scholarly journals Jasmonate Compounds and Their Derivatives in the Regulation of the Neoplastic Processes

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 2901
Author(s):  
Iwona Jarocka-Karpowicz ◽  
Agnieszka Markowska
Keyword(s):  
Jasmonic Acid ◽  
Biological Activities ◽  
Active Form ◽  
Modern Medicine ◽  
Aging Effects ◽  
Neoplastic Processes ◽  
Wide Range ◽  
Anti Cancer ◽  
Mitogen Activated Protein ◽  
Relationship Of

Cancer is a serious problem in modern medicine, mainly due to the insufficient effectiveness of currently available therapies. There is a particular interest in compounds of natural origin, which can be used in the prophylaxis, as well as in the treatment and support of cancer treatment. One such compound is jasmonic acid (3-oxo-2-(pent-2’-enyl)cyclopentane acetic acid; isolated active form: trans-(-)-(3R,7R)- and cis-(+)-(3R,7S)-jasmonic acid) and its derivatives, which, due to their wide range of biological activities, are also proposed as potential therapeutic agents. Therefore, a review of literature data on the biological activity of jasmonates was prepared, with particular emphasis on the mechanisms of jasmonate action in neoplastic diseases. The anti-tumor activity of jasmonate compounds is based on altered cellular ATP levels; induction of re-differentiation through the action of Mitogen Activated Protein Kinases (MAPKs); the induction of the apoptosis by reactive oxygen species. Jasmonates can be used in anti-cancer therapy in combination with other known drugs, such as cisplatin, paclitaxel or doxorubicin, showing a synergistic effect. The structure–activity relationship of novel jasmonate derivatives with anti-tumor, anti-inflammatory and anti-aging effects is also shown.

scholarly journals Andrographolide, A Natural Antioxidant: An Update

Antioxidants ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 571 ◽  
Author(s):  
Eugenie Mussard ◽  
Annabelle Cesaro ◽  
Eric Lespessailles ◽  
Brigitte Legrain ◽  
Sabine Berteina-Raboin ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Herbal Remedy ◽  
Biological Activities ◽  
Lung Infection ◽  
Andrographis Paniculata ◽  
Natural Antioxidant ◽  
Nuclear Factor ◽  
Wide Range ◽  
Anti Cancer ◽  
Antioxidant Mechanisms

Traditionally, Andrographis paniculata has been used as an herbal remedy for lung infection treatments. Its leaves contain a diterpenoid labdane called andrographolide responsible for a wide range of biological activities such as antioxidant, anti-inflammatory, and anti-cancer properties. This manuscript is a brief review of the antioxidant mechanisms and the regulation of the Nrf2 (nuclear factor (erythroid-derived 2)-like 2) signaling pathway by andrographolide.

scholarly journals Preliminary phytochemical screening of Lantana camara, L., a major invasive species of Kerala, using different solvents

2017 ◽  
Vol 6 (11) ◽  
pp. 1794
Author(s):  
Sushma Raj
Keyword(s):  
Biological Activities ◽  
Modern Medicine ◽  
Lantana Camara ◽  
Phytochemical Screening ◽  
Invasive Weed ◽  
Natural Form ◽  
Large Reservoir ◽  
Standard Procedures ◽  
Medicinal Use ◽  
Wide Range

Plants and plant extracts have important role in modern medicine as their chemical and medicinal constituents are found in natural form. The secondary metabolites represent a large reservoir of structural moieties which work together exhibiting a wide range of biological activities. Plants and plant based products are bases of many modern pharmaceuticals that are currently in use for various diseases. Lantana camara, L., also known as big – sage or wild – sage is one of the major invasive weed in India. Six different solvents viz; distilled water, acetone, alcohol, chloroform, petroleum ether and benzene were used to obtain extracts from powdered leaves and roots of Lantana camara, L. The extracts were subjected to qualitative phytochemical screening using standard procedures. Of the 15 phytochemicals tested, 10 were found in various solvent extracts of Lantana camara, L. By this study, it was confirmed that the selected plant species is a potent source of useful drugs. Present day, particularly in India, Lantana camara, L. is considered as a threat to our biodiversity. So a controlled management is necessary to make use its medicinal use.

