scholarly journals Effect of Thidiazuron on Terpene Volatile Constituents and Terpenoid Biosynthesis Pathway Gene Expression of Shine Muscat (Vitis labrusca × V. vinifera) Grape Berries

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2578
Author(s):  
Wu Wang ◽  
Muhammad Khalil-Ur-Rehman ◽  
Ling-Ling Wei ◽  
Niels J. Nieuwenhuizen ◽  
Huan Zheng ◽  
...  
Keyword(s):  
Volatile Compounds ◽  
Sensory Characteristics ◽  
The Novel ◽  
Terpene Biosynthesis ◽  
Grape Berries ◽  
Fruit Drop ◽  
Pathway Gene ◽  
Negative Effect ◽  
Key Genes ◽  
Almost All

Volatile compounds are considered to be essential for the flavor and aroma quality of grapes. Thidiazuron (TDZ) is a commonly used growth regulator in grape cultivation that stimulates larger berries and prevents fruit drop. This study was conducted to investigate the effect of TDZ on the production of aroma volatiles and to identify the key genes involved in the terpene biosynthesis pathways that are affected by this compound. Treatment with TDZ had a negative effect on the concentration of volatile compounds, especially on monoterpenes, which likely impacts the sensory characteristics of the fruit. The expression analysis of genes related to the monoterpenoid biosynthesis pathways confirmed that treatment with TDZ negatively regulated the key genes DXS1, DXS3, DXR, HDR, VvPNGer and VvPNlinNer1. Specifically, the expression levels of the aforementioned genes were down-regulated in almost all berry development stages in the TDZ-treated samples. The novel results from the present study can be used to aid in the development of food products which maintain the flavor quality and sensory characteristics of grape. Furthermore, these findings can provide the theoretical basis that can help to optimize the utilization of TDZ for the field production of grapes at a commercial scale.

scholarly journals Pakistan specific COVID-19 overview and recommendations

2021 ◽  
Vol 6 (4) ◽  
pp. 01-02
Author(s):  
Ome Kalsoom Afridi ◽  
Johar Ali
Keyword(s):  
Standard Operating Procedure ◽  
High Rate ◽  
Economic Losses ◽  
The Novel ◽  
Alternative Plan ◽  
First Case ◽  
Standard Operating ◽  
Negative Effect ◽  
Novel Coronavirus ◽  
Almost All

Soon after its emergence in Wuhan, China in late December, the novel coronavirus (SARS-CoV-2) spread rapidly to the other parts of the world and acquired a pandemic status. Pakistan reported its first case of SARS-CoV-2 on February 26, 2020, in Karachi. Since then, a higher prevalence of COVID-19 was reported from almost all major cities of Pakistan. Owing to the high rate of COVID-19, Pakistan enforced a lockdown across the whole country on March 24, 2020. This lockdown controlled the SARS-CoV-2 successfully; however, severe economic losses were observed in the lockdown Standard Operating Procedure (SOP) guidelines. We, therefore, proposed an alternative plan termed as “regulated reverse lockdown” which will help decrease the burden of COVID-19 without having a negative effect on the economy. The present editorial will address the potential flaws in the already imposed lockdown and will propose an alternative plan to make the lockdown more effective in terms of COVID-19 prevalence and economic growth of Pakistan.

Diligent Notes on Laziness: Oblomov, Lenin and the Capitalization of Laziness

2019 ◽  
Vol 29 (1) ◽  
pp. 243-258
Keyword(s):  
Psychiatric Hospital ◽  
The Novel ◽  
Work Analysis ◽  
Main Obstacle ◽  
Almost All ◽  
Russian Linguistic ◽  
The Way

The essay investigates the phenomenon of laziness by first analyzing the opposition between laziness and the good. Both utility and the good make reference to labor. This opposition between labor and laziness is pivotal in Oblomov, Ivan Goncharov’s famous novel written in 1859. It marks a radical transition from a feudal paradigm to a capitalistic one. The two main characters in the novel are Ilya Ilyich Oblomov, a Russian, and Andrey Ivanovich Stolz, a German, who together seem to personify the contradiction between laziness and labor. But the purpose of the essay is to deconstruct that opposition. In this connection, one can cite Kazimir Malevich, who maintained that laziness is the Mother of Perfection and is always unconsciously inherent in the conscious intent to work. Analysis of the Latin concepts of otium and negotium indicates that the laziness/labor opposition may be deconstructed as a dialectic between labor and its opposite. In other words, laziness does not stand in contradiction to labor but is instead its inseparable dialectical other. In the last part of the essay, the article considers the thinking of Anatoly Peregud, a poet who spent almost all his life in a psychiatric hospital. According to Peregud, Lenin derived his pseudonym from the Russian linguistic root “len” (laziness) in order to make laziness central to communism. For his part, Lenin saw Oblomov as an emblem of the main obstacle standing in the way of communism.

