scholarly journals Bioactivities of Lyngbyabellins from Cyanobacteria of Moorea and Okeania Genera

Molecules ◽  
2020 ◽  
Vol 25 (17) ◽  
pp. 3986
Author(s):  
Imam Fathoni ◽  
Julie G. Petitbois ◽  
Walied M. Alarif ◽  
Ahmed Abdel-Lateff ◽  
Sultan S. Al-Lihaibi ◽  
...  
Keyword(s):  
Breast Cancer Cells ◽  
Biological Activities ◽  
Essential Feature ◽  
Cytotoxic Agents ◽  
Side Chain ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Antifouling Activity ◽  
Chemical Structures ◽  
Unique Chemical

Cyanobacteria are reported as rich sources of secondary metabolites that provide biological activities such as enzyme inhibition and cytotoxicity. Ten depsipeptide derivatives (lyngbyabellins) were isolated from a Malaysian Moorea bouillonii and a Red Sea Okeania sp.: lyngbyabellins G (1), O (2), P (3), H (4), A (7), 27-deoxylyngbyabellin A (5), and homohydroxydolabellin (6). This study indicated that lyngbyabellins displayed cytotoxicity, antimalarial, and antifouling activities. The isolated compounds were tested for cytotoxic effect against human breast cancer cells (MCF7), for antifouling activity against Amphibalanus amphitrite barnacle larvae, and for antiplasmodial effect towards Plasmodium falciparum. Lyngbyabellins A and G displayed potent antiplasmodial effect against Plasmodium, whereas homohydroxydolabellin showed moderate effect. For antifouling activity, the side chain decreases the activity slightly, but the essential feature is the acyclic structure. As previously reported, the acyclic lyngbyabellins are less cytotoxic than the corresponding cyclic ones, and the side chain increases cytotoxicity. This study revealed that lyngbyabellins, despite being cytotoxic agents as previously reported, also exhibit antimalarial and antifouling activities. The unique chemical structures and functionalities of lyngbyabellin play an essential role in their biological activities.

scholarly journals Cytotoxic Flavonoids from the Leaves and Twigs of Murraya tetramera

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1284
Author(s):  
Chun-Xue You ◽  
Kun Zhang ◽  
Xin Li ◽  
Jing Liu ◽  
Wen-Juan Zhang ◽  
...  
Keyword(s):  
Cell Lines ◽  
Breast Cancer Cells ◽  
Cytotoxic Activities ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Chemical Structures ◽  
High Cytotoxicity ◽  
Leading Compounds ◽  
Structure And Activity ◽  
Murine Melanoma Cells

Cytotoxic flavonoids of Murraya tetramera were investigated in this study. A novel flavonoid and twelve known flavonoids, including seven flavones (1–7), three flavanones (8–10), and three chalcones (11–13) were isolated from the leaves and twigs of Murraya tetramera. Chemical structures were elucidated by NMR combined with MS spectral analysis, and the new compound (6) was confirmed as 3′,5′-dihydroxy-5,6,7,4′-tetramethoxyflavone. Furthermore, all the isolated flavonoids were evaluated for their cytotoxicities against murine melanoma cells (B16), and human breast cancer cells (MDA-MB-231) by CCK-8 assay. Among them, compounds 7, 13, and 5 exhibited potent cytotoxic activities against B16 cell lines (IC50 = 3.87, 7.00 and 8.66 μg/mL, respectively). Compounds 5, 13, and 12 displayed potent cytotoxicities against MDA-MB-231 cell lines (IC50 = 3.80, 5.95 and 7.89 μg/mL, respectively). According to the correlation of the structure and activity analysis, 5-hydroxyl and 8-methoxyl substituents of the flavone, 8-methoxyl substituent of the flavanone, and 3′,5′-methoxyl substituents of the chalcone could be critical factors of the high cytotoxicity. The results indicated that the active flavonoids have potential to be developed as leading compounds for treating cancers.

Polyamine contents of human breast cancer cells treated with the cytotoxic agents chlorpheniramine and dehydrodidemnin B

1997 ◽  
Vol 113 (1-2) ◽  
pp. 141-144 ◽  
Author(s):  
P.M. Gómez-Fabre ◽  
E. de Pedro ◽  
M.A. Medina ◽  
I.Núñez de Castro ◽  
J. Márquez
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Cytotoxic Agents ◽  
Human Breast Cancer Cells ◽  
Human Breast
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