scholarly journals Oral Supplementation with Hydrolyzed Fish Cartilage Improves the Morphological and Structural Characteristics of the Skin: A Double-Blind, Placebo-Controlled Clinical Study

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4880
Author(s):  
Patrícia Maria Berardo Gonçalves Maia Campos ◽  
Rodolfo Scarpino Barboza Franco ◽  
Letícia Kakuda ◽  
Gabriel Fernandes Cadioli ◽  
Gabriela Maria D’Angelo Costa ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Structural Characteristics ◽  
Oral Treatment ◽  
Reflectance Confocal Microscopy ◽  
Double Blind ◽  
Oral Supplementation ◽  
Collagen Peptides ◽  
Before And After ◽  
The Face ◽  
Clinical Benefits

Collagen and its peptides are natural ingredients used in food supplements and nutricosmetics with the claim of providing benefits for skin health and beauty. In this context, the aim of the present study was to evaluate the clinical efficacy of oral supplementation with hydrolyzed fish cartilage for the improvement of chronological and photoaging-induced skin changes. A total of 46 healthy females aged 45 to 59 years were enrolled and divided into two groups: G1—placebo and G2—oral treatment with hydrolyzed fish cartilage. Measurements of skin wrinkles, dermis echogenicity and thickness, and morphological and structural characteristics of the skin were performed in the nasolabial region of the face before and after a 90-day period of treatment using high-resolution imaging, ultrasound, and reflectance confocal microscopy image analyses. A significant reduction in wrinkles and an increase of dermis echogenicity were observed after a 90-day period of treatment with hydrolyzed fish cartilage compared to the placebo and baseline values. In addition, reflectance confocal microscopy (RCM) image analysis showed improved collagen morphology and reduced elastosis after treatment with hydrolyzed fish cartilage. The present study showed the clinical benefits for the skin obtained with oral supplementation with a low dose of collagen peptides from hydrolyzed fish cartilage.

Majocchi's granuloma on the face: dermoscopy and reflectance confocal microscopy

2019 ◽  
Vol 58 (9) ◽  
Author(s):  
Vincenzo Piccolo ◽  
Eugenia Veronica Di Brizzi ◽  
Teresa Russo ◽  
Elvira Moscarella ◽  
Ticiana Diniz ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Reflectance Confocal Microscopy ◽  
The Face ◽  
Majocchi’S Granuloma

scholarly journals In vivo Analysis of Solar Lentigines by Reflectance Confocal Microscopy Before and After Q-switched Ruby Laser Treatment

2011 ◽  
Vol 91 (2) ◽  
pp. 164-168 ◽  
Author(s):  
E Richtig ◽  
R Hofmann-Wellenhof ◽  
D Kopera ◽  
L El-Shabrawi-Caelen ◽  
V Ahlgrimm-Siess
Keyword(s):  
Confocal Microscopy ◽  
Laser Treatment ◽  
Ruby Laser ◽  
Reflectance Confocal Microscopy ◽  
Before And After ◽  
In Vivo Analysis

scholarly journals Effect of Oral Supplementation with L-Carnitine on Performance Time in a 5000 m Race and Responses of Free Fatty Acid and Carnitine Concentrations in Trained-Endurance Athletes

2021 ◽  
Vol 10 (2) ◽  
pp. 5-11
Author(s):  
Mohammad Fayiz AbuMoh'd ◽  
◽  
Michael Yong Hwa Chia ◽  
Walid Alsababha ◽  
◽  
...  
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Physiological Responses ◽  
Endurance Athletes ◽  
Carnitine Supplementation ◽  
Double Blind ◽  
Oral Supplementation ◽  
Performance Time ◽  
Supplementation Period ◽  
Before And After

This study was designed to determine the effect of oral supplementation with L-carnitine on the performance time in a 5000 m race. In addition, free fatty acid, blood carnitine, lactate, and glucose responses to the race following the supplementation period were measured. Twenty male trained-endurance athletes were randomly divided into two groups (L-carnitine, n = 10 (22.13 ± 2.66 yrs) or placebo, n = 10 (21.63 ± 2.23 yrs)). The study was performed with a randomized, double-blind, placebo-controlled parallel-group, in which participants ingested an L-carnitine supplement or a placebo 2 × 1.5 g/day for 3 weeks. Athletes completed a 5000 m race before and after the supplementation period. Blood samples were collected from each athlete before and after the race, preand post-supplementation to measure the physiological responses. Data showed that there were no differences in performance time before (p=0.624) and after (p=0.407) supplementation period between groups and within a group (p>0.05). No differences existed in physiological responses between groups after supplementation before beginning the race (p>0.05), except for the blood carnitine level, which was significantly higher in the L-carnitine than the placebo (P=0.001) group. After the finish of the race, however, data showed better physiological responses in response to L-carnitine supplementation compared to the placebo group (p<0.05). In conclusion, although L-carnitine supplementation increases blood carnitine concentration, it has no beneficial effect on performance time of 5000 m race probably due to the short duration of the race; it might also have no ergogenic effect.

