scholarly journals D-Sorbitol Physical Properties Effects on Filaments Used by 3D Printing Process for Personalized Medicine

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 3000
Author(s):  
Stéphane Roulon ◽  
Ian Soulairol ◽  
Maxime Cazes ◽  
Léna Lemierre ◽  
Nicolas Payre ◽  
...  
Keyword(s):  
3D Printing ◽  
Physical Properties ◽  
Size Distribution ◽  
Polyethylene Oxide ◽  
Patient Characteristics ◽  
Calibration Method ◽  
Fused Filament Fabrication ◽  
The Impact ◽  
Amiodarone Hydrochloride ◽  
Hot Melt

Fused filament fabrication (FFF) is a process used to manufacture oral forms adapted to the needs of patients. Polyethylene oxide (PEO) filaments were produced by hot melt extrusion (HME) to obtain a filament suitable for the production of amiodarone hydrochloride oral forms by FFF 3D printing. In order to produce personalized oral forms adapted to the patient characteristics, filaments used by FFF must be controlled in terms of mass homogeneity along filament. This work highlights the relation between filament mass homogeneity and its diameter. This is why the impact of filler excipients physical properties was studied. It has been showed that the particle’s size distribution of the filler can modify the filament diameter variability which has had an impact on the mass of oral forms produced by FFF. Through this work it was shown that D-Sorbitol from Carlo Erba allows to obtain a diameter variability of less than 2% due to its unique particle’s size distribution. Using the filament produced by HME and an innovating calibration method based on the filament length, it has been possible to carry out three dosages of 125 mg, 750 mg and 1000 mg by 3D printing with acceptable mass uniformity.

scholarly journals The Impact of 3D Printing Process Parameters on the Dielectric Properties of High Permittivity Composites

Designs ◽  
2019 ◽  
Vol 3 (4) ◽  
pp. 50 ◽  
Author(s):  
Athanasios Goulas ◽  
Shiyu Zhang ◽  
Darren A. Cadman ◽  
Jan Järveläinen ◽  
Ville Mylläri ◽  
...  
Keyword(s):  
3D Printing ◽  
Process Parameters ◽  
Relative Permittivity ◽  
Main Process ◽  
Fused Filament Fabrication ◽  
Layer Height ◽  
Additive Manufacturing Technology ◽  
The Impact ◽  
Printing Speed ◽  
Hatch Spacing

Fused filament fabrication (FFF) is a well-known and greatly accessible additive manufacturing technology, that has found great use in the prototyping and manufacture of radiofrequency componentry, by using a range of composite thermoplastic materials that possess superior properties, when compared to standard materials for 3D printing. However, due to their nature and synthesis, they are often a great challenge to print successfully which in turn affects their microwave properties. Hence, determining the optimum printing strategy and settings is important to advance this area. The manufacturing study presented in this paper shows the impact of the main process parameters: printing speed, hatch spacing, layer height and material infill, during 3D printing on the relative permittivity (εr), and loss tangent (tanδ) of the resultant additively manufactured test samples. A combination of process parameters arising from this study, allowed successful 3D printing of test samples, that marked a relative permittivity of 9.06 ± 0.09 and dielectric loss of 0.032 ± 0.003.

scholarly journals Development of a hot-melt extrusion (HME) process to produce drug loaded Affinisol™ 15LV filaments for fused filament fabrication (FFF) 3D printing

2019 ◽  
Vol 29 ◽  
pp. 100776 ◽  
Author(s):  
Elke Prasad ◽  
Muhammad T. Islam ◽  
Daniel J. Goodwin ◽  
Andrew J. Megarry ◽  
Gavin W. Halbert ◽  
...  
Keyword(s):  
3D Printing ◽  
Hot Melt Extrusion ◽  
Melt Extrusion ◽  
Fused Filament Fabrication ◽  
Hot Melt

Does kraft hardwood and softwood pulp viscosity correlate to paper properties?

TAPPI Journal ◽  
2016 ◽  
Vol 15 (10) ◽  
pp. 643-651 ◽  
Author(s):  
ROBERT J. OGLESBY ◽  
HUMPHREY J. MOYNIHAN ◽  
RICARDO B. SANTOS ◽  
ASHOK GHOSH ◽  
PETER W. HART
Keyword(s):  
Physical Properties ◽  
Strength Loss ◽  
Strength Properties ◽  
Clear Correlation ◽  
Paper Properties ◽  
Physical Strength ◽  
Pulp Viscosity ◽  
Softwood Pulp ◽  
The Impact ◽  
Related Paper

The impact of commercially prepared, fully bleached pulp viscosity variation on handsheet physical properties was evaluated at different levels of pulp refining. Hardwood pulps from the same brownstock species mix, cooking parameters, and kappa numbers were processed through two different commercial bleach plants: one with a D0(EP)D1D2 sequence and the second with an OD0(EOP)D1 sequence. Additionally, a commercial softwood (predominately Scotts pine) brownstock pulp bleached by an OD0(EP)D1D2 sequence was employed in this study. Pulps with viscosities ranging from 14 to 21 mPa∙s were refined in a Valley beater to two freeness levels, and the associated handsheet physical properties were measured in this study. Over the pulp viscosity range of 14 to 21 mPa∙s, no clear correlation was found to exist between pulp viscosity and related paper physical properties. Finally, a series of laboratory prepared bleached pulps were purposely prepared under non-ideal conditions to reduce their final viscosities to lower values. Handsheets made from these pulps were tested in their unbeaten condition for physical strength properties. Significant and rapid strength loss occurred when the measured pulp viscosity dropped below 12 mPa∙s; overall strength properties showed no correlation to viscosity above the critical 12 mPa∙s value.