scholarly journals Modelling spreading of an infection using time series by a novel family of models; fitting the time series of the confirmed cases of COVID-19 in China

2020 ◽  
Vol 9 (s1) ◽  
Author(s):  
Babak Jamshidi ◽  
Shahriar Jamshidi Zargaran ◽  
Mansour Rezaei
Keyword(s):  
Infectious Disease ◽  
Time Series ◽  
Communicable Disease ◽  
Time Series Models ◽  
Cumulative Number ◽  
The Novel ◽  
New Family ◽  
Two Samples ◽  
Almost All ◽  
Number Of Individuals

AbstractIntroductionTime series models are one of the frequently used methods to describe the pattern of spreading an epidemic.MethodsWe presented a new family of time series models able to represent the cumulative number of individuals that contracted an infectious disease from the start to the end of the first wave of spreading. This family is flexible enough to model the propagation of almost all infectious diseases. After a general discussion on competent time series to model the outbreak of a communicable disease, we introduced the new family through one of its examples.ResultsWe estimated the parameters of two samples of the novel family to model the spreading of COVID-19 in China.DiscussionOur model does not work well when the decreasing trend of the rate of growth is absent because it is the main presumption of the model. In addition, since the information on the initial days is of the utmost importance for this model, one of the challenges about this model is modifying it to get qualified to model datasets that lack the information on the first days.

scholarly journals Barley Seeds miRNome Stability during Long-Term Storage and Aging

2021 ◽  
Vol 22 (9) ◽  
pp. 4315
Author(s):  
Marta Puchta ◽  
Jolanta Groszyk ◽  
Magdalena Małecka ◽  
Marek D. Koter ◽  
Maciej Niedzielski ◽  
...  
Keyword(s):  
Seed Viability ◽  
Small Rna Sequencing ◽  
The Novel ◽  
Seed Aging ◽  
Long Term Storage ◽  
Novel Mirna ◽  
Complex Biological Process ◽  
Almost All ◽  
Term Storage

Seed aging is a complex biological process that has been attracting scientists’ attention for many years. High-throughput small RNA sequencing was applied to examine microRNAs contribution in barley seeds senescence. Unique samples of seeds that, despite having the same genetic makeup, differed in viability after over 45 years of storage in a dry state were investigated. In total, 61 known and 81 novel miRNA were identified in dry seeds. The highest level of expression was found in four conserved miRNA families, i.e., miR159, miR156, miR166, and miR168. However, the most astonishing result was the lack of significant differences in the level of almost all miRNAs in seed samples with significantly different viability. This result reveals that miRNAs in dry seeds are extremely stable. This is also the first identified RNA fraction that is not deteriorating along with the loss of seed viability. Moreover, the novel miRNA hvu-new41, with higher expression in seeds with the lowest viability as detected by RT-qPCR, has the potential to become an indicator of the decreasing viability of seeds during storage in a dry state.

scholarly journals Current Understanding of Exosomal MicroRNAs in Glioma Immune Regulation and Therapeutic Responses

2022 ◽  
Vol 12 ◽  
Author(s):  
Jinwu Peng ◽  
Qiuju Liang ◽  
Zhijie Xu ◽  
Yuan Cai ◽  
Bi Peng ◽  
...  
Keyword(s):  
Immune Regulation ◽  
Response Prediction ◽  
Cell Types ◽  
Clinicopathological Characteristics ◽  
The Novel ◽  
Multiple Cancer ◽  
Exosomal Mirnas ◽  
Multiple Cell ◽  
Almost All ◽  
Therapeutic Responses

