acuña ◽  
Gabriel Rada

Objective To provide a review of the literature on the presence of SARS-CoV-2 in the sexual fluids of patients with COVID-19 and to observe its possible sexual transmission in a timely, rigorous, and continuously updated manner. Data sources We will conduct searches in PubMed/Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), grey literature, and a centralized repository in L·OVE (Living OVerview of Evidence). L·OVE is a platform that maps PICO questions to evidence from the Epistemonikos database. In response to the COVID-19 emergency, L·OVE was adapted to expand the range of evidence it covers and customized to group all COVID-19 evidence in one place. The search will cover the period until the day before submission to a journal. Eligibility criteria for selecting studies and methods We adapted an already published standard protocol for multiple parallel systematic reviews to the specificities of this question. We will include randomized trials evaluating the sexual transmission of the SARS-CoV-2 virus. Randomized trials evaluating the sexual transmission of other coronaviruses, such as MERS-CoV and SARS-CoV, and non-randomized studies in COVID-19 will be searched if no direct evidence from randomized trials is found or if the direct evidence provides a low to a very low level of certainty for critical outcomes. Two reviewers will independently screen each study for eligibility, extract data, and assess the risk of bias. We will perform random-effects meta-analyses and use GRADE to assess the certainty of the evidence for each outcome. A living, web-based version of this review will be openly available during the COVID-19 pandemic. We will resubmit the review if the conclusions change or if there are substantial updates. PROSPERO Registration (CRD42020189368).


Author(s):  
Elsa A. Campbell ◽  
Jiří Kantor ◽  
Lucia Kantorová ◽  
Zuzana Svobodová ◽  
Thomas Wosch

Dementia is a growing issue in modern society. Non-pharmacological interventions such as music are suggested as the primary methods for symptom management. Therapeutic potential may also be found in sound/mechanical low frequency vibrations (LFV) that share the core characteristics of music, but these are lesser understood. The aim of the proposed scoping review is to explore the responses of persons with dementia to LFV, e.g., vibroacoustic therapy or whole-body vibration. The scoping review will follow the Joanna Briggs Institute methodology guidelines. An extensive search in BMC, CINAHL, Cochrane Central Register of Controlled Trials, EMBASE, ERIC, MEDLINE (OvidSP), Pedro, ProQuest Central, PsycINFO, Scopus, Web of Science, and grey literature sources in Clinical Trials, Current Controlled Trials, Google Scholar, and manual search of relevant journals is planned to find all relevant research papers. The paper selection, full-text assessment, and data extraction will be performed by two independent reviewers. Participants’ responses to the interventions and the experiment designs, including methodological challenges, will be analysed and compared. Results may highlight potential gaps in reporting and comparing sound and mechanical vibration approaches and promote better understanding of their potential for managing the symptoms of dementia. Furthermore, the possible relationships between LFV and music-based interventions may become clearer.


2018 ◽  
Vol 43 (2) ◽  
pp. 33-41
Author(s):  
Duniel Ricardo Ortuño Borroto ◽  
Beatriz Mellado ◽  
Sebastián Prado ◽  
Juan Pablo Vargas ◽  
Gabriel Rada

Introducción: Las lesiones cervicales no cariosas son condiciones patológicas no bacterianas localizadas en el límite amelocementario de los dientes. Los principales biomateriales descritos para el tratamiento restaurador de estas lesiones son: vidrios ionómeros, vidrios ionómeros modificados con resinas, compómeros y resinas compuestas. El objetivo de este protocolo, consiste en establecer los elementos metodológicos de una revisión sistemática que evaluará el comportamiento clínico de restauraciones cervicales realizadas con estos biomateriales. Métodos: El protocolo fue diseñado, y será reportado, en línea con Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P 2015). Se realizará una búsqueda sensible en MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials y ClinicalTrials.gov, sin restricción por lenguaje o publicación, para identificar ensayos controlados aleatorizados que comparen dos o más tratamientos restauradores en lesiones cervicales no cariosas. Los desenlaces a evaluar serán la retención de las restauraciones y caries secundaria, según criterios RYGE/USPHS. Al menos dos investigadores realizarán de manera independiente la selección de los ensayos y la extracción de los datos. El riesgo de sesgo será evaluado utilizando la herramienta recomendada por la colaboración Cochrane. Si es posible, se realizará un metanálisis y los datos serán presentados en tablas de resúmenes de resultados mediante el método Grading of Recommendations Assesment, Development and Evaluation (GRADE). Fortalezas y debilidades: Esta revisión sistemática entregará evidencia actualizada sobre el comportamiento de cuatro biomateriales en el tratamiento de lesiones cervicales no cariosas. La principal limitación proviene de la baja cantidad o deficiencias metodológicas de los estudios primarios. Número de registro (PROSPERO): CRD42017071114.


