scholarly journals Multi-Gram Synthesis of Enantiopure 1,5-Disubstituted Tetrazoles Via Ugi-Azide 3-Component Reaction

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2758 ◽  
Author(s):  
Pietro Capurro ◽  
Lisa Moni ◽  
Andrea Galatini ◽  
Christian Mang ◽  
Andrea Basso
Keyword(s):  
Large Scale ◽  
Combinatorial Libraries ◽  
Biological Properties ◽  
Target Product ◽  
Three Component Reaction ◽  
Efficient Route ◽  
Large Scale Synthesis

Tetrazoles have been widely studied for their biological properties. An efficient route for large-scale synthesis of 1,5-disubstituted tetrazoles (1,5-DTs) is presented. The strategy exploits a reductive approach to synthetize a cyclic chiral imine substrate which is then converted into the target product through an Ugi-azide three-component reaction (UA-3CR). The final products are equipped with additional functionalities which can be further elaborated for the generation of combinatorial libraries of enantiopure heterocycles.

Exogenous Directing Group Free, Ligand-Enabled gamma-C(sp3)–H Arylation of Free Primary Aliphatic Amines and α-Amino Esters

2019 ◽  
Author(s):  
Yongzheng Ding ◽  
Shuai Fan ◽  
Xiaoxi Chen ◽  
yuzhen gao ◽  
Gang Li
Keyword(s):  
Amino Acids ◽  
Large Scale ◽  
Free Ligand ◽  
Aliphatic Amines ◽  
Rapid Synthesis ◽  
Amino Esters ◽  
Directing Group ◽  
Large Scale Synthesis ◽  
Primary Aliphatic Amines

A Pdᴵᴵ-catalyzed, ligand-enabled gamma-C(sp3)–H arylation of free primary aliphatic amines and amino esters without using an exogenous directing group is reported. This reaction is compatible with unhindered free aliphatic amines, and it is also be applicable to the rapid synthesis of biologically and synthetically valuable unnatural α-amino acids. Large scale synthesis is also feasible using this method.<br>

A Simplified Protocol for the ortho-Deuteration of Acidic Aromatic Compounds in D2O

2019 ◽  
Author(s):  
Alyssa Garreau ◽  
Hanyang Zhou ◽  
Michael Young
Keyword(s):  
Carboxylic Acid ◽  
Aromatic Compounds ◽  
Large Scale ◽  
Simplified Approach ◽  
Directing Group ◽  
Large Scale Synthesis

<div>Methods to catalytically introduce deuterium in synthetically useful yields ortho to a carboxylic acid directing group on arenes typically requires D2 or CD3CO2D, which makes using these approaches cost prohibitive for large scale synthesis (equipment and reagent costs respectively). Herein we present a simplified approach using catalytic RhIII and D2O as deuterium source, and show its application to H/D exchange on various acidic substrates.</div>

A Simplified Protocol for the ortho-Deuteration of Acidic Aromatic Compounds in D2O

2019 ◽  
Author(s):  
Alyssa Garreau ◽  
Hanyang Zhou ◽  
Michael Young
Keyword(s):  
Carboxylic Acid ◽  
Aromatic Compounds ◽  
Large Scale ◽  
Simplified Approach ◽  
Directing Group ◽  
Large Scale Synthesis

<div>Methods to catalytically introduce deuterium in synthetically useful yields ortho to a carboxylic acid directing group on arenes typically requires D2 or CD3CO2D, which makes using these approaches cost prohibitive for large scale synthesis (equipment and reagent costs respectively). Herein we present a simplified approach using catalytic RhIII and D2O as deuterium source, and show its application to H/D exchange on various acidic substrates.</div>

Improved and Large-Scale Synthesis of N-methyl-D-aspartic Acid

2015 ◽  
Vol 12 (2) ◽  
pp. 197-201 ◽  
Author(s):  
Liang Xi ◽  
Di Wu ◽  
Hong-You Zhu ◽  
Cong-Hai Zhang ◽  
Yi Jin ◽  
...  
Keyword(s):  
Aspartic Acid ◽  
Large Scale ◽  
Large Scale Synthesis

Large-scale synthesis of copper nanoparticles by chemically controlled reduction for applications of inkjet-printed electronics

