scholarly journals Styrylpyrazoles: Properties, Synthesis and Transformations

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5886
Author(s):  
Pedro M. O. Gomes ◽  
Pedro M. S. Ouro ◽  
Artur M. S. Silva ◽  
Vera L. M. Silva
Keyword(s):  
Biological Activity ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Review Article ◽  
Pyrazole Derivatives ◽  
Huge Number ◽  
Timely Review ◽  
Methods Of Synthesis ◽  
Reduced Forms ◽  
Over Time

The pyrazole nucleus and its reduced forms, pyrazolines and pyrazolidine, are privileged scaffolds in medicinal chemistry due to their remarkable biological activities. A huge number of pyrazole derivatives have been studied and reported over time. This review article gives an overview of pyrazole derivatives that contain a styryl (2-arylvinyl) group linked in different positions of the pyrazole backbone. Although there are studies on the synthesis of styrylpyrazoles dating back to the 1970s and even earlier, this type of compound has rarely been studied. This timely review intends to summarize the properties, biological activity, methods of synthesis and transformation of styrylpyrazoles; thus, highlighting the interest and huge potential for application of this kind of compound.

Methyl linked pyrazoles: Synthetic and Medicinal Perspective

2021 ◽  
Vol 21 ◽  
Author(s):  
Tulika Sharma ◽  
Joginder Singh ◽  
Bijender Singh ◽  
Ramesh Kataria ◽  
Vinod Kumar
Keyword(s):  
Medicinal Chemistry ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Review Article ◽  
Present Review ◽  
Pyrazole Derivatives ◽  
High Efficacy ◽  
Depth Analysis ◽  
Synthetic Approaches ◽  
Substituted Pyrazoles

: Pyrazoles, an important and well known class of the azole family, have been found to show a large number of applications in various fields specially of medicinal chemistry. Among pyrazole derivatives, particularly, methyl substituted pyrazoles have been reported as the potent medicinal scaffolds that exhibit a wide spectrum of biological activities. The present review is an attempt to highlight the detailed synthetic approaches for methyl substituted pyrazoles along with in depth analysis of their respective medical significances till March2021. It is hoped that literature sum-up in the form of present review article would certainly be a great tool to assist the medicinal chemists for generating new leads possessing pyrazole nucleus with high efficacy and less microbial resistance.

Synthesis and Biological Activity of Hydrazones and Derivatives: A Review

2020 ◽  
Vol 20 (5) ◽  
pp. 342-368 ◽  
Author(s):  
Juliana de Oliveira Carneiro Brum ◽  
Tanos Celmar Costa França ◽  
Steven R. LaPlante ◽  
José Daniel Figueroa Villar
Keyword(s):  
Biological Activity ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
New Drugs ◽  
New Drug ◽  
Cancer Inflammation

Hydrazones and their derivatives are very important compounds in medicinal chemistry due to their reported biological activity for the treatment of several diseases, like Alzheimer’s, cancer, inflammation, and leishmaniasis. However, most of the investigations on hydrazones available in literature today are directed to the synthesis of these molecules with little discussion available on their biological activities. With the purpose of bringing lights into this issue, we performed a revision of the literature and wrote this review based on some of the most current research reports of hydrazones and derivatives, making it clear that the synthesis of these molecules can lead to new drug prototypes. Our goal is to encourage more studies focused on the synthesis and evaluation of new hydrazones, as a contribution to the development of potential new drugs for the treatment of various diseases.

scholarly journals Pyrazolyl-Ureas as Interesting Scaffold in Medicinal Chemistry

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3457 ◽  
Author(s):  
Chiara Brullo ◽  
Federica Rapetti ◽  
Olga Bruno
Keyword(s):  
P38 Mapk ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Biological Data ◽  
Biologically Active ◽  
Pyrazole Derivatives ◽  
Intracellular Level ◽  
Active Compounds ◽  
Privileged Scaffold

The pyrazole nucleus has long been known as a privileged scaffold in the synthesis of biologically active compounds. Within the numerous pyrazole derivatives developed as potential drugs, this review is focused on molecules characterized by a urea function directly linked to the pyrazole nucleus in a different position. In the last 20 years, the interest of numerous researchers has been especially attracted by pyrazolyl-ureas showing a wide spectrum of biological activities, ranging from the antipathogenic activities (bacteria, plasmodium, toxoplasma, and others) to the anticarcinogenic activities. In particular, in the anticancer field, pyrazolyl-ureas have been shown to interact at the intracellular level on many pathways, in particular on different kinases such as Src, p38-MAPK, TrKa, and others. In addition, some of them evidenced an antiangiogenic potential that deserves to be explored. This review therefore summarizes all these biological data (from 2000 to date), including patented compounds.