Technological Advancements in Oral Films

2019 ◽  
Vol 9 (01) ◽  
pp. 15-20
Author(s):  
B Pandey ◽  
A B Khan
Keyword(s):  
3D Printing ◽  
Historical Background ◽  
Poorly Soluble Drugs ◽  
Modern Approach ◽  
Poorly Soluble ◽  
Critical Process Parameters ◽  
Biopharmaceutical Properties ◽  
Oral Films ◽  
Hot Melt ◽  
Modern Technologies

The aim of the review was to explore the necessity, advantages and different techniques of oral films for enhancing solubility of poorly soluble drugs with an emphasis on the newer, state-of the art technologies, such as 3D printing and hot-melt extrusion (HME). The historical background of oral films is presented along with the regularly used techniques. The modern approach of quality-by-design (QbD) is unravelled, identifying appropriate critical process parameters (CPP) and applied to oral films. A section is devoted modern technologies such as 3D printing and HME of oral films. Oral films are innovative formulations by which poorly soluble drugs have been founds to give positive results in enhancing their solubility and dissolution characteristics. With modern sophisticated techniques, precise mass production of oral films has been given a thrust. Oral films have better patient compliance, improved biopharmaceutical properties, improved efficacy, and better safety. By applying QbD and implementation of modern technologies the newer generation of oral films are yielding promising results

TACTIX 740 and TACTIX 741 RESINS

Alloy Digest ◽  
1991 ◽  
Vol 40 (12) ◽  
Keyword(s):  
Physical Properties ◽  
Acetone Solution ◽  
Chemical Company ◽  
High Durability ◽  
Melt Adhesives ◽  
Hot Melt

Abstract TACTIX 740 resin offers high durability for hot melt adhesives. TACTIX 741, an acetone solution of TACTIX 740, is designed for composites prepared by solution prepregging. This datasheet provides information on composition and physical properties. Filing Code: P-32. Producer or source: The Dow Chemical Company, Dow Plastics.

scholarly journals The Direct 3D Printing of Functional PEEK/Hydroxyapatite Composites via a Fused Filament Fabrication Approach

Polymers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 545
Author(s):  
Krzysztof Rodzeń ◽  
Preetam K. Sharma ◽  
Alistair McIlhagger ◽  
Mozaffar Mokhtari ◽  
Foram Dave ◽  
...  
Keyword(s):  
Tensile Strength ◽  
3D Printing ◽  
Selective Laser Sintering ◽  
Fused Filament Fabrication ◽  
Bone Apposition ◽  
Innovative Solutions ◽  
3D Printed ◽  
Work Samples ◽  
Viable Approach ◽  
Crystalline Domains

The manufacture of polyetheretherketone/hydroxyapatite (PEEK/HA) composites is seen as a viable approach to help enhance direct bone apposition in orthopaedic implants. A range of methods have been used to produce composites, including Selective Laser Sintering and injection moulding. Such techniques have drawbacks and lack flexibility to manufacture complex, custom-designed implants. 3D printing gets around many of the restraints and provides new opportunities for innovative solutions that are structurally suited to meet the needs of the patient. This work reports the direct 3D printing of extruded PEEK/HA composite filaments via a Fused Filament Fabrication (FFF) approach. In this work samples are 3D printed by a custom modified commercial printer Ultimaker 2+ (UM2+). SEM-EDX and µCT analyses show that HA particles are evenly distributed throughout the bulk and across the surface of the native 3D printed samples, with XRD highlighting up to 50% crystallinity and crystalline domains clearly observed in SEM and HR-TEM analyses. This highlights the favourable temperature conditions during 3D printing. The yield stress and ultimate tensile strength obtained for all the samples are comparable to human femoral cortical bone. The results show how FFF 3D printing of PEEK/HA composites up to 30 wt% HA can be achieved.

scholarly journals Comparison of Osmotic Resistance, Shape and Transmembrane Potential of Erythrocytes Collected from Healthy and Fed with High Fat-Carbohydrates Diet (HF-CD) Pigs—Protective Effect of Cistus incanus L. Extracts

Materials ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 1050
Author(s):  
Sylwia Cyboran-Mikołajczyk ◽  
Robert Pasławski ◽  
Urszula Pasławska ◽  
Kacper Nowak ◽  
Michał Płóciennik ◽  
...  
Keyword(s):  
Biological Activity ◽  
Physical Properties ◽  
Plasma Lipid ◽  
Membrane Lipid ◽  
Osmotic Resistance ◽  
High Fat ◽  
Atherosclerotic Lesions ◽  
Cistus Incanus ◽  
Osmotic Resistance Of Erythrocytes ◽  
The Impact

Long-term high fat-carbohydrates diet (HF-CD) contributes to the formation of irreversible changes in the organism that lead to the emergence of civilization diseases. In this study, the impact of three-month high-fat diet on the physical properties of erythrocytes (RBCs) was studied. Furthermore, the biological activity of Cistus incanus L. extracts, plant known with high pro-health potential, in relation to normal and HF-CD RBCs, was determined. Obtained results have shown that, applied HF-CD modified shape, membrane potential and osmotic resistance of erythrocytes causing changes in membrane lipid composition and the distribution of lipids. The impact of HF-CD on physical properties of RBCs along with atherosclerotic lesions of the artery was visible, despite the lack of statistically significant changes in blood morphology and plasma lipid profile. This suggests that erythrocytes may be good markers of obesity-related diseases. The studies of biological activity of Cistus incanus L. extracts have demonstrated that they may ameliorate the effect of HF-CD on erythrocytes through the membrane-modifying and antioxidant activity.

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