scholarly journals Phytochemical Study of Aerial Parts of Leea asiatica

Molecules ◽  
2019 ◽  
Vol 24 (9) ◽  
pp. 1733 ◽  
Author(s):  
Hyun Woo Kil ◽  
Taewoong Rho ◽  
Kee Dong Yoon
Keyword(s):  
2D Nmr ◽  
Healthcare Systems ◽  
Phytochemical Analysis ◽  
Phytochemical Study ◽  
Aerial Parts ◽  
Spectroscopic Analyses ◽  
Antioxidative Effects ◽  
Phenolic Glucoside ◽  
Phytochemical Constituents ◽  
Local Healthcare

Leea asiatica (L.) Ridsdale (Leeaceae) is found in tropical and subtropical countries and has historically been used as a traditional medicine in local healthcare systems. Although L. asiatica extracts have been found to possess anthelmintic and antioxidant-related nephroprotective and hepatoprotective effects, little attention has been paid toward the investigation of phytochemical constituents of this plant. In the current study, phytochemical analysis of isolates from L. asiatica led to the identification of 24 compounds, including a novel phenolic glucoside, seven triterpenoids, eight flavonoids, two phenolic glycosides, four diglycosidic compounds, and two miscellaneous compounds. The phytochemical structures of the isolates from L. asiatica were elucidated using spectroscopic analyses including 1D- and 2D-NMR and ESI-Q-TOF-MS. The presence of triterpenoids and flavonoids supports the evidence for anthelmintic and antioxidative effects of L. asiatica.

scholarly journals Phytochemical Study of Stem and Leaf of Clausena lansium

Molecules ◽  
2019 ◽  
Vol 24 (17) ◽  
pp. 3124 ◽  
Author(s):  
Wenwen Peng ◽  
Xiaoxiang Fu ◽  
Yuyan Li ◽  
Zhonghua Xiong ◽  
Xugen Shi ◽  
...  
Keyword(s):  
Biological Activities ◽  
Healthcare Systems ◽  
Water Soluble ◽  
Phytochemical Analysis ◽  
Phytochemical Study ◽  
Spectroscopic Analyses ◽  
First Time ◽  
Local Healthcare ◽  
Carbazole Alkaloids ◽  
Aromatic Glycoside

Clausena lansium Lour. Skeels (Rutaceae) is widely distributed in South China and has historically been used as a traditional medicine in local healthcare systems. Although the characteristic components (carbazole alkaloids and coumarins) of C. lansium have been found to possess a wide variety of biological activities, little attention has been paid toward the other components of this plant. In the current study, phytochemical analysis of isolates from a water-soluble stem and leaf extract of C. lansium led to the identification of 12 compounds, including five aromatic glycosides, four sesquiterpene glycosides, two dihydrofuranocoumarin glycosides, and one adenosine. All compounds were isolated for the first time from the genus Clausena, including a new aromatic glycoside (1), a new dihydrofuranocoumarin glycoside (6), and two new sesquiterpene glycosides (8 and 9). The phytochemical structures of the isolates were elucidated using spectroscopic analyses including NMR and MS. The existence of these compounds demonstrates the taxonomic significance of C. lansium in the genus Clausena and suggests that some glycosides from this plant probably play a role in the anticancer activity of C. lansium to some extent.

scholarly journals Six New 3,5-Dimethylcoumarins from Chelonopsis praecox, Chelonopsis odontochila and Chelonopsis pseudobracteata

2021 ◽  
Author(s):  
Chang-An Geng ◽  
Zhen-Tao Deng ◽  
Qian Huang ◽  
Chun-Lei Xiang ◽  
Ji-Jun Chen
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
2D Nmr ◽  
Cell Protein ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Aerial Parts ◽  
Spectroscopic Analyses ◽  
New Compounds

AbstractTen 3,5-dimethylcoumarins (1–6 and 8‒11) involving six new ones (1–6), together with a known 3-methylcoumarin (7), were isolated from the aerial parts of three Chelonopsis plants, C. praecox, C. odontochila, and C. pseudobracteata. The structures of the new compounds were determined by extensive HRESIMS, 1D and 2D NMR spectroscopic analyses. According to the substitution at C-5, these coumarins were classified into 5-methyl, 5-hydroxymethyl, 5-formyl, and 5-nor types. All the isolates were assayed for their inhibition on α-glucosidase, protein tyrosine phosphatase 1B, and T-cell protein tyrosine phosphatase in vitro. Graphic Abstract

scholarly journals A PHYTOCHEMICAL STUDY ON EUPATORIUM GLANDULOSUM

2019 ◽  
pp. 77-80
Author(s):  
SILPA M ◽  
SURESH JOGHEE ◽  
HAMSALAKSHMI
Keyword(s):  
Ethyl Acetate ◽  
Water Soluble ◽  
Phytochemical Analysis ◽  
Flavonoid Content ◽  
Plant Materials ◽  
Phytochemical Study ◽  
Aerial Parts ◽  
Standard Procedures ◽  
Soxhlet Method ◽  
Alcohol Ethyl

