scholarly journals A Novel Resorbable Composite Material Containing Poly(ester-co-urethane) and Precipitated Calcium Carbonate Spherulites for Bone Augmentation—Development and Preclinical Pilot Trials

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 102
Author(s):  
Claudia Rode ◽  
Ralf Wyrwa ◽  
Juergen Weisser ◽  
Matthias Schnabelrauch ◽  
Marijan Vučak ◽  
...  
Keyword(s):  
Composite Material ◽  
Calcium Carbonate ◽  
Bone Substitute ◽  
Pilot Trial ◽  
Carbonate Content ◽  
Precipitated Calcium Carbonate ◽  
Degradation Behaviour ◽  
Biodegradable Composite ◽  
Loss Of Mass

Polyurethanes have the potential to impart cell-relevant properties like excellent biocompatibility, high and interconnecting porosity and controlled degradability into biomaterials in a relatively simple way. In this context, a biodegradable composite material made of an isocyanate-terminated co-oligoester prepolymer and precipitated calcium carbonated spherulites (up to 60% w/w) was synthesized and investigated with regard to an application as bone substitute in dental and orthodontic application. After foaming the composite material, a predominantly interconnecting porous structure is obtained, which can be easily machined. The compressive strength of the foamed composites increases with raising calcium carbonate content and decreasing calcium carbonate particle size. When stored in an aqueous medium, there is a decrease in pressure stability of the composite, but this decrease is smaller the higher the proportion of the calcium carbonate component is. In vitro cytocompatibility studies of the foamed composites on MC3T3-E1 pre-osteoblasts revealed an excellent cytocompatibility. The in vitro degradation behaviour of foamed composite is characterised by a continuous loss of mass, which is slower with higher calcium carbonate contents. In a first pre-clinical pilot trial the foamed composite bone substitute material (fcm) was successfully evaluated in a model of vertical augmentation in an established animal model on the calvaria and on the lateral mandible of pigs.

Osteogenic Potential Using a Malleable, Biodegradable Composite Added Traditional Chinese Medicine: in vitro and in vivo Evaluations

2006 ◽  
Vol 34 (05) ◽  
pp. 873-886 ◽  
Author(s):  
Chun-Hsu Yao ◽  
Bai-Shuan Liu ◽  
Chau-Guey Liu ◽  
Yueh-Sheng Chen
Keyword(s):  
Bone Substitute ◽  
Bone Growth ◽  
In Vitro Study ◽  
Osteogenic Potential ◽  
Calvarial Bone ◽  
Large Defect ◽  
Biodegradable Composite ◽  
Calvarial Bone Defect

The purpose of this investigation was to prepare and evaluate the feasibility and biocompatibility of a new composite as a large defect bone substitute. The new GTGG was mainly composed of tricalcium phosphate ceramic particles and glutaraldehyde crosslinked gelatin in which Gui-Lu-Jiao was added (a mixture of Cervi Colla Cornus and Colla Plastri Testudinis). In the in vitro study, rat's calvaria osteoblasts were used to study bone characteristics upon exposure to different concentrations of the Gui-Lu-Jiao solution. In the in vivo study, GTGG composites were implanted into the defects of calvarial bones in mature New Zealand rabbits to test their osteogenerative characteristics. As a result, we found that Gui-Lu-Jiao added to the culture could promote the proliferation of osteoblasts. In addition, GTGG could induce a large amount of new bone growth in the rabbit's calvarial bone defect. Therefore, the GTGG composite might be a potential bone substitute.

scholarly journals Effect of Calcium Carbonate on the Mechanical Properties and Microstructure of Red Clay

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Lijie Chen ◽  
Xuejun Chen ◽  
Xin Yang ◽  
Pengyan Bi ◽  
Xiang Ding ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Calcium Carbonate ◽  
Carbonate Content ◽  
Shear Tests ◽  
Red Clay ◽  
Precipitated Calcium Carbonate ◽  
Sem Images ◽  
Clay Particles ◽  
Calcium Carbonate Content ◽  
Analysis System

