scholarly journals Synthesis of Carvone-Derived 1,2,3-Triazoles Study of Their Antioxidant Properties and Interaction with Bovine Serum Albumin

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2991 ◽  
Author(s):  
Armen Galstyan ◽  
Armen Martiryan ◽  
Karine Grigoryan ◽  
Armine Ghazaryan ◽  
Melanya Samvelyan ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Serum Albumin ◽  
Hydrophobic Interactions ◽  
Click Reaction ◽  
Antioxidant Properties ◽  
Synthetic Route ◽  
Efficient Synthesis ◽  
Solubility In Water ◽  
Reversible Binding ◽  
High Antioxidant Activity

Natural L-carvone was utilized as a starting material for an efficient synthesis of some terpenyl-derived 1,2,3-triazoles. Chlorination of carvone, followed by nucleophilic substitution with sodium azide resulted in the preparation of 10-azidocarvone. Subsequent CuAAC click reaction with propargylated derivatives provided an efficient synthetic route to a set of terpenyl-derived conjugates with increased solubility in water. All investigated compounds exhibit high antioxidant activity, which is comparable with that of vitamin C. It was also found that serum albumin and the terpenyl-1,2,3-triazoles hybrids spontaneously undergo reversible binding driven by hydrophobic interactions, suggesting that serum albumin can transport the target triazoles.

scholarly journals The Effect of Rosa spinosissima Fruits Extract on Lactic Acid Bacteria Growth and Other Yoghurt Parameters

Foods ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 1167
Author(s):  
Marek Szołtysik ◽  
Alicja Z. Kucharska ◽  
Anna Sokół-Łętowska ◽  
Anna Dąbrowska ◽  
Łukasz Bobak ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Lactic Acid ◽  
Phenolic Compounds ◽  
Antioxidant Properties ◽  
Positive Influence ◽  
Quality Characteristics ◽  
Additive Concentration ◽  
Bacteria Growth ◽  
High Antioxidant Activity ◽  
Positive Effect

The aim of the study was to evaluate the effect of purified extract from Rosa spinosissima fruits on the quality characteristics and antioxidant properties of yoghurt. The extract, added to yoghurt at a concentration of 0.1% and 0.2%, contained high quantities of phenolic compounds and exhibited high antioxidant activity due to the presence of anthocyanins flavan-3-ols, flavonols and ellagitannins. Yoghurt physicochemical properties, microbiology and antioxidant properties were evaluated after 1, 7 and 14 days of storage at a temperature of 4 °C. The data revealed a positive influence of rose preparation on yoghurt’s microflora and on its other properties. The highest count of traditional yoghurt microflora was observed in samples with 0.2% of extract. Its addition had a positive effect on the yoghurts’ color, giving them a characteristic pink color of an intensity dependent on additive concentration. It also significantly affected the yoghurts’ antioxidant properties, which were stable during storage, as well as the content of the introduced phenolic compounds.

ANTIOXIDANT ACTIVITY OF AMINOTHIAZOL HYDROXYCOUMARIN DERIVATIVES

2013 ◽  
Vol 12 (06) ◽  
pp. 1350058 ◽  
Author(s):  
DAVOOD FARMANZADEH ◽  
MEYSAM NAJAFI
Keyword(s):  
Antioxidant Activity ◽  
Gas Phase ◽  
Antioxidant Activities ◽  
Antioxidant Properties ◽  
Experimental Studies ◽  
Structure Parameters ◽  
Coumarin Derivatives ◽  
Polar Solvents ◽  
B3lyp Method ◽  
High Antioxidant Activity

