scholarly journals Magnetic Marking and Intraoperative Detection of Primary Draining Lymph Nodes in High-Risk Prostate Cancer Using Superparamagnetic Iron Oxide Nanoparticles: Additional Diagnostic Value

Molecules ◽  
2017 ◽  
Vol 22 (12) ◽  
pp. 2192 ◽  
Author(s):  
Alexander Winter ◽  
Svenja Engels ◽  
Lena Reinhardt ◽  
Clara Wasylow ◽  
Holger Gerullis ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Iron Oxide ◽  
High Risk ◽  
Superparamagnetic Iron Oxide ◽  
Diagnostic Value ◽  
Oxide Nanoparticles ◽  
High Risk Prostate Cancer ◽  
Intraoperative Detection ◽  
Risk Prostate Cancer ◽  
Draining Lymph Nodes

scholarly journals Ultra-small superparamagnetic iron oxide contrast agents for lymph node staging of high-risk prostate cancer

2018 ◽  
Vol 7 (S4) ◽  
pp. S453-S461 ◽  
Author(s):  
Marcin Czarniecki ◽  
Filippo Pesapane ◽  
Bradford J. Wood ◽  
Peter L. Choyke ◽  
Baris Turkbey
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Iron Oxide ◽  
High Risk ◽  
Contrast Agents ◽  
Superparamagnetic Iron Oxide ◽  
Lymph Node Staging ◽  
High Risk Prostate Cancer ◽  
Risk Prostate Cancer

scholarly journals Accuracy of Magnetometer-Guided Sentinel Lymphadenectomy after Intraprostatic Injection of Superparamagnetic Iron Oxide Nanoparticles in Prostate Cancer: The SentiMag Pro II Study

2019 ◽  
Author(s):  
Alexander Winter ◽  
Svenja Engels ◽  
Philipp Goos ◽  
Marie-Christin Süykers ◽  
Stefan Gudenkauf ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Iron Oxide ◽  
High Risk ◽  
Diagnostic Accuracy ◽  
Iron Oxide Nanoparticles ◽  
Predictive Value ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles

Targeted radioisotope-guided sentinel lymph node dissection (sLND) has shown high diagnostic accuracy in prostate cancer (PCa). To overcome the downsides of the radioactive tracers, magnetometer-guided sLND using superparamagnetic iron oxide nanoparticles (SPIONs) was successfully applied in PCa. This prospective study (SentiMag Pro II, DRKS00007671) determined the diagnostic accuracy of magnetometer-guided sLND in intermediate- and high-risk PCa. Fifty intermediate- or high-risk PCa patients (PSA≥10 ng/ml and/or Gleason score ≥7; median PSA 10.8 ng/ml, IQR 7.4–19.2 ng/ml) were enrolled. After intraprostatic SPIONs injection a day earlier, patients underwent magnetometer-guided sLND and eLND, followed by radical prostatectomy. SLNs were detected in vivo and in ex vivo samples. Diagnostic accuracy of sLND was assessed using eLND as the reference. SLNs were detected in all patients (detection rate 100%), with 447 SLNs (median 9, IQR 6–12) being identified and 966 LNs (median 18, IQR 15-23) being removed. Thirty-six percent (18/50) of patients had LN metastases (median 2, IQR 1–3). Magnetometer-guided sLND had 100% sensitivity, 97.0% specificity, 94.4% positive predictive value, 100% negative predictive value, 0.0% false negative rate, and 3.0% additional diagnostic value (LN metastases only in SLNs outside the eLND template). In vivo, one positive SLN/LN-positive patient was missed, resulting in a sensitivity of 94.4%. In conclusion, this new magnetic sentinel procedure has high accuracy for nodal staging in intermediate- and high-risk PCa. The reliability of intraoperative SLN detection using this magnetometer system requires verification in further multicentric studies.

scholarly journals Magnetic Marking and Intraoperative Detection of Primary Draining Lymph Nodes in High-Risk Prostate Cancer Using Superparamagnetic Iron Oxide Nanoparticles: Additional Diagnostic Value?

