scholarly journals Insight into Potential Anticancer Activity of Algal Flavonoids: Current Status and Challenges

Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6844
Author(s):  
Umme Tamanna Ferdous ◽  
Zetty Norhana Balia Yusof
Keyword(s):  
Anticancer Agents ◽  
Arable Land ◽  
High Growth ◽  
High Growth Rate ◽  
Current Status ◽  
Terrestrial Plants ◽  
Anticancer Activities ◽  
Anticancer Properties ◽  
Chemical Structures ◽  
Insight Into

Flavonoids are some of the most precious phytochemicals, believed to be found largely in terrestrial plants. With the advancement of phytochemical research and marine bioprospecting, flavonoids have also been reported by the research of microalgae and macroalgae. High growth rate with minimal nutritional and growth requirement, saving arable land and rich metabolic profile make microalgae an excellent repertoire of novel anticancer compounds, such as flavonoids. In addition, marine algae, especially seaweeds contain different types of flavonoids which are assumed to have unique chemical structures and bioactivities than their terrestrial counterparts. Flavonoids are not only good antioxidants but also have the abilities to kill cancer cells by inducing apoptosis and autophagy. However, the study of the anticancer properties of flavonoids is largely limited to terrestrial plants. This review offers an insight into the distribution of different classes of flavonoids in eukaryotic microalgae, cyanobacteria and seaweeds with their possible anticancer activities. In addition, extraction and purification methods of these flavonoids have been highlighted. Finally, prospects and challenges to use algal flavonoids as anticancer agents have been discussed.

Recent development of tetrahydro-quinoline/isoquinoline based compounds as anticancer agents

2021 ◽  
Vol 21 ◽  
Author(s):  
Pratik Yadav ◽  
Ashish Kumar ◽  
Ismail Althagafi ◽  
Vishal Nemaysh ◽  
Reeta Rai ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Anticancer Agents ◽  
Human Cancer ◽  
Biological Activities ◽  
Cancer Cell Lines ◽  
New Drugs ◽  
Anticancer Activities ◽  
Human Cancer Cell Lines ◽  
Anticancer Properties

: Tetrahydroquinoline and isoquinoline scaffolds are important class heterocyclic compounds, which is implied for the development of new drugs and diagnostic for therapeutic function. Naturally occurring as well as synthetic tetrahydroquinolines/isoquinolines possess many different biological activities and have been testified as remarkable cytotoxic and potency in human cancer cell lines. Tetrahydroquinoline/isoquinolines based compounds displayed a key role in the development of anticancer drugs or lead molecules and acting through various mechanisms such as cell proliferation, apoptosis, DNA fragmentation, inhibition of tubulin polymerization, induced cell cycle arrest, interruption of cell migration, and modulation. The number of tetrahydroquinoline/isoquinoline derivatives has been reported as potent anticancer agents. Due to promising anticancer activities and wide-ranging properties of these molecules, we have compiled the literature for the synthesis and anticancer properties of various tetrahydroquinolines and isoquinolines. We have reported the synthesis of potent tetrahydroquinoline/isoquinoline molecules of the last 10 years with their anticancer properties in various cancer cell lines and stated their half-maximal inhibitory concentration (IC50). In addition, we also considered the discussion of molecular docking and structural activity relationship wherever provided to understand the possible mode of activity a target involved and structural feature responsible for the better activity, so the reader can directly find the detail for designing new anticancer agents.

Novel Phytochemical Constituents and Anticancer Activities of the Genus, Typhonium

2020 ◽  
Vol 20 (12) ◽  
pp. 946-957 ◽  
Author(s):  
Shaik I. Khalivulla ◽  
Arifullah Mohammed ◽  
Kuttulebbai N.S. Sirajudeen ◽  
Mannur I. Shaik ◽  
Weibing Ye ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Apoptotic Cell ◽  
Human Cancer ◽  
Inhibitory Effect ◽  
Anticancer Activities ◽  
Southeast Asians ◽  
Human Cancer Cells ◽  
Anticancer Properties ◽  
Chemical Structures ◽  
Growth Inhibitory