2008 ◽  
Vol 19 (41) ◽  
pp. 415604 ◽  
Author(s):  
Youngil Lee ◽  
Jun-rak Choi ◽  
Kwi Jong Lee ◽  
Nathan E Stott ◽  
Donghoon Kim
Keyword(s):  
Copper Nanoparticles ◽  
Large Scale ◽  
Printed Electronics ◽  
Large Scale Synthesis

Large-scale synthesis of ionic liquid [BMIM]Br in a microbore tube

2021 ◽  
Author(s):  
Nirvik Sen ◽  
Sameer Ekhande ◽  
K.K. Singh ◽  
S. Mukhopadhyay ◽  
R.S. Sirsam ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Large Scale ◽  
Large Scale Synthesis

scholarly journals A Facile Urea-Assisted Thermal Decomposition Process of TiO2 Nanoparticles and Their Photocatalytic Activity

Coatings ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 165
Author(s):  
Sandip Madhukar Deshmukh ◽  
Mohaseen S. Tamboli ◽  
Hamid Shaikh ◽  
Santosh B. Babar ◽  
Dipak P. Hiwarale ◽  
...  
Keyword(s):  
Thermal Decomposition ◽  
Photocatalytic Activity ◽  
Tio2 Nanoparticles ◽  
Large Scale ◽  
Ultra Violet ◽  
Tio2 Nps ◽  
Transmission Electron ◽  
Structures And Properties ◽  
Ft Ir ◽  
Large Scale Synthesis

In the present work, we have reported a facile and large-scale synthesis of TiO2 nanoparticles (NPs) through urea-assisted thermal decomposition of titanium oxysulphate. We have successfully synthesized TiO2 NPs by using this effective route with different weight ratios of titanium oxysulphate: urea. The structures and properties of TiO2 NPs were confirmed by scanning electron microscope) (SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), fourier transform infrared spectroscopy (FT-IR), ultra violet–visible spectroscopy (UV-vis), and photoluminescence (Pl) techniques. XRD demonstrated that TiO2 NPs holds of anatase crystal phase with crystallizing size 14–19 nm even after heating at 600 °C. TGA, SEM, and TEM images reveal urea’s role, which controls the size, morphology, and aggregation of TiO2 NPs during the thermal decomposition. These TiO2 NPs were employed for photodegradation of Methyl Orange (MO) in the presence of ultraviolet (UV) radiation. An interesting find was that the TiO2 NPs exhibited better photocatalytic activity and excellent recycling stability over several photodegradation cycles. Furthermore, the present method has a great perspective to be used as an efficient method for large-scale synthesis of TiO2 NPs.

Large-scale synthesis of colloidal bowl-shaped particles

Soft Matter ◽  
2021 ◽  
Author(s):  
Kazem V Edmond ◽  
Joon Suk Oh ◽  
Gi-Ra Yi ◽  
Andrew D Hollingsworth ◽  
Stefano Sacanna ◽  
...  
Keyword(s):  
Large Scale ◽  
Colloidal Particles ◽  
General Procedure ◽  
Seed Particles ◽  
Large Scale Synthesis ◽  
Emulsion Templating ◽  
Templating Technique

We describe a general procedure for the large-scale fabrication of bowl-shaped colloidal particles using an emulsion templating technique. Following this method, single polymeric seed particles become located on individual oil...

In-situ construction of direct Z-scheme AgBr/α-Ag2WO4 heterojunction with promoted spatial charge migration and photocatalytic performance

2021 ◽  
Author(s):  
Xiao-Ya Zhai ◽  
Yifan Zhao ◽  
Guo-Ying Zhang ◽  
Bing-Yu Wang ◽  
Qi-Yun Mao
Keyword(s):  
Anion Exchange ◽  
Large Scale ◽  
Room Temperature ◽  
Photocatalytic Performance ◽  
Charge Migration ◽  
Time Saving ◽  
Spatial Charge ◽  
Construction Strategy ◽  
Large Scale Synthesis

In the work, a direct Z-scheme AgBr/α-Ag2WO4 heterojunction was prepared by in-situ anion exchange at room temperature. The construction strategy is energy- and time-saving for large scale synthesis. The α-Ag2WO4...

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