scholarly journals Tabebuia impetiginosa: A Comprehensive Review on Traditional Uses, Phytochemistry, and Immunopharmacological Properties

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4294 ◽  
Author(s):  
Jianmei Zhang ◽  
Stephanie Triseptya Hunto ◽  
Yoonyong Yang ◽  
Jongsung Lee ◽  
Jae Youl Cho
Keyword(s):  
Skin Diseases ◽  
Fungal Infections ◽  
Scientific Evidence ◽  
Inflammatory Activity ◽  
Future Research ◽  
Pharmacological Activities ◽  
Traditional Uses ◽  
New Strategy ◽  
Anti Inflammatory ◽  
Underlying Mechanisms

Tabebuia impetiginosa, a plant native to the Amazon rainforest and other parts of Latin America, is traditionally used for treating fever, malaria, bacterial and fungal infections, and skin diseases. Additionally, several categories of phytochemicals and extracts isolated from T. impetiginosa have been studied via various models and displayed pharmacological activities. This review aims to uncover and summarize the research concerning T. impetiginosa, particularly its traditional uses, phytochemistry, and immunopharmacological activity, as well as to provide guidance for future research. A comprehensive search of the published literature was conducted to locate original publications pertaining to T. impetiginosa up to June 2020. The main inquiry used the following keywords in various combinations in titles and abstracts: T. impetiginosa, Taheebo, traditional uses, phytochemistry, immunopharmacological, anti-inflammatory activity. Immunopharmacological activity described in this paper includes its anti-inflammatory, anti-allergic, anti-autoimmune, and anti-cancer properties. Particularly, T. impetiginosa has a strong effect on anti-inflammatory activity. This paper also describes the target pathway underlying how T. impetiginosa inhibits the inflammatory response. The need for further investigation to identify other pharmacological activities as well as the exact target proteins of T. impetiginosa was also highlighted. T. impetiginosa may provide a new strategy for prevention and treatment of many immunological disorders that foster extensive research to identify potential anti-inflammatory and immunomodulatory compounds and fractions as well as to explore the underlying mechanisms of this herb. Further scientific evidence is required for clinical trials on its immunopharmacological effects and safety.

scholarly journals ANTI-INFLAMMATORY ACTIVITY OF NEURACANTHUS SPHAEROSTACHYUS DALZ. LEAVES

2019 ◽  
pp. 227-229
Author(s):  
DANGAR DK ◽  
PATEL NJ
Keyword(s):  
Vascular Permeability ◽  
Skin Diseases ◽  
Protein Denaturation ◽  
Scientific Evidence ◽  
Inflammatory Activity ◽  
Screening Methods ◽  
Paw Edema ◽  
Anti Inflammatory

Objective: Neuracanthus sphaerostachyus has been traditionally used to treat skin diseases, cough, and asthma. Lack of sufficient scientific evidence indicating the utility of this plant in the treatment of inflammation prompted us to investigate the anti-inflammatory activity of the plant in different experimental screening methods. Methods: In vitro and in vivo anti-inflammatory activity of the methanolic and aqueous extracts of N. sphaerostachyus (MENS and AENS) leaves at doses of 125, 250, and 500 mg/kg was evaluated with albumin denaturation and carrageenan-induced paw edema in rats and acetic acid-induced increased vascular permeability in mice. Results: Methanolic and aqueous extract significantly inhibited protein denaturation as well as edema induced by carrageenan and vascular permeability in mice dose dependently. Aspirin (0.1 mg/ml), indomethacin (10 mg/kg), and dexamethasone (5 mg/kg) were used as a standard control. Conclusion: It is concluded that MENS and AENS leaves exhibited significant anti-inflammatory activity.

scholarly journals Demonstration of Phytochemicals and In-vitro Antioxidant and Anti-inflammatory activity by methanolic extract of Elettaria cardamomum

