scholarly journals Combined Minimum-Run Resolution IV and Central Composite Design for Optimized Removal of the Tetracycline Drug Over Metal–Organic Framework-Templated Porous Carbon

Molecules ◽  
2019 ◽  
Vol 24 (10) ◽  
pp. 1887 ◽  
Author(s):  
Thuan Van Tran ◽  
Duyen Thi Cam Nguyen ◽  
Hanh T. N. Le ◽  
Long Giang Bach ◽  
Dai-Viet N. Vo ◽  
...  
Keyword(s):  
Central Composite Design ◽  
Removal Efficiency ◽  
Metal Organic Framework ◽  
Response Surfaces ◽  
Diagnostic Plots ◽  
Initial Ph ◽  
Metal Organic ◽  
Ph Level ◽  
Central Composite ◽  
Organic Framework

In this study, a minimum-run resolution IV and central composite design have been developed to optimize tetracycline removal efficiency over mesoporous carbon derived from the metal-organic framework MIL-53 (Fe) as a self-sacrificial template. Firstly, minimum-run resolution IV, powered by the Design–Expert program, was used as an efficient and reliable screening study for investigating a set of seven factors, these were: tetracycline concentration (A: 5–15 mg/g), dose of mesoporous carbons (MPC) (B: 0.05–0.15 g/L), initial pH level (C: 2–10), contact time (D: 1–3 h), temperature (E: 20–40 °C), shaking speed (F: 150–250 rpm), and Na+ ionic strength (G: 10–90 mM) at both low (−1) and high (+1) levels, for investigation of the data ranges. The 20-trial model was analyzed and assessed by Analysis of Variance (ANOVA) data, and diagnostic plots (e.g., the Pareto chart, and half-normal and normal probability plots). Based on minimum-run resolution IV, three factors, including tetracycline concentration (A), dose of MPC (B), and initial pH (C), were selected to carry out the optimization study using a central composite design. The proposed quadratic model was found to be statistically significant at the 95% confidence level due to a low P-value (<0.05), high R2 (0.9078), and the AP ratio (11.4), along with an abundance of diagnostic plots (3D response surfaces, Cook’s distance, Box-Cox, DFFITS, Leverage versus run, residuals versus runs, and actual versus predicted). Under response surface methodology-optimized conditions (e.g., tetracycline concentration of 1.9 mg/g, MPC dose of 0.15 g/L, and pH level of 3.9), the highest tetracycline removal efficiency via confirmation tests reached up to 98.0%–99.7%. Also, kinetic intraparticle diffusion and isotherm models were systematically studied to interpret how tetracycline molecules were absorbed on an MPC structure. In particular, the adsorption mechanisms including “electrostatic attraction” and “π–π interaction” were proposed.

Highly efficient simultaneous ultrasonic-assisted adsorption of methylene blue and rhodamine B onto metal organic framework MIL-68(Al): central composite design optimization

RSC Advances ◽  
2016 ◽  
Vol 6 (33) ◽  
pp. 27416-27425 ◽  
Author(s):  
Mahnaz Saghanejhad Tehrani ◽  
Rouholah Zare-Dorabei
Keyword(s):  
Aqueous Solution ◽  
Methylene Blue ◽  
Rhodamine B ◽  
Low Cost ◽  
Metal Organic Framework ◽  
Simultaneous Removal ◽  
Ultrasonic Assisted ◽  
Metal Organic ◽  
Central Composite ◽  
Organic Framework

In this work, metal organic framework (MIL-68(Al)), was synthesized by a simple, fast and low-cost process for simultaneous removal of methylene blue and Rhodamine B, regarded to be toxic and even carcinogenic, from aqueous solution.

Selective Th(iv) capture from a new metal–organic framework with O− groups

2020 ◽  
Vol 49 (13) ◽  
pp. 4060-4066
Author(s):  
Xiang-Guang Guo ◽  
Jia Su ◽  
Wen-Qi Xie ◽  
Shuai-Nan Ni ◽  
Yun Gao ◽  
...  
Keyword(s):  
Removal Efficiency ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Organic Framework

New MOF adsorbent with functional N+–O− groups was designed. The material shows fast adsorption of Th(iv) and high removal efficiency, and is selective over La(iii), Sm(iii), Ho(iii), Cd(ii), Pb(ii) and K(i) ions.

