scholarly journals Anxiolytic Effect of Two Tobacco Essential Oils (Nicotiana tabacum Linn.) on Mice

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4171
Author(s):  
Danqing Xie ◽  
Lei Yao ◽  
Yan Huang ◽  
Shuaifan Wu ◽  
Li Ma ◽  
...  
Keyword(s):  
Nicotiana Tabacum ◽  
Essential Oil ◽  
Essential Oils ◽  
Elevated Plus Maze ◽  
Folk Medicine ◽  
Anxiolytic Effect ◽  
Transdermal Administration ◽  
Icr Mice ◽  
Elevated Plus Maze Test ◽  
Plus Maze

Tobacco (Nicotiana tabacum Linn.) is a famous traditional herb used in folk medicine. The essential oils of tobacco have been demonstrated in modern studies to possess antioxidant, anti-inflammatory, and neuroprotective properties, while its anxiolytic effect has not been reported. The purpose of this study was to evaluate the anxiolytic effect of Yunnan tobacco essential oil (YTO) and Zimbabwe tobacco essential oil (ZTO) on mice. The constituents of YTO and ZTO were analyzed by GC/MS. The anxiolytic effect of YTO and ZTO (0.1%, 1%, and 10%, v/v) on male ICR mice was evaluated in the light–dark box test (LDB) and the elevated plus maze test (EPM) test via inhalation and transdermal administration. After the behavioral tests, salivary corticosterone levels in mice were measured. The behavioral analysis showed that the administration of both YTO and ZTO elevated the time that the mice spent in the light chamber in the LDB test compared to the untreated control. In the EPM test, YTO and ZTO increased the time spent in open arms and the number of entries into the open arms. In addition, both YTO and ZTO significantly decreased salivary corticosterone levels in mice (p ≤ 0.001). In summary, our results demonstrated that inhalation and transdermal administration of both YTO and ZTO showed anxiolytic effect on male ICR mice.

scholarly journals Anxiolytic Effect and Tissue Distribution of Inhaled Alpinia zerumbet Essential Oil in Mice

2010 ◽  
Vol 5 (1) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Tadaaki Satou ◽  
Shio Murakami ◽  
Mariko Matsuura ◽  
Shinichiro Hayashi ◽  
Kazuo Koike
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Tissue Distribution ◽  
Anxiolytic Effect ◽  
The Body ◽  
Elevated Plus Maze Test ◽  
Multiple Components ◽  
Plus Maze ◽  
Behavioral Assessments ◽  
Alpinia Zerumbet

The use of essential oils is common throughout the world, and clarification of their detailed effects and pharmaceutical potencies is necessary. Additionally, detailed information regarding the pharmacokinetics of essential oils is needed. In this report, GC-MS analysis was used to observe the tissue distribution of the multiple components of Alpinia zerumbet (Pers.) B.L. Burtt. et Sm. Anxiety-related behavior was evaluated by the light and dark box test (LD), open field test (OF), and elevated plus maze test (EPM). GC-MS quantification of the major components of A. zerumbet essential oil (AZEO) (α-pinene, p-cymene, 1,8-cineole, and limonene) was almost identical using either the injection or headspace injection method. All the behavioral assessments indicated that inhalation of AZEO had a positive anxiolytic effect. This was especially evident in the EPM (time spent in the open arms), where anxiolytic effects were clearly observed (P < 0.05). α-Pinene accumulated in the brain at almost the same rate as in the liver. However, the oil components chiefly accumulated in the kidney. Therefore, the essential oil component in the largest proportion will not necessarily be distributed to organs throughout the body in the same quantities and/or ratios. It is necessary to consider tissue distribution for investigating the effects of essential oil inhalation.

scholarly journals Adaptogenic activity of Cinnamomum camphora, Eucalyptus globulus, Lavandula stœchas and Rosmarinus officinalis essential oil used in North-African folk medicine

2021 ◽  
Vol 67 (2) ◽  
pp. 83-88
Author(s):  
Mahieddine Boumendjel ◽  
Abdennour Boucheker ◽  
Sandra Feknous ◽  
Faiza Taibi ◽  
Naouel Rekioua ◽  
...  
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Emotional Disorders ◽  
Eucalyptus Globulus ◽  
Elevated Plus Maze ◽  
Rosmarinus Officinalis ◽  
Cinnamomum Camphora ◽  
Lavandula Stoechas ◽  
Plus Maze ◽  
Adaptogenic Activity

