scholarly journals Sequence Identification of Bioactive Peptides from Amaranth Seed Proteins (Amaranthus hypochondriacus spp.)

Molecules ◽  
2019 ◽  
Vol 24 (17) ◽  
pp. 3033 ◽  
Author(s):  
Alexis Ayala-Niño ◽  
Gabriela Mariana Rodríguez-Serrano ◽  
Luis Guillermo González-Olivares ◽  
Elizabeth Contreras-López ◽  
Patricia Regal-López ◽  
...  
Keyword(s):  
Biological Activity ◽  
Bioactive Peptides ◽  
Continuous Process ◽  
Seed Proteins ◽  
Thrombin Inhibitors ◽  
Amaranthus Hypochondriacus ◽  
Potential Source ◽  
Sequence Identification ◽  
Amaranth Seed ◽  
Bioactive Potential

Amaranthus hypochondriacus spp. is a commonly grown cereal in Latin America, known for its high protein content. The objective of this study was to separate and identify bioactive peptides found in amaranth seeds through enzymatically-assisted hydrolysis using alcalase and flavourzyme. Hydrolysis was carried out for each enzyme separately and compared to two-step continuous process where both enzymes were combined. The biological activity of the resulting three hydrolysates was analyzed, finding, in general, higher bioactive potential of the hydrolysate obtained in a continuous process (combined enzymes). Its fractions were separated by RP-HPLC, and their bioactivity was analyzed. In particular, two fractions showed the highest biological activity as ACE inhibitors with IC50 at 0.158 and 0.134, thrombin inhibitors with IC50 of 167 and 155, and antioxidants in ABTS assay with SC50 at 1.375 and 0.992 mg/L, respectively. Further sequence analysis of the bioactive peptides was carried out using MALDI-TOF, which identified amino acid chains that have not been reported as bioactive so far. Bibliographic survey allowed identification of similarities between peptides reported in amaranth and other proteins. In conclusion, amaranth proteins are a potential source of peptides with multifunctional activity.

Bioactive Peptides in Amaranth (Amaranthus hypochondriacus) Seed

2008 ◽  
Vol 56 (4) ◽  
pp. 1233-1240 ◽  
Author(s):  
C. Silva-Sánchez ◽  
A. P. Barba de la Rosa ◽  
M. F. León-Galván ◽  
B. O. de Lumen ◽  
A. de León-Rodríguez ◽  
...  
Keyword(s):  
Bioactive Peptides ◽  
Amaranthus Hypochondriacus

Amaranth seed proteins: Effect of defatting on extraction yield and on electrophoretic patterns

1995 ◽  
Vol 47 (1) ◽  
pp. 49-53 ◽  
Author(s):  
N. E. Leyva-Lopez ◽  
N. Vasco ◽  
A. P. Barba de la Rosa ◽  
O. Paredes-Lopez
Keyword(s):  
Seed Proteins ◽  
Extraction Yield ◽  
Electrophoretic Patterns ◽  
Amaranth Seed

scholarly journals Nutritional Composition of Grain and Seed Proteins

2021 ◽  
Author(s):  
Adeola Abiola Oso ◽  
Anofi Omotayo Ashafa
Keyword(s):  
Bioactive Peptides ◽  
Raw Materials ◽  
Protein Biosynthesis ◽  
Alternative Therapy ◽  
Health Benefits ◽  
Brown Rice ◽  
Seed Proteins ◽  
Pigeon Pea ◽  
Nutritional Composition ◽  
Functional Health

Grains including wheat, brown rice, millet, oat, and seeds from crops such as pumpkins, almonds, cashew, peas are important staple foods in many parts of the world. Grains and seeds contain proteins and bioactive peptides classified as nutraceuticals. Proteins and peptides are essential components in man’s diet because they provide the raw materials needed for protein biosynthesis and are also a good source of energy. Incorporating grains and seeds into the human diet provide nutritional, functional health benefits, reducing contracting some chronic diseases. They avail the body with a balanced nutrient profile such as carbohydrate, fatty-acid, fibre, B vitamins, minerals and protein. The quest at exploring staples for their functional and health benefits, as well as reducing risks to diseases, has resulted in the investigation of the potentials of grains and seeds, especially the underutilised ones (African yam bean, pigeon pea, Bambara groundnut etc.) for consumption and as an alternative therapy against diseases. This chapter discusses grains and seeds as sources of nutrition protagonist, their nutritive property, health benefits, and the pharmacological properties of bioactive peptides in grains and seeds. However, some under-utilised grain and seed proteins would also be explored for their nutritive potentials.

scholarly journals Sesquiterpene lactones – occurrence and biological properties. A review

2018 ◽  
Vol 73 (3) ◽  
pp. 83-95
Author(s):  
KATARZYNA OLESIŃSKA
Keyword(s):  
Biological Activity ◽  
Secondary Metabolites ◽  
Plant Pathogens ◽  
Higher Plants ◽  
Sesquiterpene Lactones ◽  
Biological Properties ◽  
Chemical Structures ◽  
Potential Source ◽  
Active Substances ◽  
Carbon Pathways