Exosomes, the small extracellular vesicles, are released by multiple cell types, including tumor cells, and represent a novel avenue for intercellular communication via transferring diverse biomolecules. Recently, microRNAs (miRNAs) were demonstrated to be enclosed in exosomes and therefore was protected from degradation. Such exosomal miRNAs can be transmitted to recipient cells where they could regulate multiple cancer-associated biological processes. Accumulative evidence suggests that exosomal miRNAs serve essential roles in modifying the glioma immune microenvironment and potentially affecting the malignant behaviors and therapeutic responses. As exosomal miRNAs are detectable in almost all kinds of biofluids and correlated with clinicopathological characteristics of glioma, they might be served as promising biomarkers for gliomas. We reviewed the novel findings regarding the biological functions of exosomal miRNAs during glioma pathogenesis and immune regulation. Furthermore, we elaborated on their potential clinical applications as biomarkers in glioma diagnosis, prognosis and treatment response prediction. Finally, we summarized the accessible databases that can be employed for exosome-associated miRNAs identification and functional exploration of cancers, including glioma.

scholarly journals Portrayal of Bangladeshi Existentialism: “Like a Diamond in the Sky” in Context

2021 ◽  
Vol 9 (2) ◽  
pp. 51-58
Author(s):  
Moniruzzaman ◽  
Safi Ullah
Keyword(s):  
Drug Addiction ◽  
Meaning Of Life ◽  
The Novel ◽  
Dhaka City ◽  
Meaningful Life ◽  
Capacity Limitation ◽  
Existential Crisis ◽  
The People ◽  
Almost All ◽  
Power Play

Shazia Omar, a Bangladeshi novelist, depicts the less-known imagery of modern Dhaka in her debut novel “Like a Diamond in the Sky” (2009) where she portrays Bangladesh infected with depression, drug addiction, power-play, corruption and fundamentalism. Deen, the protagonist, is lost in addiction, isolated from his mother and outer world but in love with Maria, aware of the future of Bangladesh and eager to search for the meaning of life. Deen, which literally implies the earthly life in Bangla, is an existentialist who is conscious of himself and the people around him. He is aware of his capacity, limitation, existence and essence. He comments on different orders and institutions that hinder at the path of freedom, and about politicization and islamisation in Bangladesh. Not only Deen but also his widowed mother, his friend AJ, drug peddler Falani, the sergeant of the Police, Deen’s girlfriend Maria- all are conscious of their existence and essence. This novel is about a journey from a dark and aimless world to redemption, to a meaningful life. Omar presents existentialism and existential crisis as noticed in Bangladesh in her novel where almost all characters try to find the meaning of life, though in different ways. Omar says in an interview that the novel “explores their feeling of alienation in the chaotic metropolis of Dhaka city” and her protagonist struggles “to find a spiritual connection”. Before writing this novel, Shazia Omar researched in a rehab in Mumbai, visited slums of    Bangladesh and thus shaded light on the darker and less-discussed imagery of Bangladesh. “Like a Diamond in the Sky” is thoroughly examined in the light of existentialism, developed by Descartes, Kierkegaard, Sartre and Heidegger. This paper analyses how “Like a Diamond in the Sky” represents Bangladeshi existentialism, and existentialists who are conscious of existence and essence. It also discusses the observation, of Omar’s characters projected in the novel, about established orders and institutions and finally, desire for freedom and searching for meaning of life.

scholarly journals Respiratory Care in Corona

2021 ◽  
Vol 58 (2) ◽  
pp. 613-620
Author(s):  
Mustafa Amdani, Dr. Swaroopa Chakole
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Human Life ◽  
The Body ◽  
Respiratory Care ◽  
The Novel ◽  
Specific Therapy ◽  
History Of ◽  
Novel Coronavirus ◽  
Almost All ◽  
The Impact

BACKGROUND The expanse of the coronavirus disease 2019 or COVID-19 is huge. The impact is multispectral and affected almost all aspects of human life. SUMMARY Respiratory impact of the COVID-19 is the most felt and widely reported impact. As the novel coronavirus maintained its history of affecting lungs as seen previously in severe acute respiratory syndrome (SARS) outbreak. Ventilators and oxygen support system are required mostly in comorbid patients particularly amongpatientsbearing illnesses like asthma, bronchial impairment and so on. CONCLUSION More study needs to be done in order to assess the impact on the respiratory functioning of the body. Respiratory care must be including proper instruments so that more efficient result can be obtained. Research is needed to promote the invention of specific therapy for targeted action for respiratory functioning improvement.