Depressive anxiety is one of the most emotional disorders in our industrial societies. Many treatments of phobias exist and are based on plant extracts therapies, which play an important role in the amelioration of the behavior. Our study aimed to evaluate the adaptogenic activity of different essential oils provided from local plants: Cinnamomum camphora (Camphora), Eucalyptus globulus (Blue gum), Lavandula stœchas (Topped lavender) and Rosmarinus officinalis (Rosemary) on Wistar rats. The adaptogenic activity was evaluated on the elevated plus-maze. The efficacy of the extract (200 mL/kg) was compared with the standard anxiolytic drug Diazepam® 1 mg. Animals administered by the essential oil of Lavandula stœchas, Cinnamomum camphora, Rosmarinus officinalis and Eucalyptus globulus showed a behavior similar to those treated with Diazepam®. For groups treated with the following essential oils: Rosmarinus officinalis, Lavandula stoechas and Cinnamomum camphora at a dose of 200 mL/kg, we notice an increase in the time spent on the open arms of the elevated plus-maze and a decrease in time spent on the closed arms of the elevated plus-maze, especially for Rosmarinus officinalis, which explains the anxiolytic effect of these plants. We also notice a decrease in the number of entries in closed arms, open arms and the number of passing to the central square. The increase in the number of entries to open arms with Eucalyptus globulus essential oil shows a reduction in anxiety behavior in rodents and this shows that these plants have an inhibitory effect.

scholarly journals Effects of Simultaneous Reinforcement of Endocannabinoid and Cholinergic Systems on Anxiety-Like Behavior in Mice

2021 ◽  
Author(s):  
Siamak Shahidi ◽  
Asghar Dindar ◽  
Alireza Komaki ◽  
Reihaneh Sadeghian
Keyword(s):  
Elevated Plus Maze ◽  
Enzyme Inhibitor ◽  
Endocannabinoid System ◽  
Anxiolytic Effect ◽  
Control Group ◽  
Concurrent Administration ◽  
Elevated Plus Maze Test ◽  
Cholinergic Systems ◽  
Plus Maze ◽  
High Doses

Abstract ObjectiveAnxiety behavior is regulated by different neurotransmitter systems. There has been no direct relationship between endocannabinoid and cholinergic systems on anxiety in previous studies. This study investigated the effects of each of these systems separately and simultaneously using Donepezil (Cholinesterase inhibitor) and URB-597 (endocannabinoid degrading enzyme inhibitor) on anxiety-like behavior. MethodEighty-eight male mice were divided into eleven groups (n=8) including control (saline), diazepam (0.3 mg /kg), URB-597 (0.1, 0.3, or 1 mg /kg), donepezil (0.5, 1 or 2 mg/kg) and the combination of the two drugs at low, medium and high doses. All treatments were injected intraperitoneally 30 minutes before the elevated plus maze test. ResultsSeparate administration of URB597, donepezil or diazepam increased the number and time spent of open arms compared to the control group. Concurrent administration of URB and donepezil at low, medium and high doses did not change the number of open arms entries compared to the control group, but they reduced the number of entries to the closed arms. ConclusionsThese results suggest that strengthening any cholinergic or endocannabinoid system has anxiolytic effect similar to diazepam. However, the interaction of these two systems has fewer anxiolytic effects compared to the effects of each alone. It seems that these drugs alone may represent a strategy for the treatment of anxiety disorders.

scholarly journals Chemical Composition of Essential Oil from Flower of ‘Shanzhizi’ (Gardenia jasminoides Ellis) and Involvement of Serotonergic System in Its Anxiolytic Effect

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4702
Author(s):  
Nan Zhang ◽  
Mu Luo ◽  
Lei He ◽  
Lei Yao
Keyword(s):  
Essential Oil ◽  
Elevated Plus Maze ◽  
Anxiolytic Effect ◽  
Serotonergic System ◽  
Control Treatment ◽  
Monoamine Neurotransmitters ◽  
Neurotransmitter Receptor ◽  
Gardenia Jasminoides ◽  
Plus Maze ◽  
Gardenia Jasminoides Ellis