In this work, the antioxidant properties of the series of 10 aminothiazol hydroxyl coumarin derivatives have been investigated with DFT/B3LYP method. For these antioxidants all reaction enthalpies related to HAT, SPLET, SET-PT mechanisms were calculated in the gas phase and polar solvents. Based on calculated reaction enthalpies (BDE, IP and PA values) the derivations 2, 3 and 4 have the highest antioxidant activity among the studied compounds. Calculated results show that derivations 7, 5 and 6 have the lowest antioxidant activity. The observed theoretical trends for antioxidant activities of studied compounds were similar to trends of previous experimental studies that OH50, TAC50, IC50, CE50 values have been used as a benchmark for measuring the antioxidant properties of these compounds. These results can be useful in synthesis of novel aminothiazol hydroxycoumarin derivatives with high antioxidant activity. Calculated results show that BDE, PA and IP values of studied derivations have linear dependence with structure parameters such as R( O – H ), q( O ) and E HOMO . These observed linear dependences can be useful in synthesis of novel aminothiazol hydroxyl coumarin derivatives with high antioxidant activity. For studied compounds, results indicated that the SPLET and HAT mechanisms represent the thermodynamically preferred mechanism both, in solvent and the gas phase.

scholarly journals Novel agonists of melatonin receptors as promising hypotensive and neuroprotective agents for therapy of glaucoma

2017 ◽  
Vol 63 (1) ◽  
pp. 75-80 ◽  
Author(s):  
N.B. Chesnokova ◽  
O.V. Beznos ◽  
N.A. Lozinskaya ◽  
M.S. Volkova ◽  
E.V. Zaryanova ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Intraocular Pressure ◽  
Superoxide Anion ◽  
Anion Radical ◽  
Antioxidant Properties ◽  
Hypotensive Effect ◽  
Melatonin Receptors ◽  
Neuroprotective Agents ◽  
High Antioxidant Activity ◽  
Therapeutic Tools

Melatonin is a pineal hormone that has a capacity to lower intraocular pressure; it exhibits neuroprotective and antioxidant properties that make it possible to use melatonin in the therapy of glaucoma. Analogs of melatonin having affinity to melatonin receptors are promising candidates for application as antiglaucomatous drugs. Chemical modification of the melatonin structure can in-crease efficiency, bioavailability and selectivity of these analogs. We have designed and synthe-sized a number of new 2-oxindole derivatives – ligands of melatonin MT3 subtype receptors that displayed ability to lower intraocular pressure in normotensive rabbits and high antioxidant activity against hydroxyl radical and superoxide anion-radical. The antioxidant activity of new ligands was several times higher than one of melatonin that makes them prospective therapeutic tools for the diseases that include oxidative stress. The maximal hypotensive effect of analogs was comparable to that of melatonin itself but prolonged. Combination of these properties gives an opportunity of using the presented melatonin analogs in complex therapy of glaucoma.

scholarly journals A Facile Electrochemical Analysis to Determine Antioxidant Activity of Bee Pollen

2013 ◽  
Vol 14 ◽  
pp. 31-38 ◽  
Author(s):  
Abdelkrim Rebiai ◽  
Touhami Lanez
Keyword(s):  
Antioxidant Activity ◽  
Cyclic Voltammetry ◽  
Antioxidant Activities ◽  
Antioxidant Properties ◽  
Electrochemical Analysis ◽  
Polyphenolic Compounds ◽  
Bee Pollen ◽  
Cyclic Voltammetry Method ◽  
High Antioxidant Activity ◽  
Phenolic And Flavonoid

The aim of this study was to determine the phenolic and flavonoid content, and antioxidant properties of tow samples of bee pollen harvested from Algeria. The content of total polyphenolic compounds, flavonoids, and antioxidant activity by the cyclic voltammetry method were determined. The contents of polyphenolic compounds was 22.68 mg/g for the pollen from Blida and 21,9 mg/g for Tipaza pollen. High antioxidant activities were found for the cyclic voltammetry method, with values that ranged from 22,3 to 27,63 mg of AAE·g–1 pollen. The bee pollen of Blida showed high antioxidant activity probably due to the high content of polyphenolic compounds present in pollen.

scholarly journals Potency of endophytic fungi from Nauclea orientalis L. as antioxidant producer