Background: Typhonium is the largest genus in the Araceae family (~70 species), distributed in South Asia, Southeast Asia and Australia. Typhonium is well-known for its ethnopharmacological uses, and Southeast Asians consider it as an alternative medicine to treat cancer. This review elucidated the confirmed chemical structures of the isolated compounds of Typhonium and emphasized on their anticancer activities against various human cancer cells. Methods: Among several species, Typhonium blumei, T. flagelliforme, T. divaricatum and T. giganteum were extensively studied due to the presence of a class of secondary metabolites. All the available reports on Typhonium were included and discussed in this article. Results: Until now several groups of compounds, namely amino acids (1, 2), cinnamic acid (3), fatty acids (4-14), glycerol derivatives (15-18) and cerebrosides (19-34), flavonoids (35), hydantoins (36-38), lignin monomers (39-44), nucleobases (45-48), pheophorbides (49-52), phthalate (53), terpene and steroids (54-59) and vitamins (60, 61) were isolated and characterized from Typhonium. These phytochemicals were investigated for their anticancer properties, and results confirmed the promising growth inhibitory effect and anticancer activities against human lung, breast, prostate and colon cancer cells. The anticancer activity of these compounds appears to be mediated through the induction of apoptotic cell death. These phytochemicals further reported to exhibit other pharmacological efficacies, including anti-inflammatory, antioxidant, antiviral, anti-allergic, neuroprotective and hepato-protective properties. Conclusion: This is the first review to summarize the anticancer properties of all isolated compounds of Typhonium genus with confirmed chemical structures. Further advanced studies are necessary to establish the detailed signaling pathways that are involved in the anticancer property of the compounds.

Potential Study of Electricity Generation 1000 MW with Biogas in Thailand

2012 ◽  
Vol 622-623 ◽  
pp. 1209-1212
Author(s):  
Supawat Vivanpatarakij ◽  
Weerin Wangjiraniran ◽  
Raksanai Nidhiritdhikrai ◽  
Dawan Wiwattanadat
Keyword(s):  
Electricity Generation ◽  
Power Plants ◽  
High Growth ◽  
High Growth Rate ◽  
Napier Grass ◽  
Electricity Production ◽  
Current Status ◽  
Additional Energy ◽  
Production Form ◽  
High Production

Thailand, electricity production form biogas has been interested for replacement nuclear and fossil power plants. Current status of electricity production from biogas is 155 MWe, and more potential of current capacity is 380 MWe. Additional, energy crops have a potential for another source of biogas. For this study, electricity production to 1000 MW was determined. Napier grass was considered, high growth rate and high production yield. Napier grass 190,000 acre can produce 1000 MW electricity. And economic analysis of electricity production 1 MW was studied, these results show that biogas for electricity 1MW power plant project is not economic under current condition in Thailand.

scholarly journals Synthesis of novel indole-isoxazole hybrids and evaluation of their cytotoxic activities on hepatocellular carcinoma cell lines

BMC Chemistry ◽  
2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Mohammed Hawash ◽  
Deniz Cansen Kahraman ◽  
Sezen Guntekin Ergun ◽  
Rengul Cetin-Atalay ◽  
Sultan Nacak Baytas
Keyword(s):  
Liver Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Anticancer Agents ◽  
Cancer Cell Lines ◽  
Cytotoxic Activities ◽  
Anticancer Activities ◽  
Element Analysis ◽  
Chemical Structures ◽  
Huh7 Cells

Abstract Background Liver cancer is predicted to be the sixth most diagnosed cancer globally and fourth leading cause of cancer deaths. In this study, a series of indole-3-isoxazole-5-carboxamide derivatives were designed, synthesized, and evaluated for their anticancer activities. The chemical structures of these of final compounds and intermediates were characterized by using IR, HRMS, 1H-NMR and 13C-NMR spectroscopy and element analysis. Results The cytotoxic activity was performed against Huh7, MCF7 and HCT116 cancer cell lines using sulforhodamine B assay. Some compounds showed potent anticancer activities and three of them were chosen for further evaluation on liver cancer cell lines based on SRB assay and real-time cell growth tracking analysis. Compounds were shown to cause arrest in the G0/G1 phase in Huh7 cells and caused a significant decrease in CDK4 levels. A good correlation was obtained between the theoretical predictions of bioavailability using Molinspiration calculation, Lipinski’s rule of five, and experimental verification. These investigations reveal that indole-isoxazole hybrid system have the potential for the development of novel anticancer agents. Conclusions This study has provided data that will form the basis of further studies that aim to optimize both the design and synthesis of novel compounds that have higher anticancer activities.

