scholarly journals Bee Products in Dermatology and Skin Care

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 556 ◽  
Author(s):  
Anna Kurek-Górecka ◽  
Michał Górecki ◽  
Anna Rzepecka-Stojko ◽  
Radosław Balwierz ◽  
Jerzy Stojko
Keyword(s):  
Natural Products ◽  
Functional Properties ◽  
Phenolic Acids ◽  
Royal Jelly ◽  
Biological Activities ◽  
Biological Properties ◽  
Decenoic Acid ◽  
Pharmacological Activities ◽  
Bee Bread ◽  
Ancient Times

Honey, propolis, bee pollen, bee bread, royal jelly, beeswax and bee venom are natural products which have been used in medicine since ancient times. Nowadays, studies indicate that natural bee products can be used for skin treatment and care. Biological properties of these products are related to flavonoids they contain like: chrysin, apigenin, kaempferol, quercetin, galangin, pinocembrin or naringenin. Several pharmacological activities of phenolic acids and flavonoids, and also 10-hydroxy-trans-2-decenoic acid, which is present in royal jelly, have been reported. Royal jelly has multitude of pharmacological activities: antibiotic, antiinflammatory, antiallergenic, tonic and antiaging. Honey, propolis and pollen are used to heal burn wounds, and they possess numerous functional properties such as: antibacterial, anti-inflammatory, antioxidant, disinfectant, antifungal and antiviral. Beeswax is used for production of cosmetics and ointments in pharmacy. Due to a large number of biological activities, bee products could be considered as important ingredients in medicines and cosmetics applied to skin.

scholarly journals Health Promoting Properties of Bee Royal Jelly: Food of the Queens

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 543
Author(s):  
Nicolas Collazo ◽  
Maria Carpena ◽  
Bernabe Nuñez-Estevez ◽  
Paz Otero ◽  
Jesus Simal-Gandara ◽  
...  
Keyword(s):  
Functional Foods ◽  
Royal Jelly ◽  
Current Knowledge ◽  
Biological Activities ◽  
Biological Properties ◽  
Lower Proportion ◽  
Decenoic Acid ◽  
Health Promoting ◽  
Health Applications ◽  
Key Substances

Royal jelly (RJ) demand is growing every year and so is the market for functional foods in general. RJ is formed by different substances, mainly carbohydrates, proteins, and lipids, but also vitamins, minerals, and phenolic or volatile compounds in lower proportion. Major royal jelly proteins (MRJP) are, together with 10-hydroxy-2-decenoic acid (10-HDA), key substances of RJ due to their different biological properties. In particular, 10-HDA is a unique substance in this product. RJ has been historically employed as health enhancer and is still very relevant in China due to the traditional medicine and the apitherapy. Nowadays, it is mainly consumed as a functional food or is found in supplements and other formulations for its health-beneficial properties. Within these properites, anti-lipidemic, antioxidant, antiproliferative, antimicrobial, neuroprotective, anti-inflammatory, immunomodulatory, antiaging, and estrogenic activities have been reported for RJ or its specific components. This manuscript is aimed at reviewing the current knowledge on RJ components, their assessment in terms of authenticity, their biological activities, and related health applications.

scholarly journals Bal Arısı Ürünleri ve Apiterapi

2019 ◽  
Vol 7 (9) ◽  
pp. 1249
Author(s):  
Sibel Silici
Keyword(s):  
Royal Jelly ◽  
Biological Properties ◽  
Bee Bread ◽  
Therapeutic Activities ◽  
Made In

Honey is the most known among the honeybee products. But apart from honey, there are other bee products that are nutritious and supportive of treatment. Pollen, royal jelly, and propolis are among the bee products that have the highest number of researches made in the last years. However, products such as bee bread (perga) and drone larvae (apilarnil) are very unknown products with little work. Apitherapy; bee and bee products as a method of complementary application in the protection and treatment of certain diseases. However, in order for these applications to be successful, the chemical and biological properties of these products need to be known. For this purpose, the definition, chemical and biological properties and therapeutic activities of bee products are included in this study.

scholarly journals A Review of the Traditional Uses, Phytochemistry and Biological Activities of the Genus Santolina