2021 ◽  
Vol 27 (1) ◽  
pp. 34-40
Author(s):  
Elisa Nurnawati ◽  
Hary Widjajanti ◽  
Vivi Hendra Sutandar ◽  
Maulida Harwati ◽  
Eka Amelia ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Secondary Metabolites ◽  
Host Plant ◽  
Secondary Metabolite ◽  
Endophytic Fungi ◽  
Antioxidant Properties ◽  
Antioxidant Compounds ◽  
Genetic Transfer ◽  
High Antioxidant Activity ◽  
Antioxidant Agent

Nauclea orientalis L. is widely distributed in Indonesia. Secondary metabolites such as flavonoids, polyphenols, and saponins are abundant in the bark of N. orientalis L. These compounds have the potential to act as antioxidants. Endophytic fungi, through genetic transfer and coevolution, can produce the same metabolites as their host plant. As a result, understanding the potential of endophytic fungi from N. orientalis L. to produce antioxidant compounds that can be developed is critical. According to the findings of this study, twelve isolates have the potential to produce secondary metabolites with antioxidant properties. Three isolates had high antioxidant activity: DB2 was identified as Aspergillus minisclerotigenes with an IC50 of 21 g/mL containing tannins, terpenes, and flavonoids, AB3 as Colletotrichum perseae with an IC50 of 31 g/mL containing tannins and terpenoids, and AB1 as Diaporthe tulliensis with an IC50 of 48 g/mL containing tannins. The secondary metabolite group has the potential to be developed into an antioxidant agent

Extraction of bioactive proteins from seeds (corn, sorghum, and sunflower) and sunflower byproduct: enzymatic hydrolysis and antioxidant properties

2020 ◽  
Vol 16 ◽  
Author(s):  
Danielle Maria Fernandes do Prado ◽  
Adrielle Borges de Almeida ◽  
Josemar Gonçalves Oliveira Filho ◽  
Cassia Cristina Fernandes Alves ◽  
Mariana Buranelo Egea ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Enzymatic Hydrolysis ◽  
Food Systems ◽  
Protein Extraction ◽  
Proteolytic Enzymes ◽  
Antioxidant Properties ◽  
Natural Antioxidants ◽  
Extraction Methods ◽  
Degree Of Hydrolysis ◽  
High Antioxidant Activity

Background: Food proteins have benefits for human health, which justifies their production and use. In this context, we highlight the use of seeds and byproduct that would be otherwise discarded to produce protein extracts and hydrolyzed proteins generating opportunities to reduce environmental impacts Objective: This work aimed to use different extraction methods to obtain protein extracts from seeds (corn, sorghum, sunflower) and sunflower byproduct to determine their antioxidant activity, and apply different proteolytic enzymes in the hydrolysis of sunflower byproduct Method: The seeds of corn, sorghum, and sunflower, and sunflower byproduct were ground to produce flour and the protein extracts were prepared using five different methods. The bioactivity of fractions was analyzed by different methods (ABTS, DPPH, and FRAP) to evaluate antioxidant activity Results: The most effective methods, which resulted in higher protein extraction and antioxidant activity, were those in which NH4HCO3 (5 mM, pH 8.0) and H2O/C2H6O (2:3) were used in the extraction. The highest protein contents were 797.9, 303.8, and 11296.5 μg/g, and the highest antioxidant activity was 34417.5, 9732.6, and 47473.1 μg TE/g from Soxhlet and Bligh and Dyer defatted extractions for sunflower seed, and sunflower byproduct, respectively. Regarding enzymatic hydrolysis, sunflower byproduct was the substrate that presented the highest degree of hydrolysis (11.06%) when Neutrase® enzyme was used. Enzymatic hydrolysis increased antioxidant activity in the hydrolyzed proteins, approximately 20.0% using Neutrase® and 22.3% using Flavourzyme® treatments. Conclusion: The protein extracts and the hydrolyzed proteins exhibited high antioxidant activity, demonstrating great potential for use as natural antioxidants in food systems

scholarly journals Antioxidant and Antiglycation Properties of Seventeen Fruit Teas Obtained from One Manufacturer

