Lactoferrin in Aseptic and Septic Inflammation

Maria Stefania Lepanto; Luigi Rosa; Rosalba Paesano; Piera Valenti; Antimo Cutone

doi:10.3390/molecules24071323

Lactoferrin in Aseptic and Septic Inflammation

Molecules ◽

10.3390/molecules24071323 ◽

2019 ◽

Vol 24 (7) ◽

pp. 1323 ◽

Cited By ~ 23

Author(s):

Maria Stefania Lepanto ◽

Luigi Rosa ◽

Rosalba Paesano ◽

Piera Valenti ◽

Antimo Cutone

Keyword(s):

Iron Homeostasis ◽

Inflammatory Activity ◽

Significant Activity ◽

Aseptic Inflammation ◽

Chlamydia Trachomatis Infection ◽

Iron Saturation ◽

Septic Inflammation ◽

Inflammatory Processes ◽

Anti Inflammatory

Lactoferrin (Lf), a cationic glycoprotein able to chelate two ferric irons per molecule, is synthesized by exocrine glands and neutrophils. Since the first anti-microbial function attributed to Lf, several activities have been discovered, including the relevant anti-inflammatory one, especially associated to the down-regulation of pro-inflammatory cytokines, as IL-6. As high levels of IL-6 are involved in iron homeostasis disorders, Lf is emerging as a potent regulator of iron and inflammatory homeostasis. Here, the role of Lf against aseptic and septic inflammation has been reviewed. In particular, in the context of aseptic inflammation, as anemia of inflammation, preterm delivery, Alzheimer’s disease and type 2 diabetes, Lf administration reduces local and/or systemic inflammation. Moreover, Lf oral administration, by decreasing serum IL-6, reverts iron homeostasis disorders. Regarding septic inflammation occurring in Chlamydia trachomatis infection, cystic fibrosis and inflammatory bowel disease, Lf, besides the anti-inflammatory activity, exerts a significant activity against bacterial adhesion, invasion and colonization. Lastly, a critical analysis of literature in vitro data reporting contradictory results on the Lf role in inflammatory processes, ranging from pro- to anti-inflammatory activity, highlighted that they depend on cell models, cell metabolic status, stimulatory or infecting agents as well as on Lf iron saturation degree, integrity and purity.

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Synthesis of some New Azo Compounds of Salicylic Acid Derivatives and Determination of their In vitro Anti-inflammatory Activity

Oriental Journal Of Chemistry ◽

10.13005/ojc/350251 ◽

2019 ◽

Vol 35 (2) ◽

pp. 870-876

Author(s):

Husam Hamza Salman ◽

Huda Salih Abood ◽

Usama Hamid Ramadhan

Keyword(s):

Salicylic Acid ◽

Positive Control ◽

Inflammatory Activity ◽

Azo Compounds ◽

Significant Activity ◽

Diazo Coupling ◽

Salicylic Acid Derivatives ◽

Stability Method ◽

Anti Inflammatory

This study included the preparation of a series of some new azo compounds by diazo coupling aromatic amines with salicylic acid derivatives. The prepared compounds identified using precise elemental analysis (C.H.N.), the results supported the structure of concerned compounds. The synthesized azo compounds also identified by using infrared spectroscopy and 1H-NMR spectroscopy. Anti-inflammatory activity of the compounds were determined in-vitro by human red blood cell (HRBC) membrane stability method, the compounds showed a significant activity to protection of the cell membrane. Other compounds show moderate to low activity, sodium diclofenac was used as positive control.