Current Pharmaceutical Aspects of Synthetic Quinoline Derivatives

2020 ◽  
Vol 20 ◽  
Author(s):  
Rukhsana Tabassum ◽  
Muhammad Ashfaq ◽  
Hiroyuki Oku
Keyword(s):  
Fungal Infections ◽  
Biological Activities ◽  
Chemical Properties ◽  
New Drugs ◽  
Quinoline Derivatives ◽  
Wide Range ◽  
Anti Cancer ◽  
Anti Fungal ◽  
Physical And Chemical ◽  
And Chemical Properties

Abstract:: Quinoline derivatives are considered as broad spectrum pharmacological compounds that exhibit wide range of biological activities. Integration of quinoline moiety can improve its physical and chemical properties and also pharmacological behavior. Due to its wide range of pharmaceutical applications it is very popular compound to design new drugs for treatment of multiple diseases like cancer, dengue fever, malaria, tuberculosis, fungal infections, AIDS, Alzheimer’s disease and diabetes . In this review our major focus is to pay attention on biological activities of quinoline compounds in treatment of these diseases such as, anti-viral, anti-cancer, anti-malarial, anti-bacterial, anti-fungal, anti-tubercular and anti-diabetic.

Synthesis, Antioxidant and Antitumor Activity of Some Substituted 9-Anilinoacridine and 4-Anilinoquinolines Derivatives

2018 ◽  
Vol 15 (6) ◽  
pp. 846-852 ◽  
Author(s):  
Fatimah A. Agili
Keyword(s):  
Antioxidant Activity ◽  
Antitumor Activity ◽  
Biological Activities ◽  
Radical Scavenging ◽  
Breast Adenocarcinoma ◽  
Liver Carcinoma ◽  
Quinoline Derivatives ◽  
Wide Range ◽  
Anti Cancer ◽  
Radical Scavenging Ability

Background: Acridine and quinoline derivatives have a wide range of biological activities such as antioxidant and antitumor where quinoline derivatives intercalate between base pairs of double-stranded DNA through π-π interactions. Therefore, the development of new compounds with antitumor activity could be an important therapeutic strategy against this metabolic syndrome. Objective: This study was undertaken to synthesize different series of new anilinoacridines and anlinoquinoline with different substituents having biological activity. Materials and Methods: A series of new anilinoacridines and anlinoquinoline with different substituents was prepared by condensation of methyl 3-amino-4-methoxybenzoate hydrochloride with 9- chloroacridine and 4- chloroquinoline to give the target derivatives. Results: New anilinoacridines and anlinoquinoline with different substituents have been synthesized as antioxidant and anti-cancer agents. The structure of the synthesized compounds was confirmed by using spectral methods (FT-IR, 1H-NMR). The antioxidant activity of the synthesized compounds was evaluated by using DPPH radical scavenging ability. Also, the anti-cancer activity was evaluated using lung carcinoma, breast adenocarcinoma and liver carcinoma. The developed compounds 4a, b, 5a,b, 7a,b and 8a,b have shown a potent antioxidant activity. On the other hand, 4a, b, 5a and 7a exhibited the best antitumor activity against both A-549 and MCF7 cancer cells. Conclusion: For the active developed compounds, the most active antioxidant and antitumor one was 4a which registered the highest radical scavenging as well as antitumor activity.

