scholarly journals Recent Advances in Encapsulation, Protection, and Oral Delivery of Bioactive Proteins and Peptides using Colloidal Systems

Molecules ◽  
2020 ◽  
Vol 25 (5) ◽  
pp. 1161 ◽  
Author(s):  
Sarah L. Perry ◽  
David Julian McClements
Keyword(s):  
Ace Inhibitors ◽  
Oral Delivery ◽  
Colloidal Particles ◽  
Functional Performance ◽  
Delivery Systems ◽  
Colloidal Systems ◽  
Adverse Conditions ◽  
Bioactive Proteins ◽  
Food Applications ◽  
Proteins And Peptides

There are many areas in medicine and industry where it would be advantageous to orally deliver bioactive proteins and peptides (BPPs), including ACE inhibitors, antimicrobials, antioxidants, hormones, enzymes, and vaccines. A major challenge in this area is that many BPPs degrade during storage of the product or during passage through the human gut, thereby losing their activity. Moreover, many BPPs have undesirable taste profiles (such as bitterness or astringency), which makes them unpleasant to consume. These challenges can often be overcome by encapsulating them within colloidal particles that protect them from any adverse conditions in their environment, but then release them at the desired site-of-action, which may be inside the gut or body. This article begins with a discussion of BPP characteristics and the hurdles involved in their delivery. It then highlights the characteristics of colloidal particles that can be manipulated to create effective BPP-delivery systems, including particle composition, size, and interfacial properties. The factors impacting the functional performance of colloidal delivery systems are then highlighted, including their loading capacity, encapsulation efficiency, protective properties, retention/release properties, and stability. Different kinds of colloidal delivery systems suitable for encapsulation of BPPs are then reviewed, such as microemulsions, emulsions, solid lipid particles, liposomes, and microgels. Finally, some examples of the use of colloidal delivery systems for delivery of specific BPPs are given, including hormones, enzymes, vaccines, antimicrobials, and ACE inhibitors. An emphasis is on the development of food-grade colloidal delivery systems, which could be used in functional or medical food applications. The knowledge presented should facilitate the design of more effective vehicles for the oral delivery of bioactive proteins and peptides.

Recent insights in the use of nanocarriers for the oral delivery of bioactive proteins and peptides

Peptides ◽  
2018 ◽  
Vol 101 ◽  
pp. 112-123 ◽  
Author(s):  
Patrícia Batista ◽  
Pedro M. Castro ◽  
Ana Raquel Madureira ◽  
Bruno Sarmento ◽  
Manuela Pintado
Keyword(s):  
Oral Delivery ◽  
Bioactive Proteins ◽  
Proteins And Peptides

scholarly journals Donkey Milk Bioactive Proteins and Peptides, Health and Food Applications – A review

2020 ◽  
Author(s):  
Reda Derdak ◽  
Oana Lelia Pop ◽  
Souraya Sakoui ◽  
Carmen Muresan ◽  
Dan Cristian Vodnar ◽  
...  
Keyword(s):  
Immune System ◽  
Protein Fraction ◽  
Milk Protein ◽  
Inflammatory Diseases ◽  
Antidiabetic Activity ◽  
Donkey Milk ◽  
Bioactive Proteins ◽  
Food Applications ◽  
Nutritional Effects ◽  
Proteins And Peptides

Due to its similarity with human milk and its low allergenic properties, donkey milk has long been used as an alternative for infants and patients with cow's milk protein allergy. In addition, this milk is attracting growing interest in human nutrition because of presumed health benefits. It has antioxidant, antimicrobial, antitumoral, antiproliferative, and antidiabetic activity. Also, it stimulates the immune system, regulates the gastrointestinal flora, and prevents inflammatory diseases. Although all components of donkey milk can contribute to functional and nutritional effects, it is generally accepted that the whey protein fraction plays a major role. The purpose of this review is to highlight the active proteins and peptides of donkey milk in comparison with other types of milk, emphasizing their properties and their roles in different fields.

Rational Surface Engineering of Colloidal Drug Delivery Systems for Biological Applications

2018 ◽  
Vol 18 (14) ◽  
pp. 1224-1241 ◽  
Author(s):  
Noe Escareno ◽  
Antonio Topete ◽  
Pablo Taboada ◽  
Adrian Daneri-Navarro
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Colloidal Particles ◽  
Surface Engineering ◽  
Biological Response ◽  
Rational Surface ◽  
Delivery Systems ◽  
Inorganic Materials ◽  
Great Promise ◽  
Colloidal Systems

The use of colloidal particles as drug delivery carriers holds a great promise in terms of improvement of traditional treatment and diagnosis of human diseases. Nano- and microsized particles of a different composition including organic and inorganic materials can be fabricated with a great control over size, shape and surface properties. Nevertheless, only some few formulations have surpassed the benchtop and reached the bedside. The principal obstacle of colloidal drug delivery systems is their poor accumulation in target tissues, organs and cells, mainly by efficient sequestration and elimination by the mononuclear phagocytic system. Recent evidence suggests that, besides size, the surface character of colloidal systems is the most determinant design parameter that may ultimately guarantee successful biological performance. To approach these issues, materials designers and engineers can make use of multiple strategies and tools to finely modulate the particles’ surface towards highly efficient and biocompatible materials. In this article, we provide an overview of the most relevant colloidal drug delivery systems, a summary of the available literature regarding the effects of surface charge, hydrophobicity and softness on biological response, and finally, we review the key points of surface modification strategies with organic, inorganic and biological materials.