2017 ◽  
Author(s):  
Alexander Winter ◽  
Svenja Engels ◽  
Lena Reinhardt ◽  
Clara Wasylow ◽  
Holger Gerullis ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
High Risk ◽  
Lymph Nodes ◽  
Lymph Node Metastases ◽  
Superparamagnetic Iron Oxide ◽  
Diagnostic Value ◽  
Sentinel Lymph Nodes ◽  
Oxide Nanoparticles ◽  
Node Metastases

Sentinel lymph node dissection (sLND) using a magnetometer and superparamagnetic iron oxide nanoparticles (SPIONs) as a tracer was successfully applied in prostate cancer (PCa). Radioisotope-guided sLND combined with extended pelvic LND (ePLND) achieved better node removal, increasing the number of affected nodes or the detection of sentinel lymph nodes outside the established ePLND template. We determined the diagnostic value of additional magnetometer-guided sLND after intraprostatic SPION-injection in high-risk PCa. This retrospective study included 104 high-risk PCa patients (PSA >20 ng/ml and/or Gleason score ≥8 and/or cT2c) from a prospective cohort who underwent radical prostatectomy with magnetometer-guided sLND and ePLND. The diagnostic accuracy of sLND was assessed using ePLND as a reference standard. Lymph node metastases were found in 61 of 104 patients (58.7%). sLND had a 100% diagnostic rate, 96.6% sensitivity, 95.6% specificity, 96.6% positive predictive value, 95.6% negative predictive value, 3.4% false negative rate, and 4.4% false positive rate (detecting lymph node metastases outside the ePLND template). These findings demonstrate the high sensitivity and additional diagnostic value of magnetometer-guided sLND, exceeding that of ePLND through the individualized extension of PLND or the detection of sentinel lymph nodes / lymph node metastases outside the established node template in high-risk PCa.

scholarly journals The significance of pelvis positron emission tomography and magnetic resonance tomography for surgical planning in patients with high risk prostate cancer

2019 ◽  
Vol 9 (1) ◽  
pp. 38-41
Author(s):  
M. Sh. Shikhzadaev ◽  
M. I. Shkolnik ◽  
A. A. Stanjevskiy ◽  
O. A. Bogomolov ◽  
A. L. Dolbov
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Surgical Planning ◽  
Magnetic Resonance Tomography ◽  
Diagnostic Value ◽  
High Risk Prostate Cancer ◽  
Positron Emission ◽  
Pet Ct ◽  
Risk Prostate Cancer ◽  
Pet Ct Scan

The article concerns the diagnostic value of PET/CT scan for surgical planning in patients with high‑risk prostate cancer.

390: Durable Cancer Control in High Risk Prostate Cancer Patients Treated with Radical Prostatectomy

2007 ◽  
Vol 177 (4S) ◽  
pp. 130-130
Author(s):  
Markus Graefen ◽  
Jochen Walz ◽  
Andrea Gallina ◽  
Felix K.-H. Chun ◽  
Alwyn M. Reuther ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Cancer Patients ◽  
Cancer Control ◽  
High Risk Prostate Cancer ◽  
Risk Prostate Cancer

1413: Radical Retropubic Prostatectomy in Patients with High Risk Prostate Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 466-466
Author(s):  
David Thüer ◽  
Carsten H. Ohlmann ◽  
David Pfister ◽  
Dina Sahi ◽  
Udo Engelmann ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Radical Retropubic Prostatectomy ◽  
Retropubic Prostatectomy ◽  
High Risk Prostate Cancer ◽  
Risk Prostate Cancer

820: Adjuvant Weekly Docetaxel for High-Risk Prostate Cancer Patients after Radical Prostatectomy

2005 ◽  
Vol 173 (4S) ◽  
pp. 222-222 ◽  
Author(s):  
Adam S. Kibel ◽  
Joel Picus ◽  
Michael S. Cookson ◽  
Bruce Roth ◽  
David F. Jarrard ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Cancer Patients ◽  
Weekly Docetaxel ◽  
High Risk Prostate Cancer ◽  
Risk Prostate Cancer
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