Medicinal Properties of Cinchona Alkaloids - A Brief Review

2021 ◽  
Vol 11 (3) ◽  
pp. 224-228
Author(s):  
Anubhav Dubey ◽  
Yatendra Singh
Keyword(s):  
Toxic Effect ◽  
Antimalarial Activity ◽  
Biological Activities ◽  
Folk Medicine ◽  
Modern Medicine ◽  
Cinchona Alkaloids ◽  
Literature Study ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Medicinal Properties

Cinchona which belongs to family Rubiaceae, got its importance from the centuries because of its anti- malarial activity. Alkaloids present in this herb, Quinine, Chichonine, Quinidine and Cinchonidine are the main, but percentage may vary in species to species. Since the early 17th century, these alkaloid are frequently used in Indian ayurvedic, sidha and traditional folk medicine to treating fever and Still now in modern medicine cinchona alkaloids are used for the treatment of malaria as well as for other diseases and became the well-known drug after the treatment of malaria caused by Plasmodium Sp. Literature study revealed that along with the antimalarial activity the cinchona alkaloids has other potentiality like anti-obesity, anti-cancer, anti-oxidant, anti-inflammatory, anti-microbial activity. These article reviews the biological activities of cinchona alkaloids along with its toxic effect.

scholarly journals Antibacterial, Antiviral, Antioxidant, and Anticancer Activities of Postbiotics: A review of Mechanisms and Therapeutic Perspectives

2021 ◽  
Vol 12 (2) ◽  
pp. 2629-2645
Keyword(s):  
Human Health ◽  
Fermentation Process ◽  
Biological Activities ◽  
Scientific Evidence ◽  
Food Allergies ◽  
Live Cells ◽  
Anticancer Activities ◽  
Wide Range ◽  
Anti Cancer ◽  
Improve Health

Several scientific evidence has shown the advantageous effects of probiotic-derived metabolites on human health. Postbiotics are a wide range of bioactive compounds derived from probiotics through a fermentation process and/or produced in pure forms in laboratory scales. These compounds have native biological activities that have been extensively studied in recent years. Immunomodulation, antimicrobial, anti-cancer, antioxidant, anti-diabetic, and reduction of food allergies compose the most important biological roles of postbiotics. In terms of safety, it has been confirmed that postbiotics, as potential substitute elements, might be superior to their parent live cells. Also, due to their appropriate economic, technological, and clinical features, they could be employed as favorable apparatuses in the food and drug industry to improve health benefits. This review comprehensively discusses the concept of postbiotics and their characteristics, emphasizing their potential antibacterial, antiviral, antioxidant, and anticancer activities.

scholarly journals Bunium persicum: A Review of Ethnopharmacology, Phytochemistry, and Biological Activities

2020 ◽  
Author(s):  
Zahra Majidi ◽  
Fatemeh Bina ◽  
Niloofar Kahkeshani ◽  
Roja Rahimi
Keyword(s):  
Biological Activities ◽  
Chemical Constituents ◽  
Antimicrobial Activities ◽  
Modern Medicine ◽  
Pharmacological Activities ◽  
Bunium Persicum ◽  
Comprehensive Information ◽  
Wide Range ◽  
Coa Reductase ◽  
Biological And Pharmacological Activities

Bunium persicum (Boiss) B. Fedtsh (Apiaceae, Persian name: Zireh Kermani) has been used to treat various diseases in traditional and folkloric medicine including gastrointestinal, respiratory, nasopharyngeal, cardiac, ocular, neurological, rheumatological and urinary tract diseases. Its essential oil contains different monoterpenes, sesquiterpenes and phenyl propenes. Other chemical constituents identified in B. persicum are phenolic compounds, fatty acids, carboxylic acids, and carbohydrates. Wide range of biological and pharmacological activities including antioxidant, analgesic, anti-inflammatory, acetylcholinesterase inhibitory, anticonvulsant, HMG-CoA reductase inhibitory, anti-pancreatic lipase, anticancer, antidiabetic, antihistamine, antidiarrheal, antispasmodic, antihematoxic, antityrosinase and antimicrobial activities have been reported from this plant in modern medicine. This article summarizes comprehensive information attributing traditional uses, phytochemistry, and pharmacological activities of Zireh Kermani.