Objective: Eupatorium glandulosum is a useful medicinal plant belongs to the family Asteraceae. It is traditionally used to treat various diseases such as wound healing, antioxidant, and antiproliferative. The present study was aimed to investigate the physicochemical and phytochemical properties of various extracts of aerial parts of E. glandulosum. Methods: The E. glandulosum plant materials were extracted using the solvents alcohol, ethyl acetate, and chloroform by Soxhlet method. The extracts were screened for physiochemical constants, preliminary phytochemical analysis for carbohydrates, glycosides, alkaloids, flavonoids, phenols, tannins, and saponins. The quantitative phytochemical analysis was carried out for total flavonoid and total phenols using standard procedures. Results: The physiochemical constituents such as total ash, acid-insoluble ash, and water-soluble ash were found to be 14.25% (w/w), 5% (w/w), and 7.30% (w/w), respectively. The preliminary phytochemical screening confirmed the presence of carbohydrates, glycosides, alkaloids, flavonoids, phenols, tannins, and saponins. The flavonoid content of the plant extracts was found to be in the descending order ethyl acetate ˃alcohol ˃chloroform and the phenolic content was found to be alcohol ˃ethyl acetate ˃chloroform. Conclusion: The result showed the presence of phytochemical constituents and higher values of phenolic and flavonoid content make the plant useful for the formulation of the different drugs for human uses for treating various diseases.

LC-MS- and NMR-Guided Isolation of Monoterpene Dimers from Cultivated Thymus vulgaris Varico 3 Hybrid and Their Antityrosinase Activity

Planta Medica ◽  
2019 ◽  
Vol 85 (11/12) ◽  
pp. 941-946 ◽  
Author(s):  
Ilias Stefanis ◽  
Dimitra Hadjipavlou-Litina ◽  
Anna-Rita Bilia ◽  
Anastasia Karioti
Keyword(s):  
Ursolic Acid ◽  
Oleanolic Acid ◽  
Inhibitory Activity ◽  
Kojic Acid ◽  
2D Nmr ◽  
Thymus Vulgaris ◽  
Reference Compound ◽  
Aerial Parts ◽  
Spectroscopic Analyses ◽  
Antityrosinase Activity

AbstractTargeted isolation based on a combination of NMR and HPLC-PDA-MS of a dichloromethane extract of Thymus vulgaris Varico 3 aerial parts afforded one new p-cymene dimer, 6,3′,4′-trihydroxy-5,5′-diisopropyl-2,2′-dimethylbiphenyl (1), together with two known p-cymene derivatives (2 and 3), as well as five known compounds, namely, thymol (4), oleanolic acid (5), ursolic acid (6), cirsimaritin (7), and xanthomicrol (8). The structural elucidation of all compounds was performed by spectroscopic analyses, including 1D and 2D NMR, and HRESIMS experiments. The biphenyls were assayed for their inhibitory activity on tyrosinase. Compounds 2 and 3 showed negligible activity on tyrosinase, while compound 1 effectively inhibited the enzyme with 35% (± 0.3) inhibitory activity, higher than the inhibition of the reference compound kojic acid (18.6 ± 0.02).

scholarly journals Chemical composition and antioxidant activity of Astragalus monspessulanus L. growing in semiarid areas of Algeria

2018 ◽  
Vol 83 (1) ◽  
pp. 31-38 ◽  
Author(s):  
Sawsen Bourezzane ◽  
Hamada Haba ◽  
Christophe Long ◽  
Mohammed Benkhaled
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Activities ◽  
Optical Rotation ◽  
Radical Scavenging ◽  
2D Nmr ◽  
Test Method ◽  
Phytochemical Study ◽  
Butanol Extract ◽  
Aerial Parts ◽  
Nmr Techniques