scholarly journals ETHNOPHARMACOLOGICAL REVIEW OF NATURAL PRODUCTS IN CANCER PREVENTION AND THERAPY

2018 ◽  
Vol 11 (6) ◽  
pp. 32 ◽  
Author(s):  
Zeenat Ayoub ◽  
Archana Mehta ◽  
Siddhartha Kumar Mishra
Keyword(s):  
Medicinal Plants ◽  
Anticancer Agents ◽  
World Health ◽  
Care Needs ◽  
Beneficial Effects ◽  
Synthetic Drugs ◽  
Anticancer Properties ◽  
Chemical Structures ◽  
Health Organization ◽  
Pharmaceutical Agents

The World Health Organization reports that approximately 80% population from developing countries are facing complications from synthetic drugs used in maintaining their primary health-care needs. The chemotherapeutic strategies are very striking and have earned serious concern as potential means of controlling the incidence of this dreadful disease. However, the major problem in cancer is the long lasting toxicity of the well reputable chemical drugs. Since ancient times, medicinal plants have attracted enormous attention, to fight against various diseases with their broad-spectrum biological and therapeutic properties. Although plants, phytochemicals and their analogues have been confirmed to be safe and effective, having strong anticancer properties. A number of pharmaceutical agents with diverse chemical structures of natural origin from plants have been discovered as anticancer agents such as vincristine, vinblastine, podophyllotoxin, camptothecin, taxol, resveratrol, withaferin A, quercetin, and curcumin. Further modifications of these phytochemicals led to the development of numerous outstanding molecules such as drugs like topotecan, irinotecan, taxotere, etoposide, and teniposide. In this in-depth review, we meticulously investigated the selected medicinal plants for their anticancer properties. In particular, novel compounds from plants have beneficial effects on human health. Our observations suggest the preventive and therapeutic use of phytochemicals in managing various human malignancies.

scholarly journals Acetylenic Aquatic Anticancer Agents and Related Compounds

2006 ◽  
Vol 1 (9) ◽  
pp. 1934578X0600100 ◽  
Author(s):  
Valery M Dembitsky ◽  
Dmitri O Levitsky ◽  
Tatyana A Gloriozova ◽  
Vladimir V Poroikov
Keyword(s):  
Anticancer Agents ◽  
Biological Activities ◽  
Aquatic Organisms ◽  
Structural Features ◽  
Biologically Active ◽  
Terrestrial Plants ◽  
Anticancer Activities ◽  
Pharmaceutical Industries ◽  
New Applications

Although acetylenes are common as components of terrestrial plants, it is only within the last 30 years that biologically active polyacetylenes having unusual structural features have been reported from aquatic organisms: cyanobacteria, algae, fungi, invertebrates, and other sources. Naturally occurring aquatic acetylenes are of particular interest since many of them display important biological activities and possess antitumor, antibacterial, antimicrobial, antifouling, antifungal, pesticidal, phototoxic, HIV inhibitory, and immuno-suppressive properties. There is no doubt that they are of great interest, especially for the medicinal and/or pharmaceutical industries. This review presents structures and describes cytotoxic and anticancer activities of more than 230 acetylenic metabolites isolated from aquatic organisms. With the computer program PASS some additional biological activities are also predicted, which point toward possible new applications of these compounds. This review emphasizes the role of aquatic acetylenic compounds as an important source of leads for drug discovery.

scholarly journals Synthesis and Biological Evaluation of m-PEG Attached Acridinedione Derivatives as Antimicrobial, Antioxidant and Anticancer Agents

2021 ◽  
Vol 33 (7) ◽  
pp. 1603-1610
Author(s):  
Tathagata Dey ◽  
Indira Viswambaran Asharani
Keyword(s):  
Anticancer Agents ◽  
Antimicrobial Activities ◽  
Biological Evaluation ◽  
Anticancer Activities ◽  
Gram Positive ◽  
Spectral Techniques ◽  
Drug Candidates ◽  
Anticancer Properties ◽  
Gram Negative Organisms