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IN VITRO ANTI-INFLAMMATORY ACTIVITY OF 4-BENZYLPIPERIDINE

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2016.v9s2.12623 ◽

2016 ◽

pp. 108 ◽

Cited By ~ 1

Author(s):

Jayashree V ◽

Bagyalakshmi S ◽

Manjula Devi K ◽

Richard Daniel D

Keyword(s):

Inhibitory Activity ◽

Protein Denaturation ◽

In Vitro Models ◽

Inflammatory Activity ◽

Significant Activity ◽

Standard Drug ◽

Study Results ◽

Anti Inflammatory ◽

Dose Dependent

ABSTRACT Objective: To study the in vitro anti-inflammatory activity of 4-benzylpiperidine. Methods: This study was conducted to evaluate the in vitro anti-inflammatory activity of 4-benzylpiperidine using in vitro models such as inhibition of albumin denaturation and proteinase inhibitory activity. Results: This study revealed the dose-dependent inhibition of protein denaturation and proteinase inhibitory activity by 4-benzylpiperidine. Conclusion: In the present study, results indicate that the 4-benzylpiperidine possess anti-inflammatory properties. The drug inhibited the heat induced albumin denaturation and proteinase inhibitory activity. It shows dose-dependent significant activity when compared with a standard drug. Hence, this study gives an idea that the 4-benzylpiperidine can be used as a lead compound for designing a potent anti-inflammatory drug which can be used to cure inflammation. Keywords: Anti-inflammatory activity, 4-Benzylpiperidine, Protein denaturation, Proteinase inhibitory activity.

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In vitro and In vivo Anti-inflammatory Activity of the Extracts of Whole Plant Argyreia imbricata (Roth) Sant. & Patel

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11i4.3872 ◽

2020 ◽

Vol 11 (4) ◽

pp. 7317-7322

Author(s):

Sebastin V ◽

Gopalakrishnan G ◽

Sreejith M ◽

Anoob Kumar K I

Keyword(s):

Ethyl Acetate ◽

Diclofenac Sodium ◽

Inflammatory Activity ◽

Albino Rats ◽

Significant Activity ◽

In Vivo Evaluation ◽

Whole Plant ◽

Anti Inflammatory

Plants of the genus Argyreia have ethnomedicinal importance, and several pharmacological activities are also reported. In this study, the anti-inflammatory activity of different extracts of Argyreia imbricata was evaluated by in vitro and in vivo methods. In both evaluations, standard, Diclofenac sodium was used for comparative evaluation. In this study, extraction of powdered whole plant material was done with different solvents viz., petroleum ether, chloroform, ethyl acetate and methanol by soxhelation. In vitro anti-inflammatory activity of all the prepared extracts was evaluated by stabilization of human red blood cell (HRBC) membrane in different temperature and tonicity conditions. Among the six different concentrations of four tested extracts, the ethyl acetate and methanol extracts (1000μg/ml) showed significant activity in the in vitro evaluation. They were selected for the in vivo evaluation on the paw oedema induced by carrageenan on Wistar albino rats. Two doses, 200mg.kg-1 and 400mg.kg-1 of the test extracts were subjected to evaluation. Both the tested extracts showed the activity, particularly, the methanol extract in the dose of 400mg.kg-1 showed significant activity. Results of this study strongly supported the anti-inflammatory activity of the tested extracts. Further, studies on toxicity, identification, isolation of the active constituents may give useful results.

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The Anti-Inflammatory Activity of Pentacyclic Triterpenes In Vitro

Applied Mechanics and Materials ◽

10.4028/www.scientific.net/amm.138-139.1174 ◽

2011 ◽

Vol 138-139 ◽

pp. 1174-1178

Author(s):

Li Ming Bai ◽

Fan Xu Meng ◽

Li Jie Zhao ◽

Ming Zhao

Keyword(s):

Ursolic Acid ◽

Inhibitory Activity ◽

Inflammatory Activity ◽

Nerium Oleander ◽

Significant Activity ◽

Pentacyclic Triterpenes ◽

Anti Inflammatory

The Anti-inflammatory activity of pentacyclic triterpenes, oleananes (1,2), urasanes (3-11), lupanes (12,13), taraxasteranes (14,15), which isolated from Nerium oleander L, were examined. Ursolic acid (5) showed significant activity and compounds (1, 12) and (14) showed weak to modelate activity toward inhibitory activity on ICAM-1 expression.