2020 ◽  
Vol 10 (15) ◽  
pp. 5195 ◽  
Author(s):  
Izabela Zieniewska ◽  
Anna Zalewska ◽  
Małgorzata Żendzian-Piotrowska ◽  
Jerzy Robert Ładny ◽  
Mateusz Maciejczyk
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Properties ◽  
Aromatic Amino Acids ◽  
Raw Material ◽  
Quantitative Composition ◽  
Production Location ◽  
Dried Fruit ◽  
Health Promoting ◽  
High Antioxidant Activity

The antioxidant activity of teas depends on the type and quality of the ingredients used in the process of tea production, location of the crops, and manner of the raw material processing. Our study is the first to compare the antioxidant and antiglycation properties of seventeen fruit teas obtained from one manufacturer. We evaluated three different brewing times (3, 5, and 10 min) and two brewing temperatures (70 and 100 °C). We demonstrated that infusions with the longest brewing time reveal the highest antiradical activity, while increased brewing temperature does not significantly affect the assessed parameters. The best antioxidant properties were obtained for the teas made from lemon balm with pear, forest fruits, cranberry with pomegranate, raspberry, and raspberry with linden. Fruit teas owe their high antioxidant activity to the presence of polyphenolic compounds in infusions. Extracts from fruit teas also diminish the oxidation and glycation of albumin in vitro, observed as a decrease in the fluorescence of aromatic amino acids and advanced glycation (AGE) and oxidation (AOPP) protein products levels. In conclusion, in order to prepare fruit teas with the best antioxidant properties, a longer extraction time is needed. The health-promoting properties of dried fruit infusions can be modified by changing the qualitative and quantitative composition of the ingredients.

scholarly journals A New Black Elderberry Dye Enriched in Antioxidants Designed for Healthy Sweets Production

Antioxidants ◽  
2019 ◽  
Vol 8 (8) ◽  
pp. 257 ◽  
Author(s):  
Dżugan Małgorzata ◽  
Pizoń Aleksandra ◽  
Tomczyk Monika ◽  
Kapusta Ireneusz
Keyword(s):  
Antioxidant Activity ◽  
Total Phenolics ◽  
Antioxidant Properties ◽  
Ultra Performance Liquid Chromatography ◽  
Aqueous Extracts ◽  
Organoleptic Properties ◽  
Antioxidant Power ◽  
Spectrophotometric Methods ◽  
Ferric Reducing Antioxidant Power ◽  
High Antioxidant Activity

The aim of the study was to obtain a dye from black elder fruits and flowers and to study their potential in production of jellies with high antioxidant activity. Three dyes were produced by lyophilization of aqueous extracts: (1) fruits dye (F), (2) flowers dye (FL), and (3) fruits and flowers dye (F + FL). Their polyphenol profiles were compared by means of ultra-performance liquid chromatography (UPLC). The antioxidant activity [ferric reducing/antioxidant power assay (FRAP) and DPPH radicals scavenging test and total phenolics were compared by spectrophotometric methods. Jellies were produced from agar and gelatin with the addition of three obtained dyes, and their antioxidant water- and lipid soluble fractions were tested with a Photochem device. Results indicated that black elder fruits are rich in anthocyanins, especially cyanidin-3-O-sambubioside (7.56 mg/g d.w.), while flowers are rich in polyphenols, especially chlorogenic acid (2.82 mg/g d.w.) and rutin (4.04 mg/g d.w.). FL dye exhibited higher antioxidant activity compared to F dye (for about 30–40%), regardless of the used method, whereas F + FL dye was characterized by intermediate antioxidant activity. Jellies produced with the addition of FL dye had better antioxidant properties but unattractive color and unpleasant taste, but the use of F + FL dye created a product of favorable organoleptic properties and antioxidant activity comparable to jellies with F dye addition.

scholarly journals Synthesis of Coumarins Linked With 1,2,3-Triazoles under Microwave Irradiation and Evaluation of their Antimicrobial and Antioxidant Activity

