scholarly journals In Vivo Positive Magnetic Resonance Imaging Applications of Poly(methyl vinyl ether-alt-maleic acid)-coated Ultra-small Paramagnetic Gadolinium Oxide Nanoparticles

Molecules ◽  
2020 ◽  
Vol 25 (5) ◽  
pp. 1159 ◽  
Author(s):  
Mohammad Yaseen Ahmad ◽  
Md. Wasi Ahmad ◽  
Huan Yue ◽  
Son Long Ho ◽  
Ji Ae Park ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Surface Coating ◽  
Proton Spin ◽  
Water Proton ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Methyl Vinyl ◽  
Methyl Vinyl Ether

The study of ultra-small paramagnetic gadolinium oxide (Gd2O3) nanoparticles (NPs) as in vivo positive (T1) magnetic resonance imaging (MRI) contrast agents is one of the most attractive fields in nanomedicine. The performance of the Gd2O3 NP imaging agents depends on the surface-coating materials. In this study, poly(methyl vinyl ether-alt-maleic acid) (PMVEMA) was used as a surface-coating polymer. The PMVEMA-coated paramagnetic ultra-small Gd2O3 NPs with an average particle diameter of 1.9 nm were synthesized using the one-pot polyol method. They exhibited excellent colloidal stability in water and good biocompatibility. They also showed a very high longitudinal water proton spin relaxivity (r1) value of 36.2 s−1mM−1 (r2/r1 = 2.0; r2 = transverse water proton spin relaxivity) under a 3.0 tesla MR field which is approximately 10 times higher than the r1 values of commercial molecular contrast agents. High positive contrast enhancements were observed in in vivo T1 MR images after intravenous administration of the NP solution sample, demonstrating its potential as a T1 MRI contrast agent.

scholarly journals Polyaspartic Acid-Coated Paramagnetic Gadolinium Oxide Nanoparticles as a Dual-Modal T1 and T2 Magnetic Resonance Imaging Contrast Agent

2021 ◽  
Vol 11 (17) ◽  
pp. 8222
Author(s):  
Shanti Marasini ◽  
Huan Yue ◽  
Adibehalsadat Ghazanfari ◽  
Son Long Ho ◽  
Ji Ae Park ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Proton Spin ◽  
Water Proton ◽  
Resonance Imaging ◽  
Polyaspartic Acid ◽  
Mri Contrast ◽  
T1 And T2

Surface-coating polymers contribute to nanoparticle-based magnetic resonance imaging (MRI) contrast agents because they can affect the relaxometric properties of the nanoparticles. In this study, polyaspartic acid (PASA)-coated ultrasmall Gd2O3 nanoparticles with an average particle diameter of 2.0 nm were synthesized using the one-pot polyol method. The synthesized nanoparticles exhibited r1 and r2 of 19.1 and = 53.7 s−1mM−1, respectively, (r1 and r2 are longitudinal and transverse water–proton spin relaxivities, respectively) at 3.0 T MR field, approximately 5 and 10 times higher than those of commercial Gd-chelate contrast agents, respectively. The T1 and T2 MR images could be obtained due to an appreciable r2/r1 ratio of 2.80, indicating their potential as a dual-modal T1 and T2 MRI contrast agent.

scholarly journals Uniform Fe3O4/Gd2O3-DHCA nanocubes for dual-mode magnetic resonance imaging

2020 ◽  
Vol 11 ◽  
pp. 1000-1009
Author(s):  
Miao Qin ◽  
Yueyou Peng ◽  
Mengjie Xu ◽  
Hui Yan ◽  
Yizhu Cheng ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Clinical Diagnostics ◽  
Resonance Imaging ◽  
Dual Mode ◽  
Mri Contrast ◽  
Magnetic Resonance Imaging Mri

The multimodal magnetic resonance imaging (MRI) technique has been extensively studied over the past few years since it offers complementary information that can increase diagnostic accuracy. Simple methods to synthesize contrast agents are necessary for the development of multimodal MRI. Herein, uniformly distributed Fe3O4/Gd2O3 nanocubes for T 1–T 2 dual-mode MRI contrast agents were successfully designed and synthesized. In order to increase hydrophilicity and biocompatibility, the nanocubes were coated with nontoxic 3,4-dihydroxyhydrocinnamic acid (DHCA). The results show that iron (Fe) and gadolinium (Gd) were homogeneously distributed throughout the Fe3O4/Gd2O3-DHCA (FGDA) nanocubes. Relaxation time analysis was performed on the images obtained from the 3.0 T scanner. The results demonstrated that r 1 and r 2 maximum values were 67.57 ± 6.2 and 24.2 ± 1.46 mM−1·s−1, respectively. In vivo T 1- and T 2-weighted images showed that FGDA nanocubes act as a dual-mode contrast agent enhancing MRI quality. Overall, these experimental results suggest that the FGDA nanocubes are interesting tools that can be used to increase MRI quality, enabling accurate clinical diagnostics.