2020 ◽  
Vol 3 (3) ◽  
pp. 01-04
Author(s):  
Md. Shahidul Islam
Keyword(s):  
Methanolic Extract ◽  
Research Work ◽  
Inflammatory Activity ◽  
Pharmacological Activities ◽  
Elettaria Cardamomum ◽  
Ic50 Values ◽  
Phytochemical Profile ◽  
Anti Inflammatory ◽  
Dpph Scavenging

The existing research study attempts to untie novel avenues for development of the medicinal exercises of Elettaria cardamomum, fashionable known as the “Queen of Spices” and locally recognized as “elaichi”. Its seeds are utilized as abortifacient, acrid, alexiteric, aromatic, sweet, cardiac tonic, cooling, carminative, digestive, diuretic, expectorant, stimulant and also tonic beneficial in the asthma, haemorrhoids, bronchitis, strangury, renal in addition to vesical calculi, anorexia, halitosis, gastropathy dyspepsia as well as burning sensation. The prime goal of this research work is to evaluate antioxidant as well as anti-inflammatory properties of the traditional Bangladeshi medicinal extracts in addition to examine these activities. The aim in present work was to screen the phytochemical profile as well as pharmacological activities of the methanolic extract of this plant’s leaves. To explore pharmacological actions DPPH scavenging test and the HRBC membrane stabilization techniques were done for the antioxidant and also anti-inflammatory test respectively. The pharmacological works revealed that plant extracts might have noteworthy antioxidant effect which is possibly mediated by the inhibition of DPPH free radical which is accountable for oxidation. The IC50 values by the DPPH scavenging test observed for the standard and the leaves were 106.38µg/ml & 594.47µg/ml respectively. There is also moderate anti-inflammatory activity. The IC50 values for anti-inflammatory activity by standard & leaves were 35.04µg/ml and 944.0 µg/ml respectively.

Archidendron lucidum Exerts Anti-Inflammatory Effects by Targeting PDK1 in the NF-κB Pathway

2020 ◽  
Vol 48 (02) ◽  
pp. 429-444
Author(s):  
Minkyeong Jo ◽  
Young-Su Yi ◽  
Jae Youl Cho
Keyword(s):  
Signaling Pathway ◽  
Hplc Analysis ◽  
Inflammatory Diseases ◽  
Interleukin 1 ◽  
Inflammatory Activity ◽  
Raw264.7 Cells ◽  
Luciferase Reporter ◽  
No Production ◽  
Pharmacological Activities ◽  
Anti Inflammatory

Pharmacological activities of some Leguminosae family members were reported. Pharmacological activities of Archidendron lucidum, a Leguminosae family member have never been explored. Therefore, this study investigated anti-inflammatory effects of an Archidendron lucidum methanol extract (Al-ME). In this study, anti-inflammatory effects of Al-ME were investigated in LPS-stimulated RAW264.7 cells and HCl/EtOH-induced gastritis mice by MTT assay, nitric oxide (NO) production assay, semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR), luciferase reporter assay, and Western blotting. High-performance liquid chromatography (HPLC) analysis identified ethnopharmacological compounds in Al-ME. Al-ME inhibited NO production without cytotoxicity in peritoneal macrophages and RAW264.7 cells stimulated with LPS or Pam3CSK4. Al-ME downregulated mRNA expression of inflammatory genes (inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2)) and pro-inflammatory cytokines (tumor necrosis factor-[Formula: see text] (TNF-[Formula: see text]), interleukin-1[Formula: see text] (IL-1[Formula: see text]), and IL-6). Al-ME exerted anti-inflammatory activity in LPS-stimulated RAW264.7 cells by inhibiting nuclear factor-kappa B (NF-[Formula: see text]B) signaling pathway. HPLC analysis identified quercetin, luteolin, and kaempferol as major anti-inflammatory components in Al-ME. Al-ME ameliorated HCl/EtOH-induced gastritis symptoms in mice by suppressing iNOS and IL-6 mRNA expressions and I[Formula: see text]B[Formula: see text] phosphorylation. Therefore, these results suggest that Al-ME exhibited anti-inflammatory activity by targeting NF-[Formula: see text]B signaling pathway, implying that Al-ME could be potent anti-inflammatory medications to prevent and treat inflammatory diseases.

