scholarly journals One-Pot Synthesis of Triazolobenzodiazepines Through Decarboxylative [3 + 2] Cycloaddition of Nonstabilized Azomethine Ylides and Cu-Free Click Reactions

Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 601 ◽  
Author(s):  
Xiaoming Ma ◽  
Xiaofeng Zhang ◽  
Weiqi Qiu ◽  
Wensheng Zhang ◽  
Bruce Wan ◽  
...  
Keyword(s):  
Reaction Process ◽  
Azomethine Ylides ◽  
One Pot ◽  
Polycyclic Compounds ◽  
Click Reactions ◽  
One Pot Synthesis

A one-pot synthesis of triazolobenzodiazepine-containing polycyclic compounds is introduced. The reaction process involves a decarboxylative three-component [3 + 2] cycloaddition of nonstabilized azomethine ylides, N-propargylation, and intramolecular click reactions.

scholarly journals Synthesis of Aromatic Rings Embedded in Polycyclic Scaffolds by Triyne Cycloaddition: Competition between Carbonylative and Non-Carbonylative Pathways

Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 595
Author(s):  
Laura Salacz ◽  
Nicolas Girard ◽  
Jean Suffert ◽  
Gaëlle Blond
Keyword(s):  
Aromatic Ring ◽  
Aromatic Rings ◽  
One Pot ◽  
Polycyclic Compounds ◽  
One Pot Synthesis ◽  
The One

Cycloadditions have emerged as some of the most useful reactions for the formation of polycyclic compounds. The carbonylative cycloaddition of triynes can lead to carbonylative and non-carbonylative competitive pathways, each leading to the formation of an aromatic ring. We report herein the one-pot synthesis of fully- and unsymmetrically-substituted tetracyclic 6,5,7,5-troponic and 6,5,6,5-benzenoid scaffolds using pre-organized triynes showing the competition between these two pathways.

A One-Pot Synthesis of Highly Functionalized Indolizines by 1,3-Dipolar Cycloaddition of Azomethine Ylides and Phosphorylated Hydroxyketenimines

Synlett ◽  
2016 ◽  
Vol 27 (18) ◽  
pp. 2601-2605 ◽  
Author(s):  
Issa Yavari ◽  
Maryam Naeimabadi ◽  
Reza Hosseinpour ◽  
Mohammad Halvagar
Keyword(s):  
Azomethine Ylides ◽  
Dipolar Cycloaddition ◽  
One Pot ◽  
One Pot Synthesis
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