scholarly journals Lignan Glycosides from Urena lobata

Molecules ◽  
2019 ◽  
Vol 24 (15) ◽  
pp. 2850
Author(s):  
Yuan Luo ◽  
Cong Su ◽  
Ning Ding ◽  
Bowen Qi ◽  
Fangfang Jia ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
2D Nmr ◽  
Positive Control ◽  
Raw 264.7 ◽  
Nitric Oxide Production ◽  
Spectrometric Data ◽  
Oxide Production ◽  
Ic50 Values ◽  
Raw 264.7 Macrophage Cells ◽  
Lignan Glycosides

Four new lignan glycosides; urenalignosides A–D (1–4), along with 12 known ones (5–16) were isolated from Urena lobata. Their structures were determined on the basis of extensive spectroscopic and spectrometric data (1D and 2D NMR; IR; CD; and HRESIMS). Compounds 2–4; 6; 7; 10; and 11 showed inhibition of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophage cells with IC50 values in the range of 25.5–98.4 μM (positive control; quercetin; IC50 = 7.2 ± 0.2 μM).

Novel phthalide derivatives from the rhizomes of Ligusticum chuanxiong and their inhibitory effect against lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophage cells

RSC Advances ◽  
2016 ◽  
Vol 6 (66) ◽  
pp. 61037-61046 ◽  
Author(s):  
Wei Wei ◽  
Xiu-Wen Wu ◽  
Xiu-Wei Yang
Keyword(s):  
Nitric Oxide ◽  
Inhibitory Effect ◽  
Raw 264.7 ◽  
Nitric Oxide Production ◽  
Ligusticum Chuanxiong ◽  
Macrophage Cells ◽  
Raw 264.7 Macrophage ◽  
Oxide Production ◽  
Raw 264.7 Macrophage Cells

Five new phthalide derivatives, including one with a new skeleton and one unusual phthalide dimer, were isolated from the rhizomes of Ligusticum chuanxiong.

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