Planta Medica ◽  
2018 ◽  
Vol 84 (09/10) ◽  
pp. 627-637 ◽  
Author(s):  
Rosa Tundis ◽  
Monica Loizzo
Keyword(s):  
Biological Activities ◽  
Biological Properties ◽  
Future Research ◽  
Chemical Profile ◽  
Bioactive Constituents ◽  
Mediterranean Flora ◽  
Traditional Uses ◽  
Ancient Times ◽  
Analgesic Activities ◽  
First Time

AbstractThe genus Santolina is a taxonomically complex group of plant species widely distributed in the Mediterranean flora and used in traditional medicine since ancient times for their biological properties, including antimicrobial, anti-inflammatory, antispasmodic, digestive, and analgesic activities. Phytochemical investigations of Santolina species have revealed the presence of terpenoids as the main bioactive constituents of the genus. Coumarins and flavonoids were also identified. This review deals, for the first time, with information on the traditional uses, chemical profile, and biological properties of plants of the genus Santolina in order to provide input for future research prospects.

scholarly journals Gmelina arborea: chemical constituents, pharmacological activities and applications

2017 ◽  
Vol 9 (4) ◽  
pp. 528 ◽  
Author(s):  
Charu Arora ◽  
Vinita Tamrakar
Keyword(s):  
Biological Activities ◽  
Chemical Constituents ◽  
Iridoid Glycoside ◽  
Immunomodulatory Activity ◽  
Gmelina Arborea ◽  
Β Cells ◽  
Pharmacological Activities ◽  
Flavone Glycoside ◽  
Ancient Times ◽  
Medicinal Properties

<p><em>Gmelina arborea </em>(<em>G. arborea</em>) is a bio-prospective plant belonging to family verbenaceae. It is widely used for it’s medicinal properties from ancient times. The present paper comprehensively reviewed the traditional uses, medicinal properties and chemical constituents isolated from <em>G. arborea</em> based on literature reported as well as critical analysis of the research. The present article is aimed to provide information on recent advances and new foundations and direction for further exploring <em>G. arborea </em>for its applications. Pharmacological research reviewed that <em>G. arborea </em>possess various medicinal properties and biological  activities including antidiuretic, antidiarrhoeal, antipyretic, antianalgesic, antioxidant, antidiabetic, antihelmintic, antibacterial, antifungal, cardiopotective, insecticidal, antiulcer, gastro-protective, anticancer, antihyperlipidemic and immunomodulatory activity. It has been reported for its applications in treatment of bone fracture, hypertension and regeneration of β-cells. The main chemical constituents of <em>G. arborea</em> include lignans, iridoid glycoside, flavonoids, flavons, flavone glycoside and sterols. The present review provides all the references and beneficial directions to explore further application of <em>G. arborea.</em></p>

scholarly journals Uncovering Novel Peptide Chemistry from Bacterial Natural Products

2021 ◽  
Vol 75 (6) ◽  
pp. 543-547
Author(s):  
Florian Hubrich ◽  
Alessandro Lotti ◽  
Thomas A. Scott ◽  
Jörn Piel
Keyword(s):  
Natural Products ◽  
Bioactive Peptides ◽  
Biological Activities ◽  
Biological Properties ◽  
Post Translational Modifications ◽  
Peptide Chemistry ◽  
Chemical Structures ◽  
Therapeutic Value ◽  
Modified Peptides ◽  
Unique Chemical

Nature has evolved a remarkable array of biosynthetic enzymes that install diverse chemistries into natural products (NPs), bestowing them with a range of important biological properties that are of considerable therapeutic value. This is epitomized by the ribosomally synthesized and post-translationally modified peptides (RiPPs), a class of peptide natural products that undergo extensive post-translational modifications to produce structurally diverse bioactive peptides. In this review, we provide an overview of our research into the proteusin RiPP family, describing characterized members and the maturation enzymes responsible for their unique chemical structures and biological activities. The diverse enzymology identified in the first two proteusin pathways highlights the enormous potential of the RiPP class for new lead structures and novel pharmacophore-installing maturases as biocatalytic tools for drug discovery efforts.

