scholarly journals The Diverse World of Foldamers: Endless Possibilities of Self-Assembly

Molecules ◽  
2020 ◽  
Vol 25 (14) ◽  
pp. 3276 ◽  
Author(s):  
Samuele Rinaldi
Keyword(s):  
Self Assembly ◽  
Structural Investigation ◽  
Driving Forces ◽  
Correct Choice ◽  
The Self ◽  
Bioactive Molecules ◽  
Diverse World ◽  
The Subject ◽  
Order Structures

Different classes of foldamers, which are synthetic oligomers that adopt well-defined conformations in solution, have been the subject of extensive studies devoted to the elucidation of the forces driving their secondary structures and their potential as bioactive molecules. Regardless of the backbone type (peptidic or abiotic), the most important features of foldamers are the high stability, easy predictability and tunability of their folding, as well as the possibility to endow them with enhanced biological functions, with respect to their natural counterparts, by the correct choice of monomers. Foldamers have also recently started playing a starring role in the self-assembly of higher-order structures. In this review, selected articles will be analyzed to show the striking number of self-assemblies obtained for foldamers with different backbones, which will be analyzed in order of increasing complexity. Starting from the simplest self-associations in solution (e.g., dimers of β-strands or helices, bundles, interpenetrating double and multiple helices), the formation of monolayers, vesicles, fibers, and eventually nanostructured solid tridimensional morphologies will be subsequently described. The experimental techniques used in the structural investigation, and in the determination of the driving forces and mechanisms underlying the self-assemblies, will be systematically reported. Where applicable, examples of biomimetic self-assembled foldamers and their interactions with biological components will be described.

Towards Radiolabeled G∧C Module for Cellular Imaging of Bioactive Rosette Nanotubes

2011 ◽  
Vol 1316 ◽  
Author(s):  
Alaaeddin Alsbaiee ◽  
Mustapha St. Jules ◽  
Rachel L. Beingessner ◽  
Hicham Fenniri
Keyword(s):  
Self Assembly ◽  
Single Photon ◽  
Photon Emission ◽  
Immunological Response ◽  
The Self ◽  
Bioactive Molecules ◽  
Emission Computed Tomography ◽  
Rosette Nanotubes ◽  
Aqueous Conditions

ABSTRACTRosette nanotubes (RNTs) are obtained through the self-organization of biologically inspired self-complementary guanine-cytosine modules (G∧C motif) under physiological conditions. These architectures can express bioactive molecules on their surface by functionalizing the G∧C motif prior to self-assembly. As a result, RNTs are promising drug delivery vehicles for the treatment of diseases such as cancer and inflammatory disorders. Towards these studies, we have explored the toxicity and immunological response of RNTs and are now focused on understanding their cellular uptake, biological distribution and kinetics in vivo. For these investigations, we need to construct a RNT labeled with a radionuclide that can be followed in vivo by SPECT (single photon emission computed tomography) imaging. In this proceeding, we describe a twin G∧C motif that is functionalized with mercaptoacetyl triglycine (MAG3). This is a well known ligand which is able to form a stable chelate with the radionuclides 99mTc or 186/188Re. In order to develop the chemistry for this radiolabeling strategy for the RNTs, we demonstrate the chelation of the MAG3 functionalized twin-G∧C motif with cold rhenium and investigate the self-assembly properties of the complex into RNTs under aqueous conditions.

scholarly journals Unraveling the Driving Forces in the Self-Assembly of Monodisperse Naphthalenediimide-Oligodimethylsiloxane Block Molecules

ACS Nano ◽  
2017 ◽  
Vol 11 (4) ◽  
pp. 3733-3741 ◽  
Author(s):  
José Augusto Berrocal ◽  
R. Helen Zha ◽  
Bas F. M. de Waal ◽  
Jody A. M. Lugger ◽  
Martin Lutz ◽  
...  
Keyword(s):  
Self Assembly ◽  
Driving Forces ◽  
The Self

scholarly journals Urethane tetrathiafulvalene derivatives: synthesis, self-assembly and electrochemical properties

