scholarly journals Δ1-Dehydrogenation and C20 Reduction of Cortisone and Hydrocortisone Catalyzed by Rhodococcus Strains

Molecules ◽  
2020 ◽  
Vol 25 (9) ◽  
pp. 2192
Author(s):  
Stefania Costa ◽  
Federico Zappaterra ◽  
Daniela Summa ◽  
Bruno Semeraro ◽  
Giancarlo Fantin
Keyword(s):  
Pharmaceutical Industry ◽  
Carbonyl Group ◽  
Scale Up ◽  
Point Of View ◽  
Process Efficiency ◽  
Steroid Nucleus ◽  
Inflammatory Drugs ◽  
Biotechnological Processes ◽  
Anti Inflammatory ◽  
Efficiency And Productivity

Prednisone and prednisolone are steroids widely used as anti-inflammatory drugs. Development of the pharmaceutical industry is currently aimed at introducing biotechnological processes and replacing multiple-stage chemical syntheses. In this work we evaluated the ability of bacteria belonging to the Rhodococcus genus to biotransform substrates, such as cortisone and hydrocortisone, to obtain prednisone and prednisolone, respectively. These products are of great interest from a pharmaceutical point of view as they have higher anti-inflammatory activity than the starting substrates. After an initial lab-scale screening of 13 Rhodococcus strains, to select the highest producers of prednisone and prednisolone, we reported the 200 ml-batch scale-up to test the process efficiency and productivity of the most promising Rhodococcus strains. R. ruber, R. globerulus and R. coprophilus gave the Δ1-dehydrogenation products of cortisone and hydrocortisone (prednisone and prednisolone) in variable amounts. In these biotransformations, the formation of products with the reduced carbonyl group in position C20 of the lateral chain of the steroid nucleus was also observed (i.e., 20β-hydroxy-prednisone and 20β-hydroxy-prednisolone). The yields, the absence of collateral products, and in some cases the absence of starting products allow us to say that cortisone and hydrocortisone are partly degraded.

scholarly journals Degradation of Anti-Inflammatory Drugs in Synthetic Wastewater by Solar Photocatalysis

Catalysts ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1330
Author(s):  
Marwan Al-Jemeli ◽  
Mahmoud Abbas Mahmoud ◽  
Hasan Sh. Majdi ◽  
Mohammad Fadhil Abid ◽  
Hiba M. Abdullah ◽  
...  
Keyword(s):  
Diclofenac Sodium ◽  
Health Sector ◽  
Clean Energy ◽  
Process Efficiency ◽  
Solar Irradiation ◽  
Synthetic Wastewater ◽  
Key Variables ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Clean Energy Source

Due to the high number of anti-inflammatory drugs (AIMDs) used by the public health sector in Iraq and distributed all over the country and due to their toxicity, there is a need for an environmental-friendly technique to degrade any wasted (AIMD) present in aquatic ecosystem. The degradation of diclofenac sodium (DCF), ibuprofen (IBN), and mefenamic acid (MFA) in synthetic hospital wastewater were investigated utilizing locally-made Cu-coated TiO2 nanoparticles in a solar-irradiated reactor. Different key variables were studied for their effects on process efficiency, such as loadings of catalyst (C CU-TiO2 = 100–500 mg/L), AIMDs (100 µg/L), pH (4–9), and hydrogen peroxide (CH2O2 = 200–800 mg/L). The results revealed that degradation percentages of 96.5, 94.2, and 82.3%, were obtained for DCF, IBN, and MFA, respectively, using our Cu-coated TiO2 catalyst within 65 min at pH = 9, while other parameters were C CU-TiO2 = 300 mg/L, and CH2O2 = 400 mg/L. The experimental results revealed coupling photocatalysis with solar irradiation as a clean energy source could be utilized for the degradation of toxic pollutants in surface water.

scholarly journals Role of Immunity and Inflammation Mediators in Early COVID-19 Management: Genetic Results Interpretations Versus Real-life Practice.

2021 ◽  
Author(s):  
Mina Kelleni
Keyword(s):  
Real Life ◽  
Point Of View ◽  
Academic Experience ◽  
Clinical Perspective ◽  
Altered Expression ◽  
Inflammation Mediators ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Genetic Results

Pairo-Castineira et al. have recently demonstrated that altered expression of certain genes related to the immune and inflammatory systems reduced the odds of severe COVID-19 and protected against it; we agree with their results from a clinical perspective. However, they have suggested some drugs, including barictinib, to be of priority to be tested basing on their results. We present a concise analysis of these results according to our real-life and academic experience that disagree with some of their recommendations from a clinical and pharmacovigilant point of view. Further, we confirm that the important results released Pairo-Castineira et al. confirm the validity to our recommended real-life used protocol using non-steroidal anti-inflammatory drugs, nitazoxanide and azithromycin to manage COVID-19 patients.

Polyphenols from Cymbopogon citratus inhibit iNOS expression and NO production – a promising source of new anti-inflammatory drugs

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
V Francisco ◽  
A Figueirinha ◽  
B Neves ◽  
C Garcia-Rodriguez ◽  
M Lopes ◽  
...  
Keyword(s):  
Inos Expression ◽  
No Production ◽  
Cymbopogon Citratus ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Promising Source

Heparin and proteoglycans as anti-inflammatory drugs

1996 ◽  
Vol 16 (01) ◽  
pp. 56-59
Author(s):  
D. J. Tyrrell ◽  
C. P. Page
Keyword(s):  
Inflammatory Diseases ◽  
Therapeutic Applications ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

SummaryEvidence continues to accumulate that the pleiotropic nature of heparin (beyond its anticoagulant potency) includes anti-inflammatory activities at a number of levels. It is clear that drugs exploiting these anti-inflammatory activities of heparin may offer exciting new therapeutic applications to the treatment of a wide range of inflammatory diseases.

Non-Steroidal Anti-inflammatory Drugs (NSAIDs): Synthesis of Ibuprofen, Naproxen and Nabumetone

2019 ◽  
pp. 19-27
Keyword(s):  
Review Paper ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Synthetic Approaches

This review paper covers the major synthetic approaches attempted towards the synthesis of some Non-Steroidal Anti-Inflammatory Drugs (Naproxen, Ibuprofen and Nabumetone)

Sign in / Sign up

Export Citation Format

Share Document