The influence of precipitated calcium carbonate on the strength and microstructure of red clay was studied. Precipitated calcium carbonate was added to red clay at ratios of 0%, 5%, 10%, 15%, and 20%. Shear tests were carried out on the samples to observe the effect of calcium carbonate on the mechanical properties of red clay. The results showed that, with increasing calcium carbonate content, the strength of red clay first decreased and then increased. The maximum strength was obtained for the sample with 20% calcium carbonate. Scanning electron microscopy (SEM) was used to observe the changes in microstructure caused by addition of calcium carbonate. The pores and cracks analysis system (PCAS) was used to quantitatively characterize the microstructure changes detected in SEM images. The addition of calcium carbonate decreased the pore area and increased the total number of pores of red clay. The incorporation of calcium carbonate caused the red clay particles to agglomerate. The higher the calcium carbonate content, the stronger the agglomeration of red clay particles in the soil samples.

scholarly journals In vitro preliminary findings on the effect of biodegradable composite material in fibroblasts‐stimulated angiogenesis

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Ana Pirraco ◽  
Ana Sofia Rocha ◽  
André Vieira ◽  
Joana Vieira ◽  
Rui Guedes ◽  
...  
Keyword(s):  
Composite Material ◽  
Biodegradable Composite

Nanoceramics Composite Biomaterials in the Calcium Carbonate-Hydroxyapatite System

2010 ◽  
Vol 123-125 ◽  
pp. 339-342 ◽  
Author(s):  
Margarita Goldberg ◽  
Valeriy Smirnov ◽  
Sergey Kucev ◽  
Natalia Sergeeva ◽  
Irina Sviridova ◽  
...  
Keyword(s):  
Calcium Carbonate ◽  
Sintering Temperature ◽  
Specific Area ◽  
Carbonate Content ◽  
Fibroblast Cells ◽  
Composite Powders ◽  
Highly Active ◽  
Human Fibroblast Cells ◽  
Micrometer Size

Composite powders in the calcium carbonate (CC) – hydroxyapatite (HA) system with carbonate content up to 50 wt. % were synthesized by the precipitation from aqueous solution and characterized in detail. Specific area of the powders decreases with an increase in carbonate content due to appearance of large elongated CC crystals of about 0,5 micrometer size. The use of highly active to sintering nanodisperse powders resulted in lowering of sintering temperature below 7200C, preventing thermal decomposition. Ceramics of about 20 wt.% carbonate content revealed the highest strength of about 77 MPa, having the grain size of about 100 nm. According to in vitro testing, the materials are non toxic for human fibroblast cells.

A method for measuring the in-plane compressive strength and the compression behavior of coating layers

TAPPI Journal ◽  
2011 ◽  
Vol 10 (7) ◽  
pp. 29-34
Author(s):  
TEEMU PUHAKKA ◽  
ISKO KAJANTO ◽  
NINA PYKÄLÄINEN
Keyword(s):  
Tensile Strength ◽  
Compressive Strength ◽  
Calcium Carbonate ◽  
Coating Layer ◽  
Test Methods ◽  
Coating Films ◽  
Precipitated Calcium Carbonate ◽  
Coating Color ◽  
Mineral Coatings ◽  
Styrene Butadiene

Cracking at the fold is a quality defect sometimes observed in coated paper and board. Although tensile and compressive stresses occur during folding, test methods to measure the compressive strength of a coating have not been available. Our objective was to develop a method to measure the compressive strength of a coating layer and to investigate how different mineral coatings behave under compression. We used the short-span compressive strength test (SCT) to measure the in-plane compressive strength of a free coating layer. Unsupported free coating films were prepared for the measurements. Results indicate that the SCT method was suitable for measuring the in-plane compressive strength of a coating layer. Coating color formulations containing different kaolin and calcium carbonate minerals were used to study the effect of pigment particles’ shape on the compressive and tensile strengths of coatings. Latices having two different glass transition temperatures were used. Results showed that pigment particle shape influenced the strength of a coating layer. Platy clay gave better strength than spherical or needle-shaped carbonate pigments. Compressive and tensile strength decreased as a function of the amount of calcium carbonate in the coating color, particularly with precipitated calcium carbonate. We also assessed the influence of styrene-butadiene binder on the compressive strength of the coating layer, which increased with the binder level. The compressive strength of the coating layer was about three times the tensile strength.

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