2015 ◽  
Vol 11 ◽  
pp. 2343-2349 ◽  
Author(s):  
Xiang Sun ◽  
Guoqiao Lai ◽  
Zhifang Li ◽  
Yuwen Ma ◽  
Xiao Yuan ◽  
...  
Keyword(s):  
Self Assembly ◽  
Driving Forces ◽  
Noncovalent Interactions ◽  
Electronic Conductivity ◽  
The Self ◽  
Stacking Interactions ◽  
X Ray Diffraction ◽  
X Ray ◽  
Hydrogen Bond Interactions ◽  
Better Than

This paper reports the self-assembly of two new tetrathiafulvalene (TTF) derivatives that contain one or two urethane groups. The formation of nanoribbons was evidenced by scanning electron microscopy (SEM) and X-ray diffraction (XRD), which showed that the self-assembly ability of T 1 was better than that of T 2 . The results revealed that more urethane groups in a molecule did not necessarily instigate self-assembly. UV–vis and FTIR spectra were measured to explore noncovalent interactions. The driving forces for self-assembly of TTF derivatives were mainly hydrogen bond interactions and π–π stacking interactions. The electronic conductivity of the T 1 and T 2 films was tested by a four-probe method.

scholarly journals Driving forces for the self-assembly of graphene oxide on organic monolayers

Nanoscale ◽  
2014 ◽  
Vol 6 (19) ◽  
pp. 11344-11350 ◽  
Author(s):  
Johannes Kirschner ◽  
Zhenxing Wang ◽  
Siegfried Eigler ◽  
Hans-Peter Steinrück ◽  
Christof M. Jäger ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Self Assembly ◽  
Driving Forces ◽  
The Self ◽  
Organic Monolayers

A colorimetric sensor for protamine detection based on the self-assembly of gold nanorods on graphene oxide

2019 ◽  
Vol 43 (22) ◽  
pp. 8502-8507 ◽  
Author(s):  
Natpapas Wiriyachaiporn ◽  
Petpimon Srisurat ◽  
Jarumeth Cherngsuwanwong ◽  
Natcha Sangsing ◽  
Jaruwan Chonirat ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Gold Nanorods ◽  
Self Assembly ◽  
Detection Method ◽  
Colorimetric Detection ◽  
Colorimetric Sensor ◽  
The Self

Here, we report a simple colorimetric detection method for the determination of protamine based on the self-assembly of gold nanorods (AuNRs) on graphene oxide (GO).

scholarly journals Higher-order interfiber interactions in the self-assembly of benzene-1,3,5-tricarboxamide-based peptides in water

2021 ◽  
Author(s):  
Oleksandr Zagorodko ◽  
Tetiana Melnyk ◽  
Olivier Rogier ◽  
Vicent J. Nebot ◽  
María J. Vicent
Keyword(s):  
Aqueous Solution ◽  
Amino Acids ◽  
Self Assembly ◽  
Higher Order ◽  
The Self ◽  
Order Structures

Benzene-1,3,5-tricarboxamide-based di- and tripeptide derivatives can form various higher-order structures in aqueous solution depending on the order, hydrophobicity, and bulkiness of the amino acids in the substituent.

Self-Assembly of an Amphiphilic OEG-Linked Glutamide Lipid

2017 ◽  
Vol 70 (1) ◽  
pp. 52 ◽  
Author(s):  
Shuo Wang ◽  
Youguo Zhang ◽  
Qiang Li ◽  
Rongqin Sun ◽  
Lin Ma ◽  
...  
Keyword(s):  
Self Assembly ◽  
Driving Forces ◽  
Size Control ◽  
The Self ◽  
Amphiphilic Peptides ◽  
Hydrogen Bonding Interactions ◽  
Assembly Mechanism ◽  
Wide Range ◽  
Added Water ◽  
Amphiphilic Peptide

Amphiphilic peptides with or without oligoethylene glycol (OEG) chains based on 3,4-bis(benzyloxy)benzoic-linked glutamide were designed and their self-assembly was investigated. It was found that the amphiphilic peptide 3 with OEG chains could not only form stable gels in a wide range of solvents, but also showed better solubility in solvents than those without OEG chains. Fibrillar and nanotube structures were found in the gels formed and the width of the fibres could be tuned with added water content. The UV-vis and XRD results suggested that the driving forces for the peptide self-assembly were mainly intermolecular π–π and hydrogen-bonding interactions. These results provide a deeper understanding of the self-assembly mechanism and size control of nanofibrils formed by an OEG-based amphiphilic peptide.

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