Gardenia jasminoides Ellis is a famous fragrant flower in China. Previous pharmacological research mainly focuses on its fruit. In this study, the essential oil of the flower of ‘Shanzhizi’, which was a major variety for traditional Chinese medicine use, was extracted by hydro distillation and analyzed by GC-MS. Mouse anxiety models included open field, elevated plus maze (EPM), and light and dark box (LDB), which were used to evaluate its anxiolytic effect via inhalation. The involvement of monoamine system was studied by pretreatment with neurotransmitter receptor antagonists WAY100635, flumazenil and sulpiride. The monoamine neurotransmitters contents in the prefrontal cortex (PFC) and hippocampus after aroma inhalation were also analyzed. The results showed that inhalation of G. jasminoides essential oil could significantly elevated the time and entries into open arms in EPM tests and the time explored in the light chamber in LDB tests with no sedative effect. WAY100635 and sulpiride, but not flumazenil, blocked its anxiolytic effect. Inhalation of G. jasminoides essential oil significantly down-regulated the 5-HIAA/5-HT in the PFC and reduced the 5-HIAA content in hippocampus compared to the control treatment. In conclusion, inhalation of gardenia essential oil showed an anxiolytic effect in mice. Monoamine, especially the serotonergic system, was involved in its anxiolytic effect.

Vigabatrin has an anxiolytic effect in the elevated plus-maze test of anxiety

1992 ◽  
Vol 43 (2) ◽  
pp. 529-535 ◽  
Author(s):  
Ümit Sayin ◽  
Nuhan Purali ◽  
Tuncer Özkan ◽  
Tuncay Altug ◽  
Sevim Büyükdevrim
Keyword(s):  
Elevated Plus Maze ◽  
Anxiolytic Effect ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze

Anticompulsive effects of novel derivatives of coumarin in rats

2021 ◽  
Vol 19 (3) ◽  
pp. 339-344
Author(s):  
Bakhodir B. Daliev ◽  
Eugenii R. Bychkov ◽  
Leonid V. Myznikov ◽  
Andrei A. Lebedev ◽  
Petr D. Shabanov
Keyword(s):  
Elevated Plus Maze ◽  
Anxiolytic Effect ◽  
Emotional Behavior ◽  
Central Action ◽  
Elevated Plus Maze Test ◽  
Anxiogenic Effect ◽  
Plus Maze ◽  
Few Data ◽  
New Compounds ◽  
Dose Dependent

BACKGROUND: Until now, the neurotropic effect, in particular the effect on the emotional behavior of oxy-coumarins, has not been adequately studied. There are only few data on their central action. Currently, research is underway on the synthesis of new compounds based on natural oxy-coumarins, which will potentially have a higher biological activity. AIM: Was to study the central action of new oxycoumarin-based compounds IEM-2886, LVM-99, LVM-S144, in particular, on compulsive behavior in rats. MATERIALS AND METHODS: To assess the behavior of Wistar rats, the Marble-test and Elevated plus maze methods were used. Oxycoumarin derivatives (IEM-2886, LVM-99, LVM-S144) were injected intraperitoneally at doses of 1, 10 and 25 mg/kg. The effectiveness of the drugs was judged by the number of balls buried in the Marble test and by the duration of staying in the open and closed sleeves of the Elevated plus maze. Results. It was shown that in the Marble test, oxycoumarin-based compounds (IEM-2886, LVM-99, LVM-S144) caused a decrease in the number of buried balls, which shows their anti-compulsive effect. After administration of IEM-2886, LVM-99, LVM-S144 (125 mg / kg) compounds, dose-dependent effects were observed (p 0.05). The elevated plus maze test did not show the anxiolytic effect typical for tranquilizers. Moreover, after the administration of IEM-2886 and LVM-S144 at a dose of 25 mg / kg, an increase in the time spent in the closed sleeve of the maze (p 0.05) was observed, i.e. an anxiogenic effect. CONCLUSION: Thus, oxy-coumarin-based compounds are selective for the assessment of anticompulsive effects.