What makes users willing or hesitant to use Fintech?: the moderating effect of user type

2018 ◽  
Vol 118 (3) ◽  
pp. 541-569 ◽  
Author(s):  
Hyun-Sun Ryu
Keyword(s):  
Least Squares Method ◽  
Original Data ◽  
The Novel ◽  
Continuance Intention ◽  
Content Type ◽  
Factors Affecting ◽  
Proposed Model ◽  
Negative Effect ◽  
Partial Least Squares Method ◽  
Benefit And Risk

Purpose The purpose of this paper is to better understand why people are willing or hesitant to use Financial technology (Fintech) as well as to determine whether the effect of perceived benefits and risks of continuance intention differs depending on user types. Design/methodology/approach Original data were collected via a survey of 243 participants with Fintech usage experience. The partial least squares method was used to test the proposed model. Findings The results reveal that legal risk had the most negative effect on the Fintech continuance intention, while convenience had the strongest positive effect. Differences in specific benefit and risk impacts are found between early and late adopters. Originality/value This empirical study contributes to the novel understanding of the benefit and risk factors affecting the Fintech continuance intention.

The Impact of COVID-19 on Stock Markets

2022 ◽  
pp. 250-262
Author(s):  
Aslı Aybars ◽  
Mehtap Öner
Keyword(s):  
Literature Review ◽  
Financial Markets ◽  
Stock Returns ◽  
Empirical Studies ◽  
The Novel ◽  
The World ◽  
Fast Pace ◽  
Novel Coronavirus ◽  
Almost All ◽  
The Impact

The novel coronavirus, COVID-19, which emerged at the end of 2019 and spread to the world at a very fast pace, resulted in a pandemic affecting the finance industry besides many other industries though at varying extents. Financial markets, which can be regarded as cornerstones of each and every country's economic success, have been adversely influenced due to the fear and uncertainty arising with the emergence of the novel coronavirus at different degrees. This chapter provides a summary of a literature review based on the impact of this pandemic on stock returns and volatility in the stock exchanges of different countries and regions of the world. What has been captured as a result of this literature review is that almost all of the financial markets around the world have been influenced due to the virus. Further, industry-wise empirical studies demonstrate that not all industries are affected at the same level or even in the same direction.

scholarly journals A Prime-Boost Immunization Strategy with Vaccinia Virus Expressing Novel gp120 Envelope Glycoprotein from a CRF02_AG Isolate Elicits Cross-Clade Tier 2 HIV-1 Neutralizing Antibodies

Vaccines ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 171
Author(s):  
Rita Calado ◽  
Joana Duarte ◽  
Pedro Borrego ◽  
José Maria Marcelino ◽  
Inês Bártolo ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Envelope Glycoproteins ◽  
The Novel ◽  
Tier 2 ◽  
Broadly Neutralizing Antibodies ◽  
Immunization Strategy ◽  
Vaccinia Viruses ◽  
Boost Immunization ◽  
Almost All ◽  
Hiv 1

Development of new immunogens eliciting broadly neutralizing antibodies (bNAbs) is a main priority for the HIV-1 vaccine field. Envelope glycoproteins from non-B-non-C HIV-1clades have not been fully explored as components of a vaccine. We produced Vaccinia viruses expressing a truncated version of gp120 (gp120t) from HIV-1 clades CRF02_AG, H, J, B, and C and examined their immunogenicity in mice and rabbits. Mice primed with the recombinant Vaccinia viruses and boosted with the homologous gp120t or C2V3C3 polypeptides developed antibodies that bind potently to homologous and heterologous envelope glycoproteins. Notably, a subset of mice immunized with the CRF02_AG-based envelope immunogens developed a cross-reactive neutralizing response against tier 2 HIV-1 Env-pseudoviruses and primary isolates. Rabbits vaccinated with the CRF02_AG-based envelope immunogens also generated potent binding antibodies, and one animal elicited antibodies that neutralized almost all (13 of 16, 81.3%) tier 2 HIV-1 isolates tested. Overall, the results suggest that the novel CRF02_AG-based envelope immunogens and prime-boost immunization strategy elicit the type of immune responses required for a preventive HIV-1 vaccine.

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