Sesquiterpene lactones are secondary metabolites commonly found in higher plants as well as mosses, lichens, and fungi. Currently, over 5000 of such compounds have been identified with a majority isolated from Asteraceae plants. They are characterised by different chemical structures associated with the presence of various carbon pathways and functional groups, which exert an impact on their pharmacological activity. These colourless substances are soluble in fats, alcohols, or water. They are often bitter ingredients regarded as bitter compounds. They are accumulated mainly in leaves, flower parts and seeds; less frequently, they are present in roots. Sesquiterpene lactones exhibit multidirectional biological activity: some of them have anticancer, anti-inflammatory, antidiabetic, analgesic, antiparasitic, antifungal, and bacteriostatic effects. Therefore, high hopes are placed on the medical and pharmaceutical use of these substances. Lactone compounds are also regarded as a potential source of new active substances used in agriculture to combat plant pathogens

scholarly journals Exploration and profiling of hidden endophytic mycota of marine macroalgae with potential drug leads

2020 ◽  
Vol 367 (11) ◽  
Author(s):  
Manomi Sarasan ◽  
Neema Job ◽  
Jayesh Puthumana ◽  
Ravinesh R ◽  
Prabhakaran M P ◽  
...  
Keyword(s):  
Fungal Endophytes ◽  
Marine Macroalgae ◽  
Bioactive Molecules ◽  
Microbial Pathogens ◽  
Human Pathogens ◽  
Potential Source ◽  
Bioactive Potential ◽  
Marine Flora ◽  
Diversity Studies ◽  
Drug Leads

ABSTRACT Diversity studies of endophytic assemblages are emerging challenges, which unveil novel phenotypes producing interesting chemical entities and a better understanding of their ecological significance. In the present investigation, we selected an extremely complex and unique environment supporting unexplored endophytes, ‘Macroalgae of Kerala coast, India’. Unlike terrestrial flora and mangroves, reports displaying endophytic assemblages of marine flora remain limited, especially from India. The main goal of this study was to expose hidden endophytic fungi from macroalgae and examination of their bioactive potential. An ecological investigation of four red, four green and three brown algae resulted in 133 fungal taxa with 29 distinct morphospecies. Aspergillus and Penicillium were found to be the dominant genera. Penicillium chrysogenum was the sole fungi that contributed 11% of the entire endophytic community. Antimicrobial activity against various aquaculture/human pathogens revealed that around 59% of endophytes inhibited at least one of the pathogens screened. The maximum number of isolates (37%) inhibited Escherichia coli tailed by Aspergillus fumigatus (27%). Antimicrobial profile of fungal endophytes endorses them as a potential source of bioactive molecules that can be explored to find a solution for drug resistance in microbial pathogens.

Synthesis and biological activity of ketomethylene pseudopeptide analogs as thrombin inhibitors

1992 ◽  
Vol 35 (18) ◽  
pp. 3364-3369 ◽  
Author(s):  
Leifeng Cheng ◽  
Christopher A. Goodwin ◽  
Michael F. Schully ◽  
Vijay V. Kakkar ◽  
Goran Claeson
Keyword(s):  
Biological Activity ◽  
Thrombin Inhibitors

Amaranth proteins as potential source of bioactive peptides with enhanced inhibition of enzymatic markers linked with hypertension and diabetes

2021 ◽  
pp. 103308
Author(s):  
Hina Kamal ◽  
Priti Mudgil ◽  
Bincy Bhaskar ◽  
Ajayi Feyisola Fisayo ◽  
Chee-Yuen Gan ◽  
...  
Keyword(s):  
Bioactive Peptides ◽  
Potential Source ◽  
Amaranth Proteins ◽  
Enzymatic Markers

Identification of Bioactive Peptide Sequences from Amaranth (Amaranthus hypochondriacus) Seed Proteins and Their Potential Role in the Prevention of Chronic Diseases

2015 ◽  
Vol 14 (2) ◽  
pp. 139-158 ◽  
Author(s):  
Alvaro Montoya-Rodríguez ◽  
Mario A. Gómez-Favela ◽  
Cuauhtémoc Reyes-Moreno ◽  
Jorge Milán-Carrillo ◽  
Elvira González de Mejía
Keyword(s):  
Chronic Diseases ◽  
Potential Role ◽  
Seed Proteins ◽  
Bioactive Peptide ◽  
Amaranthus Hypochondriacus

Biologically active secondary metabolites from Actinomycetes

2012 ◽  
Vol 7 (3) ◽  
pp. 373-390 ◽  
Author(s):  
Jolanta Solecka ◽  
Joanna Zajko ◽  
Magdalena Postek ◽  
Aleksandra Rajnisz
Keyword(s):  
Biological Activity ◽  
Secondary Metabolites ◽  
Chemical Structure ◽  
Multidrug Resistant ◽  
Biologically Active ◽  
Plant Roots ◽  
Bacterial Strains ◽  
Genus Streptomyces ◽  
Gram Negative ◽  
Potential Source

AbstractSecondary metabolites obtained from Actinomycetales provide a potential source of many novel compounds with antibacterial, antitumour, antifungal, antiviral, antiparasitic and other properties. The majority of these compounds are widely used as medicines for combating multidrug-resistant Gram-positive and Gram-negative bacterial strains. Members of the genus Streptomyces are profile producers of previously-known secondary metabolites. Actinomycetes have been isolated from terrestrial soils, from the rhizospheres of plant roots, and recently from marine sediments. This review demonstrates the diversity of secondary metabolites produced by actinomycete strains with respect to their chemical structure, biological activity and origin. On the basis of this diversity, this review concludes that the discovery of new bioactive compounds will continue to pose a great challenge for scientists.

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