scholarly journals Ethnopharmacology, Phytochemistry, and Pharmacology of Syzygium nervosum

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Giang Nam Pham ◽  
Tu Thanh Thi Nguyen ◽  
Hieu Nguyen-Ngoc
Keyword(s):  
Skin Diseases ◽  
Inflammatory Diseases ◽  
Research Direction ◽  
Future Research ◽  
Past Study ◽  
Plant Family ◽  
Pharmacological Activities ◽  
Chemical Profiling ◽  
Study Results ◽  
Number Of Publications

Syzygium nervosum, which belongs to the Myrtaceae plant family, is widely distributed and cultivated in South East Asian countries. The decoction of S. nervosum leaves and flower buds has been consumed regularly as a beverage among the Vietnamese and Chinese communities. In addition, it has also been used in traditional medicine for a variety of purposes, notably for influenza, skin diseases, and digestive conditions. To date, there has been a considerable number of publications on chemical profiling and pharmacological activities of S. nervosum crude extract and pure isolated compounds. Our analysis indicated the characteristic chemical scaffolds and potential bioactivities on cancer, diabetes, and inflammatory diseases of this plant. The review aims to summarize up-to-date past study results and suggest future research direction on this species, in order to promote clinical applications of S. nervosum.

scholarly journals Isolation and Characterizations of new alkaloid 3-deoxy- 3, 11-epoxy cephalotaxine from Clitoria ternatea

2019 ◽  
Vol 9 (4-A) ◽  
pp. 458-462
Author(s):  
MANIVANNAN - RAJAMANICKAM
Keyword(s):  
Fungal Infections ◽  
Bioactive Compound ◽  
Inflammatory Activity ◽  
Clitoria Ternatea ◽  
E Coli ◽  
Fungal Strains ◽  
Anti Inflammatory ◽  
Isolated Compound ◽  
Anti Fungal ◽  
Dose Levels

The present study describes the isolation and structural elucidation of new alkaloid 3-deoxy-3, 11-epoxy cephalotaxine (1) from the flowers of C. ternatea. It was isolated by careful column chromatographic separation of the crude extract on silica gel 60. The structure was established based on UV, IR, 1HNMR, 13CNMR and GC-MS spectroscopy methods. The antibacterial activity of various bacterial and fungal strains and anti-inflammatory activities of the isolated compound and its crude methanol extract was studied. The highest zone of inhibition (13.0 and 12.0 mm) was shown by 1 at a dose of 200 µg/kg against E. coli and S. aureus strains and (16.0, 12.0 mm) against anti-fungal strains of C. albicans and A. flavus. The results indicated that at both dose levels (100 mg and 200 mg / kg) of isolated compound 1 had significant anti-inflammatory activity from 2nd hour onwards. The bioactive compound isolated from this plant can be employed for antimicrobial activity, also for the treatment of various bacterial and fungal infections and to show pronounced anti-inflammatory effects after three hours of injection. Keywords: Clitoria ternatea, Alkaloid, 3-deoxy-3, 11-epoxy cephalotaxine, Anti-microbial activity, Anti-inflammatory activity 

scholarly journals Anti-inflammatory Potentials of Fibraurea tinctoria Leaves Extract in Experimental Rats or Animals

2020 ◽  
pp. 79-83
Author(s):  
Fahad I. Al-Saikhan
Keyword(s):  
Inflammatory Activity ◽  
Hydroalcoholic Extract ◽  
Percent Inhibition ◽  
Traditional Uses ◽  
Paw Oedema ◽  
Anti Inflammatory ◽  
Treatment Of Wounds

The activity of the hydroalcoholic extract of Fibraurea tinctoria leaves and anti-inflammatory was investigated. We utilized rats for which oedema was induced by carrageenan.  The extract of Fibraurea tinctoria leaves was administered orally at doses of 100, 200 and 400 mg/kg. Paw oedema was significantly minimized using all prepared doses of the extract administered. The 400 mg/kg dose producing the highest oedema reduction. The Percent Inhibition with hydroalcoholic extract of Fibraurea tinctoria and Indomethacin were 67.6% and 68.49% respectively. We concluded that this study has established the anti-inflammatory activity of hydroalcoholic extract of Fibraurea tinctoria leaves. I believe the results justify the traditional uses of the plant in the treatment of wounds and inflammation.