Chromone a Privileged Scaffold in Drug Discovery: Developments on the Synthesis and Bioactivity

2021 ◽  
Vol 21 ◽  
Author(s):  
Anjitha Theres Benny ◽  
Sonia D. Arikkatt ◽  
Cijo George Vazhappilly ◽  
Sathananthan Kannadasan ◽  
Renjan Thomas ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Medicinal Chemistry ◽  
Antimicrobial Agents ◽  
Biological Activities ◽  
Antiplatelet Agents ◽  
Materials Synthesis ◽  
Biological Responses ◽  
Metal Metal ◽  
Methods Of Synthesis ◽  
Drug Discovery Program

: Chromones are the class of secondary metabolites broadly occurred in the plant kingdom in a noticeable quantity. This rigid bicyclic system has been categorized “as privileged scaffolds in compounds” in medicinal chemistry. The wide biological responses made them an important moiety in a drug discovery program. This review provides updates on the various methods of synthesis of chromones and biological applications in medicinal chemistry. Various synthetic strategies for the construction of chromones include readily available phenols, salicylic acid and its derivatives, ynones, chalcones, enaminones, chalcones and 2-hydroxyarylalkylketones as starting materials. Synthesis of chromones by using metal, metal free, nanomaterials and different catalysts are included. Details of diverse biological activities such as anti-cancer agents, antimicrobial agents, anti-viral property, anti-inflammatory agents, antioxidants, Monoamine Oxidase-B (MAO-B) Inhibitors, anti-Alzheimer’s agents, anti-diabetic agent, antihistaminic potential, antiplatelet agents of chromone derivatives are diecussed.

Peptidomimetics and Peptide-Based Blockbuster Drugs

2021 ◽  
Vol 25 ◽  
Author(s):  
Jianlin Han ◽  
Hiroyuki Konno ◽  
Tatsunori Sato ◽  
Kunisuke Izawa ◽  
Vadim A. Soloshonok
Keyword(s):  
Amino Acids ◽  
Biological Activity ◽  
Small Molecule ◽  
Medicinal Chemistry ◽  
Structural Features ◽  
Review Article ◽  
Peptide Drugs

: Amino acids (AAs) play an important role in modern health industry. AAs’ residues are frequently found in the structures of small-molecule modern pharmaceuticals, while peptidomimetics and peptide-based drugs are entirely derived from AAs. The goal of this review article is to highlight that, currently, AAs serve as key structural features in numerous successful pharmaceuticals; they are the so-called blockbuster drugs. In this work, we provide a detailed profile of 5 peptidomimetics and 4 peptide drugs. For each compound, we describe the spectrum of biological activity, medicinal chemistry discovery, and synthetic preparation.

scholarly journals A CONCISE OVERVIEW ON HETEROCYCLIC COMPOUNDS EXHIBITING PESTICIDAL ACTIVITIES

2021 ◽  
Vol 9 (08) ◽  
pp. 989-1004
Author(s):  
Shailendra Yadav ◽  
◽  
Sushma Singh ◽  
Chitrasen Gupta ◽  
◽  
...  
Keyword(s):  
Organic Compounds ◽  
Heterocyclic Compounds ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Review Article ◽  
Diverse Group ◽  
Concise Overview ◽  
Physiological Properties ◽  
Pharmaceutical Industries

Heterocyclic compounds are numerous and diverse group of organic compounds. Heterocycles are abundantly found in nature and express various physiological properties. Heterocycles are intricately linked to all aspects of life. There are many heterocyclic compounds currently known, and the number is constantly rising owing to extensive synthetic development and their applications. Heterocyclic compounds are used significantly in a number of areas, including biochemistry and medicinal chemistry, and some others. They are predominantly synthesized in agrochemical and pharmaceutical industries due to their potential biological activities. This review article focuses on recently synthesized heterocyclic compounds and their different pesticidal activities such as antifungal, antibacterial, antiviral, nematocidal, insecticidal, acaricidal, and herbicidal.