This paper reports a phytochemical study of the aerial parts of Astragalus monspessulanus L. growing in Algeria. It deals with the isolation and structure elucidation of 13 known compounds. From the n-butanol extract, seven flavonoids 1?7, two saponins and one lignan were isolated. In addition, two phytosterols and one triterpenoid were isolated from the ethyl acetate extract. The structures of all the isolated products were determined by using 1D and 2D-NMR techniques, measurement of optical rotation, mass spectrometry ESI-MS and by comparison with literature data. Furthermore, the antioxidant activity of the n-butanol extract of the aerial parts of Astragalus monspessulanus L. was investigated using the DPPH radical scavenging and ferrous ion chelating assays. The n-butanol extract showed low (EC50 = 2.09?0.434 mg mL-1) to moderate (IC50 = 63.60?0.01 ?g mL-1) antioxidant activities depending on the test method.

scholarly journals Two New Clerodane-type Diterpenoids from Gomphostemma microdon

2009 ◽  
Vol 64 (4) ◽  
pp. 443-446 ◽  
Author(s):  
Rong-Ting Zhang ◽  
Tao Feng ◽  
Xiang-Hai Cai ◽  
Xiao-Dong Luo
Keyword(s):  
2D Nmr ◽  
Aerial Parts ◽  
Spectroscopic Analyses ◽  
Nmr Techniques

Two new clerodane-type diterpenoids, along with seven known compounds have been isolated from the aerial parts of Gomphostemma microdon. All structures were established on the basis of spectroscopic analyses, including application of MS, UV, IR, 1D and 2D NMR techniques.

scholarly journals PRELIMINARY PHYTOCHEMICAL ANALYSIS AND ANTIMICROBIAL ACTIVITY ETHANOLIC EXTRACTS OF DRIED FRUITS OF SOLANUM TORVUM (FAMILY-SOLANACEAE)

2017 ◽  
Vol 9 (3) ◽  
pp. 123
Author(s):  
Lawrence Kalita ◽  
Biswajit Dash ◽  
Uttam Borah ◽  
Juman Deka ◽  
Suvakanta Dash
Keyword(s):  
Antimicrobial Activity ◽  
Ethanolic Extract ◽  
Phytochemical Analysis ◽  
Bacterial Strains ◽  
Solanum Torvum ◽  
Dried Fruits ◽  
Standard Methods ◽  
Aerial Parts ◽  
Ethanolic Extracts ◽  
Phytochemical Constituents

Objective: To study the antimicrobial activity ethanolic extracts of dried fruits of Solanumtorvum (family-solanaceae) along with preliminary phytochemical analysis.Methods: The ethanolic extract of dried fruits of the herb Solanumtorvum (family-solanaceae) were prepared and analyzed for phytochemical constituents using standard methods. The antimicrobial activity of the plant extracts were examined against 2 bacterial strains among one is gram positive and other is gram negative and 2 fungus using agar well diffusion method.Results: The present experiment shows the phytochemical analysis, antimicrobial activity of the ethanolic extract of dried fruits of the plant Solanumtorvum (family-solanaceae). Various phytochemical analysis revealed the presence of alkaloids, saponin, flavonoids, carbohydrates, glycosides, Steroids, proteins and amino acids and tannins. All the extracts of the plant showed antimicrobial activity against most of the test organisms.Conclusion: It can be concluded ethanolic extract of whole aerial parts of the Solanumtorvum (family-solanaceae) contain the high presence of phytochemicals. This extract was found to possess promising antimicrobial activity when compared with the standards.

scholarly journals Phytochemical Screening, Pharmacognostic Evaluation and Biological Activity of Amaranthus spinosus L

2015 ◽  
Vol 1 (4) ◽  
pp. 29-34
Author(s):  
Dharma Prasad Khanal ◽  
B Raut ◽  
K S Dangol
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activity ◽  
Rural Areas ◽  
Herbal Medicines ◽  
Ethanolic Extract ◽  
Phytochemical Analysis ◽  
Amaranthus Spinosus ◽  
Aerial Parts ◽  
Safety Margins ◽  
Phytochemical Constituents