2021 ◽  
Author(s):  
Dorinda Raphine Borg ◽  
Ashley Hilton Ross ◽  
Kabelo Garosi ◽  
Avenal Jane Finlayson ◽  
Tivani P. Mashamba-Thompson

Abstract Background: The medical aesthetics industry is a very profitable and rapidly growing branch of medicine. Currently, somatologists or beauty therapists who either independently perform or assist medical directors in these aesthetic procedures, are not regulated by a professional body in most countries including South Africa. The absence of a prescribed scope of practice, attributed to absence of formal professional regulation, has resulted in an increase in anecdotal reports of complications and malpractice being referred to medical professionals. Since the mandate of regulatory bodies is to guide the professions and to protect patients and the public, currently, the absence of regulation in the somatology profession exposes patients/clients to unsafe practices predominately in the private sector. The objective of this scoping review is to map evidence on the somatology practices and regulations for non-medical aesthetic treatments. Methods: We will conduct a scoping review using peer reviewed journal articles that present literature on the practice of non-medical aesthetic treatments. Grey literature including media reports, and unpublished theses will be included. Electronic searches of databases and search engines such as Scopus, CINAHL, EBSCOhost, Health Source - Consumer Edition; Health Source: Nursing/Academic Edition, Open Dissertations, Google Scholar and MEDLINE will be undertaken to attain published articles and reports from all study designs. Duplicated documents will be deleted prior to title screening commencing. All retrieved literature will be exported into an Endnote X20 library. The quality of each publication will be appraised using the mixed methods appraisal tool (MMAT) – version 2018.Discussion: We will map the evidence of how non-medical treatments are commonly being performed by non-physicians and somatologists, including identifying which treatments and procedures are more at risk in resulting in adverse reactions if not administered ethically or correctly. Once summarised, the data could be used to develop relevant and current good practice guidelines that could be later integrated into a framework for somatologists performing non-medical aesthetics treatments in South Africa. Systematic review registration: Open Science Framework registration (https://osf.io/4fk8g/)


BMJ Open ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. e045546
Author(s):  
Henry Douglas Robb ◽  
Gemma Scrimgeour ◽  
Piers R Boshier ◽  
Svetlana Balyasnikova ◽  
Gina Brown ◽  
...  

IntroductionThree-dimensional (3D) reconstruction describes the generation of either virtual or physically printed anatomically accurate 3D models from two-dimensional medical images. Their implementation has revolutionised medical practice. Within surgery, key applications include growing roles in operative planning and procedures, surgical education and training, as well as patient engagement and education. In comparison to other surgical specialties, oesophagogastric surgery has been slow in their adoption of this technology. Herein the authors outline a scoping review protocol that aims to analyse the current role of 3D modelling in oesophagogastric surgery and highlight any unexplored avenues for future research.Methods and analysisThe protocol was generated using internationally accepted methodological frameworks. A succinct primary question was devised, and a comprehensive search strategy was developed for key databases (MEDLINE, Embase, Elsevier Scopus and ISI Web of Science). These were searched from their inception to 1 June 2020. Reference lists will be reviewed by hand and grey literature identified using OpenGrey and Grey Literature Report. The protocol was registered to the Open Science Framework (osf.io/ta789).Two independent reviewers will screen titles, abstracts and perform full-text reviews for study selection. There will be no methodological quality assessment to ensure a full thematic analysis is possible. A data charting tool will be created by the investigatory team. Results will be analysed to generate descriptive numerical tabular results and a thematic analysis will be performed.Ethics and disseminationEthical approval was not required for the collection and analysis of the published data. The scoping review report will be disseminated through a peer-reviewed publication and international conferences.Registration detailsThe scoping review protocol has been registered on the Open Science Framework (https://osf.io/ta789).


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