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RP-HPLC Estimation of Flavonol Derivatives and Phenolic Acids in Capsicum annuum L. and their Correlation with In Vitro Anti-Inflammatory Activity

Current Pharmaceutical Biotechnology ◽

10.2174/1389201020666190930115035 ◽

2020 ◽

Vol 21 (2) ◽

pp. 149-157

Author(s):

Zahra Iqbal ◽

Ausaf Ahmad ◽

Ziyaul Haque ◽

Mohammed S. Khan ◽

Mohd S. Khan ◽

...

Keyword(s):

Capsicum Annuum ◽

Phenolic Acids ◽

Inflammatory Activity ◽

Significant Activity ◽

Strong Positive Correlation ◽

Rp Hplc ◽

Phenolic Constituents ◽

Anti Inflammatory ◽

Flavonol Derivatives

Background: Flavonol derivative and phenolic acids derived from the plants function as free radical scavengers, reducing agents, and quenchers for the formation of singlet oxygen. Flavonoids and phenolic constituents also play an important role in various human diseases and disorders primarily through modulation of inflammatory responses. Objective: To estimate the Flavonol Derivatives (FD) and phenolic acids (PA) in Capsicum annuum (CA) and other important phytochemicals having an anti-inflammatory effect. Method: In the present study, FD and PA were estimated in CA and in vitro anti-inflammatory activity (pilot study) was determined and correlation was established. Results: The results were found to be significant using RP-HPLC. FD and PA were found to be 0.0659±0.0058 and 0.0862±0.0.0134 mg/gram dry weight, respectively. For in vitro anti-inflammatory activity, the inhibition of albumin denaturation and antiproteinase activity was found to be maximum in Quercetin (QE) with 98.230±1.589% and 59.906±1.529%, respectively. Heat-induced hemolysis of erythrocytes was found to be maximum in salicylic acid (SA) (71.830±2.838%). Hypotonicity-induced hemolysis showed significant activity with QE (76.770±3.475%). Lipoxygenase and cyclooxygenase inhibition was found to be maximum in QE with 56.930±4.069% and 61.660±3.135%, respectively. Conclusion: A strong positive correlation of 0.9 was observed between the extract of CA and standard QE and SA against the anti-inflammatory activity. Therefore, the role of FD and PA has been postulated to be an active phytochemical of CA accountable for its anti-inflammatory activity. However further work is desirable to fully elucidate the phytochemicals responsible for their anti-inflammatory activity and to develop better herbal drug formulations.

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Anti-inflammatory Activity of Piper Magnibaccum (Piperaceae)

Natural Product Communications ◽

10.1177/1934578x0800301028 ◽

2008 ◽

Vol 3 (10) ◽

pp. 1934578X0800301 ◽

Cited By ~ 2

Author(s):

Emrizal ◽

Farediah Ahmad ◽

Hasnah M. Sirat ◽

Fadzureena Jamaludin ◽

Nik Musa'adah Mustapha ◽

...

Keyword(s):

Inflammatory Activity ◽

Significant Activity ◽

Inhibition Assay ◽

Ear Edema ◽

Lipoxygenase Inhibition ◽

Edema Model ◽

Mouse Ear ◽

Anti Inflammatory ◽

Mouse Ear Edema

Anti-inflammatory activity of a crude extract of Piper magnibaccum (Piperaceae) and of compounds isolated from it was established using the TPA-induced mouse ear edema model and an in vitro quantitative lipoxygenase inhibition assay. Five compounds were isolated from P. magnibaccum [β-sitosterol, N-isobutyl-(2 E,4 E)-tetradecadienamide, linoleic acid, 13-(4′, 5′-dimethoxytridecanoyl)piperidine, and piperine]. The light petroleum extract of the plant exhibited significant anti-inflammatory activity in both models. N-isobutyl-(2 E,4 E)-tetradecadienamide showed significant activity, with an IE % value of 70.2 + 5.4 in the TPA-induced mouse ear edema model and 87.2 + 0.11 in the in vitro quantitative lipoxygenase inhibition assay.

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