Betulinic acid nanogels: rheological, micro structural characterization and evaluation of their anti-inflammatory activity

2020 ◽  
Vol 17 ◽  
Author(s):  
Dalis Sosa-Gutierrez ◽  
Jorge Toro-Vazquez ◽  
Cynthia Cano-Sarmiento ◽  
Peter Grube-Pagola ◽  
Alejandro Aparicio-Saguilan ◽  
...  
Keyword(s):  
Betulinic Acid ◽  
Skin Diseases ◽  
Crosslinking Agent ◽  
Skin Inflammation ◽  
Inflammatory Activity ◽  
Carbopol 940 ◽  
Spherical Structures ◽  
Anti Inflammatory ◽  
The One ◽  
Activation Times

Background: Betulinic acid (BA) is a lipophilic compound with proven beneficial results in topical inflammation. Nanogels (NG) are carriers of bioactive compounds with properties that make them good candidates to treat skin diseases. Objective: The objective of this study was to evaluate the anti-inflammatory activity of BA carried in NG. Methods: NG were composed of a nanoemulsion and a crosslinking agent (Carbopol 940®) applied at three concentrations (0.5, 1, and 1.5 %) and three activation times (6, 12 and 24 h). In order to select the optimal formulation, the NG were characterized mechanically and micro-structurally followed by evaluation of the BA anti-inflammatory activity in an in vivomodel of auricular edema. We determined the edema inhibition activity aspercent weight. Additionally, the anti-inflammatory activity of NG was validated through histological analysis. Results: The formulation with the best viscoelastic properties was the one prepared with 0.5% carbopol and 6 h of activation. Microstructural examination of this formulation showed mostly spherical structures with a mean diameter of 65 nm. From the evaluation of edema and the histological analyses, we established that the NG of BA produced 52% inhibition. In contrast, a conventional gel and freeBA produced 28% and 19% inhibition, respectively. Conclusion: The NG of BA showed to be good vehicles to treat skin inflammation.

THE GENUS ONOSMA L.: A COMPREHENSIVE REVIEW

2021 ◽  
pp. 219-227
Author(s):  
Aruna M. Rajapara ◽  
Mamta B. Shah
Keyword(s):  
Scientific Literature ◽  
Species Selection ◽  
Future Research ◽  
Asian Countries ◽  
Pharmacological Activities ◽  
Scientific Databases ◽  
Traditional Uses ◽  
Future Drug ◽  
Pharmacology And Toxicology ◽  
Selection For

In medicinal plant field ethnopharmacological knowledge aggrandizes legibility for prioritizing species selection for future research opportunities. Many plant species representing the genus Onosma have been documented to be important in communities world-wide as evidenced by the numerous records on traditional medicinal and ethno-botanical information. Various species of the genus are used in the traditional medicinal systems in Europe and Asian countries especially in India, China, Turky and Pakistan. The literature on the species distribution and their characterization was compiled from different regional floras, regional revisions and databases. The information related to traditional uses, pharmacological activities and phytochemistry was systematically collected from the scientific databases including reference books, SciFinder, Scopus, PubMed and Google Scholar. Absence of comprehensive literature review on genus Onosma species led to design present study and dig the recorded documents to comparatively gauge magnitude of studies on each of the Onosma species through an exhaustive bibliographic evaluation of scientifically studied species of genus Onosma that are also taxonomically identified and are valued as traditional medicinal remedy for diseases in their countries of origin. The study hinted about lack of scientific literature on most of the species. A comprehensive bibliographic review on the geographical distribution, identification, traditional uses, phytochemistry, pharmacology and toxicology of the genus Onosma is attempted here to give insights into promising future drug discovery strategies. KEYWORDS: Onosma, Distribution, Traditional uses, Phyto-Pharmacology