scholarly journals Interspecies Comparison of Chemical Composition and Anxiolytic-like Effects of Lavender Oils upon Inhalation

2011 ◽  
Vol 6 (11) ◽  
pp. 1934578X1100601 ◽  
Author(s):  
Mizuho Takahashi ◽  
Tadaaki Satou ◽  
Mai Ohashi ◽  
Shinichiro Hayashi ◽  
Kiyomi Sadamoto ◽  
...  
Keyword(s):  
Essential Oils ◽  
Elevated Plus Maze ◽  
Linalyl Acetate ◽  
Interspecies Comparison ◽  
Qualitative And Quantitative ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze ◽  
Mental Problems ◽  
Different Origins

Essential oils have traditionally been used for decades to alleviate the symptoms of various mental problems. In terms of anxiolytic-like properties, lavender oil is probably the most commonly used and best-studied essential oil. Although there is compositional variance among the oils extracted from different origins, there have been few studies performed to date to investigate how these differences affect the expression of anxiolytic-like activity. This paper discusses the interspecies differences and contributions of the main constituents in the expression of anxiolytic-like effects upon inhalation, as assessed in mice by the elevated-plus maze test, by comparing the essential oils from six different species of Lavandula. The results showed qualitative and quantitative variations in the tested oils, which results in significant differences in their anxiolytic-like activities. Our findings also suggest that linalyl acetate (LA) works synergistically with linalool (LO) and that the presence of both LA and LO is essential for the whole oil to work as an inhaled anti-anxiety agent.

The anxiolytic effect of Sho-ju-sen, a Japanese herbal medicine, assessed by an elevated ­plus-maze test in mice

2001 ◽  
Vol 15 (2) ◽  
pp. 142-147 ◽  
Author(s):  
Hisashi Kuribara ◽  
Hisato Iwata ◽  
Hideo Tomioka ◽  
Reiko Takahashi ◽  
Kazumi Goto ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Elevated Plus Maze ◽  
Anxiolytic Effect ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze ◽  
Japanese Herbal Medicine

scholarly journals Evaluation of the anxiolytic effects of the aqueous and ethanolic extracts of the leaves and bark of Annona muricata using the elevated plus maze test

2020 ◽  
Vol 9 (5) ◽  
pp. 329-332
Author(s):  
Kwasi Adomako Ohemeng ◽  
◽  
Peace Doe ◽  
Mariam Adoley Pappoe ◽  
Dzifa Thywill Gordor ◽  
...  
Keyword(s):  
Elevated Plus Maze ◽  
Anxiolytic Effect ◽  
Traditional Healers ◽  
Bark Extract ◽  
Annona Muricata ◽  
Traditional Use ◽  
Standard Drug ◽  
Elevated Plus Maze Test ◽  
Plus Maze ◽  
Ethanolic Extracts

Introduction: Natural products since time immemorial have been the source of traditional medicine. A number of well-known anxiolytic agents currently used have several side effects that limit their use. Among medicinal plants, leaves of Annona muricata (AM) are being recommended by traditional healers for the management of anxiety. This study is performed to evaluate the anxiolytic activity of the aqueous and ethanolic extracts of the leaves and bark of Annona muricata. Methodology: Aqueous and ethanolic extracts of the leaves and bark of Annona muricata were prepared and assessed for anxiolytic effect using the elevated plus maze (EPM) model. The antianxiety activity of the extracts were compared to the control (distilled water 10ml/kg) and standard drug Diazepam (5mg/kg). Results and discussion: All doses of the aqueous leaf extract of Annona muricata exhibited significant increase in mean entries into open arms (P<0.01) and mean time spent in open arms (P<0.05) compared to the control. 100mg/kg and 400mg/kg of the ethanolic bark extract of Annona muricata showed significant increase in open arm entries (P<0.01) with 100mg/kg also showing an increase in time spent in open arms which was significant. Conclusion: This study demonstrated that both the aqueous and ethanolic extracts of the leaves and bark of Annona muricata exert an anxiolytic effect on rats which substantiates its traditional use in the management of anxiety.

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