scholarly journals Insights on Health and Food Applications of Equus asinus (Donkey) Milk Bioactive Proteins and Peptides—An Overview

Foods ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 1302
Author(s):  
Reda Derdak ◽  
Souraya Sakoui ◽  
Oana Lelia Pop ◽  
Carmen Ioana Muresan ◽  
Dan Cristian Vodnar ◽  
...  
Keyword(s):  
Immune System ◽  
Milk Protein ◽  
Inflammatory Diseases ◽  
Antidiabetic Activity ◽  
Donkey Milk ◽  
Bioactive Proteins ◽  
Equus Asinus ◽  
Food Applications ◽  
Nutritional Effects ◽  
Proteins And Peptides

Due to its similarity with human milk and its low allergenic properties, donkey milk has long been used as an alternative for infants and patients with cow’s milk protein allergy (CMPA). In addition, this milk is attracting growing interest in human nutrition because of presumed health benefits. It has antioxidant, antimicrobial, antitumoral, antiproliferative and antidiabetic activity. In addition, it stimulates the immune system, regulates the gastrointestinal flora, and prevents inflammatory diseases. Although all donkey milk components can contribute to functional and nutritional effects, it is generally accepted that the whey protein fraction plays a significant role. This review aims to highlight the active proteins and peptides of donkey milk in comparison with other types of milk, emphasizing their properties and their roles in different fields of health and food applications.

scholarly journals Plant-Based Colloidal Delivery Systems for Bioactives

Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6895
Author(s):  
Yunbing Tan ◽  
David Julian McClements
Keyword(s):  
Colloidal Particles ◽  
Functional Performance ◽  
Delivery Systems ◽  
In Vivo Studies ◽  
Electrical Characteristics ◽  
Structure Surface ◽  
Water Dispersibility ◽  
Bioactive Agents ◽  
Selection Of

The supplementation of plant-based foods and beverages with bioactive agents may be an important strategy for increasing human healthiness. Numerous kinds of colloidal delivery systems have been developed to encapsulate bioactives with the goal of improving their water dispersibility, chemical stability, and bioavailability. In this review, we focus on colloidal delivery systems assembled entirely from plant-based ingredients, such as lipids, proteins, polysaccharides, phospholipids, and surfactants isolated from botanical sources. In particular, the utilization of these ingredients to create plant-based nanoemulsions, nanoliposomes, nanoparticles, and microgels is covered. The utilization of these delivery systems to encapsulate, protect, and release various kinds of bioactives is highlighted, including oil-soluble vitamins (like vitamin D), ω-3 oils, carotenoids (vitamin A precursors), curcuminoids, and polyphenols. The functionality of these delivery systems can be tailored to specific applications by careful selection of ingredients and processing operations, as this enables the composition, size, shape, internal structure, surface chemistry, and electrical characteristics of the colloidal particles to be controlled. The plant-based delivery systems discussed in this article may be useful for introducing active ingredients into the next generation of plant-based foods, meat, seafood, milk, and egg analogs. Nevertheless, there is still a need to systematically compare the functional performance of different delivery systems for specific applications to establish the most appropriate one. In addition, there is a need to test their efficacy at delivering bioavailable forms of bioactives using in vivo studies.

scholarly journals Addendum: Gilani et al. Formulation and Optimization of Nano Lipid Based Oral Delivery Systems for Arthritis. Coatings 2021, 11, 548

Coatings ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 781
Author(s):  
Sadaf Jamal Gilani ◽  
May Nasser Bin-Jumah ◽  
Syed Sarim Imam ◽  
Sultan Alshehri ◽  
Mohammed Asadullah Jahangir ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Delivery Systems ◽  
Oral Delivery Systems

The authors wish to make the following corrections to this paper [...]

The importance of gastrointestinal uptake of particles in the design of oral delivery systems

1995 ◽  
Vol 18 (1) ◽  
pp. 5-22 ◽  
Author(s):  
E.C. Lavelle ◽  
S. Sharif ◽  
N.W. Thomas ◽  
J. Holland ◽  
S.S. Davis
Keyword(s):  
Oral Delivery ◽  
Delivery Systems ◽  
Gastrointestinal Uptake ◽  
Oral Delivery Systems

Encapsulation of cinnamaldehyde: an insight on delivery systems and food applications

2021 ◽  
pp. 1-23
Author(s):  
Bertrand Muhoza ◽  
Baokun Qi ◽  
Jean Damascene Harindintwali ◽  
Marwa Yagoub Farag Koko ◽  
Shuang Zhang ◽  
...  
Keyword(s):  
Delivery Systems ◽  
Food Applications
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