Dermoscopy and reflectance confocal microscopy in cutaneous leishmaniasis on the face

2015 ◽  
Vol 57 (4) ◽  
pp. 316-318 ◽  
Author(s):  
Marija Buljan ◽  
Iris Zalaudek ◽  
Cesare Massone ◽  
Rainer Hofmann-Wellenhof ◽  
Regina Fink-Puches ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Cutaneous Leishmaniasis ◽  
Reflectance Confocal Microscopy ◽  
The Face

scholarly journals Oral Supplementation of Specific Collagen Peptides Combined with Calf-Strengthening Exercises Enhances Function and Reduces Pain in Achilles Tendinopathy Patients

Nutrients ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 76 ◽  
Author(s):  
Stephan F.E. Praet ◽  
Craig R. Purdam ◽  
Marijke Welvaert ◽  
Nicole Vlahovich ◽  
Gregg Lovell ◽  
...  
Keyword(s):  
Placebo Group ◽  
Achilles Tendinopathy ◽  
Crossing Over ◽  
Contrast Enhanced Ultrasound ◽  
Similar Extent ◽  
Oral Supplementation ◽  
Collagen Peptides ◽  
Contrast Enhanced ◽  
Strengthening Exercises ◽  
Clinical Benefits

The current pilot study investigates whether oral supplementation of specific collagen peptides improves symptoms and tendon vascularisation in patients with chronic mid-portion Achilles tendinopathy in combination with structured exercise. Participants were given a placebo or specific collagen peptides (TENDOFORTE®) in combination with a bi-daily calf-strengthening program for 6 months. Group AB received specific collagen peptides for the first 3 months before crossing over to placebo. Group BA received placebo first before crossing over to specific collagen peptides. At baseline (T1), 3 (T2) and 6 (T3) months, Victorian Institute of Sports Assessment–Achilles (VISA-A) questionnaires and microvascularity measurements through contrast-enhanced ultrasound were obtained in 20 patients. Linear mixed modeling statistics showed that after 3 months, VISA-A increased significantly for group AB with 12.6 (9.7; 15.5), while in group BA VISA-A increased only by 5.3 (2.3; 8.3) points. After crossing over group AB and BA showed subsequently a significant increase in VISA-A of, respectively, 5.9 (2.8; 9.0) and 17.7 (14.6; 20.7). No adverse advents were reported. Microvascularity decreased in both groups to a similar extent and was moderately associated with VISA-A (Rc2:0.68). We conclude that oral supplementation of specific collagen peptides may accelerate the clinical benefits of a well-structured calf-strengthening and return-to-running program in Achilles tendinopathy patients.

scholarly journals Visualizing the in-vivo application of zinc in sensitive skin using reflectance confocal microscopy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hye-Jin Ahn ◽  
Hae Jin Kim ◽  
Hyein Ham ◽  
Ji Hwoon Baek ◽  
Young Lee ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Skin Barrier ◽  
Transepidermal Water Loss ◽  
Reflectance Confocal Microscopy ◽  
Sensitive Skin ◽  
The Face ◽  
Self Assessments ◽  
Different Depths ◽  
Imagej Software

AbstractFindings obtained on objective assessments to evaluate sensitive skin do not correlate well with the symptomatology. We utilized reflectance confocal microscopy (RCM) to compare transepidermal application of zinc in sensitive and non-sensitive skin. Thirty-six subjects participated in this study. They were divided into groups based on lactic acid sting test (LAST):‘stinger’ and ‘non-stinger’; transepidermal water loss (TEWL) measurements; and sensitivity self-assessments: ‘sensitive’ and ‘non-sensitive’. RCM images were taken to visualize transepidermal application of topically-applied zinc. The intensity of zinc reflectance at different depths was measured by ImageJ software. Based on LAST scores, the ‘stinger’ group showed significantly higher reflectance of zinc at 8 µm (stratum corneum) [face (P < 0.001), forearm (P = 0.004)], and at 80–104 µm (dermo-epidermal junction layer) on the face. High-TEWL group showed increased zinc reflectance at 8–24 µm (tight junction layer, P < 0.001). There were no significant differences amongst subjects self-reporting ‘sensitive’ and ‘non-sensitive’ skin. RCM demonstrates that in sensitive skin, there is deeper and higher reflectance of zinc at multiple depths. Structural differences are also visualized. We suggest that RCM is a useful tool for evaluating skin barrier integrity.