Herbal medicines possess a great demand in both developed and developing countries as a source of primary health care owing to their attributes having wide biological and medicinal activities, high safety margins and lesser costs. People living in rural areas of Nepal depend largely in the herbal medicines for the treatment. The present study concerns with the study of pharmacognostic characteristics, phytochemical constituents and the biological activity of Amaranthus spinosus L. The hexane, chloroform, ethanolic and aqueous extract of its aerial parts were subjected to preliminary phytochemical analysis and detected saponin, carbohydrate, tannin, protein, glycoside, flavonoid and phenol as phytoconstituents. The transverse section of the stem and leaves showed characteristic vascular bundle tissues. All the extracts were used for testing the antimicrobial activity and brine shrimp lethality. No extract showed the antimicrobial activity and ethanolic extract showed LC50 value of 31.62 ppm. Hexane, chloroform and water extracts were less toxic with LC50 values 236.88 ppm,194.98 ppm and 320.71 ppm respectively.DOI: http://dx.doi.org/10.3126/jmmihs.v1i4.11999Journal of Manmohan Memorial Institute of Health Sciences Vol. 1, Issue 4, 2015Page: 29-34

scholarly journals Sugar Containing Compounds and Biological Activities of Lagochilus setulosus

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1755
Author(s):  
Davlat Kh. Akramov ◽  
Nilufar Z. Mamadalieva ◽  
Andrea Porzel ◽  
Hidayat Hussain ◽  
Mthandazo Dube ◽  
...  
Keyword(s):  
Methanolic Extract ◽  
Biological Activities ◽  
2D Nmr ◽  
Septoria Tritici ◽  
2D Nmr Spectroscopy ◽  
Aerial Parts ◽  
Spectroscopic Analyses ◽  
Phytochemical Investigation ◽  
Diphenyl Tetrazolium Bromide

Phytochemical investigation of the methanolic extract obtained from the aerial parts of Lagochilus setulosus (Lamiaceae) afforded the new compound 1-methoxy-3-O-β-glucopyranosyl-α-l-oliose (1) together with five known glycosides, namely sitosterol-3-O-β-glucoside (2), stigmasterol-3-O-β-glucoside (3), pinitol (4), 6β-hydroxyl-7-epi-loganin (5), and chlorotuberoside (6). The structures of these compounds were elucidated by extensive spectroscopic analyses, especially HR-MS, 1D and 2D NMR spectroscopy. The in vitro cytotoxic activity of the methanolic extract and the isolated compounds was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and crystal violet (CV) staining assays. In addition, the antifungal activities of the components were evaluated against Botrytis cinerea, Septoria tritici, and Phytophthora infestans. The anthelmintic potential was determined against Caenorhabditis elegans nematodes. Neither the extract nor the isolated compounds showed promising activity in all the bioassays.

scholarly journals PHYTOCHEMICAL ANALYSIS & IN-VITRO ANTI OBESITY ACTIVITY OF DIFFERENT FRACTIONS OF METHANOLIC EXTRACT OF FAGONIA CRETICA L.

2020 ◽  
pp. 282-286
Author(s):  
Divyang Patel ◽  
Vimal Kumar
Keyword(s):  
Inhibitory Action ◽  
Methanolic Extract ◽  
Age Groups ◽  
Phytochemical Analysis ◽  
Phytochemical Study ◽  
Mortality And Morbidity ◽  
Methanolic Extracts ◽  
Aerial Parts ◽  
Phytochemical Studies

Obesity is one of the most prevalent health concerns among all age groups & populations worldwide, resulting into a significant increase in mortality and morbidity related to metabolic disorders. Targeting one or more enzymes involved in lipid metabolism can be selective for evaluation of anti obesity action of drug. The present study was aimed to evaluate in vitro anti obesity action by inhibiting pancreatic lipase & ᾳ amylase enzyme by various fractions of methanolic extract of aerial parts Fagonia cretica L. along with their phytochemical analysis. The n- hexane (HFFC), Chloroform (CFFC), Ethyl acetate (EAFFC), n-butanol (BFFC) & aqueous fractions (AQFFC) were prepared from methanolic extracts of F. cretica L & were analyzed for qualitative as well as quantitative phytochemical study using reported methods. The qualitative phytochemical studies of prepared extract & fractions showed presence of flavonoids, saponins, phenolics, alkaloids & carbohydrates. All the fractions were then examined for their in-vitro lipase inhibitory & ᾳ amylase inhibitory activities at a concentration level of 50, 100, 150 & 200µg/ml and their percentage inhibitory effects were reported. Among the analyzed samples, BFFC showed highest lipase inhibitory action i.e. 83.02 ± 2.47% as compared to other fractions. EAFFC showed significantly higher ᾳ amylase inhibitory action i.e. 80.22 ± 1.18% as compared to other fractions.

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