scholarly journals A Review on Daphnane-Type Diterpenoids and Their Bioactive Studies

Molecules ◽  
2019 ◽  
Vol 24 (9) ◽  
pp. 1842 ◽  
Author(s):  
Yue-Xian Jin ◽  
Lei-Ling Shi ◽  
Da-Peng Zhang ◽  
Hong-Yan Wei ◽  
Yuan Si ◽  
...  
Keyword(s):  
Biological Activities ◽  
Structural Diversity ◽  
Cytotoxic Activities ◽  
Hydroxyl Groups ◽  
Substitution Pattern ◽  
In Vivo Experiments ◽  
Wide Range ◽  
Anti Cancer

Natural daphnane diterpenoids, mainly distributed in plants of the Thymelaeaceae and Euphorbiaceae families, usually include a 5/7/6-tricyclic ring system with poly-hydroxyl groups located at C-3, C-4, C-5, C-9, C-13, C-14, or C-20, while some special types have a characteristic orthoester motif triaxially connectedat C-9, C-13, and C-14. The daphnane-type diterpenoids can be classified into five types: 6-epoxy daphnane diterpenoids, resiniferonoids, genkwanines, 1-alkyldaphnanes and rediocides, based on the oxygen-containing functions at rings B and C, as well as the substitution pattern of ring A. Up to now, nearly 200 daphnane-type diterpenoids have been isolated and elucidated from the Thymelaeaceae and Euphorbiaceae families. In-vitro and in-vivo experiments of these compounds have shown that they possess a wide range of biological activities, including anti-HIV, anti-cancer, anti-leukemic, neurotrophic, pesticidal and cytotoxic effects. A comprehensive account of the structural diversity is given in this review, along with the cytotoxic activities of daphnane-type diterpenoids, up to April 2019.

Research Progress on Ways of Secondary Metabolism in Plants

2012 ◽  
Vol 178-181 ◽  
pp. 1004-1007
Author(s):  
Xiu Bo Liu ◽  
Yan Shu Jia ◽  
Na Li ◽  
He Gong ◽  
Yan He Zhang ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Biological Activities ◽  
Natural Habitat ◽  
Chemical Compounds ◽  
Research Progress ◽  
Primary Metabolites ◽  
Isolation And Characterization ◽  
Wide Range ◽  
Anti Cancer

The function of secondary metabolites has been a subject of debate since the first isolation and characterization of these often times structurally complex chemical compounds. By definition, secondary metabolites are naturally produced compounds that are not essential for the survival of the producing organism, as opposed to primary metabolites. Bioassays have revealed a wide range of biological activities, such as cytotoxicity, ichthyotoxicity, antimicrobial and antifeedant activity, antifoulant and anti-cancer activities. However, some of these activities are manifested against organisms that do not represent logical targets, since they would never be encountered by the producing organism in their natural habitat.

Design, Synthesis and Biological Activity Evaluation of Novel N-Acylation Substituted Isatin Derivatives

2013 ◽  
Vol 683 ◽  
pp. 34-37
Author(s):  
Bin Zeng ◽  
Xiao Hua Zhu
Keyword(s):  
Human Cancer ◽  
Biological Activities ◽  
Human Cancer Cell ◽  
Design Synthesis ◽  
Design And Synthesis ◽  
Wide Range ◽  
Anti Cancer ◽  
Endogenous Compound ◽  
Isatin Derivatives ◽  
Cancer Activity

Isatin, an endogenous compound existent in many organisms, shows a wide range of biological activities. In this paper, we like to report the design and synthesis of several isatin derivatives through the acetalization and N-Acylation. Six newly synthesized compounds were characterized on the basis of 1H NMR, and those compounds were determined using two different human cancer cell . Anti-cancer activity showed those compounds IC50＜50 μm.

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