scholarly journals Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 872 ◽  
Author(s):  
Gaber El-Saber Batiha ◽  
Amany Magdy Beshbishy ◽  
Lamiaa G. Wasef ◽  
Yaser H. A. Elewa ◽  
Ahmed A. Al-Sagan ◽  
...  
Keyword(s):  
Allium Sativum ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Biological Properties ◽  
Herbaceous Plant ◽  
Anticancer Activities ◽  
Active Constituent ◽  
Pharmacological Activities ◽  
Traditional Medicines ◽  
Traditional Remedy

Medicinal plants have been used from ancient times for human healthcare as in the form of traditional medicines, spices, and other food components. Garlic (Allium sativum L.) is an aromatic herbaceous plant that is consumed worldwide as food and traditional remedy for various diseases. It has been reported to possess several biological properties including anticarcinogenic, antioxidant, antidiabetic, renoprotective, anti-atherosclerotic, antibacterial, antifungal, and antihypertensive activities in traditional medicines. A. sativum is rich in several sulfur-containing phytoconstituents such as alliin, allicin, ajoenes, vinyldithiins, and flavonoids such as quercetin. Extracts and isolated compounds of A. sativum have been evaluated for various biological activities including antibacterial, antiviral, antifungal, antiprotozoal, antioxidant, anti-inflammatory, and anticancer activities among others. This review examines the phytochemical composition, pharmacokinetics, and pharmacological activities of A. sativum extracts as well as its main active constituent, allicin.

scholarly journals Chemical Characterization and Biological Properties of Royal Jelly Samples From the Mediterranean Area

2020 ◽  
Vol 15 (2) ◽  
pp. 1934578X2090808 ◽  
Author(s):  
Soukaïna El-Guendouz ◽  
Alexandra M. Machado ◽  
Smail Aazza ◽  
Badiaâ Lyoussi ◽  
Maria G. Miguel ◽  
...  
Keyword(s):  
Gas Chromatography ◽  
Total Protein ◽  
Royal Jelly ◽  
Chemical Characterization ◽  
Biological Properties ◽  
Mass Spectrometry Analysis ◽  
Gas Chromatography Mass Spectrometry ◽  
Total Phenolic ◽  
Decenoic Acid ◽  
Spectrometry Analysis

Royal jelly (RJ) is a bee product that has high nutritional value and is beneficial for the human health, earning importance as a functional food. Thus, the characterization of its main biological properties is with high importance. In this work, 6 RJ samples obtained in Morocco, Portugal, and Spain were evaluated in terms of total phenol and flavone/flavonol contents; total protein; 10-hydroxy-2-decenoic acid (10-HDA); volatiles composition; antioxidant and anti-inflammatory properties; and inhibition of tyrosinase, xanthine oxidase (XO), and acetylcholinesterase (AChE) activities. Total phenolic content ranged from 3 to 9 mg gallic acid equivalent/g RJ, and flavone/flavonol content from 0.1 to 0.5 mg quercetin equivalent/g RJ. 10-Hydroxy-2-decenoic acid content varied from 0.9% to 1.2% and total protein from 5.5% to 29.7%. Gas chromatography-flame ionization detector and gas chromatography-mass spectrometry analysis showed RJ volatiles dominated by linolenic acid, 2-decenoic acid, and octanoic acid in variable amounts. The antioxidant activity was monitored through nitric oxide (NO) scavenging activity and hydrogen peroxide (H2O2) scavenging capacity, where the IC50 ranged from 2.3 to 3.4 and 0.2 to 1.5 mg/mL, respectively. Anti-AChE activity IC50 ranged from 0.7 to 4.6 mg/mL, while XO inhibition IC50 ranged from 3.3 to 11.9 mg/mL. The results showed that phenols and flavonoids highly contributed to the RJ biological properties in contrast to 10-HDA and proteins.