scholarly journals The Effect of Citicoline on Electroretinography Abnormalities in Patients with Non-proliferative Diabetic Retinopathy

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Anna Nur Utami ◽  
Elvioza Elvioza ◽  
M Sidik
Keyword(s):  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Primary Outcome ◽  
Positive Trend ◽  
Exclusion Criteria ◽  
Double Blind ◽  
P Values ◽  
Oral Supplementation ◽  
End Of Treatment ◽  
Before And After

Introduction : to determine the effect of citicoline 1000 mg oral supplementation given for 4 weeks on electroretinography abnormalities in patients with NPDR (non-proliferative diabetic retinopathy). Methods : prospective, double blind, randomized clinical trial. Thirty-eight patients who matched the inclusion and exclusion criteria were randomized into two groups: the placebo (P-NPDR) and citicoline (C-NPDR).  In the end, there were 18 eyes in citicoline group and 16 eyes in placebo group. The primary outcome was P50 and N95 amplitude in PERG within group and intergroup which were taken at the baseline and 4 weeks after treatment. Results : at the end of treatment, the N95 amplitude in C-NPDR showed improvement, 4.85 (1.9-10.3) µV, before treatment to 5.7 (1.9-17.1) µV, after treatment with P = 0.04. Median P50 amplitude improved in both groups, with C-NPDR: 3.1 µV to 3.8 µV (p = 0.89), and P-NPDR: 3.5 µV, to 4.5 µV (p = 0.10). Delta ∆N95 amplitude is higher in C-NPDR, while delta ∆P50 amplitude is higher in P-NPDR, with P values 0.35 and 0.45. Conclusion : Oral citicoline may induce a significant improvement in mean N95 amplitude before and after the treatment. P-NPDR showed positive trend in P50 amplitude while in C-NPDR showed positive trend in N95 amplitude, but these values were not statistically significant (P = 0.45; P= 0.35).

scholarly journals Kinesio tape for edema control after bichectomy: A randomized trial study

2021 ◽  
Vol 10 (5) ◽  
pp. e33610514983
Author(s):  
Gustavo Silva Pelissaro ◽  
Thábata Flavia Ribeiro Guimarães da Silva ◽  
Aline Bergman de Souza Herculano ◽  
Muryllo Eduardo Sales dos Santos ◽  
Bruno Campidelli Oliveira ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Randomized Study ◽  
Reference Points ◽  
Control Group ◽  
Double Blind ◽  
Edema Formation ◽  
Kinesio Tape ◽  
External Application ◽  
Before And After ◽  
The Face

Bichectomy surgery has been increasingly widespread and performed as an aesthetic, functional, or aesthetic-functional treatment. This study aims to describe the surgical technique of bichectomy with the application of the Kinesio tape to verify its effectiveness in controlling edema formation, with the measurement in four postoperative periods. Through a split-mouth, double-blind, randomized study, 13 participants who had an indication for the surgery were selected and divided into two groups - Control Group: bichectomy surgery and cryotherapy for a period of 12 hours, without external application of the Kinesio tape (KT) and Experimental Group: bichectomy surgery, cryotherapy for a period of 12 hours, and application of KT in the outer cheek area of the face, for 2 days. A millimeter measuring tape was used to measure three reference points on the face before and after the surgical procedure (preoperative, 24 hours, 48 hours, and 7 days postoperatively). Quantitative data were subjected to statistical analysis using the Sigma Plot 12.0 program (Exakt graphs and data analysis, San Jose, USA). The comparisons were made according to the edema measurements for the two experimental groups (2 levels: Kinesio tape versus cryotherapy) and the periods of analysis (4 levels: Preoperative, 24 hours, 48 hours and 7 days postoperatively). After obtaining the data, and the statistical analysis, the application of Kinesio Tape proved to be more effective when compared to the use of cryotherapy alone, in the control of postoperative edema in patients who underwent bichectomy surgery. The study contributes to the literature regarding the applicability of the KT and expands the therapeutic possibilities in an aesthetic-functional procedure that is increasingly sought after by patients.

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