scholarly journals Pomegranate Seed Oil and Bitter Melon Extract Affect Fatty Acids Composition and Metabolism in Hepatic Tissue in Rats

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5232
Author(s):  
Agnieszka Stawarska ◽  
Tomasz Lepionka ◽  
Agnieszka Białek ◽  
Martyna Gawryjołek ◽  
Barbara Bobrowska-Korczak
Keyword(s):  
Fatty Acids ◽  
Dietary Supplements ◽  
Seed Oil ◽  
Dietary Factors ◽  
Female Rats ◽  
Hepatic Tissue ◽  
Bitter Melon ◽  
Fatty Acids Composition ◽  
Pomegranate Seed Oil ◽  
Pomegranate Seed

Pomegranate seed oil (PSO) and bitter melon dried fruits (BME) are used as natural remedies in folk medicine and as dietary supplements. However, the exact mechanism of their beneficial action is not known. The aim of study was to assess how the diet supplementation with PSO and/or with an aqueous solution of Momordica charantia affects the metabolism of fatty acids, fatty acids composition and the level of prostaglandin E2 (PGE2) in rat liver. Animals (Sprague-Dawley female rats, n = 48) were divide into four equinumerous groups and fed as a control diet or experimental diets supplemented with PSO, BME or both PSO and BME for 21 weeks. Fatty acids were determined using gas chromatography with flame ionization detection. PSO added to the diet increased the rumenic acid content (p < 0.0001) and increased accumulation of n-6 fatty acids (p = 0.0001) in hepatic tissue. Enrichment of the diet either with PSO or with BME reduced the activity of Δ6-desaturase (D6D) (p = 0.0019), whereas the combination of those dietary factors only slightly increased the effect. Applied dietary supplements significantly reduced the PGE2 level (p = 0.0021). No significant intensification of the influence on the investigated parameters resulted from combined application of PSO and BME. PSO and BME have potential health-promoting properties because they influence fatty acids composition and exhibit an inhibiting effect on the activity of desaturases and thus they contribute to the reduction in the metabolites of arachidonic acid (especially PGE2).

Pomegranate seed oil: Effect on 3-nitropropionic acid-induced neurotoxicity in PC12 cells and elucidation of unsaturated fatty acids composition

2016 ◽  
Vol 20 (1) ◽  
pp. 40-48 ◽  
Author(s):  
Bushra N. Al-Sabahi ◽  
Majekodunmi O. Fatope ◽  
Musthafa Mohamed Essa ◽  
Selvaraju Subash ◽  
Saleh N. Al-Busafi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Pc12 Cells ◽  
Seed Oil ◽  
Unsaturated Fatty Acids ◽  
Fatty Acids Composition ◽  
Pomegranate Seed Oil ◽  
Nitropropionic Acid ◽  
Pomegranate Seed ◽  
3 Nitropropionic Acid

scholarly journals Effect of pomegranate seed oil on fatty acids composition of Oreochromis niloticus trough supplemented diet

2019 ◽  
Vol 41 (1) ◽  
pp. 37995 ◽  
Author(s):  
Vanessa Vivian de Almeida Schneider ◽  
Maria Eugênia Petenuci ◽  
Ana Paula Lopes ◽  
Vanessa Jorge Santos ◽  
Jesuí Vergílio Visentainer
Keyword(s):  
Fatty Acids ◽  
Oreochromis Niloticus ◽  
Seed Oil ◽  
Fatty Acids Composition ◽  
Pomegranate Seed Oil ◽  
Pomegranate Seed

scholarly journals Fatty Acids Composition of Red and Purple Pomegranate (Punica granatum L) Seed Oil

2010 ◽  
Vol 1 (2) ◽  
pp. 74 ◽  
Author(s):  
Hartati Soetjipto ◽  
Murda Pradipta ◽  
KH Timotius
Keyword(s):  
Fatty Acids ◽  
Neutral Lipid ◽  
Acid Content ◽  
Seed Oil ◽  
Lipid Fraction ◽  
Punica Granatum ◽  
Punicic Acid ◽  
Pomegranate Seed Oil ◽  
Pomegranate Seed ◽  
Punica Granatum L