Synthetic Approaches for Building Tricyclic Cage-like Motifs Found in Indoxamycins

2020 ◽  
Vol 24 ◽  
Author(s):  
Saqlain Haider ◽  
Ikhlas A. Khan ◽  
Hanfeng Ding ◽  
Amar G. Chittiboyina
Keyword(s):  
Natural Products ◽  
Michael Addition ◽  
Claisen Rearrangement ◽  
Biological Activities ◽  
Cascade Reactions ◽  
Biological Properties ◽  
Starting Material ◽  
Central Core ◽  
Chemical Transformations ◽  
One Pot

Abstract:: Indoxamycins A-F, a novel class of polyketides, were isolated from the saline culture of marine-derived actinomyces by Sato et al. in 2009. Intriguing stereochemical complexity involving tricyclic [5.5.6] cage-like structures with six consecutive chiral centers challenged many organic chemists. Chemical ingenuity, implementation of pioneered reactions along with fine chemical transformations allowed not only the rapid construction of the central core but also allowed minor structural revision and paved the information to delineate the absolute stereostructures of these complex polyketide marine natural products. To achieve the central core structure in indoxamycins A-F, reactions like the Ireland- Claisen rearrangement, an enantioselective 1,6-enyne reductive cyclization, and one-pot cascade reactions of 1,2- addition/oxa-Michael/methylenation were employed. Using the chiral pool approach, the readily available R-carvone was employed as a cost-effective starting material to achieve the concise total syntheses of (-)-indoxamycins A and B, in which Pauson-Khand, Cu-catalyzed Michael addition and tandem retro-oxa-Michael addition/1,2-addition/oxa-Michael addition reactions were employed. The antipodes, (+)-indoxamycins can be easily accessed by simply switching to S-carvone as the starting material. Synthetically prepared indoxamycins A-F are devoid of antiproliferative properties which disagrees with the work reported by Sato and co-workers for (-)-indoxamycins A and F. Nevertheless, ready access to such complex natural products allows probing the untapped potential biological activities of these polyketides including cytotoxicity. A concise overview of interesting, key chemical transformations including named reactions in establishing the architecture of indoxamycins was compiled to inspire organic chemists and help reinvigorate the development of novel strategies for the asymmetric synthesis as well as the development of novel derivatives of indoxamycins with unique physicochemical and biological properties.

scholarly journals A REVIEW: THIAZINES DERIVATIVES TREATED AS POTENTIAL ANTIMICROBIAL AGENTS

2016 ◽  
Vol 10 (1) ◽  
pp. 43 ◽  
Author(s):  
Praveen Kumar Sharma ◽  
Reena Makkar
Keyword(s):  
Natural Products ◽  
Organic Compounds ◽  
Heterocyclic Compounds ◽  
Antimicrobial Agents ◽  
Biological Activities ◽  
Natural World ◽  
Antimicrobial Activities ◽  
Pharmacological Activities ◽  
Strong Reflection ◽  
Anti Inflammatory

ABSTRACTIn recent days, heterocycles and their derivatives have become strong reflection in medicinal research and pharmaceutical fields because of theirpractical pharmacological and biological activities. Organic compounds; mainly heterocyclic compounds are wealthy in natural world and containextra value because their structural subunits are established in many natural products such as enzymes, vitamins, antibiotics, acids, and hormones.Thiazine nucleuses found in compounds have variety of pharmacological activities such as antitumor, antimicrobial, antibacterial, antifungal, antiviral,and anti-inflammatory. This review spotlight on the substituted thiazines with possible antimicrobial activities that are at the present in development.Keywords: Antibacterial, Substituted thiazines, Antimicrobial agents.

scholarly journals Biological Properties of Some Volatile Phenylpropanoids

2016 ◽  
Vol 11 (10) ◽  
pp. 1934578X1601101 ◽  
Author(s):  
Radmila Ilijeva ◽  
Gerhard Buchbauer
Keyword(s):  
Clinical Trials ◽  
Essential Oils ◽  
Mechanism Of Action ◽  
Biological Activities ◽  
Biological Properties ◽  
Anticancer Activities ◽  
Pharmacological Activities ◽  
Prevention And Treatment ◽  
Pharmaceutical Industries ◽  
Almost All

Plants and their extracts are the new field of interest for many scientists and also of some pharmaceutical industries. In order to provide more information for their usage in the prevention and treatment of diseases many clinical trials and researches are being carried out. In this review the biological activities and the mechanism of action of volatile phenylpropanoids (PPs) found in essential oils (EOs) are presented. The aim of this overview is to show that volatile PPs found in EOs can exert many of the biological activities which are generally attributed to EOs. Almost all of the PPs possess antimicrobial, anti-inflammatory and anticancer activities. These are related to the different substitution of the phenylpropane molecule. For each isolated group not only one, but more pharmacological activities can be credited.

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