2019 ◽  
Vol 64 (1) ◽  
Author(s):  
Nibin Joy Muthipeedika ◽  
Yadav D Bodke ◽  
Sandeep Telkar ◽  
Vasily A Bakulev
Keyword(s):  
Antioxidant Activity ◽  
In Silico ◽  
Hydrophobic Interactions ◽  
Antioxidant Properties ◽  
Cycloaddition Reaction ◽  
Antibacterial Activities ◽  
Docking Studies ◽  
In Silico Docking ◽  
Antimicrobial And Antioxidant Activity ◽  
Plausible Reason

A series of coumarin derivatives linked with 1,2,3-triazoles has been synthesized by utilizing the copper catalyzed azide-alkyne cycloaddition reaction and were screened for their antimicrobial and antioxidant properties. Some of the compounds displayed promising antibacterial activities (MIC ranging from 5-150 µg/mL) and moderate antifungal activities as compared to the respective standards. The compounds 4k and 4g displayed good antibacterial activity when compared with the standard, Ciprofloxacin, and 4n exhibited better antifungal activity when compared to other synthesized compounds. The in silico docking studies of the active compounds were carried out against the gyrase enzyme and from those studies, it was acknowledged that 4k possessed significant hydrogen bonding and hydrophobic interactions which could be the plausible reason for its superior activity as compared to the other synthesized compounds. The compounds 4h and 4q showed promising antioxidant activity when compared with the standard, BHT, which could be attributed to the presence of electron donating substituents.                                                Resumen. Una serie de derivados de cumarina enlazados con 1,2,3-triazoles fue sintetizada empleando la reacción de cicloadición azida-alquino catalizada con cobre y fue evaluada en sus propiedades antimicrobianas y antioxidantes. Algunos de los compuestos exhibieron actividad antimicrobiana promisoria (intervalo MIC de 5-150 µg/mL) y actividad antifúngica moderada con respecto a los estándares respectivos. Los compuestos 4g y 4k mostraron buena actividad antibacterial con relación al estándar. Fluconazole y 4n exhibieron mejor actividad antifúngica en comparación con el resto de los compuestos. Se llevaron a cabo estudios in silico de modelado molecular e interacción de los compuestos activos con la enzima girasa ADN. De estos estudios se observó que 4k posee enlaces puentes de hidrógeno e interacciones hidrofóbicas significativos, los cuales podrían ser una causa plausible de su actividad mayor a aquélla mostrada por los otros compuestos sintetizados. Los compuestos 4h y 4q mostraron una importante actividad antioxidante comparada con el estándar (BHT), lo cual podría atribuirse a la presencia de sustituyentes electro-donadores

scholarly journals Impact of Different Packaging Systems on Selected Antioxidant Properties of Frozen-Stored Broccoli

2019 ◽  
Vol 26 (2) ◽  
pp. 383-396
Author(s):  
Joanna Kapusta-Duch ◽  
Teresa Leszczyńska ◽  
Barbara Borczak ◽  
Adam Florkiewicz ◽  
Anna Ambroszczyk
Keyword(s):  
Antioxidant Activity ◽  
Vitamin C ◽  
Nutritive Value ◽  
Antioxidant Properties ◽  
Quality Parameters ◽  
Low Density Polyethylene ◽  
Low Density ◽  
Total Polyphenols ◽  
High Antioxidant Activity ◽  
Β Carotene

Abstract Broccoli has a very good nutritive value, high antioxidant activity and pro-healthy potential. Freezing is one of best methods for vegetable storage and broccoli belongs to the group of vegetables subjected to this process on an industrial scale. This work investigates the effect of type of container: low density polyethylene (PE-LD) bags and oriented polystyrene (OPS) boxes on selected quality parameters in frozen broccoli. The experimental material was the broccoli cultivar LordF1. The vegetable was subjected to blanching, freezing and 3-month storage. At the every stage of an experiment the material was examined in terms of: vitamin C content; β-carotene; total polyphenols; and antioxidant potential, which was determined basing on the ability to quench the ABTS˙+ free radical. It has been found that vegetables which were kept frozen for 3 months in two types of container had parallel levels of vitamin C, β-carotene; total polyphenols; and similar antioxidative potential.

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