The aim of this investigation was to determine the content and composition of fatty acid in seed oil of red and purple pomegranate (Punica granatum L). The extraction process was performed by Soxhlet extractor with petroleum ether as solvent. The separation and identification of pomegranate seed oil was done by using GCMS. The total oil content of red and purple  pomegranate  were 128 g/kg d.w  and 103 g/kg d.w respectively. Both showed the same major fatty acids  as palmitic, stearic, oleic, linoleic and  punisic acid. Oleic acid (19-21%) and linoleic acid (20-21%) were found as the most  dominant fatty acids in red pomegranate, whereas purple pomegranate seed oil was dominated by oleic acid (41-43%) and punicic acid  (0-25%). Neutral lipid  fraction of  red and purple pomegranate seed oils was more dominant than glycolipid and phospholipid. Neutral  lipid fraction  of red and purple pomegranate seed oil were  89 % and 91% respectively.  Glycolipid fraction  of red and purple pomegranate seed oil were 8 % and 5 %, whereas phosholipid fraction of red and purple pomegranate seed oil were 3 % and 4 %. The punicic acid content of  total lipid of  purple pomegranate seed oil (PPSO) (0-25%) was higher than red pomegranate (RPSO) (9-16%). On the contrary neutral lipid of red pomegranate showed higher punicic acid content (54-75%) than the purple pomegranate (14-55%). Glycolipid of red pomegranate contained  punicic acid  (0-42%). The punicic acid content  of the phospholipid fraction of  red pomegranate was higher (0-22 %) than the one of purple pomegranate (0-2%).Key words : fatty acid, pomegranate, Punica granatum, punicic acid, seed oil

Mammary cancer risk and serum lipid profile of rats supplemented with pomegranate seed oil and bitter melon extract

2019 ◽  
Vol 142 ◽  
pp. 33-45 ◽  
Author(s):  
Tomasz Lepionka ◽  
Agnieszka Białek ◽  
Małgorzata Białek ◽  
Marian Czauderna ◽  
Agnieszka Stawarska ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Mammary Cancer ◽  
Seed Oil ◽  
Serum Lipid Profile ◽  
Bitter Melon ◽  
Pomegranate Seed Oil ◽  
Pomegranate Seed

scholarly journals The protective role of Pomegranate seed oil (Pometone) on serum protein in sodium fluoride treated female rats

2016 ◽  
Vol 40 (1) ◽  
pp. 61-68
Author(s):  
Baraa Najim Al-Okaily
Keyword(s):  
Drinking Water ◽  
Sodium Fluoride ◽  
Total Protein ◽  
Seed Oil ◽  
Protective Role ◽  
Female Rats ◽  
Serum Total Protein ◽  
Pomegranate Seed Oil ◽  
Pomegranate Seed

This study is designed to determin the protective role of pomegranate seed oil against deleterious effect induced by sodium fluoride on serum proteins in rats. Forty (40) adult female rats were randomly divided into four equal group (10/group) and treated daily for 40 days as following: Group C administered distilled water (control), group T1 received sodium fluoride 120 ppm/liter in drinking water, group T2 received both sodium fluoride 120 ppm/liter in drinking water and Pometone 30 mg/kg B.w. orally and group T3 administered Pometone 30 mg/kg B.w. orally. Fasting blood samples were collected at 0, 20 and 40 days of the experimental periods and serum samples were aliquoted for estimation serum total protein, albumin and globulin concentrations. Also, protein electrophoresis was measured. The results revealed that sodium fluoride caused significant reduction in serum total protein, albumin and globulin concentrations, in addition to changes in the patterns of serum protein fractions % (albumin, α1-globulin, α2-globulin, β-globulin and γ-globulin) as compared with control rats. In conclusion Pomegranate seed oil caused elevation of proteins concentration as compared to group T1 and could potentially be beneficial in preventing the hepatic damage caused by sodium fluoride.  

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