Investigation of cyano-bridged coordination nanoparticles Gd3+/[Fe(CN)6]3−/d-mannitol as T1-weighted MRI contrast agents

Nanoscale ◽  
2015 ◽  
Vol 7 (28) ◽  
pp. 11899-11903 ◽  
Author(s):  
M. Perrier ◽  
A. Gallud ◽  
A. Ayadi ◽  
S. Kennouche ◽  
C. Porredon ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Resonance Imaging ◽  
Mri Contrast

Ultra small Gd3+/[Fe(CN)6]3− nanoparticles are investigated in vivo as contrast agents for Magnetic Resonance Imaging.

scholarly journals Nanomolar small-molecule detection using a genetically encoded129Xe NMR contrast agent

2017 ◽  
Vol 8 (11) ◽  
pp. 7631-7636 ◽  
Author(s):  
B. W. Roose ◽  
S. D. Zemerov ◽  
I. J. Dmochowski
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Mri Contrast Agents ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Non Invasive ◽  
Magnetic Resonance Imaging Mri ◽  
Small Molecule Detection ◽  
Nmr Contrast Agent

Genetically encoded magnetic resonance imaging (MRI) contrast agents enable non-invasive detection of specific biomarkersin vivo.

HP-DO3A-based amphiphilic MRI contrast agents and relaxation enhancement through their assembly with polyelectrolytes

2016 ◽  
Vol 4 (45) ◽  
pp. 7241-7248 ◽  
Author(s):  
Qin Zhu ◽  
Heng Yang ◽  
Yuanyuan Li ◽  
Yu Tian ◽  
Wei Wang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Self Assembly ◽  
Mri Contrast Agents ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Good Biocompatibility ◽  
Magnetic Resonance Imaging Mri

HP-DO3A-based amphiphilic magnetic resonance imaging (MRI) contrast agents show electrostatic self-assembly ability with polyelectrolytes, good biocompatibility, and significant contrast enhancement in in vivo imaging.

scholarly journals Imaging and Characterization of Sustained Gadolinium Nanoparticle Release from Next Generation Radiotherapy Biomaterial

Nanomaterials ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 2249
Author(s):  
Romy Mueller ◽  
Michele Moreau ◽  
Sayeda Yasmin-Karim ◽  
Andrea Protti ◽  
Olivier Tillement ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Cancer Cell Line ◽  
Lung Cancer Cell Line ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Image Guided Radiotherapy ◽  
Magnetic Resonance Imaging Mri

Smart radiotherapy biomaterials (SRBs) present a new opportunity to enhance image-guided radiotherapy while replacing routinely used inert radiotherapy biomaterials like fiducials. In this study the potential of SRBs loaded with gadolinium-based nanoparticles (GdNPs) is investigated for magnetic resonance imaging (MRI) contrast. GdNP release from SRB is quantified and modelled for accurate prediction. SRBs were manufactured similar to fiducials, with a cylindrical shell consisting of poly(lactic-co-glycolic) acid (PLGA) and a core loaded with GdNPs. Magnetic resonance imaging (MRI) contrast was investigated at 7T in vitro (in agar) and in vivo in subcutaneous tumors grown with the LLC1 lung cancer cell line in C57/BL6 mice. GdNPs were quantified in-phantom and in tumor and their release was modelled by the Weibull distribution. Gd concentration was linearly fitted to the R1 relaxation rate with a detection limit of 0.004 mmol/L and high confidence level (R2 = 0.9843). GdNP loaded SRBs in tumor were clearly visible up to at least 14 days post-implantation. Signal decrease during this time showed GdNP release in vivo, which was calculated as 3.86 ± 0.34 µg GdNPs release into the tumor. This study demonstrates potential and feasibility for SRBs with MRI-contrast, and sensitive GdNP quantification and release from SRBs in a preclinical animal model. The feasibility of monitoring nanoparticle (NP) concentration during treatment, allowing dynamic quantitative treatment planning, is also discussed.

Monitoring stem cell migration in the nervous system by in vivo magnetic resonance imaging

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S692-S692
Author(s):  
Mathias Hoehn ◽  
Uwe Himmelreich ◽  
Ralph Weber ◽  
Pedro Ramos-Cabrer ◽  
Susanne Wegener ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Nervous System ◽  
Stem Cell ◽  
Cell Migration ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Stem Cell Migration
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