scholarly journals Phycocyanin Protects Against UVB-induced Apoptosis Through the PKC α/βII-Nrf-2/HO-1 Dependent Pathway in Human Primary Skin Cells

Molecules ◽  
2018 ◽  
Vol 23 (2) ◽  
pp. 478 ◽  
Author(s):  
Ki Mo Kim ◽  
Joo Young Lee ◽  
A-Rang Im ◽  
Sungwook Chae
Keyword(s):  
Skin Cells ◽  
Primary Skin Cells ◽  
Induced Apoptosis ◽  
Dependent Pathway

scholarly journals Zamzam water protects cancer cells from chemotherapy-induced apoptosis via mitogen-activated protein kinase-dependent pathway

2019 ◽  
Vol 118 ◽  
pp. 109376
Author(s):  
Abdul Khalid Siraj ◽  
Rafia Begum ◽  
Roxanne Melosantos ◽  
Wafaa Albalawy ◽  
Jehan Abboud ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Cancer Cells ◽  
Mitogen Activated Protein Kinase ◽  
Mitogen Activated Protein ◽  
Induced Apoptosis ◽  
Dependent Pathway

Abstract 590: Increased Endoplasmic Reticulum Stress in Atherosclerotic Plaques Associated With Acute Coronary Syndrome

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Masafumi Myoishi ◽  
Testuo Minamino ◽  
Masafumi Kitakaze
Keyword(s):  
Endoplasmic Reticulum ◽  
Coronary Artery ◽  
Er Stress ◽  
Atherosclerotic Plaques ◽  
Coronary Syndrome ◽  
Er Chaperone ◽  
Unstable Plaques ◽  
Induced Apoptosis ◽  
Stress Dependent ◽  
Dependent Pathway

Background Endoplasmic reticulum (ER) responds to various stresses by up-regulation of ER chaperones, and prolonged ER stress eventually causes apoptosis. Although apoptosis is considered to be essential for the progression and rupture of atherosclerotic plaques, the influence of ER stress and apoptosis on rupture of unstable coronary plaques remains unclear. Methods and Results We obtained 152 coronary artery segments at autopsy and 40 atherectomy specimens from 71 and 40 patients, respectively . Smooth muscle cells (SMCs) and macrophages in the fibrous caps of thin cap atheroma and ruptured plaques, but not in the fibrous caps of thick cap atheroma and fibrous plaques, showed a marked increase in the expression of ER chaperone and numbers of apoptotic cells. ER chaperones also expressed higher in atherectomy specimens from patients with unstable angina pectoris than with stable angina. To explore the plausible molecular mechanism of activation of ER stress and the mechanistic link to apoptosis, we investigated plaque lipids such as oxysterols. Among oxysterols, expression of 7-ketocholesterol was increased in the fibrous caps of thin cap atheroma compared with thick cap atheroma. Treatment of either cultured coronary artery SMCs or THP-1 cells with 7-ketocholesterol induced upregulation of ER chaperones and apoptosis, while these changes were prevented by antioxidants. We also investigated possible signaling pathways for ER-initiated apoptosis and found that the CHOP (a transcription factor induced by ER stress)-dependent pathway was activated in unstable plaques. In addition, knockdown of CHOP expression by siRNA decreased ER stress-dependent death of cultured coronary artery SMCs and THP-1 cells. Conclusions Increased ER stress occurs in unstable plaques. Our findings suggest that ER stress-induced apoptosis of SMCs and macrophages may contribute to plaque vulnerability.

scholarly journals Solid lipid nanoparticle induced apoptosis of macrophages via a mitochondrial-dependent pathway in vitro and in vivo

2019 ◽  
Vol Volume 14 ◽  
pp. 3283-3295 ◽  
Author(s):  
Wan-Li Liang ◽  
Lan Xiao ◽  
Hong-Wei Gu ◽  
Xiao-Jun Li ◽  
Yu-Sang Li ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticle ◽  
Solid Lipid ◽  
Lipid Nanoparticle ◽  
Induced Apoptosis ◽  
Dependent Pathway

Flexible Nanosomes (SECosomes) Enable Efficient siRNA Delivery in Cultured Primary Skin Cells and in the Viable Epidermis of Ex Vivo Human Skin

2010 ◽  
Vol 20 (23) ◽  
pp. 4077-4090 ◽  
Author(s):  
Barbara Geusens ◽  
Mireille Van Gele ◽  
Sien Braat ◽  
Stefaan C. De Smedt ◽  
Marc C. A. Stuart ◽  
...  
Keyword(s):  
Human Skin ◽  
Ex Vivo ◽  
Sirna Delivery ◽  
Skin Cells ◽  
Viable Epidermis ◽  
Primary Skin Cells

An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes

Nature ◽  
1995 ◽  
Vol 376 (6541) ◽  
pp. 596-599 ◽  
Author(s):  
Tomohiko Tamura ◽  
Masahiko Ishihara ◽  
Marc S. Lamphier ◽  
Nobuyuki Tanaka ◽  
Isao Oishi ◽  
...  
Keyword(s):  
Dna Damage ◽  
T Lymphocytes ◽  
Activated T Lymphocytes ◽  
Induced Apoptosis ◽  
Dependent Pathway

Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria-dependent pathway in human osteosarcoma U-2 OS cells

2010 ◽  
Vol 54 (11) ◽  
pp. 1585-1595 ◽  
Author(s):  
Wen-Wen Huang ◽  
Yu-Jen Chiu ◽  
Ming-Jen Fan ◽  
Hsu-Feng Lu ◽  
Hsiu-Feng Yeh ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Human Osteosarcoma ◽  
Induced Apoptosis ◽  
Dependent Pathway

Stobadine inhibits doxorubicin-induced apoptosis through a caspase-9 dependent pathway in P815 mastocytoma cells

2007 ◽  
Vol 31 (9) ◽  
pp. 979-984 ◽  
Author(s):  
E. Ümit Bağrıaçık ◽  
Kadriye Uslu ◽  
Erkan Yurtçu ◽  
Milan Stefek ◽  
Çimen Karasu
Keyword(s):  
Caspase 9 ◽  
Mastocytoma Cells ◽  
Induced Apoptosis ◽  
Dependent Pathway ◽  
P815 Mastocytoma
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