Extraction of rare earth elements using magnetite@MOF composites

2018 ◽  
Vol 6 (38) ◽  
pp. 18438-18443 ◽  
Author(s):  
Sameh K. Elsaidi ◽  
Michael A. Sinnwell ◽  
Arun Devaraj ◽  
Tim C. Droubay ◽  
Zimin Nie ◽  
...  
Keyword(s):  
Rare Earth ◽  
Rare Earth Elements ◽  
Removal Efficiency ◽  
Metal Organic Framework ◽  
Magnetic Core ◽  
Core Shell ◽  
Metal Organic ◽  
Organic Framework

Magnetic core–shell microspheres were developed to extract rare earth elements (REEs) from aqueous and brine solutions with up to 99.99% removal efficiency. The shell, composed of a thermally and chemically stable functionalized metal–organic framework (MOF), is grown over a synthesized Fe3O4 magnetic core (magnetite@MOF).

scholarly journals Optimization of malachite green dye removal by sepiolite clay using a central composite design

2014 ◽  
Vol 16 (2) ◽  
pp. 339-347 ◽  
Keyword(s):  
Central Composite Design ◽  
Malachite Green ◽  
Removal Efficiency ◽  
Contact Time ◽  
Dye Adsorption ◽  
Malachite Green Dye ◽  
Initial Ph ◽  
Quadratic Effects ◽  
The Individual ◽  
Central Composite

<div> <p>In this study, a four-factor five-level Central Composite Design (CCD) was applied to develop mathematical model and optimize process parameters for malachite green dye (MG) removal from aqueous solutions using sepiolite. The individual, combined, and quadratic effects of four experimental factors (initial pH of solution, contact time, initial dye concentration, and sepiolite dosage) on dye adsorption were studied. Based on the analysis of variance (ANOVA) results, the order of factors from high to low contribution on removal efficiency was found as&nbsp; initial dye concentration, sepiolite dosage, initial dye concentration*initial dye concentration, sepiolite dosage*sepiolite dosage, and contact time with respect to sum of squares. Optimization results showed that the optimal settings for significant experimental factors were initial dye concentration= 77 mg l<sup>-1</sup>, sepiolite dosage= 26 g l<sup>-1</sup>, and contact time= 42 min. At this setting, predicted maximum removal efficiency was over 99%.&nbsp;</p> </div> <p>&nbsp;</p>

scholarly journals Application of MIL-53(Fe) metal-organic framework material in catalytic wet oxidation of phenol

2021 ◽  
Vol 10 (1) ◽  
pp. 28-32
Author(s):  
Danh Huynh Thanh ◽  
Nghi Nguyen Huu ◽  
Du Pham Dinh
Keyword(s):  
Metal Organic Framework ◽  
Phenol Oxidation ◽  
Oxidation Reactions ◽  
Catalytic Wet Oxidation ◽  
X Ray Diffraction ◽  
Initial Ph ◽  
Wide Ph Range ◽  
Metal Organic ◽  
Ph Range ◽  
Organic Framework

In the present study, MIL-53(Fe) metal-organic framework material was applied as catalyst for phenol oxidation reaction in aqueous solution with H2O2 under UV radiation. The materials were characterized using X-ray diffraction (XRD), and fourier transform infrared spectroscopy (FT-IR). The effects of reaction time, initial phenol concentration, and initial pH of the solution on phenol oxidation reactions were investigated. The results indicated that MIL-53(Fe) could work effectively in the wide pH range from 2 to 10. Phenol was quickly oxidized to form simple organic acids, including acetic acid, formic acid and oxalic acid.

scholarly journals APPLICATION OF CENTRAL COMPOSITE DESIGN AND RESPONSE SURFACE METHODOLOGY FOR OPTIMIZATION OF METAL ORGANIC FRAMEWORK: NOVEL CARRIER FOR DRUG DELIVERY

2019 ◽  
pp. 121-127
Author(s):  
PREETI KUSH ◽  
JITENDER MADAN ◽  
PARVEEN KUMAR
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Response Surface Methodology ◽  
Central Composite Design ◽  
Response Surface ◽  
Surface Area ◽  
Metal Organic Framework ◽  
High Yield ◽  
Metal Organic ◽  
Central Composite

Objective: The aim of the present study is to optimize the synthesis method of metal-organic framework (MOF) for high yield and larger surface area with minimum size for efficient drug loading. Materials and Methods: Materials of Institute Lavoisier (MIL)-101-NH2 was synthesized by microwave-assisted hydrothermal method. Central composite design (CCD) under response surface methodology (RSM) was used for optimization. Process optimization was done by validating the model to obtain maximum surface area, maximum yield, and minimum particle size. Final obtained formulation was characterized by particle size and zeta potential, scanning electron microscopy, powder X-ray diffraction, Fourier-transform infrared spectroscopy, Brunauer–Emmett–Teller, and thermogravimetric analysis. Furthermore, gemcitabine (GEM) was used as a model drug for encapsulation in these MOFs for drug delivery carriers. Results: The results revealed that MIL-101-NH2 of average size-158 nm with high yield (70%) and high surface area (2347 m2/g) could be produced easily and reproducibly at a selected condition. This enhances the drug delivery application of the valuable MIL-101-NH2. Optimized values for these parameters were 170°C, 5.00, and 1:1:400 for temperature, pH, and reactant ratio, respectively. MIL-101-NH2 appeared as a promising carrier for GEM delivery with higher encapsulation (77.7±2%) and loading (22.6±2%). Conclusion: The results conclude that processing parameters such as temperature pH and reactant concentration obtained from CCD-RSM significantly affect the main constraints, i.e., surface area, particle size, and yield. The faster encapsulation of GEM in MOF makes them a promising carrier for drug delivery application.

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