Among heterocycles, a wide variety of nitrogen heterocycles have been exploited to develop pharmaceutically important molecules. Particularly, acridines are clinically used potential drug candidates showing various pharmacological activities. Some of the novel m-PEG attached acridinediones 4(a-j) were synthesized with the readily available starting materials such as dimedone, glycine and aldehydes. Structures of the synthesized compounds were characterized by spectral techniques. The synthesized compounds (4a-j) were evaluated for in vitro antimicrobial, antioxidant and anticancer activities. Compounds 4d, 4e and 4g were found to produce potent antimicrobial activities against Gram-positive and Gram-negative organisms while 4c active against only Gram-positive organisms when compared with the standard, ciprofloxacin. On the other side, 4d and 4i produced potent antioxidant activity and 4a, 4d and 4g exhibited comparable anticancer properties.

Bioinorganic Chemistry of Platinum(IV) Complexes as Platforms for Anticancer Agents

2020 ◽  
Vol 16 (6) ◽  
pp. 726-737
Author(s):  
Little Nagyal ◽  
Amit Kumar ◽  
Rishipal Sharma ◽  
Rohit Yadav ◽  
Pratibha Chaudhary ◽  
...  
Keyword(s):  
Coordination Chemistry ◽  
Anticancer Agents ◽  
Binding Sites ◽  
Metal Particle ◽  
Bioinorganic Chemistry ◽  
Oxidation States ◽  
Current Status ◽  
Anticancer Properties ◽  
Current Review ◽  
Detoxification Mechanism

The current review focuses on the comprehensive studies of platinum-based complexes that are known to exhibit anticancer properties. The research on metal-particle work has helped in treating sicknesses which plays an imperative part in therapeutic bioinorganic science. Understanding the biochemistry of the detoxification mechanism of metals can help in advancing as well as enhancing the anticancer property of metal complexes for several types of a tumour. The classifications of complexes discussed have been done on the basis of Platinum oxidation states and binding sites of the ligands. Further background and current status of Pt(IV) complexes are briefly explained along with a special reference to Structural Activity Relationships and Mode of Action. The coordination chemistry of Pt(IV) has been summarised and Pt(IV) complexes are reviewed on the basis of binding of Pt(IV) with Human Serum Albumin and DNA. Finally, the results were summarized and concluded emphasizing on the most important features.

scholarly journals Does Juvenile Stand Management Matter? Regional Scenarios of the Long-Term Effects on Wood Production

Forests ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 84
Author(s):  
Soili Haikarainen ◽  
Saija Huuskonen ◽  
Anssi Ahtikoski ◽  
Mika Lehtonen ◽  
Hannu Salminen ◽  
...  
Keyword(s):  
Interest Rates ◽  
High Growth ◽  
National Forest Inventory ◽  
High Growth Rate ◽  
Regional Level ◽  
Current Status ◽  
Long Term Effects ◽  
Wood Production ◽  
Short Delay ◽  
Stand Management

We analysed the regional level effects of juvenile stand management (early cleaning and precommercial thinning), shortly termed tending on wood production and the profitability of forest management. Altogether ca. 0.4 million hectares of juvenile stands from two significant forestry regions of Finland, South and North Savo, were examined. We used plot-level data of the 11th National Forest Inventory to represent the current status of juvenile stands in the study area, and the Motti stand simulator to predict the future developments of those stands for the next 100 years. We applied three scenarios: (i) Timely tending, (ii) delayed tending, and (iii) no tending, to examine differences between these alternative levels of juvenile stand management. The results showed the benefits of tending at a regional level. Timely tending was the most profitable option when low or modest interest rates (2–3%) were applied in the assessment. Even a short delay in tending clearly increased the tending costs. Delaying and neglecting tending resulted in significant losses, especially in sawlog removals and stumpage earnings. The financial gain from tending was the highest on fertile sites. Due to the high growth rate of trees, the situation may change very quickly on such sites. For the operational forestry, this means that fertile sites should have a high priority when conducting timely tendings.

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