scholarly journals Synthesis, Molecular Recognition Study and Liquid Membrane-Based Applications of Highly Lipophilic Enantiopure Acridino-Crown Ethers

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2571
Author(s):  
Ádám Golcs ◽  
Bálint Árpád Ádám ◽  
Viola Horváth ◽  
Tünde Tóth ◽  
Péter Huszthy
Keyword(s):  
Crown Ethers ◽  
Liquid Membrane ◽  
Structural Features ◽  
Amino Acid Derivatives ◽  
Electrochemical Studies ◽  
Model Compounds ◽  
Guest Molecules ◽  
Enantiomeric Recognition ◽  
Sensor Molecules ◽  
Phase Transport

New highly lipophilic enantiopure crown ethers containing a heterocyclic unit have been synthesized. Phase transport, UV-Vis- and fluorescence spectrophotometric investigations as well as electrochemical studies on the complexation of the new macrocycles with several amine and amino acid derivatives were also carried out. Achiral amines were used for studying the structural preference of the new macrocycles. Among the studied structural features of the guest molecules, the intermolecular π-π interaction showed the most significant effect on complexation, which made the aralkylamine-type compounds the most preferable guest molecules. The studied liquid membrane-based applications and photophysical investigations showed appreciable enantiomeric recognition toward some aralkylamine model compounds with homochiral preferences. New crown ether derivatives (R,R)-2 and (S,S)-2 were successfully applied as enantioselective carrier and sensor molecules.

scholarly journals Non-Lamellar Liquid Crystalline Nanocarriers for Thymoquinone Encapsulation

Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 16 ◽  
Author(s):  
Anan Yaghmur ◽  
Boi Vi Tran ◽  
Seyed Moein Moghimi
Keyword(s):  
Liquid Crystalline ◽  
Drug Carriers ◽  
Structural Features ◽  
Drug Induced ◽  
Guest Molecules ◽  
Drug Molecules ◽  
Liquid Crystalline Nanoparticles ◽  
The Mean ◽  
Biological Performance ◽  
Glycerol Monooleate

Owing to their unique structural features, non-lamellar liquid crystalline nanoparticles comprising cubosomes and hexosomes are attracting increasing attention as versatile investigative drug carriers. Background: Depending on their physiochemical characteristics, drug molecules on entrapment can modulate and reorganize structural features of cubosomes and hexosomes. Therefore, it is important to assess the effect of guest molecules on broader biophysical characteristics of non-lamellar liquid crystalline nanoparticles, since drug-induced architectural, morphological, and size modifications can affect the biological performance of cubosomes and hexosomes. Methods: We report on alterations in morphological, structural, and size characteristics of nanodispersions composed from binary mixtures of glycerol monooleate and vitamin E on thymoquinone (a molecule with wide therapeutic potentials) loading. Results: Thymoquinone loading was associated with a slight increase in the mean hydrodynamic nanoparticle size and led to structural transitions from an internal biphasic feature of coexisting inverse cubic Fd3m and hexagonal (H2) phases to an internal inverse cubic Fd3m phase (micellar cubosomes) or an internal inverse micellar (L2) phase (emulsified microemulsions, EMEs). We further report on the presence of “flower-like” vesicular populations in both native and drug-loaded nanodispersions. Conclusions: These nanodispersions have the potential to accommodate thymoquinone and may be considered as promising platforms for the development of thymoquinone nanomedicines.

ChemInform Abstract: ENANTIOMERIC RECOGNITION OF ORGANIC AMMONIUM SALTS BY CHIRAL CROWN ETHERS BASED ON THE PYRIDINO-18-CROWN-6 STRUCTURE

1984 ◽  
Vol 15 (25) ◽  
Author(s):  
R. B. DAVIDSON ◽  
J. S. BRADSHAW ◽  
B. A. JONES ◽  
N. K. DALLEY ◽  
J. J. CHRISTENSEN ◽  
...  
Keyword(s):  
Crown Ethers ◽  
Ammonium Salts ◽  
Chiral Crown Ethers ◽  
Enantiomeric Recognition

ChemInform Abstract: Complexes of Macrocyclic Polyethers and Neutral Guest Molecules: A Systematic Approach to the Complexation of Water Molecules by 2,6-Pyridinium Crown Ethers.

1986 ◽  
Vol 17 (25) ◽  
Author(s):  
P. D. J. GROOTENHUIS ◽  
J. W. H. M. UITERWIJK ◽  
D. N. REINHOUDT ◽  
C. J. VAN STAVEREN ◽  
E. J. R. SUDHOELTER ◽  
...  
Keyword(s):  
Crown Ethers ◽  
Systematic Approach ◽  
Water Molecules ◽  
Macrocyclic Polyethers ◽  
Guest Molecules

Enantiomeric recognition of α-amino acid derivatives by chiral uranyl–salen receptors

2015 ◽  
Vol 56 (22) ◽  
pp. 2922-2926 ◽  
Author(s):  
Giuseppe Forte ◽  
Alessandro D’Urso ◽  
Francesco P. Ballistreri ◽  
Rosa M. Toscano ◽  
Gaetano A. Tomaselli ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Enantiomeric Recognition

Enantiomeric recognition of organic ammonium salts by chiral crown ethers based on the pyridino-18-crown-6 structure

1984 ◽  
Vol 49 (2) ◽  
pp. 353-357 ◽  
Author(s):  
Richard B. Davidson ◽  
Jerald S. Bradshaw ◽  
Brian A. Jones ◽  
N. Kent Dalley ◽  
James J. Christensen ◽  
...  
Keyword(s):  
Crown Ethers ◽  
Ammonium Salts ◽  
Chiral Crown Ethers ◽  
Enantiomeric Recognition

ChemInform Abstract: Synthesis of Camphor Based Chiral Crown Ethers and Their Interactions with Amino Acid Derivatives.

ChemInform ◽  
2010 ◽  
Vol 27 (4) ◽  
pp. no-no
Author(s):  
B. J. BRISDON ◽  
R. ENGLAND ◽  
M. F. MAHON ◽  
K. REZA ◽  
M. SAINSBURY
Keyword(s):  
Amino Acid ◽  
Crown Ethers ◽  
Amino Acid Derivatives ◽  
Chiral Crown Ethers

Enantiomeric recognition of amino acid derivatives by chiral schiff bases of calix[4]arene

2007 ◽  
Vol 18 (7) ◽  
pp. 900-905 ◽  
Author(s):  
Mustafa Durmaz ◽  
Sabri Alpaydin ◽  
Abdulkadir Sirit ◽  
Mustafa Yilmaz
Keyword(s):  
Amino Acid ◽  
Schiff Bases ◽  
Amino Acid Derivatives ◽  
Enantiomeric Recognition
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