scholarly journals Solid Lipid Nanoparticles of Albendazole for Enhancing Cellular Uptake and Cytotoxicity against U-87 MG Glioma Cell Lines

Molecules ◽  
2017 ◽  
Vol 22 (11) ◽  
pp. 2040 ◽  
Author(s):  
Gregory Marslin ◽  
Karthik Siram ◽  
Xiang Liu ◽  
Vinoth Khandelwal ◽  
Xiaolei Shen ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cellular Uptake ◽  
Solid Lipid Nanoparticles ◽  
Glioma Cell ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Glioma Cell Lines

Anti-glioma activity and the mechanism of cellular uptake of asiatic acid-loaded solid lipid nanoparticles

2016 ◽  
Vol 500 (1-2) ◽  
pp. 305-315 ◽  
Author(s):  
Tanem Garanti ◽  
Aneta Stasik ◽  
Andrea Julie Burrow ◽  
Mohamed A. Alhnan ◽  
Ka-Wai Wan
Keyword(s):  
Cellular Uptake ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Asiatic Acid ◽  
Solid Lipid

scholarly journals Soft Cationic Nanoparticles for Drug Delivery: Production and Cytotoxicity of Solid Lipid Nanoparticles (SLNs)

2019 ◽  
Vol 9 (20) ◽  
pp. 4438 ◽  
Author(s):  
Amélia Silva ◽  
Carlos Martins-Gomes ◽  
Tiago Coutinho ◽  
Joana Fangueiro ◽  
Elena Sanchez-Lopez ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Surface Properties ◽  
Cell Lines ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Cationic Lipids ◽  
Solid Lipid ◽  
Mcf 7

The surface properties of nanoparticles have decisive influence on their interaction with biological barriers (i.e., living cells), being the concentration and type of surfactant factors to have into account. As a result of different molecular structure, charge, and degree of lipophilicity, different surfactants may interact differently with the cell membrane exhibiting different degrees of cytotoxicity. In this work, the cytotoxicity of two cationic solid lipid nanoparticles (SLNs), differing in the cationic lipids used as surfactants CTAB (cetyltrimethylammonium bromide) or DDAB (dimethyldioctadecylammonium bromide), referred as CTAB-SLNs and DDAB-SLNs, respectively, was assessed against five different human cell lines (Caco-2, HepG2, MCF-7, SV-80, and Y-79). Results showed that the cationic lipids used in SLN production highly influenced the cytotoxic profile of the particles, with CTAB-SLNs being highly cytotoxic even at low concentrations (IC50 < 10 µg/mL, expressed as CTAB amount). DDAB-SLNs produced much lower cytotoxicity, even at longer exposure time (IC50 from 284.06 ± 17.01 µg/mL (SV-80) to 869.88 ± 62.45 µg/mL (MCF-7), at 48 h). To the best of our knowledge, this is the first report that compares the cytotoxic profile of CTAB-SLNs and DDAB-SLNs based on the concentration and time of exposure, using different cell lines. In conclusion, the choice of the right surfactant for biological applications influences the biocompatibility of the nanoparticles. Regardless the type of drug delivery system, not only the cytotoxicity of the drug-loaded nanoparticles should be assessed, but also the blank (non-loaded) nanoparticles as their surface properties play a decisive role both in vitro and in vivo.

Solid Lipid Nanoparticles for Topical Drug Delivery: Mechanisms, Dosage Form Perspectives, and Translational Status

2020 ◽  
Vol 26 (27) ◽  
pp. 3203-3217
Author(s):  
Mengyang Liu ◽  
Jingyuan Wen ◽  
Manisha Sharma
Keyword(s):  
Drug Delivery ◽  
Cellular Uptake ◽  
Solid Lipid Nanoparticles ◽  
Dosage Form ◽  
Scale Up ◽  
Form Factors ◽  
Skin Penetration ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Topical Applications

Solid lipid nanoparticles (SLNs) have shown potential as a novel lipid-based drug delivery system for the topical applications of innumerable therapeutic compounds. However, the mechanisms governing the absorption and cellular uptake of SLNs through topical route, along with the mechanism of drug release from SLNs are still ambiguous, and require further investigation. In addition, the selection of an appropriate dosage form/formulation base is essential for ease of application of SLNs and to enhance dermal and transdermal delivery. Upscaling and regulatory approvals are other challenges that may impede the clinical translation of SLNs. Therefore, this review focusses on different mechanisms involved in skin penetration and cellular uptake of SLNs. This is followed by a comprehensive discussion on the physicochemical properties of SLNs including various formulation and dosage form factors, which might influence the absorption of SLNs through the skin. Finally, translational status with respect to scale-up and regulatory aspects are also discussed. This review will be useful to researchers with an interest in topical applications of SLNs for the efficient delivery of drugs and cosmetics.

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