scholarly journals Study on a Three-Step Rapid Assembly of Zolpidem and Its Fluorinated Analogues Employing Microwave-Assisted Chemistry

Molecules ◽  
2020 ◽  
Vol 25 (14) ◽  
pp. 3161
Author(s):  
Nikola Fajkis ◽  
Monika Marcinkowska ◽  
Beata Gryzło ◽  
Anna Krupa ◽  
Marcin Kolaczkowski
Keyword(s):  
Particle Size ◽  
Fine Particle ◽  
Biological Fluids ◽  
Superior Performance ◽  
Conventional Heating ◽  
Particle Sizes ◽  
Heating Systems ◽  
Microwave Assisted ◽  
Fine Particle Size ◽  
Yield And Purity

We developed an efficient microwave-assisted three-step synthesis of zolpidem and its fluorinated analogues 1–3. The procedure relays on the utilization of easily accessible and inexpensive starting materials. Our protocol shows superior performance in terms of yield and purity of products, compared to conventional heating systems. Notably, the total time needed for reaction accomplishment is significantly lower comparing to oil bath heating systems. Finally, we have performed a detailed study on the preparation of zolpidem tartrate salt I, and we assessed its particle-sizes using a polarizing microscope. Our goal was to select the appropriate method that generates the acceptable particle-size, since the solid-size directly influences solubility in biological fluids and further bioavailability. We believe that the disclosed procedure will help to produce a lab-scale quantity of zolpidem and its fluorinated derivatives 1–3, as well as zolpidem tartrate salt I, with suitable fine-particle size for further biological experimentation.

Hydrogen Generation by Hydrolysis of the Ball Milled Al-C-KCl Composite Powder in Distilled Water

2012 ◽  
Vol 519 ◽  
pp. 87-91 ◽  
Author(s):  
Xia Ni Huang ◽  
Zhang Han Wu ◽  
Ke Cao ◽  
Wen Zeng ◽  
Chun Ju Lv ◽  
...  
Keyword(s):  
Particle Size ◽  
Reaction Temperature ◽  
Fine Particle ◽  
Composite Powder ◽  
Hydrogen Generation ◽  
Aluminum Particle ◽  
Generation Rate ◽  
Composite Powders ◽  
Fine Particle Size ◽  
Hydrolysis Of

In the present investigation, the Al-C-KCl composite powders were prepared by a ball milling processing in an attempt to improve the hydrogen evolution capacity of aluminum in water. The results showed that the hydrogen generation reaction is affected by KCl amount, preparation processing, initial aluminum particle size and reaction temperature. Increasing KCl amount led to an increased hydrogen generation volume. The use of aluminum powder with a fine particle size could promote the aluminum hydrolysis reaction and get an increased hydrogen generation rate. The reaction temperature played an important role in hydrogen generation rate and the maximum hydrogen generation rate of 44.8 cm3 min-1g-1of Al was obtained at 75oC. The XRD results identified that the hydrolysis byproducts are bayerite (Al(OH)3) and boehmite (AlOOH).

Influence of fine particle size and concentration on the clogging of labyrinth emitters

2012 ◽  
Vol 31 (4) ◽  
pp. 545-555 ◽  
Author(s):  
Wenquan Niu ◽  
Lu Liu ◽  
Xue Chen
Keyword(s):  
Particle Size ◽  
Fine Particle ◽  
Fine Particle Size

Mercury Speciation and Fine Particle Size Distribution on Combustion of Chinese Coals

2012 ◽  
pp. 313-321
Author(s):  
Lei Zhang ◽  
Michael Daukoru ◽  
Sarah Torkamani ◽  
Shuxiao Wang ◽  
Jiming Hao ◽  
...  
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Size Distribution ◽  
Fine Particle ◽  
Mercury Speciation ◽  
Fine Particle Size

Measuring Fine Particle Size with RGB Three Wavelength Bands Light Extinction Method