Recent advancements on Benzimidazole: A versatile scaffold in medicinal chemistry

2021 ◽  
Vol 21 ◽  
Author(s):  
Zohor Mohammad Mahdi Alzhrani ◽  
Mohammad Mahboob Alam ◽  
Syed Nazreen
Keyword(s):  
Clinical Trials ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Review Article ◽  
Present Review ◽  
Benzimidazole Derivatives ◽  
The Past ◽  
Anti Inflammatory

: Benzimidazole is nitrogen containing fused heterocycle which has been extensively explored in medicinal chemistry. Benzimidizole nucleus has been found to possess various biological activities such as anticancer, antimicrobial, anti-inflammatory, antiviral, antitubercular and antidiabetic. A number of benzimidazoles such as bendamustine, pantoprazole have been approved for the treatment of various illnesses whereas galeterone and GSK461364 are in clinical trials. The present review article gives an overview about the different biological activities exhibited by the benzimidazole derivatives as well as different methods used for the synthesis of benzimidazole derivatives for the past ten years.

Anti-neuropathic and anticonvulsant activities of various substituted triazoles analogues

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Heterocyclic Compounds ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Review Article ◽  
Biological Profile ◽  
Triazole Derivatives ◽  
Anti Inflammatory ◽  
New Compounds ◽  
Anticonvulsant Activities

Various heterocyclic compounds along their derivatives were evaluated for their biological activities as antiviral, antitumor, anticonvulsant, antibacterial, antifungal, antituberculosis, analgesic, anti-inflammatory, antidiabetic, antihistamine and other biological activities. The triazole moiety seems to be very small, but in the biological profile has attracted the attention of many researchers to explore this skeleton to its multiple potential against several activities. The triazole derivatives possess a great importance in medicinal chemistry and can be used for the synthesis of numerous heterocyclic compounds with different biological activities. This review article covers the information of triazoles derivatives having different psychopharmacological actions. Thus triazole acts as a promising medicinal agent for the scientists working over this field. This review can be helpful to develop various more new compounds possessing triazoles moiety that could be better in terms of efficacy and lesser toxicity.

Pyrazole Carboxylic Acid and Derivatives: Synthesis and Biological Applications

2020 ◽  
Vol 17 ◽  
Author(s):  
Adnan Cetin
Keyword(s):  
Organic Chemistry ◽  
Biological Activity ◽  
Carboxylic Acid ◽  
Heterocyclic Compounds ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Building Blocks ◽  
Literature Survey ◽  
Synthetic Methods ◽  
Biological Applications

: The heterocyclic compounds are the building blocks for synthesis of the different biological active compounds in the organic chemistry. Heterocyclic compounds have versatile synthetic applicability and biological activity. Pyrazole carboxylic acid derivatives are significant scaffold structures in heterocyclic compounds due to biologic activities such as antimicrobial, anticancer, inflammatory, antidepressant, antifungal anti-tubercular and antiviral etc. The aim of this mini-review is an overview synthesis of pyrazole carboxylic acid derivatives and their biologic applications. The summarized literature survey presents in detail biological activities of pyrazole carboxylic acid derivatives and their various synthetic methods. This mini-review can be guide to many scientists in medicinal chemistry.

Schiff Base: An Overview of its Medicinal Chemistry Potential for New Drug Molecules

1970 ◽  
Vol 5 (3) ◽  
pp. 1757-1764
Author(s):  
Rakesh Sahu ◽  
D S Thakur ◽  
Kashyap P
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Carbonyl Compound ◽  
Schiff Bases ◽  
Primary Amine ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Drug Molecules ◽  
Antibacterial And Antifungal

Schiff base denotes a reaction product of a primary amine and a carbonyl compound. Schiff bases possess a wide variety of biological activity specially antibacterial and antifungal properties. Metal complexes of Schiff base have been studied for their biological activities. This review articles provide a summary of medicinal chemistry features of Schiff base and various reports published on biological activities of Schiff base and its metal complexes.

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