Bridging Indigenous Knowledge and Scientific Evidence for Pharmacological Studies of Phaleria macrocarpa: A Review

2021 ◽  
Vol 11 ◽  
Author(s):  
Md. Abdur Rashd Mia ◽  
Sahena Ferdosh ◽  
Qamar Uddin Ahmed ◽  
Abul Bashar Mohammed Helaluddin ◽  
Md. Zaidul Islam Sarker
Keyword(s):  
Systematic Review ◽  
Skin Diseases ◽  
Scientific Evidence ◽  
Pharmacological Activities ◽  
Traditional Use ◽  
Related Data ◽  
Online Databases ◽  
Phaleria Macrocarpa ◽  
Online Library ◽  
Identification Techniques

Background: Phaleria macrocarpa (Scheff.) Boerl. (Thymelaeaceae), usually referred to as God’s crown, Mahkota dewa, Pau, grows all the year in tropical countries including Malaysia, Indonesia, Papua New Guinea and Australia. It is traditionally used to treat haemorrhoids, stroke, heart disease, tumour, impotence, diabetes, allergies, kidney and liver disorders, migraine, acne and skin ailments. Objective: The purpose of this systematic review is to provide important insight on P. macrocarpa’s traditional use, toxicity, classification of compounds, and pharmacological activities thus identifying the gap in scientific analysis and potential analytical opportunities for future directions on this herb. Method: The related data for this systematic review were collected from renowned online databases, namely Wiley Online Library, Web of Science, Springer Link, PubMed, Science Direct, Scopus, and Google scholar. Results: Around 48 compounds, including benzophenone, xanthonoids, norcucurbitacin derivatives, flavonoids, lignans, fatty acids and esters, phytosterols, aromatic acids and so on were identified from different parts. These constituents and different solvent extracts using various identification techniques have been reported to show a broad range of pharmacological activities. Besides various traditional claims and pharmacological functions, scientific evidence on its ethnopharmacological aspects has been well-documented. Studies found that the plant demonstrates antidiabetic, antioxidant, antimicrobial, anticancer, anti-hypercholesterolemia and antihypertensive. Conclusion: Despite various claims, there is still inadequate scientific evidence particularly on P. macrocarpa’s benefit in the management of dysentery, asthma, skin diseases and rheumatoid arthritis, necessitates future studies. There is also a need to test its pharmacokinetics and toxicological data on humans to verify its potential bioactive properties.

scholarly journals PHYTOCHEMICAL AND PHARMACOLOGICAL ACTIVITIES OF JUSTICIA PROCUMBENS L.: A REVIEW

2020 ◽  
Vol 11 (5) ◽  
pp. 190-193
Author(s):  
Amritha C K ◽  
Suma C ◽  
Ananya V M ◽  
Thushara P V ◽  
Deepak V S
Keyword(s):  
Pharmacological Properties ◽  
Pharmacological Activities ◽  
Active Compounds ◽  
Traditional Uses ◽  
Current Review ◽  
Snake Bites ◽  
Anti Inflammatory ◽  
Water Willow ◽  
Anti Hiv

Justicia procumbens L. is usually known as water willow which belongs to family Acanthaceae growing widely in southern regions of China, Japan, Vietnam, India and Australia. It is one of the important herbal being used in Ayurvedic system of medicine. The plant contains various active compounds like arylnaphthalide and diarylbutane lignans, glycosides, flavonoids. Few pharmacological properties including anti-inflammatory, anti-arthritic, anti-arrhythmic, anti-asthmatic, anti-proliferative, anti-allergic, antibacterial, cytotoxic and anti-HIV activities activity have been reported for this plant. Conventionally, it is used for the treatment of fever, inflammation, cold, cough, asthma, cancer, snake bites etc. The current review is created with an intended to focus on the numerous ethnobotanical and traditional uses as well as the phytochemical and pharmacological report on Justicia procumbens.

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