2015 ◽  
Vol 35 (7) ◽  
pp. 0712004 ◽  
Author(s):  
黎石竹 Li Shizhu ◽  
蔡小舒 Cai Xiaoshu ◽  
高伟 Gao Wei ◽  
刘浩 Liu Hao
Keyword(s):  
Particle Size ◽  
Fine Particle ◽  
Light Extinction ◽  
Fine Particle Size

scholarly journals Sea salt as a potential ocean mirror material

RSC Advances ◽  
2015 ◽  
Vol 5 (49) ◽  
pp. 38926-38930 ◽  
Author(s):  
T. Rowland ◽  
H. C. Hailes ◽  
J. R. G. Evans
Keyword(s):  
Particle Size ◽  
Fine Particle ◽  
Surface Albedo ◽  
Ostwald Ripening ◽  
Sea Salt ◽  
Fine Particle Size

The additives used to produce ocean foams also inhibit Ostwald ripening of seasalt producing very fine particle size and a reflectance of 77% so that seasalt can make a contribution to surface albedo.

Synthesis of Mixed Conducting Oxides SrFeCo0.5Oy Powder by Citrate Method

2007 ◽  
Vol 336-338 ◽  
pp. 971-973
Author(s):  
Zhi Jun Xu ◽  
Rui Qing Chu ◽  
S.C. Cui ◽  
Jin Son Zhang
Keyword(s):  
Fine Particle ◽  
Fine Powder ◽  
Synthesis Process ◽  
Particle Sizes ◽  
Contributing Factors ◽  
Citrate Method ◽  
Conducting Oxides ◽  
Fine Particle Size ◽  
Perovskite Type ◽  
Perovskite Type Structure

Mixed-conducting ceramic oxide SrFeCo0.5Oy powders were prepared by a citrate method, and the contributing factors to the formation of homogeneous fine powder with a pure perovskite-type structure were ascertained. The resulting powder is pure, homogeneous and possesses a reasonably fine particle size. Attempts were made to understand the synthesis process and it was confirmed that the method produces powder had greater composition uniformity, lower residual carbonate levels and smaller particle sizes.

Granulometric Characterization of Flotation Products

2012 ◽  
Vol 727-728 ◽  
pp. 1902-1907
Author(s):  
R.C. Santana ◽  
M.A. Santos ◽  
T.C.M. Santos ◽  
T.A.A. Souza ◽  
Carlos Henrique Ataíde ◽  
...  
Keyword(s):  
Particle Size ◽  
Fine Particle ◽  
Column Height ◽  
Particle Size Fractions ◽  
Granulometric Analysis ◽  
Fine Particle Size ◽  
Distribution Parameters ◽  
Parameter Values ◽  
Feed Samples

This work aimed on the granulometric characterization of flotation products and to analyze the effect of the variables (that were investigated in a flotation work) on the particle size distribution parameters. Besides to compare the parameter values of the granulometric analysis for the concentrate and tailing both results were compared with the parameter values of the flotation feed samples. The analyzed parameters showed lower values for the concentrate products as compared with the parameters for tailing and feed samples. For coarse and fine particle size fractions the column height was the variable that more influenced on the parameter values.

Effect of Quartz of Fine Particle Size on Porcelain Properties

2006 ◽  
Vol 530-531 ◽  
pp. 493-498 ◽  
Author(s):  
S.R. Bragança ◽  
C.P. Bergmann
Keyword(s):  
Mechanical Properties ◽  
Particle Size ◽  
Thermal Stress ◽  
Fine Particle ◽  
Quartz Particle ◽  
Shock Strength ◽  
Thermal Strength ◽  
Fine Particle Size ◽  
Technical Properties ◽  
The Cost

The mechanical properties of porcelain are strongly influenced by the generated thermal stress during processing. When quartz particle size is reduced its influence on the technical properties of ceramic products such as tiles and porcelains are changed. In this work, the properties of triaxial ceramics materials were evaluated using quartz of different particle size distribution. It was reported strong variations in mechanical strength and thermal shock strength. Although the cost of milling is increased to reduce quartz particle size, it can be compensated by its implicit advantages. The experimental results were very interesting showing the way that quartz particle size influences the analyzed properties. A significant improving in porcelain strength and thermal strength was obtained.

Sign in / Sign up

Export Citation Format

Share Document